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FULC

Fulcrum Therapeutics Inc

3.54

Jul 13 • 04:00PM ET +0.04 (1.14%)

3.51

Aftermarket • 07:59PM ET -0.03 (-0.81%)

Healthcare Biotechnology USA Micro NASD

Peers: INCY BMRN VKTX KRYS KYMR NUVL RYTM AXSM MDGL NBIX

| Held by: VTI IWM VXF XPH VTWO IWN IBB FESM VHT SCHA

Index	RUT
Market Cap	235.88M
Enterprise Value	-91.57M
Income	-76.12M
Sales	0.00M
Book/sh	5.00
Cash/sh	5.00
Dividend Est.	-
Dividend TTM	-
Dividend Ex-Date	-
Dividend Gr. 3/5Y	- -
Payout	-
Employees	55
IPO	Jul 18, 2019

P/E	-
Forward P/E	-
PEG	-
P/S	-
P/B	0.71
P/C	0.71
P/FCF	-
EV/EBITDA	-
EV/Sales	-
Quick Ratio	34.33
Current Ratio	34.33
Debt/Eq	0.02
LT Debt/Eq	0.01
Option/Short	Yes / Yes

EPS (ttm)	-1.15
EPS next Y	-0.67
EPS next Q	-0.22
EPS this Y	33.72%
EPS next Y	14.08%
EPS next 5Y	18.03%
EPS past 3/5Y	21.49% 15.80%
Sales past 3/5Y	- -
EPS Y/Y TTM	-2365.81%
Sales Y/Y TTM	-100.00%
EPS Q/Q	12.28%
Sales Q/Q	-
Earnings	Apr 27 BMO
EPS/Sales Surpr.	15.05% -

Insider Own	15.30%
Insider Trans	-0.32%
Inst Own	110.74%
Inst Trans	14.25%
ROA	-25.83%
ROE	-27.10%
ROIC	-22.61%
Gross Margin	-
Oper. Margin	-
Profit Margin	-
SMA20	-3.19%
SMA50	-29.29%
SMA200	-57.53%
Trades

Shs Outstand	66.61M
Shs Float	56.44M
Short Float	11.38%
Short Ratio	2.71
Short Interest	6.43M
52W High	15.74 -77.51%
52W Low	2.83 25.09%
Volatility	5.16% 5.91%
ATR (14)	0.27
RSI (14)	36.12
Beta	3.04
Rel Volume	0.73
Avg Volume	2.37M
Volume	1,721,383

Perf Week	-4.84%
Perf Month	0.85%
Perf Quarter	-53.11%
Perf Half Y	-64.99%
Perf YTD	-68.70%
Perf Year	-54.79%
Perf 3Y	-4.84%
Perf 5Y	-64.46%
Perf 10Y	-
Recom	3.12
Target Price	3.40
Prev Close	3.50
Price	3.54
Change	1.14%

Date	Action	Analyst	Rating Change	Price Target Change
Jun-03-26	Downgrade	JP Morgan	Overweight → Underweight
Jun-02-26	Downgrade	Truist	Buy → Hold	$4
Jun-02-26	Downgrade	Stifel	Buy → Hold	$3
Jun-02-26	Downgrade	Piper Sandler	Overweight → Neutral	$3
Jun-02-26	Downgrade	Leerink Partners	Outperform → Market Perform	$4
Jun-02-26	Downgrade	H.C. Wainwright	Buy → Neutral	$3
Jan-12-26	Initiated	JP Morgan	Overweight	$20
Nov-24-25	Initiated	Truist	Buy
Jul-29-25	Upgrade	H.C. Wainwright	Neutral → Buy	$4 → $12
May-23-25	Upgrade	Leerink Partners	Market Perform → Outperform	$12
May-15-25	Upgrade	Cantor Fitzgerald	Neutral → Overweight	$10
Sep-13-24	Downgrade	H.C. Wainwright	Buy → Neutral	$17 → $4
Sep-12-24	Downgrade	Stifel	Buy → Hold
Sep-12-24	Downgrade	RBC Capital Mkts	Outperform → Sector Perform	$15 → $4
Sep-12-24	Downgrade	Leerink Partners	Outperform → Market Perform	$4
Sep-12-24	Downgrade	Cantor Fitzgerald	Overweight → Neutral
Sep-12-24	Downgrade	BofA Securities	Neutral → Underperform	$10 → $2
Sep-09-24	Upgrade	BofA Securities	Underperform → Neutral	$5 → $10
May-20-24	Initiated	Cantor Fitzgerald	Overweight	$23
Mar-13-24	Initiated	RBC Capital Mkts	Outperform	$14

Show Previous Ratings

Jun-02-26 11:04PM	Why Did FULC, MVIS, HRTX Stocks Plunge To 52-Week Lows Today? (Stocktwits) -51.09%
09:43AM	Meta Platforms upgraded, Okta downgraded: Wall Street's top analyst calls (The Fly)
08:08AM	Fulcrum exploring a potential sale after FDA sidelined its sickle cell drug (BioPharma Dive)
07:53AM	This Biotech Stock Plunges 48%. Its Sickle Cell Drug Has 'No Viable Path Forward.' (Barrons.com)
Jun-01-26 05:50PM	FULC Stock Slumps Nearly 50% After Hours As FDA Kills Only Clinical Program Over Cancer Risk (Stocktwits) -7.23%
04:05PM	Loading…
04:05PM	Fulcrum Therapeutics Announces Discontinuation of Pociredir Program in Sickle Cell Disease and Initiation of Strategic Review (GlobeNewswire)
May-08-26 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire)
Apr-28-26 03:02AM	Fulcrum Therapeutics Inc (FULC) Q1 2026 Earnings Call Highlights: Strategic Advances Amid ... (GuruFocus.com)
Apr-27-26 12:46PM	Fulcrum Therapeutics, Inc. Q1 2026 Earnings Call Summary (Moby)
11:08AM	Fulcrum Therapeutics Shares Climb After Q1 Earnings Outperform Expectations (InvestorsHub)
07:00AM	Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for First Quarter 2026 (GlobeNewswire)
06:55AM	Fulcrum Therapeutics Appoints Josh Lehrer to its Board of Directors (GlobeNewswire)
Apr-20-26 08:00AM	Fulcrum Therapeutics to Host First Quarter 2026 Financial Results Conference Call and Webcast on Monday, April 27, 2026, at 8:00 a.m. ET (GlobeNewswire)
Mar-19-26 08:00AM	MedicAlert Foundation, Sickle Cell Disease Association of America, Inc. (SCDAA), and Fulcrum Therapeutics Partner to Accelerate Emergency Department Access to Critical Care Information for People Living with Sickle Cell Disease (GlobeNewswire)
Mar-06-26 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire)
08:30AM	Loading…
Mar-03-26 08:30AM	Fulcrum Therapeutics to Participate in the Leerink Partners Global Healthcare Conference (GlobeNewswire)
Feb-25-26 10:27AM	Fulcrum Therapeutics move lower overdone, says Stifel (TipRanks)
Feb-24-26 08:05PM	Fulcrum Therapeutics, Inc. Q4 2025 Earnings Call Summary (Moby) -21.21%
11:47AM	Fulcrum Therapeutics Q4 Earnings Call Highlights (MarketBeat)
09:48AM	What's Going On With Fulcrum Therapeutics Stock Tuesday? (Benzinga)
07:01AM	Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for Fourth Quarter and Full Year 2025 (GlobeNewswire)
07:00AM	Fulcrum Therapeutics Announces Positive 12-Week Results from the 20 mg Dose Cohort of the Phase 1b PIONEER Trial of Pociredir in Sickle Cell Disease (GlobeNewswire)
Feb-17-26 08:00AM	Fulcrum Therapeutics to Present 12-Week Data from the 20 mg Dose Cohort of the Phase 1b PIONEER Trial of Pociredir in Sickle Cell Disease (GlobeNewswire)
Feb-12-26 09:55AM	Wall Street Analysts See a 75.71% Upside in Fulcrum Therapeutics (FULC): Can the Stock Really Move This High? (Zacks)
Feb-06-26 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire) +5.03%
Jan-09-26 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire)
Jan-07-26 08:00AM	Fulcrum Therapeutics to Participate in the 44th Annual J.P. Morgan Healthcare Conference (GlobeNewswire)
Dec-30-25 09:55AM	Wall Street Analysts Think Fulcrum Therapeutics (FULC) Could Surge 58.47%: Read This Before Placing a Bet (Zacks) -5.42%
Dec-21-25 07:31AM	Bullish Analyst Sentiment on Fulcrum Therapeutics (FULC) Following Positive Updates from Phase 1b PIONEER Study (Insider Monkey)
Dec-10-25 07:48AM	Fulcrum Therapeutics Announces Pricing of Upsized $175.0 Million Public Offering of Common Stock and Pre-Funded Warrants (GlobeNewswire) -5.48%
04:01PM	Loading…
Dec-08-25 04:01PM	Fulcrum Therapeutics Announces Proposed $150.0 Million Public Offering of Common Stock (GlobeNewswire) +45.96% +12.39%
Dec-06-25 05:30PM	Fulcrum Therapeutics Announces Positive Initial Results from the 20 mg Dose Cohort of the Phase 1b PIONEER Trial of Pociredir in Sickle Cell Disease at the 67th American Society of Hematology Annual Meeting (GlobeNewswire)
Dec-05-25 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire) +45.96%
Dec-02-25 08:30AM	Fulcrum Therapeutics to Host Investor Event to Review New Clinical Data from the PIONEER trial of Pociredir in Sickle Cell Disease on December 7, 2025 (GlobeNewswire) -9.32%
Nov-20-25 12:33PM	AGIO Stock Hits 52-Week Low on Mixed Sickle Cell Disease Study Results (Zacks)
Nov-19-25 04:20PM	Why Agios Plummeted, Losing Half Its Value, While Fulcrum Surged (Investor's Business Daily) +18.29%
Nov-07-25 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire)
Nov-06-25 09:45AM	Caterpillar upgraded, Elf Beauty downgraded: Wall Street's top analyst calls (The Fly)
Nov-03-25 04:45PM	Fulcrum Therapeutics to Present New Clinical Data from the PIONEER trial of Pociredir in Sickle Cell Disease at the 67th American Society of Hematology Annual Meeting (GlobeNewswire) -7.21%
Oct-29-25 07:00AM	Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for Third Quarter 2025 (GlobeNewswire) -6.40%
Oct-22-25 08:54AM	Fulcrum Therapeutics to Host Third Quarter 2025 Financial Results Conference Call and Webcast on Wednesday, October 29, 2025, at 8:00 a.m. ET (GlobeNewswire) -6.80%
Oct-14-25 07:00AM	Fulcrum Therapeutics to Present Preclinical Data for EED Inhibitor FTX-6274 at European Society for Medical Oncology (ESMO) Congress 2025 (GlobeNewswire)
Oct-10-25 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire) -6.55%
Sep-12-25 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire)
Aug-26-25 08:00AM	Fulcrum Therapeutics to Present at Upcoming Investor Meetings (GlobeNewswire)
Aug-08-25 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire)
Jul-29-25 06:48AM	Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for Second Quarter 2025 (GlobeNewswire)
06:45AM	Fulcrum Therapeutics Announces Results from the 12 mg Dose Cohort of the Phase 1b PIONEER Trial of Pociredir in Sickle Cell Disease (GlobeNewswire)
Jul-28-25 04:01PM	Fulcrum Therapeutics to Present Results from the 12 mg Dose Cohort of the Phase 1b PIONEER Trial of Pociredir in Sickle Cell Disease (GlobeNewswire)
Jul-11-25 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire)
Jun-06-25 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire)
May-30-25 01:17AM	Fulcrum Therapeutics, Inc. (FULC): A Bull Case Theory (Insider Monkey)
May-29-25 04:10PM	Fulcrum Therapeutics to Present at Upcoming Medical Meetings (GlobeNewswire)
08:30AM	Fulcrum Therapeutics to Participate in the 46th Annual Goldman Sachs Global Healthcare Conference (GlobeNewswire)
May-09-25 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire) +5.77%
May-08-25 04:05PM	Fulcrum Therapeutics to Participate in Upcoming May Conferences (GlobeNewswire) +6.71%
May-02-25 03:03AM	Fulcrum Therapeutics Inc (FULC) Q1 2025 Earnings Call Highlights: Strategic Cost Reductions and ... (GuruFocus.com) +28.31%
01:27AM	Q1 2025 Fulcrum Therapeutics Inc Earnings Call (Thomson Reuters StreetEvents)
May-01-25 01:55PM	Fulcrum Therapeutics, Inc. (FULC) Q1 2025 Earnings Call Transcript (Seeking Alpha) +13.77%
07:00AM	Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for First Quarter 2025 (GlobeNewswire)
Apr-24-25 08:00AM	Fulcrum Therapeutics to Host First Quarter 2025 Financial Results Conference Call and Webcast on Thursday, May 1, 2025, at 8:00 a.m. ET (GlobeNewswire)
Apr-11-25 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire) +8.55%
Mar-26-25 10:17AM	The Risk/Reward Of Avidity Biosciences And Its 2 Promising Programs (SeekingAlpha)
Mar-04-25 04:05PM	Fulcrum Therapeutics to Participate in the Leerink Partners Global Healthcare Conference (GlobeNewswire)
Feb-26-25 02:04AM	Fulcrum Therapeutics Inc (FULC) Q4 2024 Earnings Call Highlights: Strategic Advances Amid ... (GuruFocus.com) -10.27%
01:28AM	Q4 2024 Fulcrum Therapeutics Inc Earnings Call (Thomson Reuters StreetEvents)
Feb-25-25 07:00AM	Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for Fourth Quarter and Full Year 2024 (GlobeNewswire)
01:52AM	Earnings To Watch: Fulcrum Therapeutics Inc (FULC) Reports Q4 2024 Result (GuruFocus.com)
Feb-18-25 04:05PM	Fulcrum Therapeutics to Host Fourth Quarter and Full Year 2024 Financial Results Conference Call and Webcast on Tuesday, February 25, 2025, at 8:00 a.m. ET (GlobeNewswire)
Feb-07-25 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire)
Feb-06-25 04:05PM	Fulcrum Therapeutics to Participate in the Oppenheimer 35th Annual Healthcare Life Sciences Conference (GlobeNewswire)
Nov-28-24 12:00PM	Fulcrum Therapeutics (FULC) Upgraded to Buy: Here's Why (Zacks)
Nov-26-24 04:05PM	Fulcrum Therapeutics to Participate in Upcoming December Conferences (GlobeNewswire) +11.27%
Nov-14-24 02:07AM	Fulcrum Therapeutics Inc (FULC) Q3 2024 Earnings Call Highlights: Strategic Advancements Amidst ... (GuruFocus.com) -6.74%
Nov-13-24 07:00AM	Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for Third Quarter 2024 (GlobeNewswire)
Nov-12-24 04:05PM	Fulcrum Therapeutics to Participate in the Stifel Healthcare Conference (GlobeNewswire)
Nov-06-24 08:00AM	Fulcrum Therapeutics to Host Third Quarter 2024 Financial Results Conference Call and Webcast on Wednesday, November 13, 2024 at 8:00 a.m. ET (GlobeNewswire)
Oct-18-24 08:00AM	Avidity Biosciences, Up 441%, Nears Another Record High As Dystrophy Space Heats Up (Investor's Business Daily)
Oct-11-24 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire) +6.42%
Oct-09-24 03:30PM	Fulcrum Therapeutics Inc (FULC) Q2 2024 Earnings Call Highlights: Strong Financial Performance ... (GuruFocus.com)
Oct-07-24 03:02PM	FMR LLC's Strategic Reduction in Fulcrum Therapeutics Inc Shares (GuruFocus.com) -6.54%
Oct-04-24 09:35AM	Down -57.53% in 4 Weeks, Here's Why Fulcrum Therapeutics (FULC) Looks Ripe for a Turnaround (Zacks)
Sep-17-24 01:30AM	RA Capital Management's Strategic Acquisition of Fulcrum Therapeutics Shares (GuruFocus.com) +9.75%
Sep-16-24 09:35AM	Fulcrum Therapeutics (FULC) Loses -65.58% in 4 Weeks, Here's Why a Trend Reversal May be Around the Corner (Zacks)
Sep-13-24 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire) -7.56%
Sep-12-24 11:32AM	Fulcrum Therapeutics Suspends Rare Muscular Disease Candidate After Disappointing Data From Pivotal Trial (Benzinga) -61.13%
08:10AM	Fulcrum shares collapse as Sanofi-partnered muscular dystrophy drug fails key test (BioPharma Dive)
06:55AM	Fulcrum Therapeutics Announces Topline Results from Phase 3 REACH Clinical Trial of Losmapimod in Facioscapulohumeral Muscular Dystrophy (FSHD) (GlobeNewswire)
Sep-09-24 02:28PM	Fulcrum Therapeutics Upgraded: BofA Debates Pivotal Study Success For Losmapimod In Rare Genetic Muscle Disease (Benzinga)
Aug-27-24 04:05PM	Fulcrum Therapeutics to Participate in Upcoming September Conferences (GlobeNewswire) -9.09%
Aug-23-24 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire) +6.22%
Aug-21-24 09:55AM	Wall Street Analysts Believe Fulcrum Therapeutics (FULC) Could Rally 71.02%: Here's is How to Trade (Zacks)
Aug-19-24 07:00AM	Fulcrum Therapeutics Strengthens Leadership Team with the Appointments of Isabel Kalofonos as Chief Commercial Officer and Heather Faulds as Chief Regulatory Affairs & Quality Assurance Officer (GlobeNewswire)
Aug-09-24 04:30PM	Fulcrum Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire)
Aug-05-24 12:00PM	Fulcrum Therapeutics (FULC) Upgraded to Strong Buy: Here's What You Should Know (Zacks) -11.41%
12:00PM	Fulcrum Therapeutics, Inc. (FULC) Is Up 7.55% in One Week: What You Should Know (Zacks)
09:55AM	Does Fulcrum Therapeutics (FULC) Have the Potential to Rally 68.69% as Wall Street Analysts Expect? (Zacks)
Jul-31-24 07:00AM	Fulcrum Therapeutics Announces Recent Business Highlights and Financial Results for Second Quarter 2024 (GlobeNewswire) +10.34%
Jul-24-24 08:00AM	Fulcrum Therapeutics to Host Second Quarter 2024 Financial Results Conference Call and Webcast on Wednesday, July 31, 2024, at 8:00 a.m. ET (GlobeNewswire)
Jun-12-24 08:00AM	Fulcrum Therapeutics to Present at the 31st Annual FSHD Society International Research Congress (GlobeNewswire)

Fulcrum Therapeutics, Inc. is a clinical stage biopharmaceutical company, which develops new medicines and focuses on unlocking gene control mechanisms to develop small molecule therapies. Its product candidate includes Losmapimod and FTX-HbF. The company was founded by Michael R. Green, Danny Reinberg, Rudolf Jaenisch, Jeannie T. Lee, and Bradley E. Bernstein on August 18, 2015, and is headquartered in Cambridge, MA.

CEOMr. Alexander C. Sapir

Chief Legal OfficerMr. Curtis G. Oltmans J.D.

Ph.D.Dr. Bradley E. Bernstein M.D.

FounderDr. Michael R. Green

Ph.D.Dr. Rudolf Jaenisch M.D.

Insider Trading	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
Ezekowitz Alan	Director	Jun 26 '26	Sale	3.65	18,000	65,614	10,927	Jun 30 04:30 PM
ALAN EZEKOWITZ	Director	Jun 26 '26	Proposed Sale	3.61	18,000	64,980		Jun 26 04:26 PM
Gould Robert J	Director	Feb 02 '26	Sale	10.72	15,000	160,857	454,864	Feb 04 04:10 PM
Gould Robert J	Director	Jan 02 '26	Sale	11.87	15,000	178,089	469,864	Jan 06 04:30 PM
Oltmans Curtis Gale	Chief Legal Officer	Dec 15 '25	Sale	12.92	3,452	44,600	10,252	Dec 17 04:10 PM
CURTIS G OLTMANS	Officer	Dec 15 '25	Proposed Sale	13.00	3,452	44,876		Dec 15 04:32 PM
RA CAPITAL MANAGEMENT, L.P.	10% Owner	Dec 08 '25	Sale	13.98	4,175,139	58,377,021	6,053,960	Dec 10 04:42 PM
RA Capital Healthcare Fund LP	10% Owner	Dec 08 '25	Proposed Sale	12.99	4,175,139	54,235,056		Dec 08 05:40 PM
Gould Robert J	Director	Nov 19 '25	Sale	11.03	15,000	165,495	484,864	Nov 21 04:15 PM
ROBERT J GOULD	Director	Nov 19 '25	Proposed Sale	9.73	45,000	437,850		Nov 19 04:20 PM

Open in Screener

SEPN

Septerna Inc

34.36

Jul 13 • 03:59PM ET -1.57 (-4.37%)

34.34

Aftermarket • 05:00PM ET -0.02 (-0.06%)

Healthcare Biotechnology USA Small NASD

Peers: KYMR NUVL BMRN RYTM INCY KRYS VKTX AXSM MDGL NBIX

| Held by: VTI IWM VXF IBB IWO XPH SCHA VTWO IHE IWN

Index	RUT
Market Cap	1.55B
Enterprise Value	1.22B
Income	-36.04M
Sales	72.25M
Book/sh	8.43
Cash/sh	7.71
Dividend Est.	-
Dividend TTM	-
Dividend Ex-Date	-
Dividend Gr. 3/5Y	- -
Payout	-
Employees	130
IPO	Oct 25, 2024

P/E	-
Forward P/E	-
PEG	-
P/S	21.44
P/B	4.08
P/C	4.46
P/FCF	14.48
EV/EBITDA	-
EV/Sales	16.95
Quick Ratio	4.71
Current Ratio	4.71
Debt/Eq	0.06
LT Debt/Eq	0.05
Option/Short	Yes / Yes

EPS (ttm)	-0.82
EPS next Y	-2.39
EPS next Q	-0.43
EPS this Y	-49.73%
EPS next Y	-45.36%
EPS next 5Y	-
EPS past 3/5Y	-18.79% -
Sales past 3/5Y	- -
EPS Y/Y TTM	58.57%
Sales Y/Y TTM	7295.60%
EPS Q/Q	60.52%
Sales Q/Q	12010.96%
Earnings	May 11 AMC
EPS/Sales Surpr.	54.40% 56.25%

Insider Own	39.16%
Insider Trans	-0.69%
Inst Own	65.67%
Inst Trans	-0.37%
ROA	-7.18%
ROE	-9.26%
ROIC	-9.03%
Gross Margin	97.76%
Oper. Margin	-94.37%
Profit Margin	-49.88%
SMA20	-3.10%
SMA50	11.26%
SMA200	30.61%
Trades

Shs Outstand	44.92M
Shs Float	27.42M
Short Float	11.50%
Short Ratio	7.54
Short Interest	3.15M
52W High	38.04 -9.67%
52W Low	10.62 223.66%
Volatility	7.14% 7.21%
ATR (14)	2.37
RSI (14)	51.21
Beta	2.28
Rel Volume	0.94
Avg Volume	418.41K
Volume	394,064

Perf Week	2.66%
Perf Month	12.77%
Perf Quarter	48.81%
Perf Half Y	33.49%
Perf YTD	23.24%
Perf Year	192.92%
Perf 3Y	-
Perf 5Y	-
Perf 10Y	-
Recom	1.00
Target Price	45.00
Prev Close	35.93
Price	34.36
Change	-4.37%

Date	Action	Analyst	Rating Change	Price Target Change
Jun-11-26	Initiated	Guggenheim	Buy	$52
May-01-26	Initiated	Stifel	Buy	$43
Dec-19-25	Initiated	Raymond James	Strong Buy	$38
Dec-15-25	Initiated	Truist	Buy	$34
Nov-14-25	Upgrade	Wells Fargo	Equal Weight → Overweight
Jun-23-25	Initiated	H.C. Wainwright	Buy	$26
Feb-18-25	Downgrade	Wells Fargo	Overweight → Equal Weight	$14
Nov-19-24	Initiated	Wells Fargo	Overweight	$43
Nov-19-24	Initiated	TD Cowen	Buy
Nov-19-24	Initiated	JP Morgan	Overweight	$38
Nov-19-24	Initiated	Cantor Fitzgerald	Overweight	$50

Show Previous Ratings

Jun-08-26 08:00AM	Septerna to Present Preclinical Characterization of SEP-479, an Oral PTH1R Agonist for Hypoparathyroidism, at 2026 ENDO Annual Meeting (Business Wire)
May-11-26 04:01PM	Septerna Highlights Business Progress and Reports First Quarter 2026 Financial Results (GlobeNewswire) +5.39%
May-05-26 08:00AM	Septerna to Present at Bank of America Securities Health Care Conference (GlobeNewswire)
Apr-13-26 08:00AM	Septerna Announces Initiation of Phase 1 Clinical Trial of SEP-479, an Oral Small Molecule PTH1R Agonist for the Treatment of Hypoparathyroidism (GlobeNewswire)
Mar-09-26 05:20PM	Septerna, Inc. (SEPN) Reports Q4 Loss, Tops Revenue Estimates (Zacks)
04:05PM	Loading…
04:05PM	Septerna Highlights Pipeline Progress and Reports Fourth Quarter and Full Year 2025 Financial Results (GlobeNewswire)
Mar-01-26 09:45AM	Septerna Announces Positive Phase 1 Data for SEP-631, an Oral MRGPRX2 NAM for the Treatment of Mast Cell-Driven Diseases, and Outlines Initial Phase 2 Development Strategy (GlobeNewswire)
Feb-24-26 08:00AM	Septerna to Present at TD Cowen 46th Annual Health Care Conference (GlobeNewswire) +10.21%
Feb-10-26 04:05PM	Septerna Reports Inducement Grant Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire)
08:00AM	Septerna to Present Data from Phase 1 Clinical Trial of SEP-631 for the Treatment of Mast Cell-Driven Diseases at 2026 AAAAI Annual Meeting (GlobeNewswire)
Jan-08-26 04:05PM	Septerna Expands Leadership with Appointment of Industry Veteran Mark A. Wilson as Chief Legal Officer (GlobeNewswire)
Dec-23-25 09:33AM	Coty downgraded, Spruce Biosciences initiated: Wall Street's top analyst calls (The Fly)
Dec-17-25 08:00AM	Septerna to Present at 44th Annual J.P. Morgan Healthcare Conference (GlobeNewswire)
Nov-25-25 08:00AM	Septerna to Participate in 8th Annual Evercore Healthcare Conference (GlobeNewswire)
Nov-10-25 08:20AM	Septerna, Inc. (SEPN) Reports Q3 Loss, Misses Revenue Estimates (Zacks)
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07:00AM	Septerna Highlights Company Progress and Reports Third Quarter 2025 Financial Results (GlobeNewswire)
Nov-06-25 09:15AM	Iovance Biotherapeutics (IOVA) Reports Q3 Loss, Lags Revenue Estimates (Zacks)
Nov-03-25 08:00AM	Septerna to Participate in Upcoming Investor Conferences (GlobeNewswire)
Oct-31-25 04:56AM	Strength Seen in Moderna (MRNA): Can Its 13.9% Jump Turn into More Strength? (Zacks)
Oct-22-25 05:57AM	Arcturus Therapeutics (ARCT) Moves 7.7% Higher: Will This Strength Last? (Zacks)
Oct-15-25 04:15PM	Novo Nordisk's Akero Therapeutics Buy Targets Eli Lilly's Lead (MarketBeat)
Oct-09-25 10:13AM	Strength Seen in Septerna, Inc. (SEPN): Can Its 7.0% Jump Turn into More Strength? (Zacks)
Oct-03-25 08:42AM	Are Options Traders Betting on a Big Move in Septerna Stock? (Zacks)
Sep-29-25 04:01PM	Septerna Appoints Veteran Biotechnology Leader Keith Gottesdiener, M.D., to its Board of Directors (GlobeNewswire)
Aug-27-25 08:00AM	Septerna to Participate in Upcoming Investor Conferences (GlobeNewswire)
Aug-21-25 08:00AM	Septerna Announces Dosing of the First Participants in Phase 1 Clinical Trial of SEP-631, an Oral Small Molecule MRGPRX2 Negative Allosteric Modulator for the Treatment of Mast Cell-Driven Diseases (GlobeNewswire) +5.50%
Aug-14-25 08:15AM	Lilly signs $1.3 billion deal with Superluminal to discover obesity medicines using AI (Reuters)
Aug-11-25 04:01PM	Septerna Highlights Business Progress and Reports Second Quarter 2025 Financial Results (GlobeNewswire)
May-29-25 08:00AM	Septerna to Present at Jefferies Global Healthcare Conference (GlobeNewswire)
May-23-25 07:45AM	Analysts Think These Stocks Could More Than Double in Value (MarketBeat)
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May-21-25 09:55AM	Does Septerna, Inc. (SEPN) Have the Potential to Rally 151.27% as Wall Street Analysts Expect? (Zacks)
May-15-25 04:01PM	Septerna Highlights Business Progress and Reports First Quarter 2025 Financial Results (GlobeNewswire)
10:00AM	ETFs to Capitalize on the Novo Nordisk-Septerna Deal (Zacks)
08:46AM	Septerna Stock Surges on Oral Obesity Drug Deal With Novo Nordisk (Zacks)
07:45AM	Is It Time to Buy the Dip in Novo Nordisk Stock? (MarketBeat)
01:45AM	Novo Nordisk and Septerna Strike $2.2 Billion Deal to Develop Obesity Pills (The Wall Street Journal)
May-14-25 04:06PM	Novo Nordisk Inks A Major Obesity Deal, Sending Shares Of New Partner Septerna Skyrocketing (Investor's Business Daily) +50.97%
02:22PM	eToro's Nasdaq debut, Exelixis outlook, SepternaNovo deal (Yahoo Finance Video)
01:29PM	Novo Nordisk taps Septerna in $2.2bn deal for oral obesity therapies (Pharmaceutical Technology)
10:28AM	Novo Nordisk Rises on Weight-Loss News. Its a Huge Deal for This Stock. (Barrons.com)
09:35AM	Novo Nordisk, Septerna sign $2.2B deal to develop weight-loss pill (Yahoo Finance Video)
09:32AM	Novo Nordisk's latest bet on obesity pills: $2.2 billion for biotech Septerna (Yahoo Finance)
09:32AM	Novo Nordisk's latest bet on obesity pills: $2.2 billion for biotech Sapterna (Yahoo Finance)
07:03AM	Novo Nordisk strikes $2.2 billion deal with Septerna to develop new obesity treatments (Reuters)
Apr-16-25 09:55AM	Wall Street Analysts Predict a 207.31% Upside in Septerna, Inc. (SEPN): Here's What You Should Know (Zacks)
Mar-31-25 02:34PM	Biotech Stocks Q1 2025 Recap: Winners And Underperformers (Seeking Alpha) -5.08%
Mar-27-25 08:00AM	Septerna Provides Corporate Overview and Reports Fourth Quarter and Full Year 2024 Financial Results (GlobeNewswire)
Mar-14-25 11:26AM	Septerna, Inc. (SEPN): Among Top Insider Purchases Last Month (Insider Monkey)
Mar-05-25 06:59PM	Septerna, Inc. (SEPN): Among The Stocks With At Least $30 Million In Insider Spending Recently (Insider Monkey) +7.25%
Feb-26-25 08:00AM	Septerna to Present at TD Cowen 45th Annual Health Care Conference (GlobeNewswire)
Feb-18-25 08:00AM	Septerna Announces Discontinuation of SEP-786 Phase 1 Clinical Trial and Plans to Advance Next-Generation Oral Small Molecule PTH1R Agonist (GlobeNewswire) -46.99%
Feb-14-25 06:45AM	Its not for the faint of heart. How 3 CEOs took their biotechs public (BioPharma Dive) +12.21%
Feb-06-25 07:48AM	Septerna, Inc. (SEPN): Among the Best Rebound Stocks to Invest In Now (Insider Monkey)
Jan-06-25 07:00AM	Septerna Expands Leadership with Appointment of Industry Veteran Gil Labrucherie as Chief Financial Officer (GlobeNewswire) -6.75%
Dec-18-24 08:00AM	Septerna to Present at the 43rd Annual J.P. Morgan Healthcare Conference (GlobeNewswire)
Nov-21-24 11:12PM	Septerna, Inc. Reports Q3 2024 Financials and Progress (TipRanks)
Nov-20-24 07:00AM	Septerna Reports Third Quarter 2024 Financial Results and Recent Business Highlights (GlobeNewswire) -7.02%
05:10AM	Septerna initiated with an Overweight at JPMorgan (TipRanks)
Oct-30-24 04:41PM	Septerna Announces Closing of $331.2 Million Upsized Initial Public Offering (GlobeNewswire) +12.32%
Oct-24-24 09:47PM	Septerna Prices Upsized Initial Public Offering (GlobeNewswire)

Septerna, Inc. is a clinical-stage biotechnology company, which engages in pioneering a new era of G protein-coupled receptor oral small molecule drug discovery powered by proprietary Native Complex PlatformTM. Its pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. The company was founded by Robert Joseph Lefkowitz, Arthur Christopoulos, Patrick Sexton, and Jeffrey T. Finer in December 2019 and is headquartered in South San Francisco, CA.

Ph.D.Dr. Jeffrey T. Finer M.D.

M.S.Ms. Elizabeth P. Bhatt M.B.A.

J.D.Mr. Gilbert M. Labrucherie C.F.A.

Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory BoardDr. Robert J. Lefkowitz M.D.

Ph.D.Dr. Arthur Christopoulos BPHARM

Insider Trading	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
Long Daniel D.	SVP, Drug Discovery	Jul 01 '26	Option Exercise	2.76	3,333	9,199	99,745	Jul 02 07:00 PM
Long Daniel D.	SVP, Drug Discovery	Jul 01 '26	Sale	34.36	3,333	114,528	96,412	Jul 02 07:00 PM
Shaikhly Samira	Chief People Officer	Jun 29 '26	Option Exercise	6.81	2,178	14,832	2,971	Jun 30 07:01 PM
Shaikhly Samira	Chief People Officer	Jun 29 '26	Sale	35.18	2,178	76,622	793	Jun 30 07:01 PM
JAE KIM	Officer	Jun 26 '26	Proposed Sale	36.61	2,438	89,243		Jun 26 04:02 PM
Long Daniel D.	SVP, Drug Discovery	Jun 22 '26	Option Exercise	5.42	15,000	81,371	111,412	Jun 24 07:24 PM
Long Daniel D.	SVP, Drug Discovery	Jun 22 '26	Sale	35.51	15,000	532,582	96,412	Jun 24 07:24 PM
DANIEL LONG	Officer	Jun 22 '26	Proposed Sale	36.17	25,000	904,250		Jun 22 04:40 PM
JAE KIM	Officer	Jun 22 '26	Proposed Sale	35.26	94,339	3,326,120		Jun 22 04:16 PM
Shaikhly Samira	Chief People Officer	Jun 12 '26	Option Exercise	11.70	6,250	73,125	7,043	Jun 16 08:31 PM
Shaikhly Samira	Chief People Officer	Jun 12 '26	Sale	35.08	6,250	219,224	793	Jun 16 08:31 PM
SAMIRA SHAIKHLY	Officer	Jun 12 '26	Proposed Sale	34.03	8,428	286,805		Jun 12 04:42 PM
Shaikhly Samira	Chief People Officer	Jun 01 '26	Option Exercise	1.87	5,935	11,111	6,728	Jun 03 07:11 PM
Shaikhly Samira	Chief People Officer	Jun 01 '26	Sale	28.93	5,935	171,682	793	Jun 03 07:11 PM
Shaikhly Samira	Chief People Officer	May 26 '26	Option Exercise	6.81	11,798	80,344	12,591	May 28 07:02 PM
Shaikhly Samira	Chief People Officer	May 26 '26	Sale	30.06	11,798	354,656	793	May 28 07:02 PM
SAMIRA SHAIKHLY	Officer	May 26 '26	Proposed Sale	28.36	11,798	334,591		May 26 04:41 PM
Bhatt Elizabeth	President and COO	Apr 15 '26	Option Exercise	6.81	4,000	27,240	178,209	Apr 17 07:00 PM
Bhatt Elizabeth	President and COO	Apr 15 '26	Sale	24.34	4,000	97,343	174,209	Apr 17 07:00 PM
Shaikhly Samira	Chief People Officer	Mar 02 '26	Option Exercise	1.84	70,453	129,456	71,246	Mar 04 07:00 PM
Shaikhly Samira	Chief People Officer	Mar 02 '26	Sale	28.10	70,453	1,979,838	793	Mar 04 07:00 PM
SAMIRA SHAIKHLY	Officer	Mar 02 '26	Proposed Sale	29.02	76,388	2,216,780		Mar 02 04:36 PM
Bhatt Elizabeth	President and COO	Feb 18 '26	Option Exercise	6.81	4,000	27,240	178,209	Feb 20 05:28 PM
Bhatt Elizabeth	President and COO	Feb 18 '26	Sale	28.97	4,000	115,860	174,209	Feb 20 05:28 PM
ELIZABETH BHATT	Officer	Feb 18 '26	Proposed Sale	30.30	8,000	242,400		Feb 18 04:27 PM
Long Daniel D.	SVP, Drug Discovery	Nov 10 '25	Sale	18.06	3,501	63,223	92,911	Nov 13 08:13 PM
DANIEL DAVID LONG	Officer	Nov 10 '25	Proposed Sale	18.06	3,501	63,223		Nov 10 04:07 PM
Klein Uwe	SVP, Biological Sciences	Aug 18 '25	Option Exercise	4.10	23,008	94,367	23,008	Aug 19 05:02 PM

FULC

Fulcrum Therapeutics Inc

SEPN

Septerna Inc

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