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Here's What Analysts Are Saying About Vertex Pharmaceuticals (VRTX)

By Noor Ul Ain Rehman | February 28, 2026, 2:21 AM

Vertex Pharmaceuticals Incorporated (NASDAQ:VRTX) is one of the top gene therapy stocks to buy according to hedge funds. Canaccord lifted the price target on Vertex Pharmaceuticals Incorporated (NASDAQ:VRTX) to $441 from $411 on February 17 and maintained a Hold rating on the shares, telling investors that it updated its model after the fiscal Q4 results delivered the familiar top and bottom line beat. The firm also stated that Trikafta revenue came in slightly below consensus and Alyftrek slightly above. The same day, Barclays also adjusted the price target on Vertex Pharmaceuticals Incorporated (NASDAQ:VRTX) to $607 from $606 and maintained an Overweight rating on the shares after the fiscal Q4 report.

Is Vertex Pharmaceuticals Incorporated (VRTX) the Best Stock to Buy According to Jim Simons’ Renaissance Technologies?

In another development, H.C. Wainwright lifted the price target on Vertex Pharmaceuticals Incorporated (NASDAQ:VRTX) to $591 from $518 on February 17, reaffirming a Buy rating on the shares and stating that it views povetacicept as “the best-in-class contender” in primary membranous nephropathy following Roche’s Phase 3 MAJESTY study.

The rating updates came after Vertex Pharmaceuticals Incorporated (NASDAQ:VRTX) released its fiscal Q4 and full year 2025 earnings on February 12, reporting a full year total revenue of $12.0 billion, reflecting a 9% growth compared to full year 2024. Total revenue for fiscal Q4 came up to $3.19 billion, up 10% compared to the prior year period.

Vertex Pharmaceuticals Incorporated (NASDAQ:VRTX) is a global biotechnology company that develops medicines for rare, serious diseases. The company’s product pipeline includes clinical-stage programs for various disorders, including TDT, SCD, CF, acute and neuropathic pain, APOL1-mediated kidney disease, type 1 diabetes, myotonic dystrophy type 1, and alpha-1 antitrypsin deficiency.

While we acknowledge the potential of VRTX as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you’re looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock.

READ NEXT: 30 Stocks That Should Double in 3 Years and 11 Hidden AI Stocks to Buy Right Now.

Disclosure: None. This article is originally published at Insider Monkey.

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