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RNA

Avidity Biosciences Inc

Nov 03 • 04:00PM ET

69.80

-0.05 -0.07 %

Healthcare • Biotechnology • USA • NASD

Peers: MRNA VRTX SRPT ALNY IONS ARWR NBIX BLUE EXEL SGMO

| Held by: VTI IWM XBI VB VBR VXF IWO IBB SCHA VTWO

Scroll to Statements

Index	RUT	P/E	-	EPS (ttm)	-3.56	Insider Own	8.18%	Shs Outstand	145.90M	Perf Week	-0.29%
Market Cap	10.18B	Forward P/E	-	EPS next Y	-4.72	Insider Trans	-5.29%	Shs Float	133.97M	Perf Month	48.51%
Enterprise Value	9.01B	PEG	-	EPS next Q	-1.09	Inst Own	90.58%	Short Float	14.95%	Perf Quarter	82.44%
Income	-455.74M	P/S	949.12	EPS this Y	-47.06%	Inst Trans	-2.08%	Short Ratio	3.91	Perf Half Y	116.23%
Sales	10.73M	P/B	7.07	EPS next Y	-10.98%	ROA	-33.56%	Short Interest	20.03M	Perf YTD	140.03%
Book/sh	9.87	P/C	8.61	EPS next 5Y	-8.59%	ROE	-37.76%	52W High	70.51 -1.01%	Perf Year	61.50%
Cash/sh	8.11	P/FCF	-	EPS past 3/5Y	-0.47% -34.37%	ROIC	-38.17%	52W Low	21.51 224.50%	Perf 3Y	393.29%
Dividend Est.	-	EV/EBITDA	-	Sales past 3/5Y	5.33% 36.27%	Gross Margin	71.60%	Volatility	0.34% 3.98%	Perf 5Y	155.68%
Dividend TTM	-	EV/Sales	839.33	EPS Y/Y TTM	-20.45%	Oper. Margin	-4863.30%	ATR (14)	2.80	Perf 10Y	-
Dividend Ex-Date	-	Quick Ratio	9.26	Sales Y/Y TTM	1.23%	Profit Margin	-4247.77%	RSI (14)	79.54	Recom	2.33
Dividend Gr. 3/5Y	- -	Current Ratio	9.26	EPS Q/Q	-83.30%	SMA20	26.73%	Beta	0.91	Target Price	73.00
Payout	-	Debt/Eq	0.00	Sales Q/Q	88.12%	SMA50	43.03%	Rel Volume	1.19	Prev Close	69.85
Employees	391	LT Debt/Eq	0.00	Earnings	Aug 07 AMC	SMA200	91.47%	Avg Volume	5.12M	Price	69.80
IPO	Jun 12, 2020	Option/Short	Yes / Yes	EPS/Sales Surpr.	-26.28% 158.15%	Trades		Volume	6,034,894	Change	-0.07%

Date	Action	Analyst	Rating Change	Price Target Change
Sep-17-25	Initiated	Roth Capital	Buy	$62
Jul-10-25	Resumed	Goldman	Buy	$55
Jun-24-25	Initiated	Bernstein	Outperform	$50
Jun-17-25	Initiated	Wolfe Research	Outperform	$55
Jun-11-25	Initiated	Raymond James	Strong Buy	$65
Mar-13-25	Initiated	Citigroup	Buy	$70
Mar-12-25	Initiated	BMO Capital Markets	Outperform	$72
Mar-07-25	Initiated	Scotiabank	Sector Outperform	$70
Dec-20-24	Initiated	H.C. Wainwright	Buy	$72
Nov-26-24	Initiated	RBC Capital Mkts	Outperform	$67
Sep-24-24	Initiated	Goldman	Buy	$59
Aug-28-24	Initiated	Barclays	Overweight	$63
May-03-24	Initiated	BofA Securities	Buy	$40
Mar-14-24	Initiated	Cantor Fitzgerald	Overweight	$60
May-22-23	Upgrade	Evercore ISI	In-line → Outperform	$20
Mar-31-23	Downgrade	Evercore ISI	Outperform → In-line	$20
Jul-20-22	Initiated	Chardan Capital Markets	Buy	$29
Jul-12-22	Initiated	Raymond James	Strong Buy	$29
Sep-07-21	Initiated	Evercore ISI	Outperform	$50
Jun-17-21	Initiated	Needham	Buy	$50

Show Previous Ratings

Nov-03-25 01:34AM	Avidity Biosciences (RNA) Soars 42% on $12-Billion Novartis Merger (Insider Monkey)
Oct-31-25 09:44AM	Here's Why Avidity Biosciences Stock Soared This Week (There's More to the Deal Than You Might Think) (Motley Fool)
Oct-30-25 12:23PM	Halper Sadeh LLC Encourages RNA, JAMF, AWK Shareholders to Contact the Firm to Discuss Their Rights (PR Newswire)
10:00AM	Analysts Estimate Avidity Biosciences, Inc. (RNA) to Report a Decline in Earnings: What to Look Out for (Zacks)
Oct-29-25 02:49PM	Fresh List of Stocks With Short Squeeze Potential (Schaeffer's Research)
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Oct-28-25 10:14AM	Novartis Lags Q3 Earnings, Announces $12B Avidity Biosciences Acquisition (Zacks)
09:42AM	Warner Bros. Discovery upgraded, F5 downgraded: Wall Street's top analyst calls (The Fly)
09:17AM	Avidity Biosciences (RNA) Moves 42.4% Higher: Will This Strength Last? (Zacks)
06:26AM	Novartis Expects to Ride Out Patent Losses With Sales, Profit Growth Ahead (The Wall Street Journal)
06:11AM	S&P Futures Muted After Record Rally, FOMC Meeting and Earnings in Focus (Barchart)
05:24AM	Avidity Biosciences (RNA) Soars to All-Time High on Looming $12-Billion Merger with Novartis (Insider Monkey)
04:00AM	Novartis $12B Avidity deal shows a willingness to take big swings in neuroscience (Pharma Voice)
Oct-27-25 05:12PM	Why Avidity Biosciences Stock Blasted 42% Higher Today (Motley Fool) +42.42%
05:09PM	Health Care Roundup: Market Talk (The Wall Street Journal)
04:54PM	This biotech's stock soared as investors look for the next buyout target (MarketWatch)
04:51PM	Loading…
04:51PM	Stocks to Watch Monday: Amazon, Nvidia, Novartis, Keurig Dr Pepper (The Wall Street Journal)
04:34PM	These Stocks Are Moving the Most Today: Qualcomm, MP Materials, USA Rare Earth, Tesla, Avidity, Newmont, Microsoft, and More (Barrons.com)
01:01PM	HALPER SADEH LLC ENCOURAGES ADVM, PLYM, RNA SHAREHOLDERS TO CONTACT THE FIRM TO DISCUSS THEIR RIGHTS (PR Newswire)
12:55PM	Novartis Just Dropped $12 Billion on a Biotech Moonshot--Here's What Investors Need to Know (GuruFocus.com)
12:07PM	Why Avidity Biosciences And Dyne Therapeutics Stocks Soared 40% Monday (Investopedia)
11:16AM	Novartis Avidity Deal Is a Green Light for Biotech Rally (Barrons.com)
09:38AM	Stocks to Watch Monday: Nvidia, Novartis, Keurig Dr Pepper (The Wall Street Journal)
09:24AM	Novartis to buy Avidity for $12B, Keurig Dr Pepper raises outlook (Yahoo Finance Video)
08:25AM	5 Things to Know Before the Stock Market Opens (Investopedia)
08:19AM	USA Rare Earth, Iren, Novartis, Softbank: Trending Stocks (Yahoo Finance Video)
06:49AM	Fed, Tech Earnings and Trump-Xi Talks. Why One Matters Most for Markets. (Barrons.com)
06:08AM	MP Materials slumps, Avidity Biosciences surges and other movers (MarketWatch)
05:51AM	Novartis agrees to buy Avidity Biosciences for $12bn (Pharmaceutical Technology)
05:26AM	Dyne, Avidity stocks soar as Novartis strikes $12 bln biotech deal (Investing.com)
04:59AM	Stock Market Today: Dow set for 200-point rise, S&P 500 and Nasdaq to pop after weekend talks between U.S. and China (MarketWatch)
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04:39AM	Jefferies sees Dyne as key beneficiary of Novartis Avidity buyout (Investing.com)
04:39AM	Novartis Deal Values Avidity Biosciences At $12 Billion (Barrons.com)
Oct-26-25 05:33PM	Novartis Agrees to Acquire Avidity Biosciences for $12 Billion (The Wall Street Journal)
04:25PM	Novartis acquiring US firm Avidity Biosciences for $12 bn (AFP)
03:43PM	Swiss drugmaker Novartis to buy Avidity Biosciences for $12 billion (USA TODAY)
03:29PM	Novartis Deal Values Avidity Biosciences At $12 Billion (Barrons.com)
01:07PM	Avidity Biosciences Enters into Agreement to be Acquired by Novartis AG (PR Newswire)
11:07AM	Novartis to acquire Avidity in $12B bet on RNA drugs for neuromuscular disease (BioPharma Dive)
Oct-16-25 09:00AM	Avidity Biosciences to Participate in Upcoming Investor Conference (PR Newswire)
Oct-13-25 09:00AM	Avidity Biosciences Announces Positive Pre-BLA Meeting with U.S. FDA for del-zota in DMD44 with a Submission Planned for Q1 2026 (PR Newswire)
07:31AM	What Makes Avidity Biosciences (RNA) an Investment Choice? (Insider Monkey)
Oct-06-25 09:00AM	Avidity Biosciences to Present Data from EXPLORE44 Clinical Development Program of Del-Zota in DMD44 at 30th Annual Congress of the World Muscle Society (PR Newswire)
Sep-24-25 04:06AM	Avidity Biosciences (RNA) Announces Positive One-Year Data For its, Del-Zota (Insider Monkey)
Sep-17-25 09:33AM	Netflix upgraded, Five Below initiated: Wall Street's top analyst calls (The Fly)
Sep-15-25 04:01PM	Avidity Biosciences, Inc. Announces Closing of Upsized Public Offering of Common Stock, Including Full Exercise of Underwriters' Option to Purchase Additional Shares (PR Newswire) -10.10%
Sep-13-25 12:01PM	Avidity Biosciences (RNA) Gets 9% Boost from Higher PT, Rating (Insider Monkey)
Sep-12-25 06:45AM	Takeda poaches top Lilly exec; Maze soars on early PKU drug data (BioPharma Dive) +9.02%
Sep-10-25 04:01PM	Avidity Biosciences Announces Proposed Public Offering of Common Stock (PR Newswire) -11.55%
07:00AM	Avidity Biosciences' Del-zota Demonstrated Reversal of Disease Progression Across Key Functional Endpoints in EXPLORE44 and EXPLORE44-OLE Phase 1/2 Trial in People Living with DMD44 (PR Newswire)
12:59AM	Cantor Fitzgerald Reiterates a Buy Rating on Avidity Biosciences (RNA) (Insider Monkey)
Aug-27-25 09:00AM	Avidity Biosciences to Participate in Upcoming Investor Conferences (PR Newswire)
Aug-25-25 02:23PM	RNA Stock Moves More Than 30% in a Week: What's Driving This Rally? (Zacks)
Aug-14-25 09:15AM	Clene Inc. (CLNN) Reports Q2 Loss, Misses Revenue Estimates (Zacks)
Aug-13-25 08:15AM	Mersana Therapeutics, Inc. (MRSN) Reports Q2 Loss, Lags Revenue Estimates (Zacks)
Aug-12-25 05:15PM	Fate Therapeutics (FATE) Reports Q2 Loss, Beats Revenue Estimates (Zacks)
Aug-07-25 05:10PM	Iovance Biotherapeutics (IOVA) Reports Q2 Loss, Lags Revenue Estimates (Zacks)
04:05PM	Avidity Biosciences Reports Second Quarter 2025 Financial Results and Recent Highlights (PR Newswire)
10:19AM	Avidity (RNA) Gets 26% Jump on Potential Takeover (Insider Monkey)
Aug-06-25 05:10PM	Arcutis Biotherapeutics, Inc. (ARQT) Reports Q2 Loss, Beats Revenue Estimates (Zacks) +26.14%
12:47PM	Avidity Biosciences Rockets As Novartis Reportedly Mulls A Takeover Deal (Investor's Business Daily)
12:00PM	Avidity Biosciences stock soars on Novartis takeover approach report (Investing.com)
11:41AM	Novartis weighs deal for biotech Avidity Biosciences, FT reports (Reuters)
Jul-28-25 09:39AM	Facioscapulohumeral Muscular Dystrophy Pipeline Market Insight Report 2025 \| In-depth Analysis of 10+ Companies and 12+ Pipeline Drugs (GlobeNewswire)
09:00AM	Avidity Biosciences Announces Completion of Enrollment for HARBOR, the First Global Phase 3 Trial of Delpacibart Etedesiran (del-desiran) for Treatment of DM1 and Provides Guidance on Regulatory Submission (PR Newswire)
Jul-26-25 11:03AM	Avidity (RNA) Jumps 9.2% on Drug Candidate's Breakthrough Therapy Designation (Insider Monkey)
Jul-23-25 09:00AM	Avidity Biosciences Receives FDA Breakthrough Therapy Designation for Delpacibart Zotadirsen (del-zota) for the Treatment of DMD in People with Mutations Amenable to Exon 44 Skipping (PR Newswire)
Jul-13-25 06:15AM	Raymond James Predicts Up to ~760% Surge for These 2 Strong Buy Stocks (TipRanks)
Jun-11-25 08:03PM	Avidity Biosciences, Inc. (RNA) Initiated with a Strong Buy at Raymond James (Insider Monkey)
09:45AM	Raymond James bullish on biotech firms on favorable valuation (Investing.com)
09:00AM	Avidity Biosciences to Present Topline Data from Phase 1/2 FORTITUDE Trial of Del-brax in People Living with Facioscapulohumeral Muscular Dystrophy at 32nd Annual FSHD Society International Research Congress (PR Newswire)
Jun-10-25 09:25AM	Avidity Biosciences price target raised to $75 from $65 at Chardan (TipRanks)
Jun-09-25 02:04PM	Avidity Biosciences Touts Encouraging Functional Gains And Biomarker Reductions In Rare Muscular Weakness Disease Trial (Benzinga) -9.88%
07:01AM	Avidity Biosciences Announces Positive Topline Phase 1/2 FORTITUDE Data Demonstrating Consistent Improvement Across Multiple Functional Measures Compared to Placebo in Del-Brax Treated FSHD Participants (PR Newswire)
07:00AM	Avidity Biosciences Announces the Accelerated Approval Regulatory Pathway in the U.S. is Open for Del-Brax and Initiates the Global, Confirmatory Phase 3 FORWARD Study in FSHD (PR Newswire)
May-21-25 04:05PM	Avidity Biosciences Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (PR Newswire)
May-08-25 05:55PM	Avidity Biosciences, Inc. (RNA) Reports Q1 Loss, Misses Revenue Estimates (Zacks) +9.63%
04:05PM	Avidity Biosciences Reports First Quarter 2025 Financial Results and Recent Highlights (PR Newswire)
May-06-25 09:00AM	Avidity Biosciences to Participate in Upcoming Investor Conference (PR Newswire) -18.65%
Apr-24-25 05:15PM	Gilead Sciences (GILD) Q1 Earnings and Revenues Lag Estimates (Zacks)
Apr-22-25 05:30AM	Trumps FDA Sends a Bullish Signal to Biotech (The Wall Street Journal)
Apr-21-25 04:09PM	Why Sarepta Therapeutics And Other Genetics Stocks Just Got A Sizable Boost (Investor's Business Daily) +6.98%
04:05PM	Avidity Biosciences Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (PR Newswire)
Apr-08-25 09:00AM	Avidity Biosciences Receives Orphan Drug Designation in Japan for Delpacibart Etedesiran (del-desiran) for Treatment of Myotonic Dystrophy Type 1 (PR Newswire) -5.49%
Apr-05-25 05:22PM	Avidity Biosciences (RNA): Among Unstoppable Stocks That Could Double Your Money (Insider Monkey)
Apr-03-25 09:34AM	Avidity Biosciences (RNA) Soars 11.3%: Is Further Upside Left in the Stock? (Zacks) -5.61%
Apr-01-25 11:50AM	Biotech stocks slide as Marks resignation seen being negative for sector (TipRanks) -9.42%
09:00AM	Avidity Biosciences to Participate in Upcoming Investor Conference (PR Newswire)
Mar-31-25 09:00AM	Avidity Biosciences Completes Enrollment in Biomarker Cohort in Phase 1/2 FORTITUDE Trial for Delpacibart Braxlosiran (del-brax) in People Living with Facioscapulohumeral Muscular Dystrophy (PR Newswire) -6.58%
Mar-28-25 09:00AM	RNA Biotechs: Current State And Outlook (Seeking Alpha)
Mar-26-25 10:17AM	The Risk/Reward Of Avidity Biosciences And Its 2 Promising Programs (SeekingAlpha)
Mar-21-25 04:05PM	Avidity Biosciences Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (PR Newswire) +7.98%
Mar-17-25 07:00AM	Avidity Biosciences Announces Positive Topline Del-zota Data Demonstrating Consistent, Statistically Significant Improvements in Dystrophin, Exon Skipping and Creatine Kinase in People Living with Duchenne Muscular Dystrophy Amenable to Exon 44 Skipping in Phase 1/2 EXPLORE44 Trial (PR Newswire) +8.74%
Mar-12-25 04:05PM	Avidity Biosciences Announces Upcoming Presentations at the Muscular Dystrophy Association (MDA) Clinical & Scientific Conference (PR Newswire) +10.24%
Feb-28-25 09:00AM	Avidity Biosciences Honors Rare Disease Day and Global Efforts to Support People and Families Impacted by Rare Neuromuscular Diseases (PR Newswire) +5.36%
Feb-27-25 05:40PM	Avidity Biosciences, Inc. (RNA) Reports Q4 Loss, Tops Revenue Estimates (Zacks)
04:05PM	Avidity Biosciences Reports Fourth Quarter 2024 Financial Results and Recent Highlights (PR Newswire)
Feb-25-25 09:00AM	Avidity Biosciences to Participate in Upcoming Investor Conferences (PR Newswire)
Feb-21-25 04:05PM	Avidity Biosciences Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (PR Newswire)
Jan-20-25 04:05PM	Avidity Biosciences Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) (PR Newswire)
Jan-17-25 11:06AM	Avidity Biosciences, Inc. (RNA): The Biotech Stock with Biggest Upside Potential (Insider Monkey)

Avidity Biosciences, Inc. engages in the development of a new class of oligonucleotide-based therapies called Antibody Oligonucleotide Conjugates (AOC). It utilizes its AOC platform to design, engineer, and develop therapeutics that combine the tissue selectivity of monoclonal antibodies and the precision of oligonucleotide-based therapies in order to access previously undruggable tissue and cell types and more effectively target underlying genetic drivers of diseases. The company was founded by Troy E. Wilson, Kent Hawryluk, Mark E. Davis, and Francis Patrick McCormick on November 13, 2012 and is headquartered in San Diego, CA.

Insider Trading	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
Hughes Steven George	Chief Medical Officer	Oct 22 '25	Option Exercise	10.16	2,209	22,443	41,076	Oct 24 04:56 PM
Hughes Steven George	Chief Medical Officer	Oct 22 '25	Sale	47.54	2,209	105,015	38,867	Oct 24 04:56 PM
McCarthy Teresa	Chief Human Resources Officer	Oct 15 '25	Option Exercise	22.34	20,000	446,800	117,130	Oct 17 04:27 PM
McCarthy Teresa	Chief Human Resources Officer	Oct 15 '25	Sale	50.15	20,000	1,003,058	97,130	Oct 17 04:27 PM
Mosbrooker Eric	Chief Commercial Officer	Oct 03 '25	Option Exercise	9.05	6,562	59,386	61,562	Oct 07 04:11 PM
Mosbrooker Eric	Chief Commercial Officer	Oct 03 '25	Sale	45.38	6,562	297,771	55,000	Oct 07 04:11 PM
Hughes Steven George	Chief Medical Officer	Sep 22 '25	Option Exercise	10.16	2,208	22,433	41,075	Sep 23 04:57 PM
Hughes Steven George	Chief Medical Officer	Sep 22 '25	Sale	40.58	2,208	89,601	38,867	Sep 23 04:57 PM
McCarthy Teresa	Chief Human Resources Officer	Sep 15 '25	Option Exercise	22.34	15,000	335,100	112,130	Sep 17 04:03 PM
McCarthy Teresa	Chief Human Resources Officer	Sep 15 '25	Sale	41.41	15,000	621,142	97,130	Sep 17 04:03 PM
Hughes Steven George	Chief Medical Officer	Sep 15 '25	Option Exercise	6.57	1,542	10,131	40,409	Sep 17 04:02 PM
Hughes Steven George	Chief Medical Officer	Sep 15 '25	Sale	45.41	1,542	70,022	38,867	Sep 17 04:02 PM
Flanagan W. Michael	Chief Scientific Officer	Sep 11 '25	Option Exercise	14.22	20,000	284,400	100,195	Sep 12 04:07 PM
Flanagan W. Michael	Chief Scientific Officer	Sep 11 '25	Sale	38.94	20,000	778,702	80,195	Sep 12 04:07 PM
WILLIAM MICHAEL FLANAGAN	Officer	Sep 11 '25	Proposed Sale	46.40	20,000	928,000		Sep 11 04:24 PM
WILSON TROY EDWARD	Director	Sep 05 '25	Option Exercise	12.48	14,500	180,960	83,925	Sep 09 05:53 PM
WILSON TROY EDWARD	Director	Sep 05 '25	Sale	50.00	29,500	1,475,000	54,425	Sep 09 05:53 PM
Boyce Sarah	President and CEO	Sep 05 '25	Option Exercise	1.24	50,000	62,000	355,871	Sep 05 06:56 PM
Boyce Sarah	President and CEO	Sep 05 '25	Sale	49.95	50,000	2,497,435	305,871	Sep 05 06:56 PM
Mosbrooker Eric	Chief Commercial Officer	Sep 03 '25	Option Exercise	9.05	6,563	59,395	61,563	Sep 05 06:32 PM
Mosbrooker Eric	Chief Commercial Officer	Sep 03 '25	Sale	47.07	6,563	308,936	55,000	Sep 05 06:32 PM
SARAH BOYCE	Director	Sep 05 '25	Proposed Sale	48.47	50,000	2,423,500		Sep 05 04:25 PM
WILSON TROY EDWARD	Chairman	Sep 05 '25	Proposed Sale	50.00	95,052	4,752,600		Sep 05 04:10 PM
ERIC MOSBROOKER	Officer	Sep 03 '25	Proposed Sale	47.23	19,688	929,864		Sep 03 04:31 PM
Gallagher Kathleen P.	Chief Program Officer	Sep 02 '25	Sale	47.42	188	8,915	50,204	Sep 02 08:30 PM
Boyce Sarah	President and CEO	Aug 28 '25	Option Exercise	1.24	25,000	31,000	330,871	Aug 29 04:28 PM
Boyce Sarah	President and CEO	Aug 28 '25	Sale	49.39	25,000	1,234,700	305,871	Aug 29 04:28 PM
SARAH BOYCE	Director	Aug 28 '25	Proposed Sale	47.82	25,000	1,195,500		Aug 28 04:21 PM
Hughes Steven George	Chief Medical Officer	Aug 22 '25	Option Exercise	10.16	2,208	22,433	41,075	Aug 22 05:20 PM
Hughes Steven George	Chief Medical Officer	Aug 22 '25	Sale	46.40	2,208	102,462	38,867	Aug 22 05:20 PM
McCarthy Teresa	Chief Human Resources Officer	Aug 15 '25	Option Exercise	22.34	10,000	223,400	107,130	Aug 15 05:50 PM
McCarthy Teresa	Chief Human Resources Officer	Aug 15 '25	Sale	46.56	10,000	465,632	97,130	Aug 15 05:50 PM
TERESA MCCARTHY	Officer	Aug 15 '25	Proposed Sale	46.07	45,000	2,073,150		Aug 15 04:27 PM
MacLean Michael F	Chief Financial Officer	Aug 06 '25	Sale	42.73	30,914	1,320,844	65,806	Aug 15 04:09 PM
Hughes Steven George	Chief Medical Officer	Aug 13 '25	Option Exercise	6.57	1,542	10,131	40,409	Aug 15 04:07 PM
Hughes Steven George	Chief Medical Officer	Aug 13 '25	Sale	46.66	1,542	71,950	38,867	Aug 15 04:07 PM
STEVEN GEORGE HUGHES	Officer	Aug 13 '25	Proposed Sale	46.23	9,709	448,847		Aug 13 04:31 PM
Mosbrooker Eric	Chief Commercial Officer	Aug 06 '25	Option Exercise	9.05	124,687	1,128,417	185,807	Aug 08 05:45 PM
Mosbrooker Eric	Chief Commercial Officer	Aug 06 '25	Sale	44.06	130,807	5,763,697	55,000	Aug 08 05:45 PM
WILSON TROY EDWARD	Director	Aug 06 '25	Option Exercise	12.14	29,500	358,260	91,425	Aug 08 05:42 PM
WILSON TROY EDWARD	Director	Aug 06 '25	Sale	45.00	65,554	2,949,930	17,776	Aug 08 05:42 PM
WILSON TROY EDWARD	Director	Aug 06 '25	Sale	45.00	29,500	1,327,500	69,425	Aug 08 05:42 PM
LEVIN ARTHUR A	Director	Aug 06 '25	Option Exercise	22.34	107,500	2,401,550	127,150	Aug 08 05:41 PM
LEVIN ARTHUR A	Director	Aug 06 '25	Sale	47.62	107,500	5,118,881	19,650	Aug 08 05:41 PM
Hughes Steven George	Chief Medical Officer	Aug 06 '25	Option Exercise	12.21	47,451	579,180	90,517	Aug 08 05:39 PM
Hughes Steven George	Chief Medical Officer	Aug 06 '25	Sale	42.74	81,434	3,480,269	38,867	Aug 08 05:39 PM
ERIC MOSBROOKER	Officer	Aug 06 '25	Proposed Sale	38.26	130,807	5,004,676		Aug 06 04:23 PM
STEVEN GEORGE HUGHES	Officer	Aug 06 '25	Proposed Sale	38.26	81,434	3,115,665		Aug 06 04:23 PM
ARTHUR LEVIN	Director	Aug 06 '25	Proposed Sale	38.26	107,500	4,112,950		Aug 06 04:23 PM
MICHAEL MACLEAN	Officer	Aug 06 '25	Proposed Sale	38.26	30,914	1,182,770		Aug 06 04:22 PM
WILSON TROY EDWARD	Chairman	Aug 06 '25	Proposed Sale	45.00	95,054	4,277,430		Aug 06 04:08 PM
Moriarty John B	Chief Legal Officer	Aug 04 '25	Sale	36.21	2,245	81,291	47,755	Aug 05 05:27 PM
Gallagher Kathleen P.	Chief Program Officer	Jun 17 '25	Sale	30.24	911	27,549	50,392	Jun 18 06:02 PM
KATHLEEN GALLAGHER	Officer	Jun 17 '25	Proposed Sale	29.80	911	27,148		Jun 17 04:19 PM
Flanagan W. Michael	Chief Scientific Officer	Jun 11 '25	Option Exercise	14.22	20,000	284,400	100,195	Jun 12 06:18 PM
Flanagan W. Michael	Chief Scientific Officer	Jun 11 '25	Sale	32.88	20,000	657,694	80,195	Jun 12 06:18 PM
WILLIAM MICHAEL FLANAGAN	Officer	Jun 11 '25	Proposed Sale	33.62	20,000	672,400		Jun 11 04:31 PM
Gallagher Kathleen P.	Chief Program Officer	Jun 02 '25	Option Exercise	16.65	5,875	97,819	56,429	Jun 04 04:48 PM
Gallagher Kathleen P.	Chief Program Officer	Jun 02 '25	Sale	32.48	5,875	190,833	50,554	Jun 04 04:48 PM
KATHLEEN GALLAGHER	Officer	Jun 02 '25	Proposed Sale	30.98	5,875	182,008		Jun 02 04:37 PM
Gallagher Kathleen P.	Chief Program Officer	May 01 '25	Option Exercise	16.65	5,875	97,819	56,429	May 02 07:55 PM
Gallagher Kathleen P.	Chief Program Officer	May 01 '25	Sale	32.40	5,875	190,324	50,554	May 02 07:55 PM
KATHLEEN GALLAGHER	Officer	May 01 '25	Proposed Sale	32.65	5,875	191,819		May 01 04:57 PM
Gallagher Kathleen P.	Chief Program Officer	Apr 01 '25	Option Exercise	14.81	5,875	87,004	56,100	Apr 03 04:56 PM
Gallagher Kathleen P.	Chief Program Officer	Apr 01 '25	Sale	27.83	5,875	163,486	50,554	Apr 03 04:56 PM
Hughes Steven George	Chief Medical Officer	Mar 20 '25	Sale	31.06	9,578	297,491	72,850	Mar 21 06:44 PM
Boyce Sarah	President and CEO	Mar 20 '25	Sale	31.06	31,540	979,563	305,871	Mar 21 06:42 PM
Flanagan W. Michael	Chief Scientific Officer	Mar 20 '25	Sale	31.06	11,780	365,868	80,195	Mar 21 06:40 PM
MacLean Michael F	Chief Financial Officer	Mar 20 '25	Sale	31.06	7,935	246,425	96,720	Mar 21 06:38 PM
McCarthy Teresa	Chief Human Resources Officer	Mar 20 '25	Sale	31.06	7,778	241,583	97,130	Mar 21 06:36 PM
Flanagan W. Michael	Chief Scientific Officer	Mar 11 '25	Option Exercise	14.22	20,000	284,400	111,975	Mar 12 04:23 PM
Flanagan W. Michael	Chief Scientific Officer	Mar 11 '25	Sale	30.13	20,000	602,614	91,975	Mar 12 04:23 PM
WILLIAM MICHAEL FLANAGAN	Officer	Mar 11 '25	Proposed Sale	30.04	20,000	600,800		Mar 11 04:35 PM
Gallagher Kathleen P.	Chief Program Officer	Mar 03 '25	Option Exercise	14.70	5,875	86,362	56,429	Mar 04 06:17 PM
Gallagher Kathleen P.	Chief Program Officer	Mar 03 '25	Sale	29.41	5,875	172,807	50,554	Mar 04 06:17 PM
Gallagher Kathleen P.	Chief Program Officer	Feb 03 '25	Option Exercise	16.65	5,875	97,819	56,429	Feb 05 05:01 PM
Gallagher Kathleen P.	Chief Program Officer	Feb 03 '25	Sale	32.16	5,875	188,918	50,554	Feb 05 05:01 PM
KATHLEEN GALLAGHER	Officer	Feb 03 '25	Proposed Sale	32.93	17,625	580,391		Feb 03 04:34 PM
LEVIN ARTHUR A	Director	Jan 21 '25	Sale	28.60	1,872	53,537	12,958	Jan 23 08:17 PM
MacLean Michael F	Chief Financial Officer	Jan 21 '25	Sale	28.59	3,287	93,985	104,655	Jan 23 08:15 PM
McCarthy Teresa	Chief Human Resources Officer	Jan 21 '25	Sale	28.59	2,959	84,612	104,908	Jan 23 08:14 PM
Flanagan W. Michael	Chief Scientific Officer	Jan 21 '25	Sale	28.60	5,672	162,192	91,975	Jan 23 08:12 PM
Boyce Sarah	President and CEO	Jan 21 '25	Sale	28.59	10,397	297,291	337,411	Jan 23 08:10 PM
Gallagher Kathleen P.	Chief Program Officer	Jan 22 '25	Sale	30.16	5,629	169,776	50,554	Jan 23 08:08 PM
Gallagher Kathleen P.	Chief Program Officer	Jan 21 '25	Sale	28.59	3,782	108,136	56,183	Jan 23 08:08 PM
Hughes Steven George	Chief Medical Officer	Jan 21 '25	Sale	28.59	3,947	112,856	82,428	Jan 23 08:06 PM
KATHLEEN GALLAGHER	Officer	Jan 22 '25	Proposed Sale	30.84	6,924	213,536		Jan 22 04:25 PM
Flanagan W. Michael	CSTO	Dec 18 '24	Sale	32.66	12,742	416,154	72,647	Dec 19 06:17 PM
MacLean Michael F	Chief Financial Officer	Dec 18 '24	Sale	32.66	11,151	364,192	82,942	Dec 19 06:16 PM
Boyce Sarah	President and CEO	Dec 18 '24	Sale	32.66	31,855	1,040,384	265,308	Dec 19 06:15 PM
McCarthy Teresa	Chief Human Resources Officer	Dec 18 '24	Sale	32.66	11,151	364,192	82,867	Dec 19 06:15 PM
McCarthy Teresa	Chief Human Resources Officer	Dec 16 '24	Option Exercise	14.22	25,000	355,500	119,018	Dec 18 04:46 PM
McCarthy Teresa	Chief Human Resources Officer	Dec 16 '24	Sale	33.26	25,000	831,605	94,018	Dec 18 04:46 PM
TERESA MCCARTHY	Officer	Dec 16 '24	Proposed Sale	32.49	25,000	812,250		Dec 16 04:29 PM
Flanagan W. Michael	CSTO	Dec 11 '24	Option Exercise	22.47	24,000	539,280	109,389	Dec 13 06:08 PM
Flanagan W. Michael	CSTO	Dec 11 '24	Sale	35.77	24,000	858,401	85,389	Dec 13 06:08 PM
W. MICHAEL FLANAGAN	Officer	Dec 11 '24	Proposed Sale	36.10	24,000	866,400		Dec 11 04:59 PM
McCarthy Teresa	Chief Human Resources Officer	Nov 18 '24	Option Exercise	14.22	25,000	355,500	119,018	Nov 20 06:10 PM
McCarthy Teresa	Chief Human Resources Officer	Nov 18 '24	Sale	41.14	25,000	1,028,520	94,018	Nov 20 06:10 PM
LEVIN ARTHUR A	Director	Nov 19 '24	Option Exercise	1.24	3,323	4,121	18,153	Nov 20 06:06 PM

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