| Insider Trading |
Relationship |
Date |
Transaction |
Cost |
#Shares |
Value ($) |
#Shares Total |
SEC Form 4 |
| Pelish Henry E. | Chief Scientific Officer | Jan 06 '26 | Sale | 97.17 | 2,664 | 258,848 | 65,888 | Jan 07 05:27 PM | | Pelish Henry E. | Chief Scientific Officer | Jan 05 '26 | Sale | 97.32 | 2,496 | 242,905 | 68,552 | Jan 07 05:27 PM | | Noci Darlene | Chief Development Officer | Jan 05 '26 | Sale | 97.32 | 4,236 | 412,239 | 43,798 | Jan 07 05:26 PM | | Noci Darlene | Chief Development Officer | Jan 06 '26 | Sale | 97.16 | 3,181 | 309,081 | 40,617 | Jan 07 05:26 PM | | Miller Deborah Ann | Chief Legal Officer | Jan 05 '26 | Sale | 97.32 | 4,363 | 424,598 | 44,723 | Jan 07 05:26 PM | | Miller Deborah Ann | Chief Legal Officer | Jan 06 '26 | Sale | 97.16 | 2,589 | 251,560 | 42,134 | Jan 07 05:26 PM | | Turner Christopher Durant | Chief Medical Officer | Jan 05 '26 | Sale | 97.32 | 4,236 | 412,239 | 58,311 | Jan 07 05:26 PM | | Turner Christopher Durant | Chief Medical Officer | Jan 06 '26 | Sale | 97.16 | 3,181 | 309,081 | 55,130 | Jan 07 05:26 PM | | Balcom Alexandra | Chief Financial Officer | Jan 05 '26 | Sale | 97.32 | 4,236 | 412,239 | 84,914 | Jan 07 05:25 PM | | Balcom Alexandra | Chief Financial Officer | Jan 06 '26 | Sale | 97.16 | 3,181 | 309,081 | 81,733 | Jan 07 05:25 PM | | Porter James Richard | President and CEO | Jan 05 '26 | Sale | 97.32 | 17,890 | 1,741,016 | 288,172 | Jan 07 05:25 PM | | Porter James Richard | President and CEO | Jan 06 '26 | Sale | 97.16 | 9,543 | 927,244 | 278,629 | Jan 07 05:25 PM | | Henry E. Pelish | Officer | Jan 05 '26 | Proposed Sale | 97.32 | 2,496 | 242,901 | | Jan 05 08:58 PM | | Darlene Noci | Officer | Jan 05 '26 | Proposed Sale | 97.32 | 4,236 | 412,232 | | Jan 05 08:58 PM | | Deborah Ann Miller | Officer | Jan 05 '26 | Proposed Sale | 97.32 | 4,363 | 424,591 | | Jan 05 08:57 PM | | Christopher Durant Turner | Officer | Jan 05 '26 | Proposed Sale | 97.32 | 4,236 | 412,232 | | Jan 05 08:55 PM | | Alexandra Balcom | Officer | Jan 05 '26 | Proposed Sale | 97.32 | 4,236 | 412,232 | | Jan 05 08:54 PM | | James Richard Porter | Officer | Jan 05 '26 | Proposed Sale | 97.32 | 17,890 | 1,740,989 | | Jan 05 08:53 PM | | Noci Darlene | Chief Development Officer | Dec 30 '25 | Option Exercise | 27.85 | 4,000 | 111,400 | 52,034 | Jan 02 04:20 PM | | Noci Darlene | Chief Development Officer | Dec 30 '25 | Sale | 100.04 | 4,000 | 400,179 | 48,034 | Jan 02 04:20 PM | | Darlene Noci | Officer | Dec 30 '25 | Proposed Sale | 101.60 | 15,000 | 1,524,000 | | Dec 30 04:03 PM | | Pelish Henry E. | Chief Scientific Officer | Dec 22 '25 | Option Exercise | 1.08 | 5,085 | 5,492 | 71,048 | Dec 23 04:31 PM | | Balcom Alexandra | Chief Financial Officer | Dec 22 '25 | Option Exercise | 1.08 | 34,500 | 37,260 | 89,150 | Dec 23 04:30 PM | | Porter James Richard | President and CEO | Dec 19 '25 | Option Exercise | 0.65 | 57,000 | 37,050 | 306,062 | Dec 23 04:30 PM | | Balcom Alexandra | Chief Financial Officer | Dec 08 '25 | Sale | 110.32 | 7,084 | 781,537 | 54,650 | Dec 10 04:30 PM | | Alexandra Balcom | Officer | Dec 08 '25 | Proposed Sale | 109.60 | 7,084 | 776,406 | | Dec 08 08:36 PM | | Noci Darlene | Chief Development Officer | Nov 28 '25 | Option Exercise | 27.85 | 4,000 | 111,400 | 52,034 | Dec 02 04:30 PM | | Noci Darlene | Chief Development Officer | Nov 28 '25 | Sale | 108.58 | 4,000 | 434,319 | 48,034 | Dec 02 04:30 PM | | Shair Matthew | Director | Nov 24 '25 | Sale | 109.37 | 5,850 | 639,814 | 1,377,194 | Nov 26 04:30 PM | | Shair Matthew | Director | Nov 24 '25 | Sale | 109.37 | 1,650 | 180,460 | 201,672 | Nov 26 04:30 PM | | Flynn James E | Director by Deputization | Nov 24 '25 | Sale | 95.44 | 742,574 | 70,874,975 | 8,299,225 | Nov 24 08:00 PM | | Balcom Alexandra | Chief Financial Officer | Nov 17 '25 | Option Exercise | 49.85 | 20,000 | 996,962 | 81,734 | Nov 19 05:14 PM | | Balcom Alexandra | Chief Financial Officer | Nov 18 '25 | Option Exercise | 72.35 | 729 | 52,743 | 62,463 | Nov 19 05:14 PM | | Balcom Alexandra | Chief Financial Officer | Nov 17 '25 | Sale | 99.45 | 20,000 | 1,989,025 | 61,734 | Nov 19 05:14 PM | | Balcom Alexandra | Chief Financial Officer | Nov 18 '25 | Sale | 104.26 | 729 | 76,005 | 61,734 | Nov 19 05:14 PM | | Miller Deborah Ann | Chief Legal Officer | Nov 17 '25 | Option Exercise | 6.89 | 24,200 | 166,738 | 73,286 | Nov 19 05:13 PM | | Miller Deborah Ann | Chief Legal Officer | Nov 17 '25 | Sale | 105.50 | 24,200 | 2,552,999 | 49,086 | Nov 19 05:13 PM | | DEBORAH MILLER | Officer | Nov 17 '25 | Proposed Sale | 96.50 | 17,200 | 1,659,800 | | Nov 17 04:37 PM | | Alexandra Balcom | Officer | Nov 17 '25 | Proposed Sale | 93.72 | 13,854 | 1,298,397 | | Nov 17 04:09 PM | | Noci Darlene | Chief Development Officer | Oct 30 '25 | Option Exercise | 27.85 | 4,000 | 111,400 | 52,034 | Oct 31 04:31 PM | | Noci Darlene | Chief Development Officer | Oct 30 '25 | Sale | 102.92 | 4,000 | 411,661 | 48,034 | Oct 31 04:31 PM | | Miller Deborah Ann | Chief Legal Officer | Oct 30 '25 | Option Exercise | 6.89 | 21,800 | 150,202 | 70,886 | Oct 31 04:30 PM | | Miller Deborah Ann | Chief Legal Officer | Oct 30 '25 | Sale | 103.16 | 21,800 | 2,248,943 | 49,086 | Oct 31 04:30 PM | | DEBORAH MILLER | Officer | Oct 30 '25 | Proposed Sale | 102.97 | 22,800 | 2,347,716 | | Oct 30 04:16 PM | | Shair Matthew | Director | Oct 28 '25 | Sale | 100.27 | 32,455 | 3,254,263 | 1,383,044 | Oct 29 04:31 PM | | Shair Matthew | Director | Oct 27 '25 | Sale | 100.23 | 14,345 | 1,437,799 | 1,415,499 | Oct 29 04:31 PM | | Shair Matthew | Director | Oct 28 '25 | Sale | 100.27 | 9,154 | 917,872 | 203,322 | Oct 29 04:31 PM | | Shair Matthew | Director | Oct 27 '25 | Sale | 100.23 | 4,046 | 405,531 | 212,476 | Oct 29 04:31 PM | | Matthew Shair | Director | Oct 27 '25 | Proposed Sale | 100.00 | 64,350 | 6,435,000 | | Oct 27 04:09 PM | | Matthew Shair | Director | Oct 27 '25 | Proposed Sale | 100.00 | 18,150 | 1,815,000 | | Oct 27 04:06 PM | | Miller Deborah Ann | Chief Legal Officer | Oct 20 '25 | Option Exercise | 6.89 | 5,000 | 34,450 | 54,086 | Oct 22 04:32 PM | | Miller Deborah Ann | Chief Legal Officer | Oct 20 '25 | Sale | 94.91 | 5,000 | 474,550 | 49,086 | Oct 22 04:32 PM | | Porter James Richard | President and CEO | Oct 16 '25 | Option Exercise | 18.93 | 27,000 | 511,110 | 276,062 | Oct 17 04:32 PM | | Porter James Richard | President and CEO | Oct 16 '25 | Sale | 90.63 | 27,000 | 2,447,021 | 249,062 | Oct 17 04:32 PM | | Miller Deborah Ann | Chief Legal Officer | Oct 15 '25 | Option Exercise | 6.89 | 15,624 | 107,649 | 64,710 | Oct 17 04:32 PM | | Miller Deborah Ann | Chief Legal Officer | Oct 16 '25 | Option Exercise | 6.89 | 12,376 | 85,271 | 61,462 | Oct 17 04:32 PM | | Miller Deborah Ann | Chief Legal Officer | Oct 15 '25 | Sale | 89.98 | 15,624 | 1,405,848 | 49,086 | Oct 17 04:32 PM | | Miller Deborah Ann | Chief Legal Officer | Oct 16 '25 | Sale | 91.66 | 12,376 | 1,134,442 | 49,086 | Oct 17 04:32 PM | | Pelish Henry E. | Chief Scientific Officer | Oct 15 '25 | Option Exercise | 35.08 | 14,205 | 498,260 | 80,168 | Oct 17 04:31 PM | | Pelish Henry E. | Chief Scientific Officer | Oct 15 '25 | Sale | 90.04 | 14,205 | 1,279,018 | 65,963 | Oct 17 04:31 PM | | Balcom Alexandra | Chief Financial Officer | Oct 15 '25 | Option Exercise | 18.93 | 1,683 | 31,859 | 63,417 | Oct 17 04:31 PM | | Balcom Alexandra | Chief Financial Officer | Oct 15 '25 | Sale | 85.57 | 1,683 | 144,014 | 61,734 | Oct 17 04:31 PM | | James Richard Porter | Officer | Oct 16 '25 | Proposed Sale | 90.01 | 27,000 | 2,430,270 | | Oct 16 04:02 PM | | DEBORAH MILLER | Officer | Oct 15 '25 | Proposed Sale | 84.66 | 54,000 | 4,571,640 | | Oct 15 04:37 PM | | Balcom Alexandra | Chief Financial Officer | Oct 14 '25 | Option Exercise | 18.93 | 20,000 | 378,600 | 81,734 | Oct 15 04:30 PM | | Balcom Alexandra | Chief Financial Officer | Oct 13 '25 | Option Exercise | 14.79 | 20,000 | 295,825 | 81,734 | Oct 15 04:30 PM | | Balcom Alexandra | Chief Financial Officer | Oct 13 '25 | Sale | 88.51 | 20,000 | 1,770,288 | 61,734 | Oct 15 04:30 PM | | Balcom Alexandra | Chief Financial Officer | Oct 14 '25 | Sale | 86.20 | 20,000 | 1,724,016 | 61,734 | Oct 15 04:30 PM | | Pelish Henry E. | Chief Scientific Officer | Oct 13 '25 | Option Exercise | 36.39 | 7,637 | 277,903 | 73,600 | Oct 15 04:30 PM | | Pelish Henry E. | Chief Scientific Officer | Oct 14 '25 | Option Exercise | 25.67 | 2,433 | 62,460 | 68,396 | Oct 15 04:30 PM | | Pelish Henry E. | Chief Scientific Officer | Oct 13 '25 | Sale | 89.81 | 7,637 | 685,879 | 65,963 | Oct 15 04:30 PM | | Pelish Henry E. | Chief Scientific Officer | Oct 14 '25 | Sale | 85.78 | 2,433 | 208,699 | 65,963 | Oct 15 04:30 PM | | Alexandra Balcom | Officer | Oct 13 '25 | Proposed Sale | 89.32 | 48,558 | 4,337,206 | | Oct 14 04:08 PM | | HENRY E PELISH | Officer | Oct 13 '25 | Proposed Sale | 88.10 | 21,842 | 1,924,280 | | Oct 14 07:43 AM | | Balcom Alexandra | Chief Financial Officer | Oct 01 '25 | Option Exercise | 8.82 | 20,000 | 176,485 | 81,734 | Oct 03 04:28 PM | | Balcom Alexandra | Chief Financial Officer | Oct 01 '25 | Sale | 85.48 | 20,000 | 1,709,512 | 61,734 | Oct 03 04:28 PM | | Balcom Alexandra | Chief Financial Officer | Sep 30 '25 | Option Exercise | 6.89 | 20,000 | 137,800 | 81,734 | Oct 01 08:17 PM | | Balcom Alexandra | Chief Financial Officer | Sep 29 '25 | Option Exercise | 6.89 | 7,588 | 52,281 | 69,322 | Oct 01 08:17 PM | | Balcom Alexandra | Chief Financial Officer | Sep 30 '25 | Sale | 85.06 | 20,000 | 1,701,200 | 61,734 | Oct 01 08:17 PM | | Balcom Alexandra | Chief Financial Officer | Sep 29 '25 | Sale | 85.01 | 7,588 | 645,056 | 61,734 | Oct 01 08:17 PM | | Noci Darlene | Chief Development Officer | Sep 29 '25 | Option Exercise | 27.85 | 4,000 | 111,400 | 52,034 | Oct 01 08:14 PM | | Noci Darlene | Chief Development Officer | Sep 29 '25 | Sale | 83.07 | 4,000 | 332,288 | 48,034 | Oct 01 08:14 PM | | Darlene Noci | Officer | Sep 29 '25 | Proposed Sale | 81.30 | 12,000 | 975,600 | | Sep 29 04:08 PM | | Alexandra Balcom | Officer | Sep 29 '25 | Proposed Sale | 81.30 | 60,000 | 4,878,000 | | Sep 29 04:07 PM | | Porter James Richard | President and CEO | Sep 15 '25 | Option Exercise | 18.93 | 27,000 | 511,110 | 276,062 | Sep 17 04:31 PM | | Porter James Richard | President and CEO | Sep 15 '25 | Sale | 79.08 | 27,000 | 2,135,055 | 249,062 | Sep 17 04:31 PM | | Pelish Henry E. | Chief Scientific Officer | Sep 10 '25 | Option Exercise | 26.94 | 3,725 | 100,354 | 69,688 | Sep 12 04:30 PM | | Pelish Henry E. | Chief Scientific Officer | Sep 10 '25 | Sale | 78.83 | 3,725 | 293,642 | 65,963 | Sep 12 04:30 PM | | HENRY E PELISH | Officer | Sep 10 '25 | Proposed Sale | 78.73 | 6,158 | 484,819 | | Sep 10 04:38 PM | | Pelish Henry E. | Chief Scientific Officer | Aug 29 '25 | Option Exercise | 1.00 | 5,007 | 4,986 | 65,963 | Sep 03 04:30 PM | | Noci Darlene | Chief Development Officer | Aug 25 '25 | Option Exercise | 27.85 | 4,000 | 111,400 | 52,034 | Aug 27 04:30 PM | | Noci Darlene | Chief Development Officer | Aug 25 '25 | Sale | 74.62 | 4,000 | 298,489 | 48,034 | Aug 27 04:30 PM | | Porter James Richard | President and CEO | Aug 15 '25 | Option Exercise | 18.93 | 27,000 | 511,110 | 276,062 | Aug 19 04:30 PM | | Porter James Richard | President and CEO | Aug 15 '25 | Sale | 75.42 | 27,000 | 2,036,325 | 249,062 | Aug 19 04:30 PM | | Pelish Henry E. | Chief Scientific Officer | Aug 07 '25 | Option Exercise | 27.71 | 5,500 | 152,415 | 66,456 | Aug 08 04:30 PM | | Pelish Henry E. | Chief Scientific Officer | Aug 07 '25 | Sale | 74.85 | 5,500 | 411,675 | 60,956 | Aug 08 04:30 PM | | Noci Darlene | Chief Development Officer | Jul 30 '25 | Option Exercise | 27.85 | 4,000 | 111,400 | 52,034 | Aug 01 04:30 PM | | Noci Darlene | Chief Development Officer | Jul 30 '25 | Sale | 80.36 | 4,000 | 321,440 | 48,034 | Aug 01 04:30 PM | | BCLS II INVESTCO, LP | Former Affiliate | Jul 24 '25 | Proposed Sale | 82.08 | 4,253 | 349,086 | | Jul 24 08:42 PM | | BCIP Life Sciences Associates, | Former Affiliate | Jul 24 '25 | Proposed Sale | 82.08 | 156,670 | 12,859,474 | | Jul 24 08:35 PM |
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