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CAI

Caris Life Sciences Inc

May 12 • 12:03PM ET

16.22

+0.28 1.76 %

Healthcare • Biotechnology • USA • Mid • NASD

May 11, 12:20 PMCaris Life Sciences real-world study validates ultra-deep whole exome tumor mutational burden assay as superior predictor of pembrolizumab benefit vs targeted panels

Peers: TEM GH TXG NTRA NEO

| Held by: VTI VB VBK IBB IWR IWP IDNA IWF IWD VONG

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Index	-	P/E	-	EPS (ttm)	-1.47	Insider Own	57.52%	Shs Outstand	282.65M	Perf Week	-14.41%
Market Cap	4.59B	Forward P/E	43.91	EPS next Y	0.37	Insider Trans	-0.02%	Shs Float	120.03M	Perf Month	-15.21%
Enterprise Value	4.19B	PEG	-	EPS next Q	0.01	Inst Own	46.94%	Short Float	10.61%	Perf Quarter	-26.84%
Income	-411.43M	P/S	5.05	EPS this Y	134.99%	Inst Trans	24.71%	Short Ratio	5.30	Perf Half Y	-36.67%
Sales	907.29M	P/B	7.72	EPS next Y	159.23%	ROA	4.67%	Short Interest	12.73M	Perf YTD	-39.88%
Book/sh	2.10	P/C	5.57	EPS next 5Y	-	ROE	28.35%	52W High	42.50 -61.84%	Perf Year	-
Cash/sh	2.91	P/FCF	39.61	EPS past 3/5Y	-7.57% -	ROIC	3.34%	52W Low	15.70 3.31%	Perf 3Y	-
Dividend Est.	-	EV/EBITDA	32.50	Sales past 3/5Y	62.87% -	Gross Margin	68.72%	Volatility	6.47% 5.43%	Perf 5Y	-
Dividend TTM	-	EV/Sales	4.62	EPS Y/Y TTM	-10.99%	Oper. Margin	11.94%	ATR (14)	1.25	Perf 10Y	-
Dividend Ex-Date	-	Quick Ratio	6.52	Sales Y/Y TTM	100.51%	Profit Margin	-45.35%	RSI (14)	36.82	Recom	1.38
Dividend Gr. 3/5Y	- -	Current Ratio	7.05	EPS Q/Q	99.60%	SMA20	-15.43%	Beta	-	Target Price	28.00
Payout	-	Debt/Eq	0.73	Sales Q/Q	78.78%	SMA50	-14.20%	Rel Volume	1.26	Prev Close	15.94
Employees	1846	LT Debt/Eq	0.72	Earnings	May 07 AMC	SMA200	-37.88%	Avg Volume	2.40M	Price	16.22
IPO	Jun 18, 2025	Option/Short	Yes / Yes	EPS/Sales Surpr.	100.00% 3.23%	Trades		Volume	1,275,861	Change	1.76%

Date	Action	Analyst	Rating Change	Price Target Change
Apr-13-26	Initiated	Jefferies	Buy	$28
Apr-10-26	Initiated	Piper Sandler	Neutral	$21
Apr-01-26	Initiated	Goldman	Buy	$27
Feb-17-26	Initiated	Robert W. Baird	Outperform	$26
Dec-02-25	Initiated	Canaccord Genuity	Hold	$28
Jul-14-25	Initiated	Wolfe Research	Outperform	$32
Jul-14-25	Initiated	TD Cowen	Buy	$32
Jul-14-25	Initiated	JP Morgan	Overweight	$31
Jul-14-25	Initiated	Guggenheim	Buy	$32
Jul-14-25	Initiated	Evercore ISI	Outperform	$33
Jul-14-25	Initiated	Citigroup	Buy	$34
Jul-14-25	Initiated	BTIG Research	Buy	$38
Jul-14-25	Initiated	BofA Securities	Buy	$31

Show Previous Ratings

May-11-26 12:15PM	Caris Life Sciences Publishes Study Showing Whole Exome Measurement of Tumor Mutational Burden Results in Increased Overall Survival Compared to Estimates from Targeted Gene Panels (PR Newswire)
May-08-26 04:05PM	Caris Life Sciences Submits Application to New York State Department of Health for Caris Assure Blood-Based Testing Authorization (PR Newswire) -18.60%
May-07-26 04:05PM	Caris Life Sciences Reports First Quarter 2026 Financial Results (PR Newswire)
May-05-26 08:30AM	Caris Life Sciences Launches Caris MI Clarity, the First and Only AI-Powered Test to Predict Both Early and Late Distant Recurrence Risk in Breast Cancer at the Time of Diagnosis (PR Newswire)
May-04-26 08:30AM	Caris Life Sciences Receives MolDX Approval for Caris ChromoSeq, Advancing Access to Comprehensive Genomic Profiling for Myeloid Malignancies (PR Newswire)
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Apr-29-26 08:30AM	Caris Life Sciences Publishes Study Validating Caris AI Insights for Temozolomide Benefit in Glioblastoma Patients (PR Newswire)
Apr-24-26 08:30AM	Caris Life Sciences to Present at the BofA Securities 2026 Health Care Conference and the Goldman Sachs 47th Annual Global Healthcare Conference (PR Newswire)
Apr-20-26 08:30AM	Caris Life Sciences to Report First Quarter 2026 Financial Results on May 7, 2026 (PR Newswire)
Apr-17-26 08:30AM	Caris Precision Oncology Alliance Welcomes UCSF Helen Diller Family Comprehensive Cancer Center (PR Newswire)
Apr-15-26 08:30AM	Caris Life Sciences Right-In-Time Clinical Trial Solution Expands Access to Precision Oncology Trials for Historically Underserved Cancer Patients (PR Newswire)
Apr-08-26 08:30AM	Caris Life Sciences Introduces Multimodal AI-Powered Molecular Insight to Identify the Benefit or Harm from the Addition of Chemotherapy for NSCLC Patients (PR Newswire)
Apr-02-26 08:30AM	Caris Life Sciences Announces Launch of Caris ChromoSeq, the World's First Whole Genome and Whole Transcriptome Tumor Profiling Assay for Myeloid Malignancies (PR Newswire)
Mar-31-26 06:00PM	Caris Life Sciences Finalizes Achieve 1 Study Results Reinforcing the Superior Sensitivity and Specificity of Caris Detect (PR Newswire) +6.11% +6.99%
Mar-26-26 08:30AM	Caris Life Sciences Advances Precision Oncology with New AI Insights Predicting Brain Metastases Risk in Breast and Lung Cancer (PR Newswire)
Mar-25-26 08:30AM	Caris Life Sciences to Present Six Oncology Studies Utilizing Proprietary Multimodal Data at the AACR Annual Meeting 2026 (PR Newswire)
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Mar-24-26 08:30AM	Caris Life Sciences Highlights the Importance of DPYD Testing in Colorectal Cancer During Colorectal Cancer Awareness Month (PR Newswire)
Mar-20-26 08:30AM	Caris Life Sciences Announces Another Breakthrough Study for GPSai in Identifying and Correcting Misdiagnosis of Cancer Patients (PR Newswire)
Mar-16-26 08:30AM	Caris Life Sciences Introduces Powerful New Caris AI Insights to Identify Early Platinum Resistance in Ovarian Cancer (PR Newswire)
Mar-11-26 08:30AM	Caris Life Sciences to Showcase Five Studies at the 2026 USCAP Annual Meeting (PR Newswire)
Mar-09-26 08:30AM	Caris Life Sciences Launches a Novel Caris AI Insights Signature to Guide First-Line Therapy Selection and Treatment De-Escalation in Pancreatic Cancer (PR Newswire)
Mar-03-26 11:40AM	BTSG vs. CAI: Which Stock Is the Better Value Option? (Zacks) -6.20%
Feb-28-26 08:00PM	Caris Life Sciences Inc (CAI) Q4 2025 Earnings Call Highlights: Record Revenue Surge and ... (GuruFocus.com)
Feb-27-26 04:40PM	Stocks Settle Lower as Bank Shares Tumble and Tech Stocks Fall (Barchart)
11:14AM	Stocks Retreat on AI Disruption Concerns and Geopolitical Risks (Barchart)
10:07AM	Stocks Fall on AI Fears and Stronger-Than-Expected Producer Prices (Barchart)
07:00AM	Cancer Test Maker Caris Life Sciences Unveils Breakthrough In Early Cancer Detection, Profit Surprise (Benzinga)
03:41AM	Caris Life Sciences (CAI) Adds New AI-powered Breast Cancer Signature to its Report (Insider Monkey)
Feb-26-26 10:07PM	Caris Life Sciences Q4 Earnings Call Highlights (MarketBeat) +5.08%
06:00PM	Caris Life Sciences Completes Interim Readout of Achieve 1 Study (PR Newswire)
04:05PM	Caris Life Sciences Reports Fourth Quarter and Full Year 2025 Financial Results and Provides 2026 Outlook (PR Newswire)
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Feb-25-26 01:58AM	Baird Initiates Coverage of Caris Life Sciences, Inc. (CAI) with an Outperform Rating (Insider Monkey)
Feb-24-26 08:30AM	Caris Launches Proprietary AI Insights Signature Which Deepens Understanding of Response to Breast Cancer Patients' Oral Chemotherapy Drug (PR Newswire)
Feb-23-26 08:30AM	Caris Life Sciences to Participate in the TD Cowen 46th Annual Health Care Conference (PR Newswire) -9.68%
Feb-20-26 01:21PM	Russell 2000 Drop, EM Stocks Hit Records After Court's Tariff Ruling: What's Moving Markets Friday? (Benzinga) -6.33%
Feb-09-26 08:30AM	Caris Life Sciences to Report Fourth Quarter and Full Year 2025 Financial Results on February 26 (PR Newswire)
Jan-28-26 08:30AM	Caris Life Sciences' Real-World Data Uncovers Metastatic Breast Cancer Patient Responses and Resistance to Trastuzumab Deruxtecan (PR Newswire)
Jan-12-26 12:43PM	Gold, Silver Spike To Record Highs As Fed Independence Falters: What's Moving Markets Monday? (Benzinga) -10.21%
08:30AM	Caris Life Sciences Announces Preliminary Fourth Quarter and Full Year 2025 Results (PR Newswire)
08:00AM	Caris Life Sciences Partners with Everlywell to Launch Caris' Forthcoming MCED Assay, Caris Detect (PR Newswire)
Jan-05-26 08:30AM	Caris Life Sciences to Present at the 44th Annual J.P. Morgan Healthcare Conference (PR Newswire)
Dec-19-25 08:30AM	The Caris Precision Oncology Alliance Welcomes Providence Swedish Cancer Institute (PR Newswire)
Dec-16-25 08:30AM	Caris Life Sciences Announces Collaboration with Genentech to Discover Novel Therapeutic Targets in Cancers with High Unmet Clinical Need (PR Newswire)
Dec-08-25 09:55AM	Can Caris Life Sciences,?Inc. (CAI) Climb 32.81% to Reach the Level Wall Street Analysts Expect? (Zacks)
Dec-04-25 08:30AM	Caris Life Sciences to Showcase 19 Studies at the 2025 San Antonio Breast Cancer Symposium (PR Newswire)
Dec-02-25 01:53PM	IP Oh No? Recent Stock Market Debuts Have Fizzled. (Barrons.com)
08:30AM	The Caris Precision Oncology Alliance Welcomes UAMS Winthrop P. Rockefeller Cancer Institute (PR Newswire)
Nov-21-25 08:30AM	Caris Precision Oncology Alliance Fellows Forum Welcomes 2025/2026 Class (PR Newswire)
Nov-17-25 08:30AM	Caris Life Sciences to Attend Q4 2025 Investor Conferences (PR Newswire)
Nov-05-25 04:05PM	Caris Life Sciences Reports Third Quarter 2025 Financial Results and Increases 2025 Revenue Guidance (PR Newswire) -6.32% -15.75%
Nov-04-25 07:27AM	What To Expect From Caris Life Sciences Inc (CAI) Q3 2025 Earnings (GuruFocus.com)
Oct-30-25 08:41AM	Caris Life Sciences announces collaborative new research on TET2 (TipRanks) +5.91%
Oct-29-25 08:30AM	Caris Data Validates TET2 Clonal Hematopoiesis as a Biomarker for Enhanced Immunotherapy Response (PR Newswire)
Oct-23-25 08:30AM	Caris Life Sciences to Report Third Quarter 2025 Financial Results on November 5, 2025 (PR Newswire) +5.39%
Oct-14-25 08:30AM	Caris Life Sciences to Share Six Collaborative Studies at ESMO 2025 (PR Newswire)
Oct-01-25 01:43PM	Caris Life Sciences, Inc. (CAI) Soars 81% YoY with $181M Q2 Revenue (Insider Monkey)
Sep-18-25 08:40AM	Strong Performance Lifted Caris Life Sciences (CAI) in Q2 (Insider Monkey)
Sep-11-25 11:17AM	Caris Life Sciences, Inc. (CAI) Secures FDA Nod for Revolutionary Tumor Profiling Test (Insider Monkey)
08:35AM	TEM Gains Validation for PurIST Amid Evolving Cancer Care Landscape (Zacks)
Aug-15-25 08:30AM	Caris Life Sciences Demonstrates Scientific Rigor with Clinical Validation of FDA-Approved MI Cancer Seek (PR Newswire)
Aug-13-25 08:30AM	New Study from Caris Life Sciences Validates Optimal Sequencing in Informing Therapy Choices for Breast Cancer Subgroups (PR Newswire) +5.61%
Aug-12-25 04:05PM	Caris Life Sciences Reports Second Quarter 2025 Financial Results (PR Newswire) +7.45%
Aug-06-25 08:30AM	Caris Life Sciences Publishes Study Showing AI Signature-positive Breast Cancer Patients Live Almost Twice as Long as AI-negative Patients When Treated with a Checkpoint Inhibitor (PR Newswire)
Aug-05-25 08:30AM	Caris Life Sciences Publishes Study Showing its Multi-Layer AI-Based Tissue of Origin Predictions are Best-in-Class and Identify when Patients have been Misdiagnosed (PR Newswire)
Jul-23-25 08:30AM	Caris Life Sciences to Report Second Quarter 2025 Financial Results on August 12, 2025 (PR Newswire)
Jul-22-25 08:30AM	Caris Life Sciences Validates and Extends Findings on Tumor-Infiltrating Clonal Hematopoiesis (PR Newswire) +7.07%
Jul-08-25 06:30AM	Caris Life Sciences Announces New Study Demonstrating the Power and Clinical Utility of its Caris Assure Blood-Based Assay for Multi-Cancer Early Detection, Minimal Residual Disease and Therapy Selection (PR Newswire)
Jun-20-25 05:01AM	Caris Life Sciences indicated to open at $30, IPO priced at $21 per share (TipRanks)
Jun-18-25 02:50PM	This 'AI TechBio' company goes public as IPO demand spreads to biotech (MarketWatch)
01:37PM	The IPO Market Extends Its Comeback (Barrons.com)

Caris Life Sciences, Inc. provides diagnostics and anatomic pathology services. It develops an unbiased profiling platform for novel target identification, drug development and delivery, diagnostic and disease monitoring, and precision medicine enabling aspects. It offers services throughout the U.S., Europe, Australia and other international markets. The company was founded by David D. Halbert in 2008 and is headquartered in Irving, TX.

Insider Trading	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
Vacirca Jeff L	Director	May 11 '26	Buy	16.15	31,050	501,426	49,671	May 12 08:22 AM
CASTLEMAN PETER M	Director	Jan 09 '26	Option Exercise	18.60	2,500	46,500	18,629	Jan 13 06:37 PM
Power Luke Thomas	See Remarks	Dec 11 '25	Option Exercise	2.44	62,250	151,890	161,821	Dec 12 07:39 PM
Power Luke Thomas	See Remarks	Dec 11 '25	Sale	26.58	62,250	1,654,461	99,571	Dec 12 07:39 PM
LUKE POWER	Officer	Dec 11 '25	Proposed Sale	27.10	62,250	1,686,975		Dec 11 04:27 PM
Denton John Russel	See Remarks	Nov 07 '25	Buy	24.09	4,184	100,793	9,184	Nov 10 08:12 AM
Spetzler David Baxley	President	Nov 07 '25	Buy	23.85	400	9,540	460,777	Nov 10 08:11 AM
PHILLIPS T DANNY	Director	Sep 11 '25	Option Exercise	2.44	100,000	244,000	116,129	Sep 12 04:29 PM
POSTE GEORGE	Director	Aug 11 '25	Option Exercise	2.44	125,000	305,000	359,754	Aug 13 08:07 PM
Spetzler David Baxley	President	Jun 20 '25	Option Exercise	2.44	75,000	183,000	558,668	Jun 23 06:41 PM
Denton John Russel	See Remarks	Jun 20 '25	Buy	21.00	7,500	157,500	123,591	Jun 23 06:34 PM
Brille Brian J	See Remarks	Jun 20 '25	Buy	21.00	30,000	630,000	162,428	Jun 23 06:30 PM

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CAI

Caris Life Sciences Inc

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