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Apellis Pharmaceuticals (APLS) Q4 Earnings: How Key Metrics Compare to Wall Street Estimates

By Zacks Equity Research | February 24, 2026, 11:00 AM

For the quarter ended December 2025, Apellis Pharmaceuticals, Inc. (APLS) reported revenue of $199.91 million, down 5.9% over the same period last year. EPS came in at $0.47, compared to -$0.29 in the year-ago quarter.

The reported revenue compares to the Zacks Consensus Estimate of $194.37 million, representing a surprise of +2.85%. The company delivered an EPS surprise of +219.14%, with the consensus EPS estimate being -$0.40.

While investors scrutinize revenue and earnings changes year-over-year and how they compare with Wall Street expectations to determine their next move, some key metrics always offer a more accurate picture of a company's financial health.

Since these metrics play a crucial role in driving the top- and bottom-line numbers, comparing them with the year-ago numbers and what analysts estimated about them helps investors better project a stock's price performance.

Here is how Apellis Pharmaceuticals performed in the just reported quarter in terms of the metrics most widely monitored and projected by Wall Street analysts:
  • Revenue- Product revenue, net: $190.34 million versus $187.07 million estimated by nine analysts on average. Compared to the year-ago quarter, this number represents a -0.4% change.
  • Revenue- Licensing and other revenue: $9.57 million versus the nine-analyst average estimate of $7.31 million. The reported number represents a year-over-year change of -55.2%.
  • Product Revenue- EMPAVELI: $35.1 million versus the eight-analyst average estimate of $28.51 million. The reported number represents a year-over-year change of +50.3%.
  • Product Revenue- SYFOVRE: $155.2 million versus the eight-analyst average estimate of $154.18 million. The reported number represents a year-over-year change of -7.5%.

View all Key Company Metrics for Apellis Pharmaceuticals here>>>

Shares of Apellis Pharmaceuticals have returned +2.2% over the past month versus the Zacks S&P 500 composite's -1% change. The stock currently has a Zacks Rank #3 (Hold), indicating that it could perform in line with the broader market in the near term.

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This article originally published on Zacks Investment Research (zacks.com).

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