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| Insider Trading | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |  | O'Day Daniel Patrick | Chairman & CEO | Oct 28 '25 | Sale | 119.39 | 10,000 | 1,193,926 | 581,203 | Oct 29 04:14 PM |  | DANIEL ODAY | Officer | Oct 28 '25 | Proposed Sale | 119.39 | 10,000 | 1,193,926 |  | Oct 28 05:47 PM |  | Dickinson Andrew D | Chief Financial Officer | Oct 15 '25 | Sale | 118.08 | 2,500 | 295,200 | 157,055 | Oct 16 09:35 PM |  | Mercier Johanna | Chief Commercial Officer | Oct 15 '25 | Sale | 118.08 | 3,000 | 354,240 | 110,193 | Oct 16 09:28 PM |  | ANDREW DICKINSON | Officer | Oct 15 '25 | Proposed Sale | 118.08 | 2,500 | 295,200 |  | Oct 15 04:05 PM |  | JOHANNA MERCIER | Officer | Oct 15 '25 | Proposed Sale | 118.08 | 3,000 | 354,240 |  | Oct 15 04:03 PM |  | O'Day Daniel Patrick | Chairman & CEO | Sep 29 '25 | Sale | 111.66 | 10,000 | 1,116,564 | 591,203 | Sep 30 04:57 PM |  | DANIEL O'DAY | Officer | Sep 29 '25 | Proposed Sale | 111.66 | 10,000 | 1,116,564 |  | Sep 29 04:09 PM |  | Mercier Johanna | Chief Commercial Officer | Sep 15 '25 | Sale | 113.57 | 3,000 | 340,710 | 113,193 | Sep 16 05:16 PM |  | Dickinson Andrew D | Chief Financial Officer | Sep 15 '25 | Sale | 113.57 | 2,500 | 283,925 | 159,555 | Sep 16 05:12 PM |  | ANDREW DICKINSON | Officer | Sep 15 '25 | Proposed Sale | 113.57 | 2,500 | 283,925 |  | Sep 15 04:38 PM |  | JOHANNA MERCIER | Officer | Sep 15 '25 | Proposed Sale | 113.57 | 3,000 | 340,710 |  | Sep 15 04:04 PM |  | O'Day Daniel Patrick | Chairman & CEO | Aug 28 '25 | Sale | 113.63 | 10,000 | 1,136,300 | 595,725 | Aug 29 04:16 PM |  | DANIEL O'DAY | Officer | Aug 28 '25 | Proposed Sale | 113.63 | 10,000 | 1,136,300 |  | Aug 28 04:47 PM |  | Mercier Johanna | Chief Commercial Officer | Aug 15 '25 | Option Exercise | 66.64 | 25,000 | 1,666,000 | 128,968 | Aug 18 08:56 PM |  | Mercier Johanna | Chief Commercial Officer | Aug 15 '25 | Sale | 118.53 | 28,000 | 3,318,927 | 114,168 | Aug 18 08:56 PM |  | Dickinson Andrew D | Chief Financial Officer | Aug 15 '25 | Sale | 118.53 | 2,500 | 296,325 | 160,110 | Aug 18 07:34 PM |  | ANDREW DICKINSON | Officer | Aug 15 '25 | Proposed Sale | 118.53 | 2,500 | 296,325 |  | Aug 15 04:23 PM |  | JOHANNA MERCIER | Officer | Aug 15 '25 | Proposed Sale | 118.53 | 28,000 | 3,318,925 |  | Aug 15 04:02 PM |  | O'Day Daniel Patrick | Chairman & CEO | Jul 28 '25 | Sale | 113.94 | 10,000 | 1,139,370 | 605,725 | Jul 29 04:54 PM |  | DANIEL ODAY | Officer | Jul 28 '25 | Proposed Sale | 113.94 | 10,000 | 1,139,369 |  | Jul 28 04:36 PM |  | Mercier Johanna | Chief Commercial Officer | Jul 15 '25 | Sale | 111.03 | 3,000 | 333,090 | 117,168 | Jul 16 05:45 PM |  | Dickinson Andrew D | Chief Financial Officer | Jul 15 '25 | Sale | 111.03 | 2,500 | 277,575 | 162,610 | Jul 16 05:41 PM |  | JOHANNA MERCIER | Officer | Jul 15 '25 | Proposed Sale | 111.03 | 3,000 | 333,090 |  | Jul 15 04:36 PM |  | ANDREW DICKINSON | Officer | Jul 15 '25 | Proposed Sale | 111.03 | 2,500 | 277,575 |  | Jul 15 04:03 PM |  | Bluestone Jeffrey | Director | Jul 14 '25 | Option Exercise | 67.45 | 5,000 | 337,250 | 13,920 | Jul 15 03:59 PM |  | Bluestone Jeffrey | Director | Jul 14 '25 | Sale | 109.74 | 5,000 | 548,700 | 8,920 | Jul 15 03:59 PM |  | JEFFREY BLUESTONE | Director | Jul 14 '25 | Proposed Sale | 109.74 | 5,000 | 548,700 |  | Jul 14 04:01 PM |  | O'Day Daniel Patrick | Chairman & CEO | Jun 30 '25 | Sale | 110.45 | 10,000 | 1,104,484 | 615,725 | Jul 01 06:02 PM |  | DANIEL O'DAY | Officer | Jun 30 '25 | Proposed Sale | 110.45 | 10,000 | 1,104,483 |  | Jun 30 04:05 PM |  | Dickinson Andrew D | Chief Financial Officer | Jun 16 '25 | Sale | 110.17 | 2,500 | 275,425 | 165,110 | Jun 17 06:08 PM |  | Mercier Johanna | Chief Commercial Officer | Jun 16 '25 | Sale | 110.17 | 3,000 | 330,510 | 120,168 | Jun 17 06:04 PM |  | JOHANNA MERCIER | Officer | Jun 16 '25 | Proposed Sale | 110.17 | 3,000 | 330,510 |  | Jun 16 04:05 PM |  | ANDREW DICKINSON | Officer | Jun 16 '25 | Proposed Sale | 110.17 | 2,500 | 275,425 |  | Jun 16 04:01 PM |  | O'Day Daniel Patrick | Chairman & CEO | May 30 '25 | Sale | 110.42 | 10,000 | 1,104,193 | 620,268 | Jun 02 08:55 PM |  | DANIEL O'DAY | Officer | May 30 '25 | Proposed Sale | 110.42 | 10,000 | 1,104,192 |  | May 30 04:16 PM |  | Mercier Johanna | Chief Commercial Officer | May 22 '25 | Option Exercise | 66.64 | 25,000 | 1,666,000 | 136,652 | May 23 03:16 PM |  | Mercier Johanna | Chief Commercial Officer | May 22 '25 | Sale | 107.52 | 28,000 | 3,010,564 | 121,152 | May 23 03:16 PM |  | JOHANNA MERCIER | Officer | May 22 '25 | Proposed Sale | 107.52 | 28,000 | 3,010,562 |  | May 22 04:01 PM |  | Dickinson Andrew D | Chief Financial Officer | May 15 '25 | Sale | 99.82 | 2,500 | 249,550 | 165,674 | May 16 04:34 PM |  | ANDREW DICKINSON | Officer | May 15 '25 | Proposed Sale | 99.82 | 2,500 | 249,550 |  | May 15 04:03 PM |  | Dickinson Andrew D | Chief Financial Officer | Apr 15 '25 | Sale | 106.40 | 2,500 | 266,000 | 168,174 | Apr 16 03:22 PM |  | ANDREW DICKINSON | Officer | Apr 15 '25 | Proposed Sale | 106.40 | 2,500 | 266,000 |  | Apr 15 04:04 PM |  | Dickinson Andrew D | Chief Financial Officer | Mar 17 '25 | Sale | 110.53 | 2,500 | 276,325 | 170,674 | Mar 18 04:37 PM |  | ANDREW DICKINSON | Officer | Mar 17 '25 | Proposed Sale | 110.53 | 2,500 | 276,325 |  | Mar 17 04:16 PM |  | Dickinson Andrew D | Chief Financial Officer | Mar 10 '25 | Option Exercise | 63.91 | 17,929 | 1,145,842 | 186,990 | Mar 12 06:41 PM |  | Dickinson Andrew D | Chief Financial Officer | Mar 10 '25 | Sale | 118.17 | 17,929 | 2,118,696 | 169,061 | Mar 12 06:41 PM |  | ANDREW DICKINSON | Officer | Mar 10 '25 | Proposed Sale | 118.17 | 17,929 | 2,118,695 |  | Mar 10 04:02 PM |  | MERDAD V PARSEY | Officer | Mar 03 '25 | Proposed Sale | 115.70 | 21,910 | 2,534,913 |  | Mar 03 04:26 PM |  | GILEAD SCIENCES, INC. | 10% Owner | Feb 18 '25 | Buy | 11.00 | 1,363,636 | 14,999,996 | 31,424,760 | Feb 20 07:42 PM |  | Dickinson Andrew D | Chief Financial Officer | Feb 18 '25 | Sale | 104.09 | 2,500 | 260,225 | 169,061 | Feb 19 04:43 PM |  | ANDREW DICKINSON | Officer | Feb 18 '25 | Proposed Sale | 104.09 | 2,500 | 260,225 |  | Feb 18 04:14 PM |  | Dickinson Andrew D | Chief Financial Officer | Feb 12 '25 | Option Exercise | 67.27 | 137,676 | 9,260,873 | 308,899 | Feb 13 09:13 PM |  | Dickinson Andrew D | Chief Financial Officer | Feb 12 '25 | Sale | 102.22 | 137,676 | 14,073,241 | 171,223 | Feb 13 09:13 PM |  | ANDREW DICKINSON | Officer | Feb 12 '25 | Proposed Sale | 102.22 | 137,676 | 14,073,241 |  | Feb 12 04:03 PM |  | Dickinson Andrew D | Chief Financial Officer | Jan 31 '25 | Option Exercise | 67.52 | 142,180 | 9,600,576 | 273,053 | Feb 03 06:09 PM |  | Dickinson Andrew D | Chief Financial Officer | Jan 31 '25 | Sale | 97.22 | 142,180 | 13,822,740 | 129,873 | Feb 03 06:09 PM |  | ANDREW DICKINSON | Officer | Jan 31 '25 | Proposed Sale | 97.22 | 142,180 | 13,822,740 |  | Jan 31 04:15 PM |  | MERDAD V PARSEY | Officer | Jan 31 '25 | Proposed Sale | 98.00 | 184,683 | 18,098,989 |  | Jan 31 04:01 PM |  | Dickinson Andrew D | Chief Financial Officer | Jan 15 '25 | Sale | 91.35 | 2,500 | 228,375 | 129,873 | Jan 16 03:31 PM |  | ANDREW DICKINSON | Officer | Jan 15 '25 | Proposed Sale | 91.35 | 2,500 | 228,375 |  | Jan 15 04:18 PM |  | GILEAD SCIENCES, INC. | 10% Owner | Dec 19 '24 | Buy | 21.37 | 940,499 | 20,098,464 | 2,209,471 | Dec 23 08:26 PM |  | GILEAD SCIENCES, INC. | 10% Owner | Dec 18 '24 | Buy | 1.04 | 1,759,978 | 1,830,377 | 9,105,451 | Dec 19 04:19 PM |  | Dickinson Andrew D | Chief Financial Officer | Dec 16 '24 | Sale | 91.96 | 8,500 | 781,660 | 132,373 | Dec 17 05:27 PM |  | ANDREW DICKINSON | Officer | Dec 16 '24 | Proposed Sale | 91.96 | 8,500 | 781,660 |  | Dec 16 04:08 PM |  | Dickinson Andrew D | Chief Financial Officer | Nov 29 '24 | Option Exercise | 70.50 | 248,645 | 17,528,577 | 387,564 | Dec 03 02:43 PM |  | Dickinson Andrew D | Chief Financial Officer | Nov 29 '24 | Sale | 92.76 | 248,645 | 23,065,271 | 138,919 | Dec 03 02:43 PM |  | Parsey Merdad | Chief Medical Officer | Nov 27 '24 | Option Exercise | 62.44 | 145,413 | 9,079,689 | 245,012 | Nov 29 08:10 PM |  | Parsey Merdad | Chief Medical Officer | Nov 27 '24 | Sale | 91.92 | 164,211 | 15,094,013 | 80,801 | Nov 29 08:10 PM |  | ANDREW DICKINSON | Officer | Nov 29 '24 | Proposed Sale | 92.76 | 248,645 | 23,065,258 |  | Nov 29 02:35 PM |  | Bluestone Jeffrey | Director | Nov 26 '24 | Option Exercise | 61.24 | 10,000 | 612,442 | 15,708 | Nov 27 06:14 PM |  | Bluestone Jeffrey | Director | Nov 26 '24 | Sale | 91.39 | 6,788 | 620,356 | 8,920 | Nov 27 06:14 PM |  | MERDAD V PARSEY | Officer | Nov 27 '24 | Proposed Sale | 91.92 | 164,211 | 15,094,008 |  | Nov 27 04:15 PM |  | Bluestone Jeffrey | Director | Nov 26 '24 | Proposed Sale | 91.39 | 6,788 | 620,356 |  | Nov 26 07:31 PM |  | Mercier Johanna | Chief Commercial Officer | Nov 06 '24 | Sale | 91.28 | 5,000 | 456,400 | 73,127 | Nov 07 04:38 PM |  | Parsey Merdad | Chief Medical Officer | Nov 06 '24 | Option Exercise | 57.92 | 25,000 | 1,448,000 | 125,189 | Nov 07 04:32 PM |  | Parsey Merdad | Chief Medical Officer | Nov 06 '24 | Sale | 91.50 | 25,590 | 2,341,485 | 99,599 | Nov 07 04:32 PM |  | MERDAD V PARSEY | Officer | Nov 06 '24 | Proposed Sale | 91.50 | 25,590 | 2,341,485 |  | Nov 06 04:19 PM |  | JOHANNA MERCIER | Officer | Nov 06 '24 | Proposed Sale | 91.28 | 5,000 | 456,400 |  | Nov 06 04:07 PM |  |