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INSM

Insmed Inc

132.55

Aug 06 • 3:59 PM ET +33.53 (33.86%)

132.50

Aftermarket • 4:33 PM ET -0.05 (-0.04%)

Healthcare Biotechnology USA Large NASD

Today, 3:25 PMInsmed lifts long-term peak annual revenue forecast for BRINSUPRI, TPIP and ARIKAYCE to over $14B after strong Q2 results

Peers: BMRN ALNY ARGX REGN RVMD VRTX RPRX BIIB AMGN GILD

| Held by: VTI VXF VB VO VUG IBB VBK IWP XBI VOT

Scroll to Statements

Index	-
Market Cap	28.73B
Enterprise Value	28.26B
Income	-1.18B
Sales	819.56M
Book/sh	3.26
Cash/sh	5.64
Dividend Est.	-
Dividend TTM	-
Dividend Ex-Date	-
Dividend Gr. 3/5Y	- -
Payout	-
Employees	1664
IPO	Feb 15, 1991

P/E	-
Forward P/E	337.07
PEG	-
P/S	35.06
P/B	40.72
P/C	23.48
P/FCF	-
EV/EBITDA	-
EV/Sales	34.48
Quick Ratio	4.10
Current Ratio	4.47
Debt/Eq	1.06
LT Debt/Eq	1.04
Option/Short	Yes / Yes

EPS (ttm)	-5.74
EPS next Y	0.39
EPS next Q	-0.58
EPS this Y	60.82%
EPS next Y	115.63%
EPS next 5Y	-
EPS past 3/5Y	-17.91% -16.32%
Sales past 3/5Y	35.20% 29.83%
EPS Y/Y TTM	3.42%
Sales Y/Y TTM	115.09%
EPS Q/Q	46.49%
Sales Q/Q	229.62%
Earnings	Aug 06 BMO
EPS/Sales Surpr.	91.33% 8.06%

Insider Own	0.95%
Insider Trans	-15.85%
Inst Own	102.17%
Inst Trans	3.80%
ROA	-61.04%
ROE	-294.46%
ROIC	-82.27%
Gross Margin	80.98%
Oper. Margin	-117.77%
Profit Margin	-144.44%
SMA20	24.00%
SMA50	26.47%
SMA200	-9.51%
Trades

Shs Outstand	216.52M
Shs Float	214.69M
Short Float	5.41%
Short Ratio	2.90
Short Interest	11.62M
52W High	212.75 -37.70%
52W Low	90.39 46.64%
Volatility	3.16% 3.62%
ATR (14)	6.31
RSI (14)	75.89
Beta	0.78
Rel Volume	2.98
Avg Volume	4.01M
Volume	11,925,090

Perf Week	30.60%
Perf Month	13.75%
Perf Quarter	-3.31%
Perf Half Y	-13.05%
Perf YTD	-23.84%
Perf Year	19.14%
Perf 3Y	502.77%
Perf 5Y	417.77%
Perf 10Y	1030.01%
Recom	1.12
Target Price	196.50
Prev Close	99.02
Price	132.55
Change	33.86%

Date	Action	Analyst	Rating Change	Price Target Change
Jul-21-26	Initiated	BMO Capital Markets	Outperform	$192
Apr-10-26	Initiated	Raymond James	Outperform	$200
Mar-30-26	Upgrade	Morgan Stanley	Equal-Weight → Overweight	$212
Mar-16-26	Resumed	Jefferies	Buy
Jan-28-26	Initiated	Barclays	Overweight	$231
Jan-23-26	Initiated	Roth Capital	Buy	$212
Dec-19-25	Resumed	Truist	Buy	$202
Dec-04-25	Initiated	Rothschild & Co Redburn	Buy	$263
Oct-28-25	Resumed	Cantor Fitzgerald	Overweight	$192
Oct-20-25	Initiated	Wells Fargo	Overweight	$171
Aug-20-25	Initiated	William Blair	Outperform
Aug-13-25	Downgrade	Morgan Stanley	Overweight → Equal-Weight	$126
May-13-25	Initiated	Jefferies	Buy	$105
Feb-25-25	Initiated	RBC Capital Mkts	Outperform	$100
Apr-23-24	Initiated	Truist	Buy	$48
Feb-15-24	Initiated	Wolfe Research	Outperform	$42
Dec-08-23	Initiated	Wells Fargo	Overweight	$55
Nov-20-23	Resumed	JP Morgan	Overweight	$36
Jul-26-23	Initiated	Guggenheim	Buy	$50
Dec-09-22	Initiated	Mizuho	Buy	$28

Show Previous Ratings

Today 03:05PM	Insmed Inc (INSM) (Q2 2026) Earnings Call Highlights: BRINSUPRI Surges 49% Sequentially, ... (GuruFocus.com) +33.86%
10:56AM	Insmed Raises BRINSUPRI Revenue Guidance After Strong Q2 Growth and Expands Peak Sales Outlook (InvestorsHub)
07:21AM	Insmed: Q2 Earnings Snapshot (Associated Press)
07:00AM	Insmed Reports Second-Quarter 2026 Financial Results and Provides Business Update (PR Newswire)
Jul-29-26 06:03AM	EMV Capital: ProAxsis eyes COPD market breakthrough with Imperial College London study (Proactive)
07:00AM	Loading…
Jul-23-26 07:00AM	Insmed to Host Second-Quarter 2026 Financial Results Conference Call on Thursday, August 6, 2026 (PR Newswire)
Jul-17-26 06:07AM	Arbutus, Sanofi escalate mRNA patent fights; InnoCares TYK2 contender advances (BioPharma Dive)
Jul-16-26 07:00AM	Insmed Announces Positive 12-Month Data from the Ongoing Open-Label Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Patients with Pulmonary Arterial Hypertension (PR Newswire)
Jun-23-26 05:33PM	Nebius and CoreWeave fall after Nasdaq 100 listing (Blockspace)
07:00AM	Insmed Appoints Samuele Butera as Senior Vice President, General Manager, Global Respiratory (PR Newswire)
Jun-22-26 12:01AM	Nasdaq-100 Onboards 5 New Stocks in AI-Fueled Rebalancing (The Daily Upside)
Jun-12-26 08:46AM	Five AI and Space Names Join the Nasdaq-100 (GuruFocus.com)
08:35AM	Nasdaq-100 Adds New AI and Space Winners. These Stocks Are Soaring (GuruFocus.com)
Jun-04-26 07:00AM	Insmed Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4) (PR Newswire)
Jun-01-26 10:08PM	ATS 2026: Insmed shines in bronchiectasis with spotlight on Brinsupri (Pharmaceutical Technology)
04:27PM	Loading…
May-28-26 04:27PM	JPMorgan says large-cap biotech is back as profits and pipelines fuel upside (Investing.com)
May-27-26 07:00AM	Insmed to Present at the 2026 Goldman Sachs Annual Global Healthcare Conference (PR Newswire)
May-20-26 03:29PM	JPMorgan sees biotech sector at inflection point, resumes coverage on 14 Firms (Investing.com)
May-07-26 04:58PM	Insmed Incorporated Q1 2026 Earnings Call Summary (Moby) -23.41%
07:38AM	Insmed Posts Narrower Loss In Q1 (RTT News)
07:17AM	Insmed: Q1 Earnings Snapshot (Associated Press)
07:00AM	Insmed Reports First-Quarter 2026 Financial Results and Provides Business Update (PR Newswire)
May-06-26 04:30PM	Insmed and Ty Pennington Team Up to Drive Awareness and Proper Diagnosis of Bronchiectasis (PR Newswire)
06:30AM	Avalo shares spike on skin drug data; BioNTech to cut staff (BioPharma Dive)
May-04-26 07:00AM	Insmed to Present Data Across Its Respiratory Portfolio, Including Late-Breaking ARIKAYCE Results from Phase 3b ENCORE Study, at the American Thoracic Society International Conference 2026 (PR Newswire) +5.07%
Apr-30-26 07:00AM	Insmed to Present at May 2026 Investor Conferences (PR Newswire)
Apr-23-26 07:00AM	Insmed to Host First-Quarter 2026 Financial Results Conference Call on Thursday, May 7, 2026 (PR Newswire)
Apr-08-26 07:01AM	Insmed freezes Brinsupris HS programme on Phase II failure (Clinical Trials Arena)
05:37AM	Novo underprices Lilly with higher-dose Wegovy; Insmed absorbs expected study failure (BioPharma Dive)
Apr-07-26 04:01PM	Insmed Provides Clinical Update on Phase 2b CEDAR Study (PR Newswire)
01:05PM	Loading…
Apr-01-26 01:05PM	Options Bulls Could Be Right About This Pharma Stock (Schaeffer's Research)
Mar-24-26 08:30AM	Insmed eyes Arikayce label expansion on Phase IIIb lung disease success (Clinical Trials Arena)
Mar-23-26 02:47PM	Nasdaq and Dow lead markets higher as Trump claims Iran peace talks (Proactive) +5.87%
11:29AM	Insmed shares rise as Arikayce trial data point to larger market opportunity (Investing.com)
10:09AM	Insmed shares rise on positive late-stage trial results for lung disease therapy (Proactive)
07:00AM	Insmed Announces Positive Topline Results from Phase 3b ENCORE Study of ARIKAYCE (Amikacin Liposome Inhalation Suspension) in Patients with MAC Lung Disease (PR Newswire)
06:16AM	FDA seeks feedback on voucher program; Study data lift overhang on Insmed shares (BioPharma Dive)
Mar-06-26 12:29PM	Insmed Incorporated (INSM) Price Target Raised to $211 at BofA (Insider Monkey)
Mar-05-26 07:00AM	Insmed Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4) (PR Newswire)
Mar-01-26 01:33AM	Insmed Incorporated (INSM) Enters 2026 With Momentum (Insider Monkey)
Feb-26-26 11:53PM	Why Insmed Incorporated (INSM) is One of the Best Strong Buy Healthcare Stocks to Invest In (Insider Monkey)
Feb-24-26 07:19AM	Insmed Incorporated (INSM) Gained from Its Lead Product ARIKAYCE (Insider Monkey)
Feb-20-26 10:20AM	Insmed Lags on Q4 Earnings, Stock Gains on 2026 Brinsupri Sales View (Zacks)
09:55AM	Wall Street Analysts Think Insmed (INSM) Could Surge 33.6%: Read This Before Placing a Bet (Zacks)
03:44AM	Insmed (INSM) Poised for 2026 Upside With Potential $1.3B Arikayce Sales Boost, Roth/MKM Initiates Buy (Insider Monkey)
Feb-19-26 04:33PM	Stocks Decline Amid AI Fears and Geopolitical Risks (Barchart) +6.54%
02:03PM	Insmed Inc (INSM) Q4 2025 Earnings Call Highlights: Strong Brin Suri Launch and Promising 2026 ... (GuruFocus.com)
12:32PM	Insmed Incorporated Q4 2025 Earnings Call Summary (Moby)
09:36AM	Insmed Q4 Earnings Call Highlights (MarketBeat)
09:30AM	Insmed (INSM) Reports Q4 Earnings: What Key Metrics Have to Say (Zacks)
08:10AM	Insmed (INSM) Reports Q4 Loss, Lags Revenue Estimates (Zacks)
07:14AM	Insmed: Q4 Earnings Snapshot (Associated Press Finance)
07:00AM	Insmed Reports Fourth-Quarter and Full-Year 2025 Financial Results and Provides Business Update (PR Newswire)
Feb-16-26 02:11PM	What to Expect From These Drug/Biotech Players This Earnings Season? (Zacks)
10:00AM	Axsome Therapeutics (AXSM) Expected to Beat Earnings Estimates: Should You Buy? (Zacks)
Feb-13-26 07:00AM	Insmed To Present at March 2026 Investor Conferences (PR Newswire)
Feb-12-26 10:00AM	Insmed (INSM) Expected to Beat Earnings Estimates: Can the Stock Move Higher? (Zacks)
Feb-05-26 07:00AM	Insmed to Host Fourth-Quarter and Full-Year 2025 Financial Results Conference Call on Thursday, February 19, 2026 (PR Newswire)
Feb-02-26 01:30AM	The Druckenmiller Connection: Meet the Man Behind Bessent and Warsh (Barrons.com)
Jan-28-26 07:00AM	Insmed to Present Multiple Abstracts on Treprostinil Palmitil Inhalation Powder (TPIP) at Pulmonary Vascular Research Institute (PVRI) 2026 Congress (PR Newswire)
Jan-23-26 07:50AM	Here Are Fridays Top Wall Street Analyst Research Calls: Applied Materials, e.l.f. Beauty, Fortinet, Freeport MacMoRan, Procter & Gamble, Spotify, and More (24/7 Wall St.)
Jan-19-26 01:04AM	Analyst Weighs Patent Cliff Risks Against Insmed's (INSM) Growth Story (Insider Monkey)
Jan-12-26 07:08PM	Insmed CEO Will Lewis talks its rare disease drug pipeline (CNBC TV)
09:32AM	INSM Stock Jumps on 2025 Preliminary Sales, 2026 Goals Announced (Zacks)
Jan-09-26 04:38PM	S&P 500 Rallies to a New Record High on US Economic Optimism (Barchart)
11:19AM	Healthcare dealmakers head to San Francisco hoping for megamergers in 2026 (Reuters)
10:58AM	Insmed Maps Aggressive 2026 As Newly Approved Lung Disease Drug Gains Traction, Pipeline Advances (Benzinga)
09:44AM	Stock Market Today: Dow Up After Surprise Jobs Data; Trump Tariff Ruling Looms (Live Coverage) (Investor's Business Daily)
07:00AM	Insmed Provides Business Update at 44th Annual J.P. Morgan Healthcare Conference (PR Newswire)
06:28AM	Insmeds ginormous lung drug sales; J&Js US pricing deal (BioPharma Dive)
Jan-08-26 07:20AM	Jim Cramer on Insmed: "This One Is Worth Keeping an Eye On" (Insider Monkey)
Jan-05-26 10:19AM	Stock Market Today: Dow Jumps After U.S. Ousts Maduro; Energy Shines, Nvidia Rallies Ahead (Live Coverage) (Investor's Business Daily)
09:01AM	Bet on These 3 Small-Cap ETFs to Ride the January Effect (Zacks)
Jan-02-26 08:15AM	INSM Stock Up 78% in 6 Months: Here's What You Need to Know (Zacks)
07:00AM	Insmed To Present at the 44th Annual J.P. Morgan Healthcare Conference (PR Newswire)
Dec-31-25 09:01AM	Ultragenyx (RARE) Moves 15.5% Higher: Will This Strength Last? (Zacks)
Dec-30-25 04:31PM	Stocks Fall Slightly in Thin Holiday Trade (Barchart)
11:06AM	Stocks Slip as Bond Yields Rise (Barchart)
Dec-26-25 02:33AM	The Zacks Analyst Blog Mineralys, Lyell, Insmed and Nektar (Zacks)
Dec-24-25 10:51AM	4 Drug, Biotech Stocks Rising More Than 50% in 2025 With Room to Grow (Zacks)
Dec-18-25 06:15PM	Mizuho's Jared Holz talks Insmed sinking double digits on sinus drug trial news (CNBC TV) -16.08%
04:33PM	Stocks Settle Higher on Upbeat Tech Outlook and Cooling Inflation (Barchart)
04:15PM	The 'Worst-Case Scenario' Why Insmed Just Reversed After A 181% Six-Month Sprint (Investor's Business Daily)
04:13PM	These Stocks Moved the Most Today: Micron, DJT, Accenture, Tilray, Lululemon, Medline, Rivian, and More (Barrons.com)
03:13PM	These Stocks Are Moving the Most Today: Micron, DJT, Accenture, Tilray, Lululemon, Medline, Rivian, and More (Barrons.com)
07:59AM	INSM Stock Plummets on Sinus Study Failure, Adds New Pipeline Asset (Zacks)
07:12AM	Insmed Stock Plummets 19%. This Is What Sparked the Selloff. (Barrons.com)
06:10AM	These Stocks Are Moving the Most Today: Micron, Sandisk, Lululemon, Insmed, Rivian, PayPal, and More (Barrons.com)
06:02AM	Insmeds win streak ends as top drug fails study in chronic nasal condition (BioPharma Dive)
Dec-17-25 04:01PM	Insmed Provides Clinical and Business Update (PR Newswire)
Dec-15-25 12:15PM	MicroStrategy retains place in key index despite delisting threats (TheStreet)
09:11AM	Western Digital stock rises after inclusion in Nasdaq-100 Index (Investing.com)
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Dec-10-25 11:30AM	Immunovant (IMVT) Down 0.6% Since Last Earnings Report: Can It Rebound? (Zacks)
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07:00AM	Insmed Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4) (PR Newswire)

Insmed, Inc. is a global biopharmaceutical company, which engages in the development and commercialization of therapies for patients with rare diseases. Its focuses on Brensocatib, and Treprostinil Palmitil Inhalation Powder (TPIP) pipeline. The company was founded in 1988 and is headquartered in Bridgewater, NJ.

M.B.A.Mr. William H. Lewis J.D.

Chief Financial OfficerMs. Sara M. Bonstein M.B.A.

Chief Operating OfficerMr. Roger Adsett M.B.A.

Chief Legal Officer & Corporate SecretaryMr. Michael Alexander Smith J.D.

M.D.Dr. Martina Flammer M.B.A.

Insider Trading	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
Martina Flammer	Officer	Aug 06 '26	Proposed Sale	128.61	27,173	3,494,755		Aug 06 04:09 PM
Lewis William	Chair and CEO	Jul 23 '26	Option Exercise	24.94	10,700	266,870	269,758	Jul 24 05:02 PM
Lewis William	Chair and CEO	Jul 23 '26	Sale	106.06	10,700	1,134,890	259,058	Jul 24 05:02 PM
William Lewis	Officer	Jul 23 '26	Proposed Sale	106.06	10,700	1,134,867		Jul 23 04:38 PM
Lewis William	Chair and CEO	Jul 09 '26	Option Exercise	24.94	10,699	266,840	269,757	Jul 10 04:02 PM
Lewis William	Chair and CEO	Jul 09 '26	Sale	117.40	10,699	1,256,084	259,058	Jul 10 04:02 PM
William Lewis	Officer	Jul 09 '26	Proposed Sale	117.40	10,699	1,256,029		Jul 09 04:29 PM
Flammer Martina M.D.	Chief Medical Officer	Jul 06 '26	Option Exercise	25.80	12,302	317,445	72,788	Jul 08 04:03 PM
Flammer Martina M.D.	Chief Medical Officer	Jul 06 '26	Sale	109.98	12,302	1,352,932	60,486	Jul 08 04:03 PM
Martina Flammer	Officer	Jul 06 '26	Proposed Sale	109.97	12,302	1,352,864		Jul 06 04:20 PM
Lewis William	Chair and CEO	Jun 25 '26	Option Exercise	24.94	21,398	533,679	280,315	Jun 26 04:03 PM
Lewis William	Chair and CEO	Jun 25 '26	Sale	103.32	21,398	2,210,763	258,917	Jun 26 04:03 PM
William Lewis	Officer	Jun 25 '26	Proposed Sale	103.31	21,398	2,210,653		Jun 25 04:14 PM
Smith Michael Alexander	Chief Legal Officer	Jun 22 '26	Sale	95.82	1,806	173,051	37,648	Jun 24 04:11 PM
Michael Smith	Officer	Jun 22 '26	Proposed Sale	95.81	1,806	173,039		Jun 22 04:20 PM
Lewis William	Chair and CEO	Jun 08 '26	Sale	94.03	6,515	612,605	258,917	Jun 10 04:05 PM
William Lewis	Officer	Jun 08 '26	Proposed Sale	94.03	6,515	612,576		Jun 08 04:34 PM
Martina Flammer	Officer	Jun 05 '26	Proposed Sale	103.77	1,858	192,811		Jun 05 04:18 PM
Adsett Roger	Chief Operating Officer	Jun 03 '26	Sale	102.27	2,370	242,380	98,603	Jun 05 04:15 PM
Bonstein Sara	Chief Financial Officer	Jun 03 '26	Sale	102.27	2,404	245,857	69,082	Jun 05 04:14 PM
Smith Michael Alexander	Chief Legal Officer	Jun 03 '26	Sale	102.27	2,159	220,801	39,454	Jun 05 04:14 PM
Lewis William	Chair and CEO	Jun 03 '26	Sale	102.27	7,605	777,763	265,432	Jun 05 04:12 PM
Flammer Martina M.D.	Chief Medical Officer	Jun 03 '26	Sale	102.27	2,566	262,425	62,344	Jun 05 04:11 PM
Flammer Martina M.D.	Chief Medical Officer	Jun 05 '26	Sale	103.78	1,858	192,823	60,486	Jun 05 04:11 PM
Sara Bonstein	Officer	Jun 03 '26	Proposed Sale	102.27	2,404	245,857		Jun 03 04:41 PM
Martina Flammer	Officer	Jun 03 '26	Proposed Sale	102.27	2,566	262,424		Jun 03 04:35 PM
Roger Adsett	Officer	Jun 03 '26	Proposed Sale	102.27	2,370	242,379		Jun 03 04:28 PM
Michael Smith	Officer	Jun 03 '26	Proposed Sale	102.27	2,159	220,800		Jun 03 04:21 PM
William Lewis	Officer	Jun 03 '26	Proposed Sale	102.27	7,605	777,763		Jun 03 04:10 PM
Michael Smith	Officer	May 22 '26	Proposed Sale	108.46	6,149	666,951		May 22 04:55 PM
Smith Michael Alexander	Chief Legal Officer	May 22 '26	Sale	108.47	6,149	666,982	41,613	May 22 04:25 PM
Lewis William	Chair and CEO	May 18 '26	Option Exercise	24.94	10,699	266,840	298,601	May 20 04:06 PM
Lewis William	Chair and CEO	May 18 '26	Sale	106.33	25,564	2,718,224	273,037	May 20 04:06 PM
William Lewis	Officer	May 18 '26	Proposed Sale	106.33	25,564	2,718,106		May 18 04:53 PM
Bonstein Sara	Chief Financial Officer	May 13 '26	Sale	116.18	8,272	961,041	71,486	May 15 04:08 PM
Adsett Roger	Chief Operating Officer	May 13 '26	Sale	116.18	5,837	678,143	100,973	May 15 04:07 PM
Flammer Martina M.D.	Chief Medical Officer	May 14 '26	Sale	117.54	10,479	1,231,702	64,910	May 15 04:07 PM
Flammer Martina M.D.	Chief Medical Officer	May 13 '26	Sale	114.23	7,854	897,190	75,389	May 15 04:07 PM
Smith Michael Alexander	Chief Legal Officer	May 13 '26	Sale	116.18	4,109	477,384	47,762	May 15 04:07 PM
Lewis William	Chair and CEO	May 13 '26	Sale	116.18	13,283	1,543,219	287,902	May 15 04:06 PM
Martina Flammer	Officer	May 14 '26	Proposed Sale	117.53	10,479	1,231,599		May 14 05:20 PM
Roger Adsett	Officer	May 13 '26	Proposed Sale	116.18	5,837	678,142		May 13 05:24 PM
Michael Smith	Officer	May 13 '26	Proposed Sale	116.18	4,109	477,383		May 13 05:18 PM
Sara Bonstein	Officer	May 13 '26	Proposed Sale	116.18	8,272	961,040		May 13 05:17 PM
Martina Flammer	Officer	May 13 '26	Proposed Sale	114.23	7,854	897,145		May 13 05:17 PM
William Lewis	Officer	May 13 '26	Proposed Sale	116.18	13,283	1,543,218		May 13 05:14 PM
Flammer Martina M.D.	Chief Medical Officer	May 11 '26	Option Exercise	17.07	12,949	221,039	96,192	May 13 04:50 PM
Flammer Martina M.D.	Chief Medical Officer	May 11 '26	Sale	100.40	12,949	1,300,121	83,243	May 13 04:50 PM
Martina Flammer	Officer	May 11 '26	Proposed Sale	100.40	12,949	1,300,105		May 11 04:46 PM
Lewis William	Chair and CEO	May 04 '26	Option Exercise	24.94	10,699	266,840	311,884	May 06 04:11 PM
Lewis William	Chair and CEO	May 04 '26	Sale	137.34	10,699	1,469,442	301,185	May 06 04:11 PM
William Lewis	Officer	May 04 '26	Proposed Sale	137.35	10,699	1,469,481		May 04 04:55 PM
Lewis William	Chair and CEO	Apr 16 '26	Option Exercise	24.94	10,699	266,840	311,884	Apr 17 04:43 PM
Lewis William	Chair and CEO	Apr 16 '26	Sale	143.97	10,699	1,540,332	301,185	Apr 17 04:43 PM
William Lewis	Officer	Apr 16 '26	Proposed Sale	143.97	10,699	1,540,292		Apr 16 04:17 PM
Lewis William	Chair and CEO	Apr 06 '26	Option Exercise	24.94	10,699	266,840	311,884	Apr 08 04:41 PM
Lewis William	Chair and CEO	Apr 06 '26	Sale	163.22	10,699	1,746,336	301,185	Apr 08 04:41 PM
William Lewis	Officer	Apr 06 '26	Proposed Sale	163.22	10,699	1,746,319		Apr 06 04:42 PM
Adsett Roger	Chief Operating Officer	Apr 01 '26	Option Exercise	14.56	88,060	1,282,154	194,870	Apr 03 04:07 PM
Adsett Roger	Chief Operating Officer	Apr 01 '26	Sale	164.63	88,060	14,497,651	106,810	Apr 03 04:07 PM
Roger Adsett	Officer	Apr 01 '26	Proposed Sale	164.27	88,060	14,465,616		Apr 01 05:10 PM
Smith Michael Alexander	Chief Legal Officer	Mar 30 '26	Option Exercise	24.78	19,638	486,582	71,509	Mar 31 04:13 PM
Smith Michael Alexander	Chief Legal Officer	Mar 30 '26	Sale	150.98	19,638	2,964,945	51,871	Mar 31 04:13 PM
Michael Smith	Officer	Mar 30 '26	Proposed Sale	150.98	19,638	2,964,929		Mar 30 05:31 PM
Lewis William	Chair and CEO	Mar 19 '26	Option Exercise	24.94	10,699	266,840	311,884	Mar 20 04:05 PM
Lewis William	Chair and CEO	Mar 19 '26	Sale	143.52	10,699	1,535,542	301,185	Mar 20 04:05 PM
William Lewis	Officer	Mar 19 '26	Proposed Sale	143.52	10,699	1,535,514		Mar 19 04:57 PM
William Lewis	Officer	Mar 05 '26	Proposed Sale	146.02	10,699	1,562,311		Mar 05 04:59 PM
Lewis William	Chair and CEO	Mar 05 '26	Option Exercise	24.94	10,699	266,840	311,884	Mar 05 04:16 PM
Lewis William	Chair and CEO	Mar 05 '26	Sale	146.03	10,699	1,562,328	301,185	Mar 05 04:16 PM
Smith Michael Alexander	Chief Legal Officer	Feb 24 '26	Option Exercise	17.07	20,248	345,633	76,645	Feb 25 04:04 PM
Smith Michael Alexander	Chief Legal Officer	Feb 24 '26	Sale	155.77	24,774	3,859,157	51,871	Feb 25 04:04 PM
Michael Smith	Officer	Feb 24 '26	Proposed Sale	155.77	24,774	3,859,153		Feb 24 04:33 PM
Lewis William	Chair and CEO	Feb 19 '26	Option Exercise	24.94	10,699	266,840	311,884	Feb 23 04:34 PM
Lewis William	Chair and CEO	Feb 19 '26	Sale	150.97	10,699	1,615,257	301,185	Feb 23 04:34 PM
William Lewis	Officer	Feb 19 '26	Proposed Sale	150.97	10,699	1,615,250		Feb 19 04:54 PM
Lewis William	Chair and CEO	Feb 09 '26	Option Exercise	24.94	10,699	266,840	314,581	Feb 11 04:42 PM
Lewis William	Chair and CEO	Feb 09 '26	Sale	147.79	13,396	1,979,764	301,185	Feb 11 04:42 PM
William Lewis	Officer	Feb 09 '26	Proposed Sale	147.79	13,396	1,979,774		Feb 09 05:32 PM
Flammer Martina M.D.	Chief Medical Officer	Feb 05 '26	Sale	152.44	869	132,470	83,243	Feb 06 04:18 PM
Martina Flammer	Officer	Feb 05 '26	Proposed Sale	152.43	869	132,462		Feb 05 05:12 PM
Adsett Roger	Chief Operating Officer	Feb 03 '26	Sale	156.17	791	123,530	106,810	Feb 04 04:20 PM
Bonstein Sara	Chief Financial Officer	Feb 03 '26	Sale	156.34	748	116,942	79,758	Feb 04 04:19 PM
Lewis William	Chair and CEO	Feb 03 '26	Sale	156.34	3,009	470,427	303,882	Feb 04 04:17 PM
Smith Michael Alexander	Chief Legal Officer	Feb 03 '26	Sale	156.27	640	100,013	56,397	Feb 04 04:15 PM
Flammer Martina M.D.	Chief Medical Officer	Feb 02 '26	Option Exercise	65.72	7,982	524,577	92,889	Feb 04 04:15 PM
Flammer Martina M.D.	Chief Medical Officer	Feb 02 '26	Sale	154.59	7,982	1,233,959	84,907	Feb 04 04:15 PM
Flammer Martina M.D.	Chief Medical Officer	Feb 03 '26	Sale	155.77	795	123,837	84,112	Feb 04 04:15 PM
Roger Adsett	Officer	Feb 03 '26	Proposed Sale	156.16	791	123,526		Feb 03 05:04 PM
Michael Smith	Officer	Feb 03 '26	Proposed Sale	156.27	640	100,012		Feb 03 05:02 PM
William Lewis	Officer	Feb 03 '26	Proposed Sale	156.33	3,009	470,412		Feb 03 04:58 PM
Martina Flammer	Officer	Feb 03 '26	Proposed Sale	155.77	795	123,837		Feb 03 04:56 PM
Sara Bonstein	Officer	Feb 03 '26	Proposed Sale	156.33	748	116,938		Feb 03 04:55 PM
Martina Flammer	Officer	Feb 02 '26	Proposed Sale	154.59	7,982	1,233,964		Feb 02 05:30 PM
Lewis William	Chair and CEO	Jan 20 '26	Option Exercise	24.94	10,699	266,840	317,590	Jan 22 04:28 PM
Lewis William	Chair and CEO	Jan 20 '26	Sale	158.93	10,699	1,700,411	306,891	Jan 22 04:28 PM
William Lewis	Officer	Jan 20 '26	Proposed Sale	158.93	10,699	1,700,420		Jan 20 04:33 PM
Lewis William	Chair and CEO	Jan 12 '26	Option Exercise	24.94	10,699	266,840	326,106	Jan 13 04:04 PM
Lewis William	Chair and CEO	Jan 12 '26	Sale	169.00	19,215	3,247,349	306,891	Jan 13 04:04 PM
Flammer Martina M.D.	Chief Medical Officer	Jan 09 '26	Sale	186.19	1,887	351,341	84,907	Jan 13 04:03 PM

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