| Insider Trading | 
Relationship | 
Date | 
Transaction | 
Cost | 
#Shares | 
Value ($) | 
#Shares Total | 
SEC Form 4 | 
 
| GORMAN KEVIN CHARLES | Director | Aug 07 '25 | Option Exercise | 35.99 | 106,322 | 3,826,529 | 620,918 | Aug 11 04:55 PM |  | GORMAN KEVIN CHARLES | Director | Aug 07 '25 | Sale | 126.41 | 106,322 | 13,440,281 | 514,596 | Aug 11 04:55 PM |  | KEVIN CHARLES GORMAN | Director | Aug 07 '25 | Proposed Sale | 128.43 | 106,322 | 13,654,934 |  | Aug 07 04:24 PM |  | Delaet Ingrid | Chief Regulatory Officer | Jul 10 '25 | Option Exercise | 79.02 | 457 | 36,112 | 5,187 | Jul 11 05:15 PM |  | Delaet Ingrid | Chief Regulatory Officer | Jul 10 '25 | Sale | 135.00 | 457 | 61,695 | 4,730 | Jul 11 05:15 PM |  | Onyia Jude | Chief Scientific Officer | Jul 09 '25 | Option Exercise | 84.74 | 59,819 | 5,069,062 | 78,108 | Jul 11 05:01 PM |  | Onyia Jude | Chief Scientific Officer | Jul 09 '25 | Sale | 130.46 | 59,819 | 7,803,688 | 18,289 | Jul 11 05:01 PM |  | INGRID DELAET | Officer | Jul 10 '25 | Proposed Sale | 133.51 | 457 | 61,014 |  | Jul 10 04:32 PM |  | Onyia Jude | Chief Scientific Officer | Jul 02 '25 | Option Exercise | 84.74 | 20,362 | 1,725,476 | 38,651 | Jul 07 04:10 PM |  | Onyia Jude | Chief Scientific Officer | Jul 02 '25 | Sale | 130.13 | 20,362 | 2,649,738 | 18,289 | Jul 07 04:10 PM |  | JUDE ONYIA | Officer | Jul 02 '25 | Proposed Sale | 128.00 | 80,181 | 10,263,168 |  | Jul 02 04:22 PM |  | GORMAN KEVIN CHARLES | Director | May 27 '25 | Sale | 120.38 | 9,613 | 1,157,211 | 514,596 | May 29 06:15 PM |  | KEVIN CHARLES GORMAN | Director | May 27 '25 | Proposed Sale | 120.18 | 9,613 | 1,155,290 |  | May 27 04:38 PM |  | RASTETTER WILLIAM H | Director | May 22 '25 | Option Exercise | 0.00 | 2,869 | 0 | 40,360 | May 22 06:15 PM |  | POON CHRISTINE A | Director | May 22 '25 | Option Exercise | 0.00 | 1,435 | 0 | 1,435 | May 22 05:32 PM |  | Sharp Shalini | Director | May 22 '25 | Option Exercise | 0.00 | 1,435 | 0 | 2,429 | May 22 05:28 PM |  | SHERWIN STEPHEN A | Director | May 22 '25 | Option Exercise | 0.00 | 2,869 | 0 | 13,542 | May 22 05:26 PM |  | POPS RICHARD F | Director | May 22 '25 | Option Exercise | 0.00 | 2,869 | 0 | 34,480 | May 22 05:23 PM |  | MORROW GEORGE J | Director | May 22 '25 | Option Exercise | 0.00 | 2,869 | 0 | 7,068 | May 22 05:20 PM |  | LYONS GARY A | Director | May 22 '25 | Option Exercise | 0.00 | 1,435 | 0 | 120,482 | May 22 05:18 PM |  | Norwalk Leslie V | Director | May 22 '25 | Option Exercise | 0.00 | 1,435 | 0 | 2,429 | May 22 05:14 PM |  | Mercier Johanna | Director | May 22 '25 | Option Exercise | 0.00 | 1,435 | 0 | 3,535 | May 22 05:12 PM |  | Cooke Julie | Chief Human Resources Officer | May 16 '25 | Option Exercise | 61.82 | 6,468 | 399,852 | 26,858 | May 20 04:43 PM |  | RASTETTER WILLIAM H | Director | May 05 '25 | Option Exercise | 42.76 | 30,000 | 1,282,800 | 67,491 | May 07 07:05 PM |  | RASTETTER WILLIAM H | Director | May 05 '25 | Sale | 110.20 | 30,000 | 3,305,952 | 37,491 | May 07 07:05 PM |  | WILLIAM H. RASTETTER | Officer | May 05 '25 | Proposed Sale | 109.68 | 30,000 | 3,290,400 |  | May 05 04:40 PM |  | Cooke Julie | Chief Human Resources Officer | Feb 13 '25 | Option Exercise | 0.00 | 2,910 | 0 | 20,945 | Feb 14 07:13 PM |  | Cooke Julie | Chief Human Resources Officer | Feb 13 '25 | Sale | 116.78 | 1,551 | 181,129 | 19,544 | Feb 14 07:13 PM |  | GORMAN KEVIN CHARLES | Director | Feb 13 '25 | Option Exercise | 0.00 | 10,979 | 0 | 527,221 | Feb 14 06:57 PM |  | GORMAN KEVIN CHARLES | Director | Feb 13 '25 | Sale | 116.69 | 5,844 | 681,914 | 521,618 | Feb 14 06:57 PM |  | SHERWIN STEPHEN A | Director | Feb 13 '25 | Sale | 116.69 | 13,831 | 1,613,923 | 10,673 | Feb 14 06:49 PM |  | ROBERTS EIRY | Chief Medical Officer | Feb 13 '25 | Option Exercise | 0.00 | 4,605 | 0 | 36,140 | Feb 14 06:42 PM |  | ROBERTS EIRY | Chief Medical Officer | Feb 13 '25 | Sale | 116.85 | 1,718 | 200,742 | 34,252 | Feb 14 06:42 PM |  | ROBERTS EIRY | Chief Medical Officer | Feb 14 '25 | Sale | 115.04 | 500 | 57,521 | 35,640 | Feb 14 06:42 PM |  | Onyia Jude | Chief Scientific Officer | Feb 13 '25 | Option Exercise | 0.00 | 5,407 | 0 | 19,536 | Feb 14 06:35 PM |  | Onyia Jude | Chief Scientific Officer | Feb 13 '25 | Sale | 116.79 | 2,879 | 336,239 | 16,846 | Feb 14 06:35 PM |  | Lippoldt Darin | Chief Legal Officer | Feb 13 '25 | Option Exercise | 0.00 | 4,100 | 0 | 44,491 | Feb 14 06:26 PM |  | Lippoldt Darin | Chief Legal Officer | Feb 13 '25 | Sale | 116.75 | 2,184 | 254,992 | 42,474 | Feb 14 06:26 PM |  | Gano Kyle | Chief Executive Officer | Feb 13 '25 | Option Exercise | 0.00 | 4,807 | 0 | 141,113 | Feb 14 06:20 PM |  | Gano Kyle | Chief Executive Officer | Feb 13 '25 | Sale | 116.85 | 2,558 | 298,908 | 138,872 | Feb 14 06:20 PM |  | Delaet Ingrid | Chief Regulatory Officer | Feb 13 '25 | Option Exercise | 0.00 | 2,759 | 0 | 5,485 | Feb 14 06:13 PM |  | Delaet Ingrid | Chief Regulatory Officer | Feb 13 '25 | Sale | 116.71 | 1,471 | 171,674 | 4,084 | Feb 14 06:13 PM |  | Boyer David W. | Chief Corp. Affairs Officer | Feb 13 '25 | Option Exercise | 0.00 | 3,352 | 0 | 4,395 | Feb 14 06:08 PM |  | Boyer David W. | Chief Corp. Affairs Officer | Feb 13 '25 | Sale | 116.74 | 1,785 | 208,387 | 2,854 | Feb 14 06:08 PM |  | BENEVICH ERIC | Chief Commercial Officer | Feb 13 '25 | Option Exercise | 0.00 | 4,044 | 0 | 45,745 | Feb 14 06:03 PM |  | BENEVICH ERIC | Chief Commercial Officer | Feb 13 '25 | Sale | 116.73 | 2,154 | 251,428 | 43,784 | Feb 14 06:03 PM |  | ABERNETHY MATT | Chief Financial Officer | Feb 13 '25 | Option Exercise | 0.00 | 4,807 | 0 | 37,016 | Feb 14 06:00 PM |  | ABERNETHY MATT | Chief Financial Officer | Feb 13 '25 | Sale | 116.86 | 2,558 | 298,923 | 34,775 | Feb 14 06:00 PM |  | EIRY WYN ROBERTS | Officer | Feb 14 '25 | Proposed Sale | 115.04 | 500 | 57,521 |  | Feb 14 04:12 PM |  | STEPHEN A SHERWIN | Director | Feb 13 '25 | Proposed Sale | 117.18 | 13,831 | 1,620,717 |  | Feb 13 04:38 PM |  | MATTHEW  ABERNETHY | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 1,352 | 158,427 |  | Feb 13 04:38 PM |  | MATTHEW C ABERNETHY | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 1,206 | 141,319 |  | Feb 13 04:37 PM |  | KEVIN CHARLES GORMAN | Director | Feb 13 '25 | Proposed Sale | 117.18 | 3,012 | 352,946 |  | Feb 13 04:37 PM |  | KYLE W GANO | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 1,206 | 141,319 |  | Feb 13 04:37 PM |  | JULIE SMITH COOKE | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 755 | 88,471 |  | Feb 13 04:37 PM |  | ERIC S BENEVICH | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 1,056 | 123,742 |  | Feb 13 04:36 PM |  | JUDE ONYIA | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 1,447 | 169,559 |  | Feb 13 04:36 PM |  | INGRID DELAET | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 755 | 88,471 |  | Feb 13 04:36 PM |  | DAVID WARREN BOYER | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 830 | 97,259 |  | Feb 13 04:35 PM |  | DARIN LIPPOLDT | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 1,086 | 127,257 |  | Feb 13 04:35 PM |  | EIRY WYN ROBERTS | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 604 | 70,777 |  | Feb 13 04:35 PM |  | EIRY  ROBERTS | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 1,114 | 130,539 |  | Feb 13 04:34 PM |  | DARIN LIPPOLDT | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 1,098 | 128,664 |  | Feb 13 04:34 PM |  | ERIC BENEVICH | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 1,098 | 128,664 |  | Feb 13 04:34 PM |  | JUDE ONYIA | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 1,432 | 167,802 |  | Feb 13 04:34 PM |  | INGRID DELAET | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 716 | 83,901 |  | Feb 13 04:33 PM |  | DAVID WARREN BOYER | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 955 | 111,907 |  | Feb 13 04:33 PM |  | JULIE  COOKE | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 796 | 93,275 |  | Feb 13 04:33 PM |  | KYLE GANO | Officer | Feb 13 '25 | Proposed Sale | 117.18 | 1,352 | 158,427 |  | Feb 13 04:32 PM |  | Kevin Charles Gorman | Director | Feb 13 '25 | Proposed Sale | 117.18 | 2,832 | 331,854 |  | Feb 13 04:31 PM |  | Cooke Julie | Chief Human Resources Officer | Feb 08 '25 | Option Exercise | 0.00 | 1,329 | 0 | 19,531 | Feb 12 07:00 PM |  | Cooke Julie | Chief Human Resources Officer | Feb 10 '25 | Sale | 118.28 | 700 | 82,792 | 18,831 | Feb 12 07:00 PM |  | GORMAN KEVIN CHARLES | Director | Feb 08 '25 | Option Exercise | 0.00 | 4,318 | 0 | 521,348 | Feb 12 06:56 PM |  | GORMAN KEVIN CHARLES | Director | Feb 10 '25 | Sale | 118.37 | 2,274 | 269,167 | 519,074 | Feb 12 06:56 PM |  | ROBERTS EIRY | Chief Medical Officer | Feb 08 '25 | Option Exercise | 0.00 | 1,860 | 0 | 34,233 | Feb 12 06:52 PM |  | ROBERTS EIRY | Chief Medical Officer | Feb 10 '25 | Sale | 118.22 | 980 | 115,853 | 33,253 | Feb 12 06:52 PM |  | Lippoldt Darin | Chief Legal Officer | Feb 08 '25 | Option Exercise | 0.00 | 1,727 | 0 | 42,590 | Feb 12 06:49 PM |  | Lippoldt Darin | Chief Legal Officer | Feb 10 '25 | Sale | 118.25 | 911 | 107,727 | 41,679 | Feb 12 06:49 PM |  | Gano Kyle | Chief Executive Officer | Feb 08 '25 | Option Exercise | 0.00 | 1,860 | 0 | 138,638 | Feb 12 06:48 PM |  | Gano Kyle | Chief Executive Officer | Feb 10 '25 | Sale | 118.39 | 980 | 116,020 | 137,658 | Feb 12 06:48 PM |  | Boyer David W. | Chief Corp. Affairs Officer | Feb 08 '25 | Option Exercise | 0.00 | 1,329 | 0 | 2,698 | Feb 12 06:46 PM |  | Boyer David W. | Chief Corp. Affairs Officer | Feb 10 '25 | Sale | 118.31 | 700 | 82,820 | 1,998 | Feb 12 06:46 PM |  | BENEVICH ERIC | Chief Commercial Officer | Feb 08 '25 | Option Exercise | 0.00 | 1,860 | 0 | 43,779 | Feb 12 06:44 PM |  | BENEVICH ERIC | Chief Commercial Officer | Feb 10 '25 | Sale | 118.31 | 980 | 115,940 | 42,799 | Feb 12 06:44 PM |  | ABERNETHY MATT | Chief Financial Officer | Feb 08 '25 | Option Exercise | 0.00 | 1,860 | 0 | 34,541 | Feb 12 06:41 PM |  | ABERNETHY MATT | Chief Financial Officer | Feb 10 '25 | Sale | 118.27 | 980 | 115,909 | 33,561 | Feb 12 06:41 PM |  | KYLE W GANO | Officer | Feb 10 '25 | Proposed Sale | 122.62 | 980 | 120,168 |  | Feb 10 04:33 PM |  | JULIE SMITH COOKE | Officer | Feb 10 '25 | Proposed Sale | 122.62 | 700 | 85,834 |  | Feb 10 04:33 PM |  | DAVID WARREN BOYER | Officer | Feb 10 '25 | Proposed Sale | 122.62 | 700 | 85,834 |  | Feb 10 04:33 PM |  | ERIC BENEVICH | Officer | Feb 10 '25 | Proposed Sale | 122.62 | 980 | 120,168 |  | Feb 10 04:32 PM |  | KEVIN CHARLES GORMAN | Director | Feb 10 '25 | Proposed Sale | 122.62 | 2,274 | 278,838 |  | Feb 10 04:32 PM |  | DARIN LIPPOLDT | Officer | Feb 10 '25 | Proposed Sale | 122.62 | 911 | 111,707 |  | Feb 10 04:32 PM |  | EIRY WYN ROBERTS | Officer | Feb 10 '25 | Proposed Sale | 122.62 | 980 | 120,168 |  | Feb 10 04:31 PM |  | MATTHEW C ABERNETHY | Officer | Feb 10 '25 | Proposed Sale | 122.62 | 980 | 120,168 |  | Feb 10 04:30 PM |  | Cooke Julie | Chief Human Resources Officer | Jan 31 '25 | Option Exercise | 0.00 | 1,740 | 0 | 19,942 | Feb 04 06:05 PM |  | Cooke Julie | Chief Human Resources Officer | Jan 31 '25 | Sale | 152.89 | 1,740 | 266,025 | 18,202 | Feb 04 06:05 PM |  | GORMAN KEVIN CHARLES | Director | Jan 31 '25 | Option Exercise | 0.00 | 5,141 | 0 | 519,737 | Feb 04 05:58 PM |  | GORMAN KEVIN CHARLES | Director | Jan 31 '25 | Sale | 152.92 | 2,707 | 413,967 | 517,030 | Feb 04 05:58 PM |  | ROBERTS EIRY | Chief Medical Officer | Jan 31 '25 | Option Exercise | 0.00 | 2,769 | 0 | 33,830 | Feb 04 05:54 PM |  | ROBERTS EIRY | Chief Medical Officer | Jan 31 '25 | Sale | 152.80 | 1,457 | 222,636 | 32,373 | Feb 04 05:54 PM |   
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