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KPTI Karyopharm Therapeutics Inc. daily Stock Chart
KPTI [NASD]
Karyopharm Therapeutics Inc.
Index- P/E- EPS (ttm)-2.92 Insider Own1.90% Shs Outstand67.63M Perf Week-17.09%
Market Cap1.27B Forward P/E- EPS next Y-1.42 Insider Trans-21.69% Shs Float66.04M Perf Month-22.36%
Income-186.40M PEG- EPS next Q-0.56 Inst Own91.03% Short Float20.15% Perf Quarter-38.24%
Sales58.90M P/S21.61 EPS this Y-2.60% Inst Trans20.14% Short Ratio6.70 Perf Half Y1.06%
Book/sh2.46 P/B6.96 EPS next Y48.40% ROA-59.80% Target Price- Perf Year203.55%
Cash/sh4.74 P/C3.62 EPS next 5Y- ROE-208.10% 52W Range5.14 - 29.61 Perf YTD-10.69%
Dividend- P/FCF- EPS past 5Y-5.80% ROI-118.50% 52W High-42.18% Beta1.51
Dividend %- Quick Ratio7.40 Sales past 5Y182.10% Gross Margin94.50% 52W Low233.34% ATR1.60
Employees347 Current Ratio7.50 Sales Q/Q11601.90% Oper. Margin- RSI (14)40.43 Volatility9.06% 8.73%
OptionableYes Debt/Eq1.12 EPS Q/Q28.00% Profit Margin- Rel Volume1.47 Prev Close18.49
ShortableYes LT Debt/Eq1.12 EarningsMay 05 BMO Payout- Avg Volume1.99M Price17.12
Recom1.70 SMA20-10.89% SMA50-15.92% SMA2006.06% Volume2,909,427 Change-7.41%
Mar-04-20Initiated Barclays Overweight $30
Jan-17-20Downgrade Wedbush Outperform → Neutral
Jul-23-19Upgrade JP Morgan Neutral → Overweight $8 → $16
Jul-05-19Reiterated Robert W. Baird Outperform $15 → $25
Jul-05-19Reiterated H.C. Wainwright Buy $29 → $32
Mar-01-19Downgrade JP Morgan Overweight → Neutral $21 → $7
Feb-28-19Reiterated BofA/Merrill Underperform $15 → $5
Feb-27-19Downgrade BofA/Merrill Neutral → Underperform $15 → $5
Jan-03-19Upgrade BofA/Merrill Underperform → Neutral
Dec-03-18Initiated B. Riley FBR Buy $23
Nov-09-18Upgrade Wedbush Neutral → Outperform $19
May-24-18Downgrade Wedbush Outperform → Neutral $20 → $19
Apr-02-18Resumed Leerink Partners Outperform $19
Nov-15-17Resumed H.C. Wainwright Buy $23
Sep-15-17Initiated RBC Capital Mkts Outperform $14
Sep-08-16Reiterated H.C. Wainwright Buy $15 → $16
Aug-30-16Upgrade Jefferies Hold → Buy
Aug-18-16Initiated H.C. Wainwright Buy $15
Jun-28-16Initiated Robert W. Baird Outperform $16
May-27-16Initiated Raymond James Outperform $13
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Karyopharm Therapeutics Inc., a pharmaceutical company, engages in the discovery, development, and commercialization of various drugs directed against nuclear export and related targets for the treatment of cancer and other diseases. The company is developing small molecule selective inhibitor of nuclear export (SINE) compounds that inhibit the nuclear export protein exportin 1. Its lead compound is XPOVIO (selinexor) tablets for the treatment of patients with heavily pretreated multiple myeloma. The company develops BOSTON, which is in Phase 3 clinical trial for the treatment of patients with multiple myeloma; STORM, which is in Phase 2b single-arm clinical trial for evaluating oral selinexor in combination with standard, low-dose dexamethasone in heavily pretreated patients, relapsed or refractory myeloma; STOMP, which is in Phase 1b/2 multi-arm clinical trial for the treatment of ow-dose dexamethasone plus standard therapies, including Velcade, Kyprolis, Revlimid, and Pomalyst or Darzalex; and SADAL, which is in Phase 2b clinical trial for the treatment of patients with relapsed or refractory diffuse large B-cell lymphoma. It also develops SEAL, which is in Phase 3 clinical trial for the treartment of liposarcoma; SIENDO, which is in Phase 2/3 clinical trial for treatment of endometrial cancer; and KING, which is in Phase 2 for the treatment of glioblastoma multiforme brain tumor. In addition, the company has various investigational programs in clinical or preclinical development, such as Eltanexor (KPT-8602), KPT-9274, and Verdinexor (KPT-335). The company has collaboration with PROMETRIKA, LLC to conduct the first randomized clinical trial for low-dose selinexor (XPOVIOA), an XPO1 inhibitor, in hospitalized patients with severe COVID-19. Karyopharm Therapeutics Inc. was founded in 2008 and is headquartered in Newton, Massachusetts.
Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total SEC Form 4
Shacham SharonPresident & CSOMay 18Option Exercise0.037,500248763,989May 19 05:34 PM
Kauffman MichaelChief Executive OfficerMay 18Option Exercise0.037,500248763,989May 19 05:36 PM
Shacham SharonPresident & CSOMay 18Sale20.007,500150,000756,489May 19 05:34 PM
Kauffman MichaelChief Executive OfficerMay 18Sale20.007,500150,000756,489May 19 05:36 PM
Shacham SharonPresident & CSOMay 15Option Exercise0.037,500248763,989May 19 05:34 PM
Kauffman MichaelChief Executive OfficerMay 15Option Exercise0.037,500248763,989May 19 05:36 PM
Shacham SharonPresident & CSOMay 15Sale18.657,500139,841756,489May 19 05:34 PM
Kauffman MichaelChief Executive OfficerMay 15Sale18.657,500139,841756,489May 19 05:36 PM
Shacham SharonPresident & CSOMay 07Option Exercise4.757,50035,640562,622May 11 04:22 PM
Shacham SharonPresident & CSOMay 07Option Exercise4.757,50035,640763,989May 11 04:22 PM
Kauffman MichaelChief Executive OfficerMay 07Option Exercise4.757,50035,640763,989May 11 04:19 PM
Kauffman MichaelChief Executive OfficerMay 07Option Exercise4.757,50035,640562,622May 11 04:19 PM
Primiano Christopher BrettEVP, CBO, GC & SecretaryMay 07Option Exercise6.542,94619,2677,595May 11 04:25 PM
Frenkel RanChief Dev Operations OfficerMay 07Sale20.001,97439,48035,088May 11 04:26 PM
Primiano Christopher BrettEVP, CBO, GC & SecretaryMay 07Sale19.739,660190,6274,649May 11 04:25 PM
Shacham SharonPresident & CSOMay 07Sale19.637,500147,209555,122May 11 04:22 PM
Shacham SharonPresident & CSOMay 07Sale19.637,500147,205756,489May 11 04:22 PM
Kauffman MichaelChief Executive OfficerMay 07Sale19.637,500147,205756,489May 11 04:19 PM
Kauffman MichaelChief Executive OfficerMay 07Sale19.637,500147,209555,122May 11 04:19 PM
Shacham SharonPresident & CSOApr 09Option Exercise4.7510,00047,520565,122Apr 10 05:06 PM
Kauffman MichaelChief Executive OfficerApr 09Option Exercise4.7510,00047,520565,122Apr 10 05:09 PM
Kauffman MichaelChief Executive OfficerApr 09Sale20.6410,000206,404555,122Apr 10 05:09 PM
Shacham SharonPresident & CSOApr 09Sale20.6410,000206,404555,122Apr 10 05:06 PM
Shacham SharonPresident & CSOApr 08Option Exercise4.7510,00047,520766,489Apr 10 05:06 PM
Kauffman MichaelChief Executive OfficerApr 08Option Exercise4.7510,00047,520766,489Apr 10 05:09 PM
Kauffman MichaelChief Executive OfficerApr 08Sale18.6110,000186,115756,489Apr 10 05:09 PM
Shacham SharonPresident & CSOApr 08Sale18.6110,000186,115756,489Apr 10 05:06 PM
Greene Barry EDirectorMar 13Option Exercise0.033,0301006,030Mar 17 05:35 PM
Kauffman MichaelChief Executive OfficerMar 10Option Exercise4.7510,00047,520565,122Mar 11 07:07 PM
Shacham SharonPresident & CSOMar 10Option Exercise4.7510,00047,520565,122Mar 11 07:10 PM
Shacham SharonPresident & CSOMar 10Sale22.2210,000222,186555,122Mar 11 07:10 PM
Kauffman MichaelChief Executive OfficerMar 10Sale22.2210,000222,186555,122Mar 11 07:07 PM
Kauffman MichaelChief Executive OfficerMar 09Option Exercise4.7510,00047,520766,489Mar 11 07:07 PM
Shacham SharonPresident & CSOMar 09Option Exercise4.7510,00047,520766,489Mar 11 07:10 PM
Shacham SharonPresident & CSOMar 09Sale22.5210,000225,195756,489Mar 11 07:10 PM
Kauffman MichaelChief Executive OfficerMar 09Sale22.5210,000225,195756,489Mar 11 07:07 PM
Mirza Mansoor RazaDirectorMar 02Option Exercise8.065,00040,3005,000Mar 04 06:51 PM
Primiano Christopher BrettEVP, CBO, GC & SecretaryMar 02Option Exercise10.3926,500275,33536,867Mar 04 08:33 PM
Primiano Christopher BrettEVP, CBO, GC & SecretaryMar 02Sale25.3726,500672,27910,367Mar 04 08:33 PM
Mirza Mansoor RazaDirectorMar 02Sale23.505,000117,5000Mar 04 06:51 PM
Frenkel RanChief Dev Operations OfficerFeb 19Sale16.482,97549,03436,066Feb 21 05:57 PM
Shah JatinEVP, Chief Medical OfficerFeb 19Sale16.481,37522,66340,759Feb 21 05:58 PM
Primiano Christopher BrettEVP, CBO, GC & SecretaryFeb 19Sale16.482,96148,80310,367Feb 21 05:55 PM
Shacham SharonPresident & CSOFeb 19Sale16.488,817145,321555,122Feb 21 05:54 PM
Shacham SharonPresident & CSOFeb 19Sale16.488,817145,321756,489Feb 21 05:54 PM
Kauffman MichaelChief Executive OfficerFeb 19Sale16.488,817145,321756,489Feb 21 05:53 PM
Kauffman MichaelChief Executive OfficerFeb 19Sale16.488,817145,321555,122Feb 21 05:53 PM
Kauffman MichaelChief Executive OfficerFeb 11Option Exercise4.7510,00047,520552,139Feb 12 04:20 PM
Shacham SharonPresident & CSOFeb 11Option Exercise4.7510,00047,520552,139Feb 12 04:21 PM
Kauffman MichaelChief Executive OfficerFeb 11Sale17.4310,000174,294542,139Feb 12 04:20 PM
Shacham SharonPresident & CSOFeb 11Sale17.4310,000174,294542,139Feb 12 04:21 PM
Kauffman MichaelChief Executive OfficerFeb 10Option Exercise4.7510,00047,520753,506Feb 12 04:20 PM
Shacham SharonPresident & CSOFeb 10Option Exercise4.7510,00047,520753,506Feb 12 04:21 PM
Shacham SharonPresident & CSOFeb 10Sale16.9310,000169,327743,506Feb 12 04:21 PM
Kauffman MichaelChief Executive OfficerFeb 10Sale16.9310,000169,327743,506Feb 12 04:20 PM
Shacham SharonPresident & CSOJan 09Option Exercise4.7510,00047,520552,139Jan 10 05:04 PM
Kauffman MichaelChief Executive OfficerJan 09Option Exercise4.7510,00047,520552,139Jan 10 05:07 PM
Mirza Mansoor RazaDirectorJan 09Option Exercise8.062,05616,5712,056Jan 13 05:02 PM
Mirza Mansoor RazaDirectorJan 09Sale20.002,05641,1200Jan 13 05:02 PM
Kauffman MichaelChief Executive OfficerJan 09Sale19.1910,000191,880542,139Jan 10 05:07 PM
Shacham SharonPresident & CSOJan 09Sale19.1910,000191,880542,139Jan 10 05:04 PM
Shacham SharonPresident & CSOJan 08Option Exercise4.7510,00047,520753,506Jan 10 05:04 PM
Kauffman MichaelChief Executive OfficerJan 08Option Exercise4.7510,00047,520753,506Jan 10 05:07 PM
Kauffman MichaelChief Executive OfficerJan 08Sale18.5710,000185,705743,506Jan 10 05:07 PM
Shacham SharonPresident & CSOJan 08Sale18.5710,000185,705743,506Jan 10 05:04 PM
Primiano Christopher BrettEVP, CBO, GC & SecretaryDec 27Option Exercise10.395,00051,9508,653Dec 31 09:06 AM
Mirza Mansoor RazaDirectorDec 27Option Exercise8.062,94423,7292,944Dec 31 09:15 AM
Mirza Mansoor RazaDirectorDec 27Sale20.002,94458,8800Dec 31 09:15 AM
Primiano Christopher BrettEVP, CBO, GC & SecretaryDec 27Sale20.005,000100,0003,653Dec 31 09:06 AM
Mirza Mansoor RazaDirectorDec 18Option Exercise1.4912,12118,00012,121Dec 20 04:04 PM
Mirza Mansoor RazaDirectorDec 18Sale17.1812,121208,2360Dec 20 04:04 PM
Shacham SharonPresident & CSODec 10Option Exercise4.7510,00047,520539,767Dec 11 05:21 PM
Kauffman MichaelChief Executive OfficerDec 10Option Exercise4.7510,00047,520539,767Dec 11 05:24 PM
Kauffman MichaelChief Executive OfficerDec 10Sale15.9910,000159,896529,767Dec 11 05:24 PM
Shacham SharonPresident & CSODec 10Sale15.9910,000159,896529,767Dec 11 05:21 PM
Shacham SharonPresident & CSODec 09Option Exercise4.7510,00047,520741,134Dec 11 05:21 PM
Kauffman MichaelChief Executive OfficerDec 09Option Exercise4.7510,00047,520741,134Dec 11 05:24 PM
Mirza Mansoor RazaDirectorDec 09Option Exercise5.6410,34258,36010,342Dec 11 05:26 PM
Mirza Mansoor RazaDirectorDec 09Sale17.0210,342176,0340Dec 11 05:26 PM
Kauffman MichaelChief Executive OfficerDec 09Sale17.0210,000170,210731,134Dec 11 05:24 PM
Shacham SharonPresident & CSODec 09Sale17.0210,000170,210731,134Dec 11 05:21 PM
Primiano Christopher BrettEVP, CBO, GC & SecretaryDec 06Option Exercise8.4710,00084,65016,653Dec 10 05:18 PM
Primiano Christopher BrettEVP, CBO, GC & SecretaryDec 06Sale17.4513,000226,9083,653Dec 10 05:18 PM
Shacham SharonPresident & CSONov 11Option Exercise4.7510,00047,520539,767Nov 12 04:34 PM
Kauffman MichaelChief Executive OfficerNov 11Option Exercise4.7510,00047,520539,767Nov 12 04:39 PM
Kauffman MichaelChief Executive OfficerNov 11Sale14.7610,000147,610529,767Nov 12 04:39 PM
Shacham SharonPresident & CSONov 11Sale14.7610,000147,610529,767Nov 12 04:34 PM
Shacham SharonPresident & CSONov 08Option Exercise4.7510,00047,520741,134Nov 12 04:34 PM
Kauffman MichaelChief Executive OfficerNov 08Option Exercise4.7510,00047,520741,134Nov 12 04:39 PM
Kauffman MichaelChief Executive OfficerNov 08Sale14.6310,000146,254731,134Nov 12 04:39 PM
Shacham SharonPresident & CSONov 08Sale14.6310,000146,254731,134Nov 12 04:34 PM
Kauffman MichaelChief Executive OfficerNov 01Option Exercise4.7510,00047,520741,134Nov 05 04:08 PM
Kauffman MichaelChief Executive OfficerNov 01Option Exercise4.7510,00047,520539,767Nov 05 04:08 PM
Shacham SharonPresident & CSONov 01Option Exercise4.7510,00047,520539,767Nov 05 04:10 PM
Shacham SharonPresident & CSONov 01Option Exercise4.7510,00047,520741,134Nov 05 04:10 PM
Kauffman MichaelChief Executive OfficerNov 01Sale12.0010,000120,000731,134Nov 05 04:08 PM
Kauffman MichaelChief Executive OfficerNov 01Sale12.0010,000120,000529,767Nov 05 04:08 PM
Shacham SharonPresident & CSONov 01Sale12.0010,000120,000529,767Nov 05 04:10 PM
Shacham SharonPresident & CSONov 01Sale12.0010,000120,000731,134Nov 05 04:10 PM
Shacham SharonPresident & CSOSep 16Option Exercise4.7510,00047,520539,767Sep 17 04:54 PM