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Ticker	Owner	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
SPRO	Aquilo Capital Management, LLC	10% Owner	Sep 22	Sale	2.25	1,901,796	4,279,612	3,419,435	Sep 26 03:32 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Apr 26	Buy	5.24	39,727	207,971	5,321,231	Apr 28 04:13 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Mar 30	Buy	8.79	50,000	439,420	5,281,504	Mar 31 03:51 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Mar 14	Buy	7.63	23,708	180,797	5,231,504	Mar 16 04:23 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Feb 28	Buy	9.53	44,833	427,227	5,207,796	Mar 02 03:52 PM

SPRO	Aquilo Capital Management, LLC	10% Owner	Feb 18	Buy	9.24	14,828	137,039	5,162,963	Feb 23 04:24 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Jan 31	Buy	11.59	125,000	1,448,262	5,148,135	Feb 01 08:26 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Jan 24	Buy	10.89	1,599	17,418	5,023,135	Jan 26 05:12 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Jan 18	Buy	12.41	48,488	601,964	5,021,536	Jan 20 01:07 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Jan 10	Buy	12.93	8,867	114,609	4,973,048	Jan 12 04:43 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Dec 29	Buy	14.64	75,493	1,105,263	4,789,181	Jan 03 02:46 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Dec 30	Buy	15.77	50,000	788,610	4,839,181	Jan 03 02:46 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Dec 31	Buy	15.75	125,000	1,969,025	4,964,181	Jan 03 02:46 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Oct 29	Buy	17.53	150,000	2,630,175	4,713,688	Nov 02 05:47 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Sep 30	Buy	18.65	134,543	2,509,173	4,563,688	Oct 04 11:36 AM

SPRO	Aquilo Capital Management, LLC	10% Owner	Sep 13	Buy	18.56	44,210	820,675	4,426,989	Sep 15 07:21 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Sep 14	Buy	18.49	2,156	39,872	4,429,145	Sep 15 07:21 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Sep 09	Buy	18.50	24,749	457,792	4,382,779	Sep 10 05:21 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Aug 30	Buy	17.87	44,042	786,859	4,309,385	Sep 01 05:42 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Aug 31	Buy	18.93	48,645	920,660	4,358,030	Sep 01 05:42 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Aug 26	Buy	16.55	22,982	380,322	4,251,386	Aug 27 05:11 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Aug 27	Buy	16.88	13,957	235,531	4,265,343	Aug 27 05:11 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Aug 20	Buy	14.86	221,190	3,286,906	4,050,399	Aug 24 04:28 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Aug 23	Buy	16.33	137,835	2,251,342	4,188,234	Aug 24 04:28 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Aug 24	Buy	16.28	40,170	653,795	4,228,404	Aug 24 04:28 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Feb 08	Sale	21.74	3,000	65,215	3,829,209	Feb 10 01:35 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Feb 01	Sale	19.24	13,661	262,861	3,918,548	Feb 04 06:46 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Feb 02	Sale	18.99	22,841	433,771	3,895,707	Feb 04 06:46 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Feb 03	Sale	18.98	29,354	557,101	3,866,353	Feb 04 06:46 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Feb 04	Sale	18.99	34,144	648,255	3,832,209	Feb 04 06:46 PM

SPRO	Aquilo Capital Management, LLC	10% Owner	Dec 16	Sale	18.62	14,933	278,035	4,182,209	Dec 18 04:43 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Dec 17	Sale	18.81	250,000	4,703,225	3,932,209	Dec 18 04:43 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Nov 09	Sale	13.77	125,900	1,734,071	4,197,142	Nov 10 07:14 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Nov 04	Sale	14.26	72,500	1,033,741	4,424,642	Nov 06 08:48 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Nov 05	Sale	13.98	96,600	1,350,333	4,328,042	Nov 06 08:48 PM
SPRO	Aquilo Capital Management, LLC	10% Owner	Nov 06	Sale	13.77	5,000	68,874	4,323,042	Nov 06 08:48 PM
PIRS	Aquilo Capital Management, LLC	10% Owner	Jul 21	Sale	2.95	1,900,000	5,605,000	3,675,530	Jul 22 06:15 PM

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