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| Latest Insider Trading | Top Insider Trading Recent Week | Top 10% Owner Trading Recent Week | Filter
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| Ticker | Owner | Relationship | Date | Transaction | Cost  |
#Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| SAGE | Greene Barry E | President and CEO | Nov 10 | Buy | 34.48 | 14,500 | 500,022 | 46,940 | Nov 15 04:04 PM |
| KPTI | Greene Barry E | Director | Aug 11 | Option Exercise | 1.49 | 7,576 | 11,250 | 13,606 | Aug 15 08:05 AM |
| SAGE | Greene Barry E | President and CEO | Aug 05 | Buy | 43.15 | 23,640 | 1,020,054 | 32,440 | Aug 09 09:07 AM |
| SAGE | Greene Barry E | President and CEO | Jun 16 | Buy | 56.32 | 8,800 | 495,627 | 8,800 | Jun 17 09:14 AM |
| ALNY | Greene Barry E | President | Sep 09 | Option Exercise | 9.14 | 44,530 | 407,004 | 114,873 | Sep 11 05:11 PM |
| ALNY | Greene Barry E | President | Sep 09 | Sale | 123.23 | 44,530 | 5,487,594 | 70,343 | Sep 11 05:11 PM |
| ALNY | Greene Barry E | President | Aug 10 | Option Exercise | 70.95 | 4,931 | 349,871 | 67,167 | Aug 11 04:09 PM |
| ALNY | Greene Barry E | President | Jul 07 | Option Exercise | 9.14 | 22,265 | 203,502 | 84,501 | Jul 09 04:02 PM |
| ALNY | Greene Barry E | President | Jul 07 | Sale | 159.99 | 22,265 | 3,562,177 | 62,236 | Jul 09 04:02 PM |
| ALNY | Greene Barry E | President | May 06 | Option Exercise | 9.14 | 22,265 | 203,502 | 84,501 | May 07 04:09 PM |
| ALNY | Greene Barry E | President | May 06 | Sale | 149.99 | 22,265 | 3,339,527 | 62,236 | May 07 04:09 PM |
| KPTI | Greene Barry E | Director | Mar 13 | Option Exercise | 0.03 | 3,030 | 100 | 6,030 | Mar 17 05:35 PM |
| ALNY | Greene Barry E | President | Oct 22 | Option Exercise | 16.43 | 58,913 | 967,941 | 111,851 | Oct 24 04:04 PM |
| ALNY | Greene Barry E | President | Oct 22 | Sale | 89.99 | 58,913 | 5,301,581 | 52,938 | Oct 24 04:04 PM |
| ACOR | Greene Barry E | Director | May 21 | Option Exercise | 20.16 | 10,000 | 201,600 | 10,000 | May 23 07:35 AM |
| ALNY | Greene Barry E | President | Mar 14 | Sale | 143.10 | 38,460 | 5,503,736 | 61,968 | Mar 16 05:05 PM |
| ALNY | Greene Barry E | President | Oct 02 | Option Exercise | 21.35 | 85,316 | 1,821,497 | 185,744 | Oct 04 07:45 PM |
| ALNY | Greene Barry E | President | Oct 02 | Sale | 125.00 | 85,316 | 10,664,500 | 100,428 | Oct 04 07:45 PM |
| ALNY | Greene Barry E | President | Sep 20 | Option Exercise | 31.39 | 76,815 | 2,411,223 | 165,399 | Sep 22 05:05 PM |
| ALNY | Greene Barry E | President | Sep 21 | Option Exercise | 12.33 | 11,844 | 146,042 | 100,428 | Sep 22 05:05 PM |
| ALNY | Greene Barry E | President | Sep 20 | Sale | 100.00 | 76,815 | 7,681,500 | 88,584 | Sep 22 05:05 PM |
| ACOR | Greene Barry E | Director | Aug 01 | Option Exercise | 18.21 | 10,000 | 182,100 | 10,000 | Aug 03 04:06 PM |
| ACOR | Greene Barry E | Director | Aug 01 | Sale | 21.57 | 10,000 | 215,697 | 0 | Aug 03 04:06 PM |
| ACOR | Greene Barry E | Director | Feb 09 | Option Exercise | 22.13 | 723 | 16,000 | 723 | Feb 13 04:14 PM |
| ACOR | Greene Barry E | Director | Feb 09 | Sale | 22.65 | 723 | 16,376 | 0 | Feb 13 04:14 PM |
| ACOR | Greene Barry E | Director | Jan 03 | Option Exercise | 15.91 | 3,017 | 48,000 | 3,017 | Jan 05 04:12 PM |
| ACOR | Greene Barry E | Director | Jan 03 | Sale | 19.26 | 3,017 | 58,113 | 0 | Jan 05 04:12 PM |
| ALNY | Greene Barry E | President | Dec 01 | Option Exercise | 22.75 | 55,605 | 1,265,014 | 120,409 | Dec 05 04:55 PM |
| ALNY | Greene Barry E | President | Dec 01 | Sale | 42.99 | 31,825 | 1,368,128 | 88,584 | Dec 05 04:55 PM |
| ALNY | Greene Barry E | President and COO | Mar 24 | Option Exercise | 8.20 | 16,540 | 135,672 | 64,804 | Mar 28 05:27 PM |
| ALNY | Greene Barry E | President and COO | Aug 04 | Option Exercise | 18.73 | 26,972 | 505,124 | 50,364 | Aug 06 05:32 PM |
| ALNY | Greene Barry E | President and COO | May 26 | Option Exercise | 13.12 | 67,379 | 884,012 | 90,771 | May 28 04:16 PM |
| ALNY | Greene Barry E | President and COO | May 26 | Sale | 125.00 | 67,379 | 8,422,375 | 23,392 | May 28 04:16 PM |
| KPTI | Greene Barry E | Director | Apr 02 | Buy | 29.31 | 3,000 | 87,938 | 3,000 | Apr 06 05:57 PM |
| ALNY | Greene Barry E | President and COO | Dec 22 | Option Exercise | 13.12 | 1,000 | 13,120 | 23,392 | Dec 22 05:30 PM |
| ALNY | Greene Barry E | President and COO | Dec 19 | Sale | 100.00 | 11,200 | 1,120,000 | 22,392 | Dec 22 05:30 PM |
| ALNY | Greene Barry E | President and COO | Nov 17 | Option Exercise | 6.78 | 33,200 | 225,096 | 66,792 | Nov 19 05:52 PM |
| ALNY | Greene Barry E | President and COO | Nov 17 | Sale | 89.63 | 33,200 | 2,975,780 | 33,592 | Nov 19 05:52 PM |
| ALNY | Greene Barry E | President and COO | Nov 11 | Option Exercise | 6.78 | 11,100 | 75,258 | 44,692 | Nov 13 05:05 PM |
| ALNY | Greene Barry E | President and COO | Nov 11 | Sale | 100.00 | 11,100 | 1,110,000 | 33,592 | Nov 13 05:05 PM |
| ALNY | Greene Barry E | President and COO | Feb 03 | Option Exercise | 6.78 | 19,500 | 132,210 | 35,272 | Feb 04 05:41 PM |
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