Revolution Medicines' Daraxonrasib Granted FDA Breakthrough Therapy Designation for Pancreatic Cancer with KRAS G12 Mutations

Revolution Medicines Inc. (NASDAQ:RVMD) is one of the most promising stocks according to Wall Street analysts. On June 23, Revolution Medicines announced that the US FDA granted Breakthrough Therapy Designation to daraxonrasib (RMC-6236). This designation is for daraxonrasib, which is a RAS(-ON) multi-selective inhibitor, for the treatment of previously treated metastatic pancreatic ductal adenocarcinoma/PDAC in patients with KRAS G12 mutations.

The Breakthrough Therapy Designation was based on encouraging early clinical evidence from the Phase 1 RMC-6236-001 clinical trial, which evaluated daraxonrasib in patients with previously treated metastatic PDAC. Pancreatic cancer is a highly lethal malignancy, with PDAC accounting for ~92% of all cases.

In 2024, an estimated 60,000 people in the US will be diagnosed with pancreatic cancer, and about 50,000 will die from it. Over 90% of PDAC tumors carry a RAS cancer driver mutation, with ~85% having a KRAS G12 mutation. The 5-year survival rate for metastatic PDAC is about 3%.

Revolution Medicines Inc. (NASDAQ:RVMD) is a clinical-stage precision oncology company that develops novel targeted therapies for RAS-addicted cancers.

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Disclosure: None. This article is originally published at Insider Monkey.