MUELLER PETER - Insider Transactions

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Ticker	Owner	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jun 16 '14	Option Exercise	32.16	7,500	241,200	151,017	Jun 18 04:16 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jun 16 '14	Sale	68.31	7,500	512,352	143,517	Jun 18 04:16 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	May 14 '14	Option Exercise	32.16	7,500	241,200	151,017	May 16 04:06 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	May 14 '14	Sale	67.45	7,500	505,849	143,517	May 16 04:06 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Mar 17 '14	Option Exercise	28.84	7,500	216,300	166,250	Mar 19 04:16 PM

VRTX	MUELLER PETER	EVP, Global R&D, CSO	Mar 17 '14	Sale	78.29	7,500	587,145	158,750	Mar 19 04:16 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Feb 18 '14	Option Exercise	28.84	7,500	216,300	166,250	Feb 20 04:07 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Feb 18 '14	Sale	82.59	7,500	619,442	158,750	Feb 20 04:07 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jan 15 '14	Option Exercise	28.84	7,500	216,300	149,000	Jan 17 04:16 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jan 15 '14	Sale	78.67	7,500	590,025	141,500	Jan 17 04:16 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Dec 16 '13	Option Exercise	28.84	7,500	216,300	149,000	Dec 17 04:21 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Dec 16 '13	Sale	64.69	7,500	485,142	141,500	Dec 17 04:21 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Dec 12 '13	Sale	65.48	2,900	189,892	141,500	Dec 12 05:51 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Nov 15 '13	Option Exercise	24.88	7,500	186,570	151,900	Nov 19 04:18 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Nov 15 '13	Sale	62.61	7,500	469,606	144,400	Nov 19 04:18 PM

VRTX	MUELLER PETER	EVP, Global R&D, CSO	Oct 15 '13	Option Exercise	18.93	7,500	141,975	151,900	Oct 17 04:07 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Oct 15 '13	Sale	73.25	7,500	549,365	144,400	Oct 17 04:07 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Sep 16 '13	Option Exercise	18.93	7,500	141,975	151,900	Sep 17 04:13 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Sep 16 '13	Sale	77.22	7,500	579,160	144,400	Sep 17 04:13 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Aug 15 '13	Option Exercise	18.93	7,500	141,975	151,900	Aug 19 04:16 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Aug 15 '13	Sale	77.41	7,500	580,560	144,400	Aug 19 04:16 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jul 15 '13	Option Exercise	18.93	7,500	141,975	151,900	Jul 17 04:38 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jul 15 '13	Sale	86.34	7,500	647,517	144,400	Jul 17 04:38 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jul 02 '13	Option Exercise	30.80	122,300	3,766,911	266,700	Jul 03 04:43 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jul 02 '13	Sale	79.80	122,300	9,758,932	144,400	Jul 03 04:43 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Oct 15 '12	Option Exercise	16.32	6,500	106,080	138,816	Oct 16 04:43 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Oct 15 '12	Sale	52.93	6,500	344,015	132,316	Oct 16 04:43 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Sep 17 '12	Option Exercise	16.32	6,500	106,080	138,816	Sep 19 05:05 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Sep 17 '12	Sale	57.52	6,500	373,880	132,316	Sep 19 05:05 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Aug 15 '12	Option Exercise	16.32	6,500	106,080	138,816	Aug 17 02:19 PM

VRTX	MUELLER PETER	EVP, Global R&D, CSO	Aug 15 '12	Sale	54.13	6,500	351,846	132,316	Aug 17 02:19 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jul 16 '12	Option Exercise	16.32	6,500	106,080	138,816	Jul 18 03:46 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jul 16 '12	Sale	52.78	6,500	343,060	132,316	Jul 18 03:46 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jun 15 '12	Option Exercise	16.32	6,500	106,080	138,816	Jun 19 04:21 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jun 15 '12	Sale	56.37	6,500	366,405	132,316	Jun 19 04:21 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	May 15 '12	Option Exercise	16.32	6,500	106,080	138,816	May 16 04:36 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	May 15 '12	Sale	64.28	6,500	417,824	132,316	May 16 04:36 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	May 07 '12	Option Exercise	16.93	79,500	1,346,025	227,736	May 09 04:37 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	May 07 '12	Sale	53.03	79,500	4,216,085	148,236	May 09 04:37 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Sep 20 '11	Option Exercise	17.66	25,000	441,390	158,735	Sep 21 02:35 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Sep 20 '11	Sale	52.50	25,000	1,312,500	133,735	Sep 21 02:35 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Sep 15 '11	Option Exercise	11.27	9,500	107,065	143,235	Sep 16 01:10 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Sep 15 '11	Sale	50.19	9,500	476,848	133,735	Sep 16 01:10 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Aug 29 '11	Option Exercise	10.88	9,500	103,367	143,235	Aug 30 03:44 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Aug 29 '11	Sale	45.01	9,500	427,595	133,735	Aug 30 03:44 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jul 15 '11	Option Exercise	10.41	2,500	26,025	136,235	Jul 18 02:14 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jul 15 '11	Sale	50.68	2,500	126,700	133,735	Jul 18 02:14 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jun 15 '11	Option Exercise	10.41	2,500	26,025	136,235	Jun 16 02:47 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jun 15 '11	Sale	46.68	2,500	116,698	133,735	Jun 16 02:47 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	May 16 '11	Option Exercise	10.41	2,500	26,025	136,235	May 18 01:45 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	May 16 '11	Sale	57.02	2,500	142,554	133,735	May 18 01:45 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Apr 25 '11	Option Exercise	16.32	12,500	204,000	146,235	Apr 26 03:41 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Apr 25 '11	Sale	50.00	12,500	625,000	133,735	Apr 26 03:41 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Apr 15 '11	Option Exercise	10.41	2,500	26,025	136,235	Apr 19 04:29 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Apr 15 '11	Sale	47.49	2,500	118,716	133,735	Apr 19 04:29 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Apr 11 '11	Option Exercise	15.95	40,000	638,025	173,735	Apr 13 02:01 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Apr 11 '11	Sale	48.03	40,000	1,921,020	133,735	Apr 13 02:01 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Nov 15 '10	Option Exercise	10.41	1,600	16,656	120,834	Nov 16 04:20 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Nov 15 '10	Sale	34.43	1,600	55,088	119,234	Nov 16 04:20 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Oct 15 '10	Option Exercise	10.41	1,600	16,656	120,834	Oct 18 03:08 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Oct 15 '10	Sale	35.65	1,600	57,035	119,234	Oct 18 03:08 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Sep 15 '10	Option Exercise	10.41	1,600	16,656	120,834	Sep 16 03:53 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Sep 15 '10	Sale	37.22	1,600	59,552	119,234	Sep 16 03:53 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Aug 16 '10	Option Exercise	10.41	1,600	16,656	120,834	Aug 17 02:08 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Aug 16 '10	Sale	36.38	1,600	58,208	119,234	Aug 17 02:08 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jul 15 '10	Option Exercise	10.41	1,600	16,656	120,834	Jul 16 04:02 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jul 15 '10	Sale	34.24	1,600	54,784	119,234	Jul 16 04:02 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jun 15 '10	Option Exercise	10.41	1,600	16,656	120,834	Jun 16 12:28 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jun 15 '10	Sale	34.93	1,600	55,888	119,234	Jun 16 12:28 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	May 17 '10	Option Exercise	10.41	1,600	16,656	120,834	May 18 03:16 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	May 17 '10	Sale	37.39	1,600	59,824	119,234	May 18 03:16 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	May 07 '10	Sale	35.97	6,271	225,571	119,234	May 10 04:53 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Apr 15 '10	Option Exercise	10.41	1,600	16,656	127,105	Apr 16 03:50 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Apr 15 '10	Sale	39.61	1,600	63,376	125,505	Apr 16 03:50 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Mar 15 '10	Option Exercise	10.41	1,600	16,656	127,105	Mar 16 04:20 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Mar 15 '10	Sale	43.08	1,600	68,928	125,505	Mar 16 04:20 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Feb 16 '10	Option Exercise	10.41	1,600	16,656	127,105	Feb 18 01:28 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Feb 16 '10	Sale	38.55	1,600	61,680	125,505	Feb 18 01:28 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Feb 03 '10	Sale	40.07	3,844	154,029	111,004	Feb 04 03:12 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	Jan 26 '10	Sale	39.39	2,026	79,804	114,848	Jan 27 05:03 PM
VRTX	MUELLER PETER	EVP Global R&D, CSO	Jan 15 '10	Option Exercise	10.41	1,600	16,656	118,474	Jan 19 01:33 PM
VRTX	MUELLER PETER	EVP Global R&D, CSO	Jan 15 '10	Sale	40.32	1,600	64,519	116,874	Jan 19 01:33 PM
VRTX	MUELLER PETER	EVP Global R&D, CSO	Dec 04 '09	Option Exercise	10.41	1,600	16,656	118,474	Dec 09 10:49 AM
VRTX	MUELLER PETER	EVP Global R&D, CSO	Dec 04 '09	Sale	39.62	1,600	63,392	116,874	Dec 09 10:49 AM
VRTX	MUELLER PETER	EVP Global R&D, CSO	Jul 15 '09	Option Exercise	9.69	2,400	23,256	119,274	Jul 17 09:32 AM
VRTX	MUELLER PETER	EVP Global R&D, CSO	Jul 15 '09	Sale	32.88	2,400	78,912	116,874	Jul 17 09:32 AM
VRTX	MUELLER PETER	EVP Global R&D, CSO	Jun 15 '09	Option Exercise	9.69	2,400	23,256	119,274	Jun 16 01:21 PM
VRTX	MUELLER PETER	EVP Global R&D, CSO	Jun 15 '09	Sale	31.02	2,400	74,448	116,874	Jun 16 01:21 PM
VRTX	MUELLER PETER	EVP Global R&D, CSO	May 15 '09	Option Exercise	9.69	2,400	23,256	119,274	May 19 02:22 PM
VRTX	MUELLER PETER	EVP Global R&D, CSO	May 15 '09	Sale	28.56	2,400	68,544	116,874	May 19 02:22 PM
VRTX	MUELLER PETER	EVP, Global R&D, CSO	May 07 '09	Sale	28.94	12,796	370,316	116,796	May 11 02:50 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Apr 15 '09	Option Exercise	9.69	2,400	23,256	132,070	Apr 16 01:39 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Apr 15 '09	Sale	26.98	2,400	64,752	129,670	Apr 16 01:39 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Mar 16 '09	Option Exercise	9.69	2,400	23,256	99,756	Mar 17 01:24 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Mar 16 '09	Sale	28.44	2,400	68,250	97,356	Mar 17 01:24 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Feb 17 '09	Option Exercise	9.69	2,400	23,256	99,756	Feb 19 04:10 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Feb 17 '09	Sale	32.88	2,400	78,912	97,356	Feb 19 04:10 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Feb 04 '09	Sale	33.65	1,118	37,622	85,272	Feb 06 04:19 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Jan 15 '09	Option Exercise	9.07	2,400	21,768	88,790	Jan 16 12:35 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Jan 15 '09	Sale	29.63	2,400	71,112	86,390	Jan 16 12:35 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Dec 15 '08	Option Exercise	9.07	2,400	21,768	88,790	Dec 16 01:25 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Dec 15 '08	Sale	25.81	2,400	61,944	86,390	Dec 16 01:25 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Nov 17 '08	Option Exercise	9.07	2,400	21,768	88,790	Nov 19 12:28 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Nov 17 '08	Sale	27.14	2,400	65,136	86,390	Nov 19 12:28 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Oct 15 '08	Option Exercise	9.07	2,400	21,768	88,790	Oct 16 03:29 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Oct 15 '08	Sale	26.69	2,400	64,049	86,390	Oct 16 03:29 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Sep 17 '08	Option Exercise	9.07	2,400	21,768	88,790	Sep 19 11:31 AM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Sep 17 '08	Sale	27.94	2,400	67,056	86,390	Sep 19 11:31 AM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Jul 15 '08	Option Exercise	9.07	2,400	21,768	88,790	Jul 17 12:37 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	Jul 15 '08	Sale	32.40	2,400	77,760	86,390	Jul 17 12:37 PM
VRTX	MUELLER PETER	EVP Drug Innov.& Realiz, CSO	May 13 '08	Sale	27.12	1,541	41,794	86,390	May 15 03:10 PM

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MUELLER PETER - Insider Transactions

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