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Jul 09, 3:40 AMAstraZeneca Phase III CARDIO-TTRansform trial of Wainua in transthyretin-mediated amyloid cardiomyopathy fails to meet primary endpoint

Peers: LLY MRK PFE ABBV JNJ NVS GSK BMY SNY AMGN

| Held by: PVAL AVDE DIHP DFIC PPH PBPH IDVO FVD DFAX BDYN

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Index	-
Market Cap	267.35B
Enterprise Value	293.64B
Income	10.39B
Sales	60.44B
Book/sh	30.52
Cash/sh	4.95
Dividend Est.	3.35 (1.94%)
Dividend TTM	3.20 (1.86%)
Dividend Ex-Date	Feb 20, 2026
Dividend Gr. 3/5Y	1.78% 3.25%
Payout	47.19%
Employees	96100
IPO	Oct 17, 2003

P/E	25.90
Forward P/E	14.88
PEG	1.22
P/S	4.42
P/B	5.65
P/C	34.83
P/FCF	22.87
EV/EBITDA	14.79
EV/Sales	4.86
Quick Ratio	0.71
Current Ratio	0.91
Debt/Eq	0.72
LT Debt/Eq	0.55
Option/Short	Yes / Yes

EPS (ttm)	6.66
EPS next Y	11.58
EPS next Q	2.49
EPS this Y	11.93%
EPS next Y	12.96%
EPS next 5Y	12.19%
EPS past 3/5Y	45.90% 22.05%
Sales past 3/5Y	9.82% 16.31%
EPS Y/Y TTM	33.66%
Sales Y/Y TTM	9.93%
EPS Q/Q	5.63%
Sales Q/Q	12.51%
Earnings	Jul 27 BMO
EPS/Sales Surpr.	2.34% 2.38%

Insider Own	3.44%
Insider Trans	-0.02%
Inst Own	62.19%
Inst Trans	-15.79%
ROA	9.43%
ROE	23.51%
ROIC	14.17%
Gross Margin	74.32%
Oper. Margin	23.23%
Profit Margin	17.19%
SMA20	-5.99%
SMA50	-6.13%
SMA200	-5.88%
Trades

Shs Outstand	1.55B
Shs Float	1.50B
Short Float	0.09%
Short Ratio	0.64
Short Interest	1.33M
52W High	212.71 -18.96%
52W Low	138.00 24.92%
Volatility	2.59% 1.96%
ATR (14)	5.76
RSI (14)	38.90
Beta	0.30
Rel Volume	1.81
Avg Volume	2.06M
Volume	2,390,241

Perf Week	-11.67%
Perf Month	-6.02%
Perf Quarter	-15.91%
Perf Half Y	-9.64%
Perf YTD	-1.77%
Perf Year	21.91%
Perf 3Y	31.34%
Perf 5Y	45.17%
Perf 10Y	191.93%
Recom	1.57
Target Price	221.10
Prev Close	178.49
Price	172.38
Change	-3.42%

Jul-09-26 04:41PM	Stocks shrug off tensions to rise on renewed tech interest (AFP) -5.70%
03:39PM	Trending: Salesforce stock dips on Keybanc downgrade, AstraZeneca drug trial falls short (Yahoo Finance Video)
02:02PM	AstraZeneca Slides 9.9% After Heart Drug Trial Misses Late-Stage Goal (GuruFocus.com)
11:28AM	AstraZeneca and Ionis stocks drop significantly on Wainua ATTR-CM trial failure (Clinical Trials Arena)
11:27AM	AstraZeneca Gets a Rare Clinical Black Eye (Moby)
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09:15AM	AstraZeneca's Wainua failure hurts credibility more than valuation, Jefferies warns (Proactive)
08:40AM	AstraZeneca Falls After Wainua Heart Disease Trial Fails (GuruFocus.com)
08:12AM	Nasdaq set to gain as chips in favor again, as oil rebounds (Proactive)
07:38AM	AstraZeneca Stock and Partner Ionis Sink After Trial Failure. Alnylam Soars. (Barrons.com)
07:14AM	AstraZeneca stock drops 9% after Wainua heart drug trial fails (Quartz)
07:11AM	IONS Stock Heads Toward Biggest Single-Day Slump In Over 5 Years Retail Calls It Opportunity Of A Lifetime (Stocktwits)
06:35AM	Sino and AstraZeneca sign licence agreement for TQC3721 (Pharmaceutical Business Review)
06:00AM	Ionis Pharma dives on drug trial failure, and other early market movers (MarketWatch)
05:53AM	Major drugmaker loses $27 billion in market value after failed trial (MarketWatch)
04:43AM	AstraZeneca Shares Plunge on Rare Trial Failure of Heart Drug (Bloomberg)
03:50AM	Loading…
03:50AM	AstraZeneca's £19bn blow as Wainua heart drug fails key late-stage trial (Proactive)
02:19AM	FTSE 100 Live: London index hit by AstraZeneca failure, Computacenter and Playtech soar (Proactive)
02:19AM	FTSE 100 Live: Index opens lower after AstraZeneca trial failure, Computacenter surges (Proactive)
Jul-08-26 07:58AM	AstraZeneca, GSK intensify China ties with Sino Biopharm deals (BioPharma Dive)
02:19AM	FTSE 100 Live: Stocks slide as oil spikes, Trump says Iran ceasefire 'over' (Proactive)
Jul-07-26 02:19AM	FTSE 100 Live: Shell and consumer giants make gains, while miners and defence sell off (Proactive)
Jul-06-26 08:55AM	As AI Models Become Commodities, a Bio-Native AI Company Just Moved to Patent the Data Layer Beneath the Models (PR Newswire)
08:45AM	The Quantum Sector Hits an Inflection Point: Federal Money, Real Milestones, and a Security Race Running in Parallel (PR Newswire)
08:03AM	Citi keeps AstraZeneca on 'buy' ahead of second-quarter results (Proactive)
02:17AM	FTSE 100 Live: Stocks slide despite airlines and defence gains, Microsoft slashes jobs (Proactive)
Jul-02-26 02:17AM	FTSE 100 Live: Stocks start to rise across Europe, Currys stumbles (Proactive) +6.14%
02:17AM	FTSE 100 Live: London stocks rocket to 2-month high after US jobs miss (Proactive)
02:17AM	FTSE 100 Live: European stocks and gold rocket after US jobs miss (Proactive)
Jun-30-26 04:10PM	Imviva Biotech Granted FDA IDE Authorization for Cancer Treatment Trial (Exec Edge)
12:57PM	Ipsens $450M blood cancer drug; FDA selects first cohort for pre-check pilot program (BioPharma Dive)
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02:15AM	FTSE 100 Live: Blue-chips little changed as Starmer unveils defence plan (Proactive)
Jun-26-26 08:03AM	Jefferies names AstraZeneca a top pick ahead of pivotal heart drug readout (Proactive)
07:42AM	Solvonis Therapeutics, Tertiary Minerals, CelLBxHealth, Coinsilium, Eco Buildings, Frontier IP (Proactive)
Jun-25-26 03:53PM	Candel Therapeutics Designates Mark Sims as CCO (Exec Edge)
Jun-24-26 05:00PM	A $30 Billion Cancer Breakthrough Is Under Threat From Global Conflicts (Bloomberg)
09:00AM	AstraZeneca and YMCA of the USA Announce Landmark Partnership Aimed to Address Gaps in Cancer Care (Business Wire)
Jun-23-26 09:00PM	CelLBxHealth PLC (ANPCF) Full Year 2025 Earnings Call Highlights: Strategic Partnerships and ... (GuruFocus.com)
02:18AM	FTSE 100 Live: London stocks inch higher as Wall Street tech sells off (Proactive)
Jun-22-26 04:51AM	Eco Buildings, Solvonis Therapeutics, CelLBxHealth, NextEnergy Solar Fund, Empire Metals, Coinsilium (Proactive)
Jun-19-26 05:30AM	CelLBxHealth CEO on strategy reset and growth plans (Proactive)
05:13AM	ASCO26: RLTs bring the buzz, but commercial and tolerability qualms remain (Pharmaceutical Technology)
04:49AM	European stocks edge higher, helped by energy and healthcare (Reuters)
Jun-17-26 08:00AM	Big pharma taps UK playbook to pressure Europe on drug prices (Reuters Videos)
Jun-15-26 03:46PM	EHA26: AstraZeneca battles Roche in untreated follicular lymphoma (Clinical Trials Arena)
07:06AM	Factbox-Global drugmakers rush to boost US presence as tariff threat looms (Reuters)
Jun-10-26 05:12AM	AstraZenecas extensive obesity drug push; $125M for ultrasound-aided genetic medicine (BioPharma Dive)
Jun-09-26 10:10AM	GSK Buys Nuvalent for $10.6 Billion in Major Cancer Push (Bloomberg)
Jun-08-26 06:25PM	AstraZeneca's GLP-1 Pill Clears Early Hurdle in Diabetes, Obesity Tests (The Wall Street Journal)
05:32PM	LLY Stock Climbs As Oral GLP-1 Pill Beats Novo Nordisk, AstraZenecas Therapies In Diabetes Trials (Stocktwits)
Jun-06-26 02:53PM	Tired of nausea or taking a GLP-1 pill every day? These experimental drugs could be better than Zepbound and Wegovy. (MarketWatch)
Jun-05-26 11:00AM	AstraZeneca CFO Dr. Aradhana Sarin Breaks Down Revenue Growth Goals (NYSE)
11:00AM	AstraZeneca Pascal Soriot Delivers Remarks as Firm Celebrates Transfer to NYSE (NYSE)
08:55AM	NYSE Content Update: AstraZeneca Celebrates Largest Transfer in NYSE History (PR Newswire)
Jun-03-26 11:00PM	A Spanish biotech banks $87M to make differentiated ADCs (BioPharma Dive)
06:32AM	Leading Bank maintains sell on AstraZeneca at 11,500p as ASCO glow fails to resolve key pipeline questions (Proactive)
Jun-01-26 10:19AM	AIM Stock Soars Over 200% As Pancreatic Cancer Trial Hits Enrollment Milestone Early CEO Sees 'Value-Inflection Period' Ahead (Stocktwits)
10:19AM	AIM Stock Soars 42% As Pancreatic Cancer Trial Hits Key Enrollment Milestone Before Schedule CEO Sees 'Significant Value-Inflection Period' Ahead (Stocktwits)
09:57AM	ASCO 2026: A quiet conference for European pharma, but AstraZeneca and Roche both have work to do (Proactive)
05:06AM	AstraZeneca aims for a new blockbuster run in cardio disease (Pharma Voice)
May-29-26 10:33AM	US bank sees positive risk-reward for AstraZeneca ahead of pivotal heart drug trial (Proactive)
06:17AM	Allogene CEO to step down; Agios drug fails key test (BioPharma Dive)
May-28-26 02:16AM	FTSE 100 Live: London stocks flop as oil and bonds kick back up on Hormuz tensions (Proactive)
May-27-26 11:30PM	SLS Stock Extends Rally Overnight: CEO Says Bullish Leukemia Data Could Drive NCCN Recognition For GPS (Stocktwits)
10:09AM	FDA delays decision on AstraZeneca breast cancer pill (BioPharma Dive)
May-26-26 06:16AM	Astellas eyes more cost cuts; FDA panel to debate Moderna vaccine (BioPharma Dive)
May-25-26 06:06AM	AstraZeneca, Daiichi Sankyo's Datroway receives FDA approval for TNBC (Pharmaceutical Business Review)
May-21-26 05:38AM	Lillys triple-acting obesity drug hits goal in Phase 3 trial (BioPharma Dive)
May-20-26 05:06AM	Big Pharma is gambling on specialized R&D. Will it pay off? (Pharma Voice)
May-18-26 09:02AM	AstraZeneca Wins FDA Approval for $5 Billion Blood Pressure Drug (GuruFocus.com)
08:04AM	FDA approves AstraZenecas new kind of hypertension drug (BioPharma Dive)
07:00AM	BAXFENDY approved in the US as the first and only aldosterone synthase inhibitor treatment for adults with hypertension (Business Wire)
02:53AM	AstraZeneca wins US approval for first-in-class blood pressure drug and expands cancer treatment Enhertu (Proactive)
02:15AM	FTSE 100 Live: Stocks spike on reports of progress in Iran-US negotiations (Proactive)
May-15-26 07:36AM	Biotech leaders campaign for Pazdur; Takeda to lay off 4,500 workers (BioPharma Dive)
May-14-26 07:00AM	Perioperative IMFINZI (durvalumab) plus neoadjuvant EV showed statistically significant and clinically meaningful improvements in event-free survival and overall survival in muscle-invasive bladder cancer in the Phase III VOLGA trial (Business Wire)
May-13-26 07:28AM	UAE approves AstraZeneca's Baxfendy for hypertension (Pharmaceutical Business Review)
05:00AM	Why the FDAs push for real-time clinical trials could favor Big Pharma (Pharma Voice)
02:17AM	FTSE 100 Live: London stocks in red, Babcock gains offset by bond worries over Starmer (Proactive)
May-11-26 06:00PM	PRIMECAP Management's Strategic Moves: AstraZeneca PLC Exits with a -2.57% Impact (GuruFocus.com)
May-07-26 11:34AM	Why This Income Pro Likes Banks, Chip-Equipment Companies, and More (Barrons.com)
May-06-26 07:07PM	Ken Fisher's Strategic Moves: AstraZeneca PLC Leads the Portfolio Additions (GuruFocus.com)
May-01-26 08:28AM	Summits self-inflicted stumble; Esperions take-private deal (BioPharma Dive)
08:10AM	AstraZeneca stock sinks after FDA advisers vote against its breast cancer drug (Quartz)
08:01AM	AstraZeneca stock falls after FDA panel rejects breast cancer drug (Quartz)
05:48AM	AstraZeneca shares drop after US regulators vote against breast cancer drug (Reuters Videos)
04:46AM	AstraZeneca falls as FDA advisers reject breast cancer drug use (Proactive)
04:06AM	AstraZeneca slips after FDA panel rejects breast cancer drug camizestrant (Investing.com)
Apr-30-26 09:42PM	TRUQAP (capivasertib) recommended by FDA Advisory Committee for PTEN-deficient metastatic hormone-sensitive prostate cancer (Business Wire)
08:32AM	Citi raises AstraZeneca earnings forecast and maintains 'buy' rating ahead of second-half pipeline catalysts (Proactive)
Apr-29-26 07:00PM	Pinetree Therapeutics Announces Exercise of Option to License EGFR Degrader Program by AstraZeneca (PR Newswire)
12:12PM	AstraZeneca to invest £300m in Britain as Starmer pays more for drugs (The Telegraph)
11:12AM	AstraZeneca beats Q1 estimates, CEO says drug pipeline is 'delivering' (Yahoo Finance Video)
08:06AM	Astrazeneca tops expectations in the first quarter on strong cancer drug sales (Associated Press)
07:58AM	AstraZeneca Q1 2026 earnings beat on cancer drug sales (Quartz)
07:21AM	FDA tests out real-time clinical trials; AbbVie closes in on a KRAS biotech (BioPharma Dive)
06:09AM	American industry is winning: White House touts factory boom how investors can ride the reshoring wave (Moneywise)
03:09AM	AstraZeneca tops Q1 forecasts on strong cancer, rare-disease drug demand (Investing.com)
02:36AM	Astrazeneca: Q1 Earnings Snapshot (Associated Press)
02:16AM	FTSE 100 Live: Stocks sink as oil pushes 4yr highs, AstraZeneca, GSK, Lloyds report (Proactive)
02:16AM	FTSE 100 Live: Sluggish start as AstraZeneca, Haleon results disappoint (Proactive)

AstraZeneca Plc is a global, science-led biopharmaceutical company focused on the discovery, development, and commercialization of prescription medicines. Its portfolio spans oncology, rare diseases, and biopharmaceuticals, including cardiovascular, renal & metabolism, and respiratory & immunology. The company was founded in 1913 and is headquartered in Cambridge, the United Kingdom.

M.B.A.Mr. Pascal Claude Roland Soriot D.V.M.

CFO & Executive DirectorDr. Aradhana Sarin M.D.

EVP of Global opt. & ITMs. Pam P. Cheng

Head of Investor RelationsMr. Joris Silon

CHROMr. Jeffrey Pott J.D.

Insider Trading	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
Sharma Mani	See Remarks	May 20 '26	Sale	185.78	11,893	2,209,482	19,262	May 22 04:05 PM

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Astrazeneca plc

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