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SEPN

Septerna Inc

Mar 09 • 04:00PM ET

29.06

+0.28 0.97 %

Healthcare • Biotechnology • USA • NASD

Mar 09, 6:16 PMSepterna beats Q4 2025 estimates with non-GAAP EPS -0.24 and revenue $24.1M, ends year with $548.7M cash

Held by: VTI IWM VXF IBB IWN XPH SCHA VTWO DWAS IHE

Scroll to Statements

Index	RUT	P/E	-	EPS (ttm)	-1.11	Insider Own	39.85%	Shs Outstand	44.81M	Perf Week	1.47%
Market Cap	1.30B	Forward P/E	-	EPS next Y	-2.06	Insider Trans	-0.44%	Shs Float	26.93M	Perf Month	18.90%
Enterprise Value	776.10M	PEG	-	EPS next Q	-0.33	Inst Own	65.62%	Short Float	6.61%	Perf Quarter	11.09%
Income	-48.88M	P/S	28.32	EPS this Y	-36.10%	Inst Trans	2.55%	Short Ratio	5.87	Perf Half Y	101.39%
Sales	45.95M	P/B	3.41	EPS next Y	-37.48%	ROA	-9.29%	Short Interest	1.78M	Perf YTD	4.23%
Book/sh	8.52	P/C	2.37	EPS next 5Y	-	ROE	-12.19%	52W High	32.63 -10.94%	Perf Year	351.94%
Cash/sh	12.25	P/FCF	11.86	EPS past 3/5Y	-18.79% -	ROIC	-12.12%	52W Low	4.66 523.61%	Perf 3Y	-
Dividend Est.	-	EV/EBITDA	-	Sales past 3/5Y	- -	Gross Margin	96.52%	Volatility	6.90% 7.65%	Perf 5Y	-
Dividend TTM	-	EV/Sales	16.89	EPS Y/Y TTM	-269.99%	Oper. Margin	-175.83%	ATR (14)	1.98	Perf 10Y	-
Dividend Ex-Date	-	Quick Ratio	4.73	Sales Y/Y TTM	4174.51%	Profit Margin	-106.37%	RSI (14)	55.06	Recom	1.00
Dividend Gr. 3/5Y	- -	Current Ratio	4.73	EPS Q/Q	62.25%	SMA20	2.88%	Beta	3.42	Target Price	45.33
Payout	-	Debt/Eq	0.06	Sales Q/Q	11276.42%	SMA50	7.67%	Rel Volume	1.86	Prev Close	28.78
Employees	130	LT Debt/Eq	0.06	Earnings	Mar 09 AMC	SMA200	50.98%	Avg Volume	303.21K	Price	29.06
IPO	Oct 25, 2024	Option/Short	Yes / Yes	EPS/Sales Surpr.	5.62% 32.52%	Trades		Volume	556,630	Change	0.97%

Date	Action	Analyst	Rating Change	Price Target Change
Dec-19-25	Initiated	Raymond James	Strong Buy	$38
Dec-15-25	Initiated	Truist	Buy	$34
Nov-14-25	Upgrade	Wells Fargo	Equal Weight → Overweight
Jun-23-25	Initiated	H.C. Wainwright	Buy	$26
Feb-18-25	Downgrade	Wells Fargo	Overweight → Equal Weight	$14
Nov-19-24	Initiated	Wells Fargo	Overweight	$43
Nov-19-24	Initiated	TD Cowen	Buy
Nov-19-24	Initiated	JP Morgan	Overweight	$38
Nov-19-24	Initiated	Cantor Fitzgerald	Overweight	$50

Mar-09-26 05:20PM	Septerna, Inc. (SEPN) Reports Q4 Loss, Tops Revenue Estimates (Zacks)
04:05PM	Septerna Highlights Pipeline Progress and Reports Fourth Quarter and Full Year 2025 Financial Results (GlobeNewswire)
Mar-01-26 09:45AM	Septerna Announces Positive Phase 1 Data for SEP-631, an Oral MRGPRX2 NAM for the Treatment of Mast Cell-Driven Diseases, and Outlines Initial Phase 2 Development Strategy (GlobeNewswire)
Feb-24-26 08:00AM	Septerna to Present at TD Cowen 46th Annual Health Care Conference (GlobeNewswire) +10.21%
Feb-10-26 04:05PM	Septerna Reports Inducement Grant Under Nasdaq Listing Rule 5635(c)(4) (GlobeNewswire)
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08:00AM	Septerna to Present Data from Phase 1 Clinical Trial of SEP-631 for the Treatment of Mast Cell-Driven Diseases at 2026 AAAAI Annual Meeting (GlobeNewswire)
Jan-08-26 04:05PM	Septerna Expands Leadership with Appointment of Industry Veteran Mark A. Wilson as Chief Legal Officer (GlobeNewswire)
Dec-23-25 09:33AM	Coty downgraded, Spruce Biosciences initiated: Wall Street's top analyst calls (The Fly)
Dec-17-25 08:00AM	Septerna to Present at 44th Annual J.P. Morgan Healthcare Conference (GlobeNewswire)
Nov-25-25 08:00AM	Septerna to Participate in 8th Annual Evercore Healthcare Conference (GlobeNewswire)
Nov-10-25 08:20AM	Septerna, Inc. (SEPN) Reports Q3 Loss, Misses Revenue Estimates (Zacks)
07:00AM	Septerna Highlights Company Progress and Reports Third Quarter 2025 Financial Results (GlobeNewswire)
Nov-06-25 09:15AM	Iovance Biotherapeutics (IOVA) Reports Q3 Loss, Lags Revenue Estimates (Zacks)
Nov-03-25 08:00AM	Septerna to Participate in Upcoming Investor Conferences (GlobeNewswire)
Oct-31-25 04:56AM	Strength Seen in Moderna (MRNA): Can Its 13.9% Jump Turn into More Strength? (Zacks)
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Oct-22-25 05:57AM	Arcturus Therapeutics (ARCT) Moves 7.7% Higher: Will This Strength Last? (Zacks)
Oct-15-25 04:15PM	Novo Nordisk's Akero Therapeutics Buy Targets Eli Lilly's Lead (MarketBeat)
Oct-09-25 10:13AM	Strength Seen in Septerna, Inc. (SEPN): Can Its 7.0% Jump Turn into More Strength? (Zacks)
Oct-03-25 08:42AM	Are Options Traders Betting on a Big Move in Septerna Stock? (Zacks)
Sep-29-25 04:01PM	Septerna Appoints Veteran Biotechnology Leader Keith Gottesdiener, M.D., to its Board of Directors (GlobeNewswire)
Aug-27-25 08:00AM	Septerna to Participate in Upcoming Investor Conferences (GlobeNewswire)
Aug-21-25 08:00AM	Septerna Announces Dosing of the First Participants in Phase 1 Clinical Trial of SEP-631, an Oral Small Molecule MRGPRX2 Negative Allosteric Modulator for the Treatment of Mast Cell-Driven Diseases (GlobeNewswire) +5.50%
Aug-14-25 08:15AM	Lilly signs $1.3 billion deal with Superluminal to discover obesity medicines using AI (Reuters)
Aug-11-25 04:01PM	Septerna Highlights Business Progress and Reports Second Quarter 2025 Financial Results (GlobeNewswire)
May-29-25 08:00AM	Septerna to Present at Jefferies Global Healthcare Conference (GlobeNewswire)
May-23-25 07:45AM	Analysts Think These Stocks Could More Than Double in Value (MarketBeat)
May-21-25 09:55AM	Does Septerna, Inc. (SEPN) Have the Potential to Rally 151.27% as Wall Street Analysts Expect? (Zacks)
May-15-25 04:01PM	Septerna Highlights Business Progress and Reports First Quarter 2025 Financial Results (GlobeNewswire)
10:00AM	ETFs to Capitalize on the Novo Nordisk-Septerna Deal (Zacks)
08:46AM	Septerna Stock Surges on Oral Obesity Drug Deal With Novo Nordisk (Zacks)
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07:45AM	Is It Time to Buy the Dip in Novo Nordisk Stock? (MarketBeat)
01:45AM	Novo Nordisk and Septerna Strike $2.2 Billion Deal to Develop Obesity Pills (The Wall Street Journal)
May-14-25 04:06PM	Novo Nordisk Inks A Major Obesity Deal, Sending Shares Of New Partner Septerna Skyrocketing (Investor's Business Daily) +50.97%
02:22PM	eToro's Nasdaq debut, Exelixis outlook, SepternaNovo deal (Yahoo Finance Video)
01:29PM	Novo Nordisk taps Septerna in $2.2bn deal for oral obesity therapies (Pharmaceutical Technology)
10:28AM	Novo Nordisk Rises on Weight-Loss News. Its a Huge Deal for This Stock. (Barrons.com)
09:35AM	Novo Nordisk, Septerna sign $2.2B deal to develop weight-loss pill (Yahoo Finance Video)
09:32AM	Novo Nordisk's latest bet on obesity pills: $2.2 billion for biotech Septerna (Yahoo Finance)
09:32AM	Novo Nordisk's latest bet on obesity pills: $2.2 billion for biotech Sapterna (Yahoo Finance)
07:03AM	Novo Nordisk strikes $2.2 billion deal with Septerna to develop new obesity treatments (Reuters)
Apr-16-25 09:55AM	Wall Street Analysts Predict a 207.31% Upside in Septerna, Inc. (SEPN): Here's What You Should Know (Zacks)
Mar-31-25 02:34PM	Biotech Stocks Q1 2025 Recap: Winners And Underperformers (Seeking Alpha) -5.08%
Mar-27-25 08:00AM	Septerna Provides Corporate Overview and Reports Fourth Quarter and Full Year 2024 Financial Results (GlobeNewswire)
Mar-14-25 11:26AM	Septerna, Inc. (SEPN): Among Top Insider Purchases Last Month (Insider Monkey)
Mar-05-25 06:59PM	Septerna, Inc. (SEPN): Among The Stocks With At Least $30 Million In Insider Spending Recently (Insider Monkey) +7.25%
Feb-26-25 08:00AM	Septerna to Present at TD Cowen 45th Annual Health Care Conference (GlobeNewswire)
Feb-18-25 08:00AM	Septerna Announces Discontinuation of SEP-786 Phase 1 Clinical Trial and Plans to Advance Next-Generation Oral Small Molecule PTH1R Agonist (GlobeNewswire) -46.99%
Feb-14-25 06:45AM	Its not for the faint of heart. How 3 CEOs took their biotechs public (BioPharma Dive) +12.21%
Feb-06-25 07:48AM	Septerna, Inc. (SEPN): Among the Best Rebound Stocks to Invest In Now (Insider Monkey)
Jan-06-25 07:00AM	Septerna Expands Leadership with Appointment of Industry Veteran Gil Labrucherie as Chief Financial Officer (GlobeNewswire) -6.75%
Dec-18-24 08:00AM	Septerna to Present at the 43rd Annual J.P. Morgan Healthcare Conference (GlobeNewswire)
Nov-21-24 11:12PM	Septerna, Inc. Reports Q3 2024 Financials and Progress (TipRanks)
Nov-20-24 07:00AM	Septerna Reports Third Quarter 2024 Financial Results and Recent Business Highlights (GlobeNewswire) -7.02%
05:10AM	Septerna initiated with an Overweight at JPMorgan (TipRanks)
Oct-30-24 04:41PM	Septerna Announces Closing of $331.2 Million Upsized Initial Public Offering (GlobeNewswire) +12.32%
Oct-24-24 09:47PM	Septerna Prices Upsized Initial Public Offering (GlobeNewswire)

Septerna, Inc. is a clinical-stage biotechnology company, which engages in pioneering a new era of G protein-coupled receptor oral small molecule drug discovery powered by proprietary Native Complex PlatformTM. Its pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. The company was founded by Robert Joseph Lefkowitz, Arthur Christopoulos, Patrick Sexton, and Jeffrey T. Finer in December 2019 and is headquartered in South San Francisco, CA.

Insider Trading	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
Shaikhly Samira	Chief People Officer	Mar 02 '26	Option Exercise	1.84	70,453	129,456	71,246	Mar 04 07:00 PM
Shaikhly Samira	Chief People Officer	Mar 02 '26	Sale	28.10	70,453	1,979,838	793	Mar 04 07:00 PM
SAMIRA SHAIKHLY	Officer	Mar 02 '26	Proposed Sale	29.02	76,388	2,216,780		Mar 02 04:36 PM
Bhatt Elizabeth	President and COO	Feb 18 '26	Option Exercise	6.81	4,000	27,240	178,209	Feb 20 05:28 PM
Bhatt Elizabeth	President and COO	Feb 18 '26	Sale	28.97	4,000	115,860	174,209	Feb 20 05:28 PM
ELIZABETH BHATT	Officer	Feb 18 '26	Proposed Sale	30.30	8,000	242,400		Feb 18 04:27 PM
Long Daniel D.	SVP, Drug Discovery	Nov 10 '25	Sale	18.06	3,501	63,223	92,911	Nov 13 08:13 PM
DANIEL DAVID LONG	Officer	Nov 10 '25	Proposed Sale	18.06	3,501	63,223		Nov 10 04:07 PM
Klein Uwe	SVP, Biological Sciences	Aug 18 '25	Option Exercise	4.10	23,008	94,367	23,008	Aug 19 05:02 PM
Finer Jeffrey	CEO and President	Apr 02 '25	Option Exercise	2.76	50,000	138,000	821,907	Apr 04 04:13 PM
Finer Jeffrey	CEO and President	Apr 03 '25	Option Exercise	2.76	5,000	13,800	826,907	Apr 04 04:13 PM

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SEPN

Septerna Inc

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