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IRON

Disc Medicine Inc

Dec 19 • 04:00PM ET

80.04

-10.40 -11.50 %

Healthcare • Biotechnology • USA • NASD

Peers: VRTX ALNY CRSP BEAM EDIT NTLA SRPT IONS BLUE SGMO

| Held by: VTI IWM XBI VXF IWO IBB SCHA VTWO VHT ITOT

Scroll to Statements

Index	RUT	P/E	-	EPS (ttm)	-5.36	Insider Own	28.72%	Shs Outstand	35.01M	Perf Week	-12.86%
Market Cap	3.02B	Forward P/E	-	EPS next Y	-6.90	Insider Trans	-10.90%	Shs Float	26.91M	Perf Month	-11.79%
Enterprise Value	2.44B	PEG	-	EPS next Q	-1.75	Inst Own	71.40%	Short Float	9.61%	Perf Quarter	30.16%
Income	-181.11M	P/S	-	EPS this Y	-55.69%	Inst Trans	1.14%	Short Ratio	4.91	Perf Half Y	54.88%
Sales	0.00M	P/B	4.89	EPS next Y	-11.99%	ROA	-32.18%	Short Interest	2.59M	Perf YTD	26.25%
Book/sh	16.38	P/C	4.91	EPS next 5Y	-12.17%	ROE	-34.78%	52W High	99.50 -19.56%	Perf Year	23.14%
Cash/sh	16.32	P/FCF	-	EPS past 3/5Y	54.09% 38.12%	ROIC	-30.00%	52W Low	30.82 159.70%	Perf 3Y	385.09%
Dividend Est.	-	EV/EBITDA	-	Sales past 3/5Y	- -	Gross Margin	-	Volatility	8.48% 5.40%	Perf 5Y	-23.04%
Dividend TTM	-	EV/Sales	-	EPS Y/Y TTM	-34.96%	Oper. Margin	-	ATR (14)	4.94	Perf 10Y	-
Dividend Ex-Date	-	Quick Ratio	23.45	Sales Y/Y TTM	-	Profit Margin	-	RSI (14)	33.60	Recom	1.00
Dividend Gr. 3/5Y	- -	Current Ratio	23.45	EPS Q/Q	-99.39%	SMA20	-12.57%	Beta	0.86	Target Price	121.67
Payout	-	Debt/Eq	0.05	Sales Q/Q	-	SMA50	-8.51%	Rel Volume	8.01	Prev Close	90.44
Employees	84	LT Debt/Eq	0.05	Earnings	Nov 06 BMO	SMA200	28.38%	Avg Volume	526.85K	Price	80.04
IPO	Aug 12, 2020	Option/Short	Yes / Yes	EPS/Sales Surpr.	-22.74% -	Trades		Volume	4,221,344	Change	-11.50%

Date	Action	Analyst	Rating Change	Price Target Change
Nov-03-25	Resumed	Stifel	Buy	$125
Jul-21-25	Initiated	Truist	Buy	$86
Jul-03-25	Resumed	Morgan Stanley	Overweight	$85
Jun-11-25	Resumed	Raymond James	Strong Buy	$89
Feb-27-25	Initiated	TD Cowen	Buy
Nov-05-24	Upgrade	Morgan Stanley	Equal-Weight → Overweight	$85
Nov-04-24	Upgrade	Raymond James	Outperform → Strong Buy	$66 → $110
Oct-23-24	Initiated	Jefferies	Buy	$89
Oct-16-24	Initiated	Scotiabank	Sector Outperform
Aug-22-24	Initiated	Wells Fargo	Overweight	$75
Apr-01-24	Downgrade	Raymond James	Strong Buy → Outperform	$40
Dec-19-23	Downgrade	Morgan Stanley	Overweight → Equal-Weight	$56 → $65
Jun-09-23	Upgrade	Raymond James	Outperform → Strong Buy	$50 → $75
Jun-07-23	Initiated	H.C. Wainwright	Buy	$55
May-17-23	Initiated	Raymond James	Outperform	$50
Apr-28-23	Initiated	Cantor Fitzgerald	Overweight	$45
Apr-21-23	Initiated	Stifel	Buy	$37
Apr-20-23	Initiated	Morgan Stanley	Overweight	$37
Mar-23-23	Initiated	BMO Capital Markets	Outperform	$40
Feb-28-23	Initiated	SVB Securities	Outperform	$36

Show Previous Ratings

Dec-11-25 07:44AM	Leering Partners Lifts Disc Medicine, Inc. (IRON) Following EPP Drug NDA Application (Insider Monkey)
Dec-09-25 12:20AM	This is Why Disc Medicine, Inc. (IRON) is a Buy on Wall Street (Insider Monkey)
Dec-06-25 08:00AM	Disc Medicine Presents Positive Initial Data from RALLY-MF Phase 2 Trial in Patients with Myelofibrosis (MF) and Anemia at the 67th American Society of Hematology (ASH) Annual Meeting (GlobeNewswire)
Nov-06-25 08:30AM	Disc Medicine Reports Third Quarter 2025 Financial Results and Provides Business Update (GlobeNewswire)
Nov-03-25 09:00AM	Disc Medicine Announces Presentation of Initial Data from RALLY-MF Phase 2 Trial in Patients with Myelofibrosis (MF) and Anemia at the 67th American Society of Hematology (ASH) Annual Meeting (GlobeNewswire)
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Oct-31-25 08:30AM	Disc Medicine to Participate in Upcoming Investor Conferences (GlobeNewswire)
Oct-27-25 12:00PM	What Makes Disc Medicine, Inc. (IRON) a Strong Momentum Stock: Buy Now? (Zacks)
Oct-22-25 09:55AM	Does Disc Medicine, Inc. (IRON) Have the Potential to Rally 26.29% as Wall Street Analysts Expect? (Zacks)
Oct-21-25 12:14AM	Disc Medicine Announces Pricing of $250 Million Upsized Public Offering of Common Stock and Pre-Funded Warrants (GlobeNewswire)
Oct-20-25 08:25AM	FDA Grants First CNPV Vouchers, Igniting Rally in Biotech Stocks (GuruFocus.com)
07:00AM	Disc Medicine Announces Proposed Public Offering of Common Stock and Pre-Funded Warrants (GlobeNewswire)
06:30AM	Disc Medicine Provides Update on Hematology Portfolio and Outlines Near-Term Business Objectives and Anticipated Milestones (GlobeNewswire)
Oct-17-25 10:17AM	The FDA Just Granted Its Speediest Review Ever. Disc Medicine, Others Fly. (Investor's Business Daily) +20.95%
09:00AM	Disc Medicine to Present Data from Phase 1b Trial of DISC-0974 in Patients with Chronic Kidney Disease (CKD) and Anemia at 2025 American Society of Nephrology (ASN) Kidney Week (GlobeNewswire)
Oct-16-25 05:35PM	Disc Medicine Announces Receipt of FDA Commissioner's National Priority Voucher (CNPV) for Bitopertin in Erythropoietic Protoporphyria (EPP) (GlobeNewswire)
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Sep-30-25 08:30AM	Disc Medicine Announces Submission of New Drug Application (NDA) to US FDA for Accelerated Approval of Bitopertin for Patients with Erythropoietic Protoporphyria (EPP) (GlobeNewswire)
Aug-27-25 08:30AM	Disc Medicine to Participate in Upcoming Investor Conferences (GlobeNewswire)
Aug-22-25 05:16PM	Rapid7, Residio Tech, and 4 More Stocks See Action From Activist Investors (Barrons.com)
Aug-07-25 08:30AM	Disc Medicine Reports Second Quarter 2025 Financial Results and Provides Business Update (GlobeNewswire)
Jul-28-25 10:05AM	Disc Medicine, Inc. (IRON) Set to Submit NDA for Bitopertin in October 2025 (Insider Monkey)
Jul-22-25 09:15AM	OrbiMed Promotes Mona Ashiya to General Partner (PR Newswire)
Jul-21-25 08:00AM	Disc Medicine Announces Positive Pre-NDA Meeting and Confirms Plans to Submit NDA for Bitopertin in Erythropoietic Protoporphyria (EPP) in October 2025 (GlobeNewswire)
Jul-14-25 08:30AM	Disc Medicine Appoints Nadim Ahmed to its Board of Directors (GlobeNewswire)
Jul-10-25 12:39AM	Morgan Stanley Assumes Coverage of Disc Medicine (IRON) With $85 PT (Insider Monkey)
Jun-24-25 05:42PM	Leerink Partners Reiterates a Buy Rating on Disc Medicine (IRON) With an $85 Price Target (Insider Monkey) +6.42%
Jun-15-25 05:42AM	Raymond James Resumes Coverage on Disc Medicine (IRON) With a Strong Buy Rating (Insider Monkey)
Jun-12-25 07:30AM	Disc Medicine Presents Positive Clinical Data Updates Across Portfolio at the European Hematology Association (EHA) 2025 Annual Congress (GlobeNewswire)
Jun-11-25 09:45AM	Raymond James bullish on biotech firms on favorable valuation (Investing.com)
May-28-25 04:01PM	Disc Medicine to Participate in Upcoming Investor Conferences (GlobeNewswire)
May-14-25 09:30AM	Disc Medicine Announces Multiple Presentations Across Portfolio at the European Hematology Association (EHA) 2025 Congress (GlobeNewswire)
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May-13-25 08:00AM	Disc Medicine to Participate in the H.C. Wainwright 3rd Annual BioConnect Investor Conference (GlobeNewswire)
May-07-25 08:00AM	Disc Medicine Reports First Quarter 2025 Financial Results and Provides Business Update (GlobeNewswire)
Apr-29-25 08:00AM	Disc Medicine to Host Webinar with Key Opinion Leaders on Anemia of Myelofibrosis (MF) (GlobeNewswire)
Apr-09-25 07:13AM	Disc Medicine: Forging Ahead In Hematology (Seeking Alpha) +12.89%
Mar-26-25 09:39PM	Is Disc Medicine, Inc. (NASDAQ:IRON) the Best Small Cap Stock to Buy Before They Explode? (InsiderMonkey)
Mar-21-25 06:35PM	Victorias Secret, Bitdeer, and More Stocks See Activist Action (Barrons.com)
Mar-14-25 12:00PM	All You Need to Know About Disc Medicine, Inc. (IRON) Rating Upgrade to Buy (Zacks)
Mar-03-25 09:55AM	Wall Street Analysts Predict a 68.78% Upside in Disc Medicine, Inc. (IRON): Here's What You Should Know (Zacks)
Feb-27-25 08:00AM	Disc Medicine Reports Fourth Quarter and Full Year 2024 Financial Results and Provides Business Update (GlobeNewswire)
Feb-26-25 08:00AM	Disc Medicine to Participate in Upcoming Investor Conferences (GlobeNewswire)
Feb-12-25 09:55AM	Disc Medicine, Inc. (IRON) May Find a Bottom Soon, Here's Why You Should Buy the Stock Now (Zacks)
Jan-23-25 08:28AM	Disc raises $225.5m as it eyes approval of rare skin disorder drug (Pharmaceutical Technology)
Jan-22-25 09:35PM	Disc Medicine Announces Pricing of $225.5 Million Upsized Public Offering of Common Stock and Pre-Funded Warrants (GlobeNewswire)
Jan-21-25 04:01PM	Disc Medicine Announces Proposed Public Offering of Common Stock and Pre-Funded Warrants (GlobeNewswire)
07:45AM	Disc Medicine Announces Successful Type C Meeting with FDA for Bitopertin in Erythropoietic Protoporphyria (EPP) and Shares Plans for NDA Submission (GlobeNewswire)
Jan-20-25 07:00PM	Disc Medicine to Host Conference Call on Type C Meeting for Bitopertin in Erythropoietic Protoporphyria (EPP) (GlobeNewswire)
Jan-17-25 04:00PM	Disc Medicine Reports Inducement Grant under Nasdaq Listing Rule 5635(C)(4) (GlobeNewswire)
Jan-10-25 09:00AM	Disc Medicine Highlights Recent Achievements Across Hematology Portfolio and Key Business Objectives and Milestones for 2025 (GlobeNewswire) -5.27%
Dec-09-24 12:00PM	Disc Medicine Presents Positive Clinical and Translational Data Across Portfolio at the 66th American Society of Hematology (ASH) Annual Meeting (GlobeNewswire)
Dec-08-24 08:00PM	Disc Medicine Presents Positive Updated Results from Phase 1b Trial in Patients with Myelofibrosis (MF) and Anemia in an Oral Presentation at the 66th American Society of Hematology (ASH) Annual Meeting (GlobeNewswire)
Nov-24-24 06:10AM	Raymond James Predicts Up to ~440% Rally for These 2 Strong Buy Stocks (TipRanks)
Nov-13-24 08:30AM	Disc Medicine to Participate in Upcoming Investor Conferences (GlobeNewswire)
Nov-12-24 08:00AM	Disc Medicine Reports Third Quarter 2024 Financial Results and Provides Business Update (GlobeNewswire)
Nov-11-24 10:38AM	Disc Medicine secures $200m financing to support trials (Clinical Trials Arena)
Nov-08-24 08:30AM	Disc Medicine Secures $200 Million in Non-Dilutive Debt Financing from Hercules Capital, Inc. (GlobeNewswire)
Nov-05-24 09:00AM	Disc Medicine Announces Multiple Presentations Across Portfolio at the 66th American Society of Hematology (ASH) Annual Meeting (GlobeNewswire) +11.20%
Nov-04-24 01:44PM	Disc teases potential NDA for rare skin disorder drug (Pharmaceutical Technology) +23.59%
07:50AM	Disc Medicine Announces Successful End of Phase 2 Meeting with FDA for Bitopertin in Erythropoietic Protoporphyria (EPP), Including Potential for Accelerated Approval (GlobeNewswire)
Nov-01-24 04:01PM	Disc Medicine to Host Conference Call on End of Phase 2 FDA Meeting for Bitopertin in Erythropoietic Protoporphyria (EPP) (GlobeNewswire) +5.15%
Oct-25-24 01:00PM	Disc Medicine Presents Positive Data from SAD Cohorts of a Phase 1b Trial in Patients with Chronic Kidney Disease (CKD) and Anemia at the 2024 American Society of Nephrology (ASN) Kidney Week (GlobeNewswire)
Oct-23-24 08:00AM	Disc Medicine Appoints Seasoned Industry Executive Rahul Kaushik, Ph.D. as Chief Technical Officer (GlobeNewswire) -7.72%
Oct-11-24 08:00AM	Disc Medicine Announces Presentation of New Data from Phase 1b Trial of DISC-0974 in Patients with Chronic Kidney Disease (CKD) and Anemia at 2024 American Society of Nephrology (ASN) Kidney Week (GlobeNewswire)
Sep-19-24 08:30AM	Disc Medicine Expands Leadership Team with Appointment of Industry Veteran Steve Caffe, MD as Chief Regulatory Officer (GlobeNewswire)
08:30AM	Disc Medicine Expands Leadership Team with Appointment of Industry Veteran Steve Caff , MD as Chief Regulatory Officer (GlobeNewswire)
Aug-30-24 08:00AM	Disc Medicine to Participate in Upcoming Investor Conferences (GlobeNewswire)
Aug-08-24 08:00AM	Disc Medicine Reports Second Quarter 2024 Financial Results and Provides Business Update (GlobeNewswire)
Jun-28-24 08:11PM	Bitfarms Technologies, Vestis, and More Stocks See Action From Activist Investors (Barrons.com)
Jun-14-24 08:03AM	Disc Medicine Announces Underwritten Offering of Common Stock (GlobeNewswire) +18.16%
07:30AM	Disc Medicine Presents Positive Clinical Data Across Portfolio at the European Hematology Association (EHA) 2024 Congress (GlobeNewswire)
May-30-24 09:00AM	Disc Medicine to Participate in the Jefferies Global Healthcare Conference (GlobeNewswire)
May-14-24 10:30AM	Disc Medicine Announces Multiple Presentations Across Portfolio at the European Hematology Association (EHA) 2024 Congress (GlobeNewswire)
May-13-24 08:00AM	Disc Medicine to Participate in the H.C. Wainwright BioConnect Investor Conference (GlobeNewswire)
May-11-24 05:31AM	Disc Medicine Inc (IRON) Reports Q1 2024 Earnings: A Detailed Financial Overview (GuruFocus.com)
May-09-24 01:54PM	IRON Stock Earnings: Disc Medicine Misses EPS for Q1 2024 (InvestorPlace)
08:00AM	Disc Medicine Reports First Quarter 2024 Financial Results and Provides Business Update (GlobeNewswire)
Apr-02-24 02:24PM	Disc Medicine (IRON) Down on Mixed Results From AURORA Study (Zacks) -6.36%
Apr-01-24 04:19PM	Disc Medicine Plummets After Placebo Effect Confounds Sunlight Sensitivity Study (Investor's Business Daily) -45.05%
08:00AM	Disc Reports Topline Results from Phase 2 AURORA Study of Bitopertin in Patients with Erythropoietic Protoporphyria (EPP) (GlobeNewswire)
Mar-23-24 05:31AM	Disc Medicine Inc (IRON) Reports Earnings: A Detailed Look at Fiscal Performance (GuruFocus.com)
Mar-21-24 08:00AM	Disc Medicine Reports Fourth Quarter and Full Year 2023 Financial Results and Provides Business Update (GlobeNewswire) -7.52%
Mar-06-24 04:30PM	Disc Medicine to Participate in the Leerink Partners Global Biopharma Conference 2024 (GlobeNewswire) -5.18%
Feb-26-24 08:30AM	Disc Medicine Expands Leadership Team with Appointment of Industry Veteran Pamela Stephenson, MPH as Chief Commercial Officer (GlobeNewswire)
Feb-20-24 08:30AM	Disc Medicine Receives FDA Fast Track Designation for DISC-0974 for the Treatment of Anemia in Non-Dialysis Dependent Chronic Kidney Disease (GlobeNewswire)
Feb-09-24 09:00AM	Disc Medicine Receives FDA Orphan Drug Designation for DISC-3405 for the Treatment of Polycythemia Vera (GlobeNewswire)
Feb-07-24 08:00AM	Disc Medicine Strengthens Leadership Team with Appointment of Seasoned Industry Executive Jean Franchi as Chief Financial Officer, and Promotion of Jonathan Yu to Chief Operating Officer (GlobeNewswire)
Jan-03-24 05:00PM	Disc Medicine to Present at the 42nd Annual J.P. Morgan Healthcare Conference (GlobeNewswire)
Dec-22-23 06:35PM	Peabody Energy, Janus International, and More Stocks See Action From Activist Investors (Barrons.com)
Dec-20-23 04:30PM	Disc Medicine Announces Retirement of Brian MacDonald, MB, ChB, PhD as Chief Innovation Officer and Appointment as Chair of Scientific Advisory Board (GlobeNewswire)
Dec-15-23 03:01PM	Insider Sell Alert: Director William White Sells 33,511 Shares of Disc Medicine Inc (IRON) (GuruFocus.com)
Dec-11-23 08:30PM	Disc Presents Positive Updated Results from Phase 2 BEACON Study of Bitopertin and Other Programs at the 65th American Society of Hematology (ASH) Annual Meeting (GlobeNewswire)
12:00PM	Disc Presents Initial Positive Data from Ongoing Phase 1b/2 Trial of DISC-0974 in Patients with Myelofibrosis (MF) and Anemia at the 65th American Society of Hematology (ASH) Annual Meeting (GlobeNewswire)
Dec-08-23 07:06AM	Insider Sell Alert: CFO Joanne Bryce Sells 2,541 Shares of Disc Medicine Inc (IRON) (GuruFocus.com) +5.98%
Nov-14-23 04:44PM	Disc Medicine Announces Grant of US Patent for Methods of Treating Erythropoietic Protoporphyrias with Bitopertin (GlobeNewswire)
Nov-13-23 09:55AM	How Much Upside is Left in Disc Medicine, Inc. (IRON)? Wall Street Analysts Think 38.17% (Zacks)
Nov-09-23 09:34AM	Disc Medicine Inc (IRON) Reports Q3 2023 Financial Results and Business Progress (GuruFocus.com)
08:30AM	Disc Medicine Reports Third Quarter 2023 Financial Results and Provides Business Update (GlobeNewswire)
Nov-08-23 04:30PM	Disc Medicine to Participate in Upcoming Investor Conferences (GlobeNewswire)
Nov-02-23 09:00AM	Disc Medicine Announces Multiple Presentations Across Portfolio at the 65th American Society of Hematology Annual Meeting and Key Program Updates (GlobeNewswire)
Oct-23-23 09:15AM	Disc Medicine Announces Planned Departure of Chief Financial Officer Joanne Bryce (GlobeNewswire)
Oct-03-23 08:30AM	Disc Medicine Initiates a Phase 1 Study of DISC-3405 (anti-TMPRSS6 mAb) in Healthy Volunteers (GlobeNewswire)

Disc Medicine, Inc. is a clinical-stage biopharmaceutical company, which engages in the discovery, development, and commercialization of treatments for hematologic diseases. It assembles a portfolio of clinical and preclinical product candidates that aim to modify fundamental biological pathways associated with the formation and function of red blood cells, specifically heme biosynthesis and iron homeostasis. The company was founded in October 2017 and is headquartered in Watertown, MA.

Insider Trading	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
Quisel John D	Chief Executive Officer	Dec 19 '25	Option Exercise	1.01	12,300	12,423	184,128	Dec 19 06:16 PM
Bitterman Kevin	Director	Dec 17 '25	Sale	91.47	754	68,968	14,013	Dec 18 06:14 PM
AI DMI LLC	Affiliate	Dec 17 '25	Proposed Sale	87.49	50	4,374		Dec 17 07:48 PM
Atlas Venture Fund XII, LP	Shareholder	Dec 17 '25	Proposed Sale	91.47	148	13,538		Dec 17 05:08 PM
Atlas Venture Opportunity Fund	Shareholder	Dec 17 '25	Proposed Sale	91.47	213	19,483		Dec 17 05:07 PM
Atlas Venture Opportunity Fund	Shareholder	Dec 17 '25	Proposed Sale	91.47	393	35,948		Dec 17 05:06 PM
Atlas Venture Fund X, LP	Shareholder	Dec 17 '25	Proposed Sale	91.47	818	74,822		Dec 17 05:05 PM
Bitterman Kevin	Director	Dec 15 '25	Option Exercise	13.50	7,000	94,500	7,000	Dec 16 09:43 PM
Bitterman Kevin	Director	Dec 16 '25	Sale	91.24	68,923	6,288,535	14,161	Dec 16 09:43 PM
Bitterman Kevin	Director	Dec 15 '25	Sale	91.28	62,693	5,722,608	28,520	Dec 16 09:43 PM
Bitterman Kevin	Director	Dec 12 '25	Sale	92.39	45,507	4,204,407	41,519	Dec 16 09:43 PM
Bitterman Kevin	Director	Dec 15 '25	Sale	91.87	7,000	643,090	0	Dec 16 09:43 PM
Savage William Jacob	Chief Medical Officer	Dec 15 '25	Sale	91.22	13,093	1,194,372	75,702	Dec 16 09:31 PM
AI DMI LLC	Affiliate	Dec 16 '25	Proposed Sale	91.47	39,769	3,637,670		Dec 16 06:27 PM
Atlas Venture Opportunity Fund	Shareholder	Dec 16 '25	Proposed Sale	92.00	10,898	1,002,616		Dec 16 05:18 PM
Atlas Venture Fund XII, LP	Shareholder	Dec 16 '25	Proposed Sale	92.00	4,359	401,028		Dec 16 05:18 PM
Atlas Venture Opportunity Fund	Shareholder	Dec 16 '25	Proposed Sale	92.00	5,666	521,272		Dec 16 05:17 PM
Atlas Venture Fund X, LP	Shareholder	Dec 16 '25	Proposed Sale	92.00	22,666	2,085,272		Dec 16 05:16 PM
Atlas Venture Opportunity Fund	Shareholder	Dec 16 '25	Proposed Sale	91.47	25,000	2,286,750		Dec 16 05:15 PM
Atlas Venture Fund X, L.P.	Shareholder	Dec 16 '25	Proposed Sale	91.47	52,000	4,756,440		Dec 16 05:03 PM
Atlas Venture Opportunity Fund	Shareholder	Dec 16 '25	Proposed Sale	91.47	13,000	1,189,110		Dec 16 04:59 PM
Atlas Venture Associates XII,	Shareholder	Dec 16 '25	Proposed Sale	91.47	10,000	914,700		Dec 16 04:56 PM
AI DMI LLC	Affiliate	Dec 15 '25	Proposed Sale	92.00	5,843	537,556		Dec 15 07:52 PM
Atlas Venture Opportunity Fund	Shareholder	Dec 15 '25	Proposed Sale	92.00	8,851	814,292		Dec 15 06:56 PM
Atlas Venture Opportunity Fund	Shareholder	Dec 15 '25	Proposed Sale	92.00	17,433	1,603,836		Dec 15 06:56 PM
Atlas Venture Fund X, L.P.	Shareholder	Dec 15 '25	Proposed Sale	92.00	36,877	3,392,684		Dec 15 06:50 PM
Atlas Venture Associates XII,	Shareholder	Dec 15 '25	Proposed Sale	92.00	6,839	629,188		Dec 15 06:44 PM
Quisel John D	Chief Executive Officer	Dec 11 '25	Option Exercise	9.86	40,000	394,400	211,828	Dec 15 05:49 PM
Quisel John D	Chief Executive Officer	Dec 11 '25	Sale	93.05	40,000	3,721,931	171,828	Dec 15 05:49 PM
KEVIN J BITTERMAN	Officer	Dec 15 '25	Proposed Sale	91.87	7,000	643,061		Dec 15 05:45 PM
Atlas Venture Opportunity Fund	Shareholder	Dec 15 '25	Proposed Sale	91.85	8,009	735,627		Dec 15 05:40 PM
Atlas Venture Fund XII, LP	Shareholder	Dec 15 '25	Proposed Sale	91.85	6,160	565,796		Dec 15 05:37 PM
Atlas Venture Opportunity Fund	Shareholder	Dec 15 '25	Proposed Sale	91.85	15,401	1,414,582		Dec 15 05:35 PM
Atlas Venture Fund X, LP	Shareholder	Dec 15 '25	Proposed Sale	91.85	32,035	2,942,415		Dec 15 05:34 PM
WILLIAM SAVAGE	Officer	Dec 15 '25	Proposed Sale	91.85	13,093	1,202,592		Dec 15 04:14 PM
AI DMI LLC	Affiliate	Dec 12 '25	Proposed Sale	91.85	29,388	2,699,288		Dec 12 09:50 PM
Atlas Venture Fund XII, LP	Shareholder	Dec 12 '25	Proposed Sale	93.60	9,481	887,422		Dec 12 05:15 PM
Atlas Venture Opportunity Fund	Shareholder	Dec 12 '25	Proposed Sale	93.60	12,325	1,153,620		Dec 12 05:13 PM
Atlas Venture Opportunity Fund	Shareholder	Dec 12 '25	Proposed Sale	93.60	23,701	2,218,414		Dec 12 05:11 PM
Atlas Venture Fund X, LP	Shareholder	Dec 12 '25	Proposed Sale	93.60	49,299	4,614,386		Dec 12 05:10 PM
JOHN QUISEL	Director	Dec 11 '25	Proposed Sale	92.85	40,000	3,714,000		Dec 11 04:25 PM
Yu Jonathan Yen-Wen	Chief Operating Officer	Nov 11 '25	Option Exercise	2.65	30,000	79,500	70,555	Nov 13 08:22 PM
Yu Jonathan Yen-Wen	Chief Operating Officer	Nov 11 '25	Sale	84.70	30,000	2,540,923	40,555	Nov 13 08:22 PM
JONATHAN YU	Officer	Nov 11 '25	Proposed Sale	83.58	30,000	2,507,400		Nov 12 06:56 AM
AI DMI LLC	10% Owner	Oct 22 '25	Sale	80.47	744,047	59,873,462	2,814,379	Oct 24 04:01 PM
OrbiMed Private Investments VI	Shareholder	Oct 20 '25	Proposed Sale	89.94	482,308	43,378,782		Oct 20 08:54 PM
OrbiMed Genesis Master Fund, L	Shareholder	Oct 20 '25	Proposed Sale	89.94	186,541	16,777,498		Oct 20 08:52 PM
OrbiMed Private Investments VI	Shareholder	Oct 20 '25	Proposed Sale	89.94	746,171	67,110,620		Oct 20 08:47 PM
Atlas Venture Opportunity Fund	Shareholder	Oct 17 '25	Proposed Sale	89.94	35,000	3,147,900		Oct 17 05:26 PM
Atlas Venture Opportunity Fund	Shareholder	Oct 17 '25	Proposed Sale	89.94	35,000	3,147,900		Oct 17 05:23 PM
Atlas Venture Fund X, LP	Shareholder	Oct 17 '25	Proposed Sale	74.36	50,000	3,718,000		Oct 17 04:42 PM
Bitterman Kevin	Director	Oct 17 '25	Sale	88.91	70,000	6,223,934	385,549	Oct 17 04:41 PM
Bitterman Kevin	Director	Oct 15 '25	Sale	77.23	22,160	1,711,436	478,461	Oct 17 04:41 PM
Bitterman Kevin	Director	Oct 16 '25	Sale	77.11	1,425	109,882	477,036	Oct 17 04:41 PM
Atlas Venture Fund X, LP	Shareholder	Oct 16 '25	Proposed Sale	76.98	1,425	109,696		Oct 16 04:46 PM
Atlas Venture Opportunity Fund	Shareholder	Oct 16 '25	Proposed Sale	76.98	1,425	109,696		Oct 16 04:46 PM
Atlas Venture Fund X, LP	Shareholder	Oct 15 '25	Proposed Sale	73.00	22,160	1,617,680		Oct 15 05:00 PM
Atlas Venture Opportunity Fund	Shareholder	Oct 15 '25	Proposed Sale	73.00	22,160	1,617,680		Oct 15 05:00 PM
Bitterman Kevin	Director	Oct 08 '25	Sale	70.58	71,961	5,079,007	500,621	Oct 09 04:07 PM
Bitterman Kevin	Director	Oct 07 '25	Sale	68.38	18,039	1,233,493	572,582	Oct 09 04:07 PM
Atlas Venture Opportunity Fund	Shareholder	Oct 08 '25	Proposed Sale	67.89	71,961	4,885,432		Oct 08 04:55 PM
Atlas Venture Opportunity Fund	Shareholder	Oct 07 '25	Proposed Sale	69.28	18,039	1,249,742		Oct 07 05:16 PM
Quisel John D	Chief Executive Officer	Sep 09 '25	Option Exercise	1.01	10,000	10,100	171,828	Sep 11 06:00 PM
Bitterman Kevin	Director	Aug 22 '25	Sale	61.03	2,287	139,576	590,621	Aug 26 06:01 PM
Atlas Venture Opportunity Fund	Shareholder	Aug 22 '25	Proposed Sale	59.75	2,287	136,648		Aug 22 04:29 PM
Atlas Venture Fund X, L.P.	Shareholder	Aug 22 '25	Proposed Sale	59.75	4,080	243,780		Aug 22 04:25 PM
Bitterman Kevin	Director	Aug 13 '25	Sale	61.15	24,962	1,526,426	600,120	Aug 15 07:23 PM
Bitterman Kevin	Director	Aug 14 '25	Sale	60.99	7,212	439,860	592,908	Aug 15 07:23 PM
Atlas Venture Opportunity Fund	Shareholder	Aug 14 '25	Proposed Sale	61.10	7,212	440,653		Aug 14 04:24 PM
Atlas Venture Fund X, L.P.	Shareholder	Aug 14 '25	Proposed Sale	61.10	12,862	785,868		Aug 14 04:16 PM
Atlas Venture Opportunity Fund	Shareholder	Aug 13 '25	Proposed Sale	59.03	24,962	1,473,507		Aug 13 04:26 PM
Atlas Venture Fund X, L.P.	Shareholder	Aug 13 '25	Proposed Sale	59.03	44,520	2,628,016		Aug 13 04:24 PM
Bitterman Kevin	Director	Aug 05 '25	Sale	60.95	395	24,075	625,082	Aug 07 05:00 PM
Atlas Venture Opportunity Fund	Shareholder	Aug 05 '25	Proposed Sale	59.79	395	23,617		Aug 05 04:31 PM
Atlas Venture Fund X, L.P.	Shareholder	Aug 05 '25	Proposed Sale	59.79	705	42,152		Aug 05 04:24 PM
Bitterman Kevin	Director	Jul 30 '25	Sale	61.04	8,492	518,352	625,477	Aug 01 04:32 PM
Atlas Venture Opportunity Fund	Shareholder	Jul 30 '25	Proposed Sale	59.80	8,492	507,822		Jul 30 04:18 PM
Atlas Venture Fund X, L.P.	Shareholder	Jul 30 '25	Proposed Sale	59.80	15,146	905,731		Jul 30 04:14 PM
Bitterman Kevin	Director	Jul 23 '25	Sale	60.97	29,837	1,819,162	647,002	Jul 25 05:22 PM
Bitterman Kevin	Director	Jul 24 '25	Sale	61.17	13,033	797,229	633,969	Jul 25 05:22 PM
Atlas Venture Opportunity Fund	Shareholder	Jul 24 '25	Proposed Sale	60.94	13,033	794,231		Jul 24 04:27 PM
Atlas Venture Fund X, L.P.	Shareholder	Jul 24 '25	Proposed Sale	60.94	23,245	1,416,550		Jul 24 04:25 PM
Atlas Venture Opportunity Fund	Shareholder	Jul 23 '25	Proposed Sale	60.74	29,837	1,812,299		Jul 23 04:30 PM
Atlas Venture Fund X, L.P.	Shareholder	Jul 23 '25	Proposed Sale	60.74	53,215	3,232,279		Jul 23 04:25 PM
Bitterman Kevin	Director	Jul 18 '25	Sale	61.13	664	40,590	676,839	Jul 22 04:44 PM
Franchi Jean M.	Chief Financial Officer	Jul 17 '25	Sale	59.00	2,031	119,829	63,499	Jul 18 04:51 PM
Atlas Venture Opportunity Fund	Shareholder	Jul 18 '25	Proposed Sale	57.79	664	38,373		Jul 18 04:33 PM
Atlas Venture Fund X, L.P.	Shareholder	Jul 18 '25	Proposed Sale	57.79	1,184	68,423		Jul 18 04:31 PM
JEAN FRANCHI	Officer	Jul 17 '25	Proposed Sale	57.34	2,031	116,458		Jul 17 04:20 PM
Franchi Jean M.	Chief Financial Officer	Jul 10 '25	Sale	57.50	2,000	115,000	65,530	Jul 14 09:36 PM
Quisel John D	Chief Executive Officer	Jul 09 '25	Option Exercise	9.86	34,800	343,128	196,628	Jul 11 04:48 PM
Quisel John D	Chief Executive Officer	Jul 09 '25	Sale	55.33	34,800	1,925,525	161,828	Jul 11 04:48 PM
JEAN FRANCHI	Officer	Jul 10 '25	Proposed Sale	55.86	2,000	111,720		Jul 10 04:34 PM
JOHN QUISEL	Director	Jul 09 '25	Proposed Sale	52.97	34,800	1,843,356		Jul 09 04:17 PM
Quisel John D	Chief Executive Officer	Jul 03 '25	Option Exercise	9.86	5,200	51,272	167,028	Jul 08 08:19 PM
Quisel John D	Chief Executive Officer	Jul 03 '25	Sale	55.09	5,200	286,454	161,828	Jul 08 08:19 PM
JOHN QUISEL	Director	Jul 03 '25	Proposed Sale	53.17	5,200	276,484		Jul 03 01:30 PM
Savage William Jacob	Chief Medical Officer	Jun 27 '25	Option Exercise	9.86	32,070	316,210	88,795	Jul 01 04:50 PM
Franchi Jean M.	Chief Financial Officer	Jun 16 '25	Sale	52.26	2,000	104,519	67,530	Jun 18 05:18 PM
JEAN FRANCHI	Officer	Jun 16 '25	Proposed Sale	53.71	2,000	107,420		Jun 16 04:22 PM

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