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Dosing underway in Phase 2a multidose portion of the INLIGHTTM trial of WVE-007 (INHBE GalNAc-siRNA) in individuals with obesity (BMI: 35-50 kg/m2) and comorbidities; trial will also inform WVE-007's potential in MASH, type 2 diabetes, and other cardiometabolic diseases
Phase 2 combination with incretin and post-incretin maintenance trials of WVE-007 on track to initiate in 2H 2026
FDA meeting scheduled for end of summer 2026 on potential accelerated approval pathway for WVE-006 (GalNAc-RNA editing); data from RestorAATion-2 trial support differentiated therapeutic approach for both lung and liver manifestations of AATD
CTA submission for WVE-008 for PNPLA3 liver disease (GalNAc-RNA editing) on track for 2H 2026
Well capitalized with cash, cash equivalents, and marketable securities of $490.6 million as of June 30, 2026 and expected cash runway into 3Q 2028
Investor conference call and webcast at 8:30 a.m. ET today
CAMBRIDGE, Mass., July 30, 2026 (GLOBE NEWSWIRE) -- Wave Life Sciences Ltd. (Nasdaq: WVE), a clinical-stage biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health, today announced financial results for the second quarter ended June 30, 2026, and provided a business update.
“Our second quarter performance reflects disciplined execution across the pipeline,” said Paul Bolno, MD, MBA, President and Chief Executive Officer at Wave Life Sciences. “We recently initiated dosing in the Phase 2a portion of our INLIGHT trial in obesity. Our Phase 1 clinical data have already demonstrated substantial reductions of fat – particularly harmful visceral fat – without muscle loss, and with the potential for once or twice-yearly dosing. We expect the Phase 2a portion of the INLIGHT trial, in individuals with higher BMI and higher body fat, to demonstrate WVE-007's broad potential to deliver even greater fat loss and improvements in body composition, as well as benefits across additional cardiometabolic biomarkers such as liver fat. In tandem with this progress, we are working expeditiously to initiate Phase 2 trials evaluating WVE-007 in combination with incretins and as post-incretin maintenance; we believe WVE-007 has the potential to transform the current obesity treatment landscape.”
Dr. Bolno added, “In RNA editing, our RestorAATion-2 clinical data support WVE-006’s potential to offer a new standard of care for individuals living with AATD by treating both lung and liver manifestations of the disease, and restoring dynamic response of AAT protein, with convenient, infrequent subcutaneous dosing, and without the risks associated with DNA editing. We look forward to meeting with the FDA to discuss a pathway for accelerated approval for WVE-006. Building on our clinical success in RNA editing, WVE-008, our PNPLA3 RNA editing program, has the potential to address the nine million individuals living with this genetic liver disease. It’s exciting to see the clinical translation of our RNAi and RNA editing programs, enabled by our unique and proprietary chemistry, and supported by human genetics. We expect to provide further updates on our pipeline and platform innovations at our annual investor day this fall.”
Recent Business Highlights and Expected Milestones
Obesity
Alpha-1 antitrypsin deficiency (AATD)
PNPLA3 I148M liver disease
Other pipeline programs (HD and DMD)
Emerging pipeline
Financial Highlights
Investor Conference Call and Webcast
Wave will host an investor conference call today at 8:30 a.m. ET to review the second quarter 2026 financial results and pipeline updates. A webcast of the conference call can be accessed by visiting “Investor Events” on the investor relations section of the Wave Life Sciences website: https://ir.wavelifesciences.com/events-publications/events. Analysts planning to participate during the Q&A portion of the live call can join the conference call at the audio-conferencing link here. Following the live event, an archived version of the webcast will be available on the Wave Life Sciences website.
About Wave Life Sciences
Wave Life Sciences (Nasdaq: WVE) is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Wave’s PRISM® platform combines multiple modalities, chemistry innovation, and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and common disorders. Its toolkit of RNA-targeting modalities, including RNAi (SpiNA) and RNA editing (AIMers), provides Wave with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Wave’s pipeline is focused on its obesity (WVE-007), alpha-1 antitrypsin deficiency (WVE-006) and PNPLA3 I148M liver disease (WVE-008) programs, and also includes clinical programs in Duchenne muscular dystrophy and Huntington’s disease, as well as several preclinical programs utilizing the company’s versatile RNA medicines platform. Driven by the calling to “Reimagine Possible,” Wave is leading the charge toward a world in which human potential is no longer hindered by the burden of disease. Wave is headquartered in Cambridge, MA. For more information on Wave’s science, pipeline and people, please visit www.wavelifesciences.com and follow Wave on X and LinkedIn.
Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, concerning our goals, beliefs, expectations, strategies, objectives and plans, and other statements that are not necessarily based on historical facts, including statements regarding the following, among others: the anticipated initiation, timing, design, progress, data and announcements related to our clinical trials, including interactions with and feedback from regulators and any potential registrational submissions based on these data; the future performance and results of our programs in clinical trials, including the anticipated therapeutic benefits of such programs, and our expectations with respect to how our clinical data may predict success for our future therapeutic candidates and data readouts; the potential commercialization of our programs the potential size of the markets that our therapeutics may address; preclinical activities and programs and their potential to transition into clinical-stage programs, and the timing, progress and announcement of such events; the progress and potential benefits, including the potential achievement of milestones, of collaborations and strategic partnerships; the expected benefits of our stereopure oligonucleotides compared with stereorandom oligonucleotides; the breadth and versatility of our PRISM® drug discovery and development platform; the potential benefits of our RNA-targeting modalities, including RNAi (SpiNA), and RNA editing (AIMers); the potential for certain of our programs to be best-in-class or first-in-class, or to change the existing treatment paradigm or show substantial benefits over existing standards of care; our financial performance, including the anticipated duration of our cash runway and our ability to fund future operations; our intended uses of capital; and our expectations regarding the impact of any potential global macro events on our business. The words “may,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “target” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual results to differ materially from those indicated by these forward-looking statements as a result of these risks, uncertainties and important factors, including, without limitation, the clinical results and timing of our programs, which may not support further development of our product candidates; actions of regulatory agencies, which may affect the initiation, timing and progress of clinical trials; our effectiveness in managing current and future clinical trials and regulatory processes; the continued development and acceptance of nucleic acid therapeutics as a class of drugs; our ability to demonstrate the therapeutic benefits of our stereopure candidates in clinical trials, including our ability to develop candidates across multiple therapeutic modalities; our ability to obtain, maintain and protect intellectual property; our ability to fund our operations and to raise additional capital as needed; competition from others developing therapies for similar uses; and any impacts on our business as a result of or related to any global economic uncertainty or market disruptions, as well as the other risks and uncertainties described in the section entitled “Risk Factors” in our most recent Annual Report on Form 10-K filed with the Securities and Exchange Commission (SEC), as amended, and in other filings we make with the SEC from time to time. In addition, any forward-looking statements represent our views only as of today and should not be relied upon as representing our views as of any subsequent date. We undertake no obligation, except to the extent required by law, to update the information contained in this press release to reflect subsequently occurring events or circumstances.
Contact:
Kate Rausch
VP, Corporate Affairs and Investor Relations
+1 617-949-4827
Investors:
James Salierno
Director, Investor Relations
+1 617-949-4043
InvestorRelations@wavelifesci.com
Media:
Katie Sullivan
Senior Director, Corporate Communications
+1 617-949-2936
MediaRelations@wavelifesci.com
Gabriely et al., Diabetes 2002; Campos et al., Diabetes & Vascular Disease Research 2019; Huang et al., Front Endocrinol 2023.; Cesaro et al., Front Cardiovasc Med 2023; Khawaja et, al., Curr Cardiol Rep 2024; Hiuge-Shimizu et al., J Atheroscler Thromb 2011.; Liao et al., PLoS ONE 2023; Jung et al., Endocrinol Metab 2020; Hanlon & Yuan, Clin Liver Dis 2021.; Liao et
al., PLoS ONE 2023; Jung et al., Endocrinol Metab 2020
| WAVE LIFE SCIENCES LTD. UNAUDITED CONSOLIDATED BALANCE SHEETS (In thousands, except share amounts) | ||||||||
| June 30, 2026 | December 31, 2025 | |||||||
| Assets | ||||||||
| Current assets: | ||||||||
| Cash and cash equivalents | $ | 368,008 | $ | 602,068 | ||||
| Marketable Securities | 122,594 | — | ||||||
| Accounts receivable | 888 | 1,276 | ||||||
| Prepaid expenses | 12,121 | 8,395 | ||||||
| Other current assets | 3,897 | 3,075 | ||||||
| Total current assets | 507,508 | 614,814 | ||||||
| Long-term assets: | ||||||||
| Property and equipment, net of accumulated depreciation of $50,819 and $49,522 as of June 30, 2026 and December 31, 2025, respectively | 6,833 | 7,405 | ||||||
| Operating lease right-of-use assets | 39,498 | 12,458 | ||||||
| Restricted cash | 3,815 | 3,806 | ||||||
| Other assets | 667 | 16 | ||||||
| Total long-term assets | 50,813 | 23,685 | ||||||
| Total assets | $ | 558,321 | $ | 638,499 | ||||
| Liabilities, Series A preferred shares, and shareholders’ equity | ||||||||
| Current liabilities: | ||||||||
| Accounts payable | $ | 20,362 | $ | 15,700 | ||||
| Accrued expenses and other current liabilities | 18,242 | 26,564 | ||||||
| Current portion of deferred revenue | 8,703 | 44,440 | ||||||
| Current portion of operating lease liability | 3,508 | 8,361 | ||||||
| Total current liabilities | 50,815 | 95,065 | ||||||
| Long-term liabilities: | ||||||||
| Deferred revenue, net of current portion | 13,904 | 7,798 | ||||||
| Operating lease liability, net of current portion | 40,082 | 9,405 | ||||||
| Total long-term liabilities | 53,986 | 17,203 | ||||||
| Total liabilities | $ | 104,801 | $ | 112,268 | ||||
| Series A preferred shares, no par value; nil and 3,901,348 shares issued and outstanding at June 30, 2026 and December 31, 2025, respectively | $ | — | $ | 7,874 | ||||
| Shareholders’ equity: | ||||||||
| Ordinary shares, no par value; 193,277,622 and 187,660,263 shares issued and outstanding at June 30, 2026 and December 31, 2025, respectively | $ | 1,627,209 | $ | 1,616,478 | ||||
| Additional paid-in capital | 248,161 | 228,365 | ||||||
| Accumulated other comprehensive loss | (172 | ) | (250 | ) | ||||
| Accumulated deficit | (1,421,678 | ) | (1,326,236 | ) | ||||
| Total shareholders’ equity | $ | 453,520 | $ | 518,357 | ||||
| Total liabilities, Series A preferred shares, and shareholders’ equity | $ | 558,321 | $ | 638,499 | ||||
| WAVE LIFE SCIENCES LTD. UNAUDITED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (In thousands, except share and per share amounts) | ||||||||||||||||
| Three Months Ended June 30, | Six Months Ended June 30, | |||||||||||||||
| 2026 | 2025 | 2026 | 2025 | |||||||||||||
| Revenue | $ | 2,272 | $ | 8,699 | $ | 40,518 | $ | 17,874 | ||||||||
| Operating expenses: | ||||||||||||||||
| Research and development | 51,293 | 43,469 | 98,733 | 84,091 | ||||||||||||
| General and administrative | 24,781 | 17,989 | 46,884 | 36,346 | ||||||||||||
| Total operating expenses | 76,074 | 61,458 | 145,617 | 120,437 | ||||||||||||
| Loss from operations | (73,802 | ) | (52,759 | ) | (105,099 | ) | (102,563 | ) | ||||||||
| Other income, net: | ||||||||||||||||
| Interest income | 4,722 | 2,372 | 10,013 | 5,247 | ||||||||||||
| Other expense | (275 | ) | (82 | ) | (356 | ) | (31 | ) | ||||||||
| Total other income, net | 4,447 | 2,290 | 9,657 | 5,216 | ||||||||||||
| Loss before income taxes | (69,355 | ) | (50,469 | ) | (95,442 | ) | (97,347 | ) | ||||||||
| Income tax benefit | — | — | — | — | ||||||||||||
| Net loss | $ | (69,355 | ) | $ | (50,469 | ) | $ | (95,442 | ) | $ | (97,347 | ) | ||||
| Net loss per share attributable to ordinary shareholders—basic and diluted | $ | (0.34 | ) | $ | (0.31 | ) | $ | (0.47 | ) | $ | (0.60 | ) | ||||
| Weighted-average ordinary shares used in computing net loss per share attributable to ordinary shareholders—basic and diluted | 204,008,712 | 163,987,640 | 202,098,901 | 163,266,106 | ||||||||||||
| Other comprehensive loss: | ||||||||||||||||
| Net loss | $ | (69,355 | ) | $ | (50,469 | ) | $ | (95,442 | ) | $ | (97,347 | ) | ||||
| Foreign currency translation gain | 123 | 43 | 119 | 101 | ||||||||||||
| Unrealized loss on marketable securities | (41 | ) | — | (41 | ) | — | ||||||||||
| Comprehensive loss | $ | (69,273 | ) | $ | (50,426 | ) | $ | (95,364 | ) | $ | (97,246 | ) | ||||
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