Insider Trading - Insider Transactions - Form 4

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Ticker	Owner	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
SYNH	Macdonald Alistair	Chief Executive Officer	Jun 01	Option Exercise	42.88	4,889	209,640	205,359	Jun 03 05:08 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Jun 01	Sale	88.20	4,889	431,210	200,470	Jun 03 05:08 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Apr 09	Sale	80.00	14,039	1,123,120	200,470	Apr 12 05:01 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Apr 01	Option Exercise	40.12	17,398	698,008	231,907	Apr 05 05:00 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Apr 01	Sale	77.61	17,398	1,350,190	214,509	Apr 05 05:00 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Mar 02	Option Exercise	0.00	36,429	0	231,631	Mar 04 05:44 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Feb 01	Sale	75.71	64,219	4,861,809	210,321	Feb 03 05:28 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Feb 02	Sale	77.11	278	21,438	210,043	Feb 03 05:28 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Dec 22	Sale	70.02	1,200	84,020	245,487	Dec 28 05:07 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Dec 23	Sale	70.52	300	21,155	245,187	Dec 28 05:07 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Aug 03	Sale	65.07	10,289	669,464	246,687	Aug 04 05:06 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Jul 15	Option Exercise	16.06	37,868	608,160	280,088	Jul 17 05:03 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Jul 15	Sale	60.14	37,868	2,277,495	261,154	Jul 17 05:03 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Jul 13	Option Exercise	10.57	3,655	38,633	264,809	Jul 15 05:03 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Jul 14	Option Exercise	10.57	5,173	54,679	266,327	Jul 15 05:03 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Jul 14	Sale	58.68	5,173	303,553	261,154	Jul 15 05:03 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Jul 13	Sale	58.21	3,655	212,747	261,154	Jul 15 05:03 PM
SYNH	Macdonald Alistair	Chief Executive Officer	Mar 05	Option Exercise	0.00	31,258	0	248,937	Apr 15 06:55 PM

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