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Exelixis (EXEL) Loses 12% on Cancer Treatment Trial Results

By Angelica Ballesteros | October 21, 2025, 12:54 PM

We recently published 10 Stocks With Massive Losses; AI Stocks Not Spared. Exelixis, Inc. (NASDAQ:EXEL) is one of the worst performers on Monday.

Exelixis tumbled by 12 percent on Monday to close at $34.54 apiece as unimpressed investors soured on the results of its phase 3 trial for the study of Zanzalintinib for colon cancer.

In an updated report, Exelixis, Inc. (NASDAQ:EXEL) said the drug candidate—Zanzalintinib, in combination with atezolizumab—improved median overall survival to 10.9 months versus 9.4 months with regorafenib, significantly reducing the risk of death by 20 percent in the intention-to-treat population.

“While treating non-MSI-high metastatic colorectal cancer remains a challenge, the combination of zanzalintinib and atezolizumab has shown consistent benefits across key subgroups of patients,” said University of Pittsburgh Section Chief of Gastrointestinal Oncology Anwaar Saeed.

Exelixis (EXEL) Loses 12% on Cancer Treatment Trial Results

Exelixis, Inc. (NASDAQ:EXEL) EVP for Research and Development Dana Aftab said that the results from the latest clinical trial provide further insight into the combination of zanzalintinib and atezolizumab “as a potential new option” to extend survival in patients with the said type of cancer.

While we acknowledge the potential of EXEL as an investment, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an extremely cheap AI stock that is also a major beneficiary of Trump tariffs and onshoring, see our free report on the best short-term AI stock.

READ NEXT: 30 Stocks That Should Double in 3 Years and 11 Hidden AI Stocks to Buy Right Now.

Disclosure: None. This article is originally published at Insider Monkey.

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