The S&P 500 (^GSPC) is home to the biggest and most well-known companies in the market, making it a go-to index for investors seeking stability.
But not all large-cap stocks are created equal - some are struggling with slowing growth, declining margins, or increased competition.
Some large-cap stocks are past their peak, and StockStory is here to help you separate the winners from the laggards. That said, here are two S&P 500 stocks positioned to outperform and one best left off your watchlist.
One Stock to Sell:
Builders FirstSource (BLDR)
Market Cap: $13.07 billion
Headquartered in Irving, TX, Builders FirstSource (NYSE:BLDR) is a construction materials manufacturer that offers a variety of lumber and lumber-related building products.
Why Are We Wary of BLDR?
- Annual sales declines of 7.2% for the past two years show its products and services struggled to connect with the market during this cycle
- Earnings per share have dipped by 22.1% annually over the past two years, which is concerning because stock prices follow EPS over the long term
- Diminishing returns on capital suggest its earlier profit pools are drying up
Builders FirstSource is trading at $118.56 per share, or 13.7x forward P/E. If you’re considering BLDR for your portfolio, see our FREE research report to learn more.
Two Stocks to Watch:
Vertex Pharmaceuticals (VRTX)
Market Cap: $98.9 billion
Founded in 1989 with a mission to create medicines that treat the underlying causes of disease rather than just symptoms, Vertex Pharmaceuticals (NASDAQ:VRTX) develops and markets transformative medicines for serious diseases, with a focus on cystic fibrosis, sickle cell disease, and pain management.
Why Are We Fans of VRTX?
- Solid 16.1% annual revenue growth over the last five years indicates its offering’s solve complex business issues
- Earnings growth has trumped its peers over the last five years as its EPS has compounded at 15.9% annually
- Industry-leading 41.8% return on capital demonstrates management’s skill in finding high-return investments
At $380 per share, Vertex Pharmaceuticals trades at 19.7x forward P/E. Is now the right time to buy? See for yourself in our full research report, it’s free.
HCA Healthcare (HCA)
Market Cap: $98.06 billion
With roots dating back to 1968 and a network spanning 20 states, HCA Healthcare (NYSE:HCA) operates a network of 190 hospitals and 150+ outpatient facilities providing a full range of medical services across the US and England.
Why Is HCA a Top Pick?
- Enormous revenue base of $72.7 billion gives it economies of scale and advantages over new entrants due to the industry’s regulatory complexity
- Share buybacks catapulted its annual earnings per share growth to 17.5%, which outperformed its revenue gains over the last five years
- Free cash flow margin increased by 8.9 percentage points over the last five years, giving the company more capital to invest or return to shareholders
HCA Healthcare’s stock price of $415 implies a valuation ratio of 15.6x forward P/E. Is now a good time to buy? Find out in our full research report, it’s free.
High-Quality Stocks for All Market Conditions
Trump’s April 2025 tariff bombshell triggered a massive market selloff, but stocks have since staged an impressive recovery, leaving those who panic sold on the sidelines.
Take advantage of the rebound by checking out our Top 9 Market-Beating Stocks. This is a curated list of our High Quality stocks that have generated a market-beating return of 183% over the last five years (as of March 31st 2025).
Stocks that made our list in 2020 include now familiar names such as Nvidia (+1,545% between March 2020 and March 2025) as well as under-the-radar businesses like the once-small-cap company Comfort Systems (+782% five-year return). Find your next big winner with StockStory today for free. Find your next big winner with StockStory today. Find your next big winner with StockStory today
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