enGene Holdings Inc (ENGN) Surging After Positive Phase 2 LEGEND Trial

By Talha Qureshi | December 04, 2025, 10:09 PM

​enGene Holdings Inc. (NASDAQ:ENGN) is one of the Best Up and Coming Canadian Stocks to Buy. enGene Holdings Inc. (NASDAQ:ENGN) has gained more than 31% since the company reported positive results from its Phase 2 LEGEND trial on November 11.

​Wall Street also maintains a positive outlook with analysts’ 12-month price target of $23 reflecting more than 190% upside from the current level. On November 12, David Dai from UBS reiterated a Hold rating on the stock with a $10 price target. On the same day, Judah Frommer from Morgan Stanley reiterated a Buy rating on the stock with a price target of $18.

​enGene Holdings Inc. (NASDAQ:ENGN) reported an improved complete response rate of 62% at 6 months of Detalimogene voraplasmid to treat high-risk, BCG-unresponsive non-muscle invasive bladder cancer. Management noted that at 3 months, the complete response rate was 56% However, at 6 months, the response rate improved to 62% among 37 patients.

​The preliminary data from the trial suggest that the company remains on track for its planned Biologics License Application submission in the second half of 2026.

​enGene Holdings Inc. (NASDAQ:ENGN) is a clinical-stage biotechnology company developing non-viral genetic medicines for the delivery of therapeutics to mucosal tissues and other organs.

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Disclosure: None. This article is originally published at Insider Monkey.

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