Insider Trading |
Relationship |
Date |
Transaction |
Cost |
#Shares |
Value ($) |
#Shares Total |
SEC Form 4 |
Valentine Karen | See Remarks | Jan 19 | Option Exercise | 11.50 | 17,203 | 197,835 | 17,203 | Jan 20 05:56 PM | Valentine Karen | See Remarks | Jan 19 | Sale | 33.97 | 17,203 | 584,463 | 0 | Jan 20 05:56 PM | Reeve Emma | Chief Financial Officer | Dec 21 | Option Exercise | 6.81 | 5,720 | 38,975 | 5,720 | Dec 22 04:53 PM | GOLDSMITH MARK A | Director | Dec 21 | Sale | 35.02 | 4,020 | 140,769 | 139,043 | Dec 28 04:02 PM | Reeve Emma | Chief Financial Officer | Dec 21 | Sale | 35.11 | 5,720 | 200,805 | 0 | Dec 22 04:53 PM | Reeve Emma | Chief Financial Officer | Jun 08 | Option Exercise | 7.60 | 589 | 4,476 | 589 | Jun 10 06:50 PM | Reeve Emma | Chief Financial Officer | Jun 08 | Sale | 37.55 | 589 | 22,118 | 0 | Jun 10 06:50 PM | Raythatha Jigar | See Remarks | May 12 | Option Exercise | 5.51 | 9,209 | 50,742 | 24,170 | May 13 06:25 PM | GOLDSMITH MARK A | Director | May 12 | Option Exercise | 4.12 | 4,225 | 17,399 | 147,288 | May 13 06:29 PM | Senderowicz Adrian | Chief Medical Officer | May 12 | Option Exercise | 5.51 | 9,357 | 51,557 | 25,241 | May 13 06:30 PM | Audia James E | Director | May 12 | Sale | 50.10 | 6,100 | 305,622 | 25,434 | May 13 06:30 PM | Senderowicz Adrian | Chief Medical Officer | May 12 | Sale | 50.18 | 9,357 | 469,488 | 15,884 | May 13 06:30 PM | GOLDSMITH MARK A | Director | May 12 | Sale | 50.05 | 4,225 | 211,474 | 143,063 | May 13 06:29 PM | Raythatha Jigar | See Remarks | May 12 | Sale | 50.17 | 9,209 | 461,981 | 14,961 | May 13 06:25 PM | Reeve Emma | Chief Financial Officer | May 11 | Option Exercise | 8.92 | 16,062 | 143,269 | 16,062 | May 12 09:41 PM | Raythatha Jigar | See Remarks | May 11 | Option Exercise | 5.51 | 26 | 143 | 14,987 | May 13 06:25 PM | GOLDSMITH MARK A | Director | May 11 | Option Exercise | 1.55 | 100 | 155 | 143,163 | May 13 06:29 PM | GOLDSMITH MARK A | Director | May 11 | Sale | 50.00 | 100 | 5,000 | 143,063 | May 13 06:29 PM | Raythatha Jigar | See Remarks | May 11 | Sale | 50.00 | 26 | 1,300 | 14,961 | May 13 06:25 PM | Reeve Emma | Chief Financial Officer | May 11 | Sale | 49.53 | 16,062 | 795,623 | 0 | May 12 09:41 PM | Reeve Emma | Chief Financial Officer | May 08 | Option Exercise | 9.85 | 12,741 | 125,467 | 12,741 | May 12 09:41 PM | Reeve Emma | Chief Financial Officer | May 08 | Sale | 49.53 | 12,741 | 631,055 | 0 | May 12 09:41 PM | GOLDSMITH MARK A | Director | May 06 | Option Exercise | 4.26 | 11,463 | 48,825 | 154,526 | May 07 04:25 PM | Valentine Karen | See Remarks | May 06 | Option Exercise | 10.96 | 12,566 | 137,749 | 12,566 | May 07 04:34 PM | Trojer Patrick | Chief Scientific Officer | May 06 | Option Exercise | 7.04 | 10,000 | 70,385 | 10,000 | May 07 04:39 PM | Trojer Patrick | Chief Scientific Officer | May 06 | Sale | 45.16 | 10,000 | 451,553 | 0 | May 07 04:39 PM | Valentine Karen | See Remarks | May 06 | Sale | 40.10 | 12,566 | 503,897 | 0 | May 07 04:34 PM | Audia James E | Director | May 06 | Sale | 45.15 | 7,500 | 338,600 | 31,534 | May 07 04:28 PM | GOLDSMITH MARK A | Director | May 06 | Sale | 45.06 | 11,463 | 516,545 | 143,063 | May 07 04:25 PM | GOLDSMITH MARK A | Director | May 05 | Option Exercise | 3.50 | 3,145 | 11,006 | 146,208 | May 07 04:25 PM | Valentine Karen | See Remarks | May 05 | Option Exercise | 11.50 | 4,744 | 54,556 | 4,744 | May 07 04:34 PM | Valentine Karen | See Remarks | May 05 | Sale | 40.01 | 4,744 | 189,817 | 0 | May 07 04:34 PM | GOLDSMITH MARK A | Director | May 05 | Sale | 40.01 | 3,145 | 125,824 | 143,063 | May 07 04:25 PM | Valentine Karen | See Remarks | Apr 27 | Option Exercise | 11.50 | 400 | 4,600 | 400 | Apr 29 08:03 PM | GOLDSMITH MARK A | Director | Apr 27 | Option Exercise | 1.55 | 400 | 620 | 143,463 | Apr 29 08:20 PM | Valentine Karen | See Remarks | Apr 27 | Sale | 40.13 | 400 | 16,052 | 0 | Apr 29 08:03 PM | GOLDSMITH MARK A | Director | Apr 27 | Sale | 40.12 | 400 | 16,049 | 143,063 | Apr 29 08:20 PM | Valentine Karen | See Remarks | Apr 20 | Option Exercise | 11.50 | 789 | 9,074 | 789 | Apr 22 08:17 PM | Valentine Karen | See Remarks | Apr 20 | Sale | 33.65 | 789 | 26,550 | 0 | Apr 22 08:17 PM | Reeve Emma | Chief Financial Officer | Apr 17 | Option Exercise | 6.61 | 760 | 5,024 | 760 | Apr 20 05:53 PM | Valentine Karen | See Remarks | Apr 17 | Option Exercise | 11.50 | 2,300 | 26,450 | 2,300 | Apr 20 05:52 PM | Valentine Karen | See Remarks | Apr 17 | Sale | 35.19 | 2,300 | 80,939 | 0 | Apr 20 05:52 PM | Reeve Emma | Chief Financial Officer | Apr 17 | Sale | 35.29 | 760 | 26,820 | 0 | Apr 20 05:53 PM | Valentine Karen | See Remarks | Apr 16 | Option Exercise | 11.50 | 2,998 | 34,477 | 2,998 | Apr 20 05:52 PM | Valentine Karen | See Remarks | Apr 16 | Sale | 33.57 | 2,998 | 100,637 | 0 | Apr 20 05:52 PM | Reeve Emma | Chief Financial Officer | Apr 14 | Option Exercise | 8.76 | 1,225 | 10,731 | 1,225 | Apr 16 02:31 PM | Reeve Emma | Chief Financial Officer | Apr 14 | Sale | 35.20 | 1,225 | 43,123 | 0 | Apr 16 02:31 PM | Valentine Karen | See Remarks | Apr 09 | Option Exercise | 8.76 | 635 | 5,563 | 635 | Apr 13 04:56 PM | Reeve Emma | Chief Financial Officer | Apr 09 | Option Exercise | 7.78 | 700 | 5,449 | 589 | Apr 13 04:55 PM | Reeve Emma | Chief Financial Officer | Apr 09 | Sale | 35.02 | 700 | 24,513 | 0 | Apr 13 04:55 PM | Valentine Karen | See Remarks | Apr 09 | Sale | 35.02 | 635 | 22,236 | 0 | Apr 13 04:56 PM | COLUMN GROUP L P | 10% Owner | Mar 20 | Buy | 23.15 | 5,539 | 128,228 | 6,051,376 | Mar 23 06:57 PM | COLUMN GROUP L P | 10% Owner | Mar 20 | Buy | 23.15 | 5,539 | 128,228 | 6,051,376 | Mar 23 06:59 PM | COLUMN GROUP L P | 10% Owner | Mar 19 | Buy | 22.38 | 36,135 | 808,701 | 6,045,837 | Mar 23 06:59 PM | COLUMN GROUP L P | 10% Owner | Mar 19 | Buy | 22.38 | 36,135 | 808,701 | 6,045,837 | Mar 23 06:57 PM | Valentine Karen | See Remarks | Mar 09 | Option Exercise | 8.76 | 617 | 5,405 | 617 | Mar 11 04:11 PM | Valentine Karen | See Remarks | Mar 09 | Sale | 32.03 | 617 | 19,763 | 0 | Mar 11 04:11 PM | Reeve Emma | Chief Financial Officer | Feb 13 | Option Exercise | 8.04 | 5,521 | 44,389 | 5,521 | Feb 14 05:09 PM | Valentine Karen | See Remarks | Feb 13 | Option Exercise | 10.33 | 4,473 | 46,217 | 4,473 | Feb 14 05:09 PM | Valentine Karen | See Remarks | Feb 13 | Sale | 35.07 | 4,473 | 156,859 | 0 | Feb 14 05:09 PM | Reeve Emma | Chief Financial Officer | Feb 13 | Sale | 35.06 | 5,521 | 193,539 | 0 | Feb 14 05:09 PM | Valentine Karen | See Remarks | Feb 12 | Option Exercise | 11.50 | 1,500 | 17,250 | 1,500 | Feb 14 05:09 PM | Reeve Emma | Chief Financial Officer | Feb 12 | Option Exercise | 8.04 | 1,103 | 8,868 | 1,103 | Feb 14 05:09 PM | Valentine Karen | See Remarks | Feb 12 | Sale | 35.02 | 1,500 | 52,527 | 0 | Feb 14 05:09 PM | Reeve Emma | Chief Financial Officer | Feb 12 | Sale | 35.02 | 1,103 | 38,624 | 0 | Feb 14 05:09 PM | Reeve Emma | Chief Financial Officer | Feb 11 | Option Exercise | 7.67 | 8,642 | 66,308 | 7,212 | Feb 12 05:36 PM | Valentine Karen | See Remarks | Feb 11 | Option Exercise | 11.50 | 8,550 | 98,325 | 8,550 | Feb 12 05:36 PM | Valentine Karen | See Remarks | Feb 11 | Sale | 35.03 | 8,550 | 299,507 | 0 | Feb 12 05:36 PM | Reeve Emma | Chief Financial Officer | Feb 11 | Sale | 35.04 | 8,642 | 302,816 | 0 | Feb 12 05:36 PM | Reeve Emma | Chief Financial Officer | Feb 10 | Option Exercise | 7.60 | 200 | 1,520 | 200 | Feb 12 05:36 PM | Valentine Karen | See Remarks | Feb 10 | Option Exercise | 11.50 | 14,096 | 162,104 | 14,096 | Feb 12 05:36 PM | Valentine Karen | See Remarks | Feb 10 | Sale | 33.51 | 14,096 | 472,357 | 0 | Feb 12 05:36 PM | Reeve Emma | Chief Financial Officer | Feb 10 | Sale | 35.00 | 200 | 7,000 | 0 | Feb 12 05:36 PM |
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