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Exelixis (EXEL) Rated Equalweight by Barclays Amid Cancer Drug Outlook

By Sheryar Siddiq | September 27, 2025, 12:59 AM

Exelixis, Inc. (NASDAQ:EXEL) ranks among the most undervalued NASDAQ stocks to buy now. On September 17, Barclays began coverage of Exelixis, Inc. (NASDAQ:EXEL), rating it Equalweight and setting a price target of $40 on the company’s shares. The firm forecasts cabozantinib, Exelixis’ major value driver, will climb in the mid-single digits until its patent expires in 2029.

Photo by National Cancer Institute on Unsplash

Barclays predicts overall revenue for 2029 to be around 8% lower than consensus, owing mostly to decreased sales contribution expectations from Exelixis, Inc. (NASDAQ:EXEL) pipeline products. Based on the current sales trajectory of cabozantinib, the firm sees possible downside risks to both its own and consensus expectations.

Meanwhile, Zanzalintinib, Exelixis’ key pipeline candidate, has the potential to improve colorectal cancer and non-clear cell renal carcinoma treatments in the near future. However, Barclays believes that zanzalintinib will find it difficult to proceed to earlier treatment lines in colorectal cancer due to the competitive landscape.

Exelixis, Inc. (NASDAQ:EXEL) focuses on developing targeted cancer treatments. The company specializes in molecular therapies that treat difficult-to-treat cancers by targeting particular mutations in the genome.

While we acknowledge the potential of EXEL as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you're looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock.

READ NEXT: 10 Best Magic Formula Stocks for 2025 and 10 Best Retirement Stocks to Buy According to Hedge Funds.

Disclosure: None. This article is originally published at Insider Monkey.

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