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| Latest Insider Trading | Top Insider Trading Recent Week | Top 10% Owner Trading Recent Week | Filter
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| Ticker | Owner | Relationship | Date | Transaction | Cost  |
#Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| AGIO | MARAGANORE JOHN | Director | May 20 | Option Exercise | 0.00 | 1,585 | 0 | 30,028 | May 24 04:10 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Dec 10 | Option Exercise | 74.50 | 5,367 | 399,829 | 220,132 | Dec 14 04:05 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Nov 12 | Option Exercise | 7.10 | 33,978 | 241,244 | 248,743 | Nov 12 05:52 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Nov 12 | Sale | 171.52 | 33,978 | 5,827,801 | 214,765 | Nov 12 05:52 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Aug 13 | Option Exercise | 7.10 | 33,979 | 241,251 | 248,744 | Aug 16 04:38 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Aug 13 | Sale | 199.78 | 33,979 | 6,788,196 | 214,765 | Aug 16 04:38 PM |
| AGIO | MARAGANORE JOHN | Director | May 28 | Option Exercise | 0.00 | 1,686 | 0 | 28,443 | Jun 02 04:09 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | May 13 | Option Exercise | 7.10 | 33,979 | 241,251 | 248,744 | May 17 07:25 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | May 13 | Sale | 130.78 | 33,979 | 4,443,725 | 214,765 | May 17 07:25 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Feb 25 | Option Exercise | 7.10 | 33,979 | 241,251 | 240,015 | Feb 26 04:03 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Feb 25 | Sale | 147.31 | 33,979 | 5,005,421 | 206,036 | Feb 26 04:03 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Nov 19 | Option Exercise | 9.14 | 34,765 | 317,752 | 232,354 | Nov 20 04:02 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Nov 19 | Sale | 124.23 | 34,765 | 4,319,025 | 197,589 | Nov 20 04:02 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Aug 20 | Option Exercise | 9.14 | 34,765 | 317,752 | 232,354 | Aug 21 04:06 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Aug 20 | Sale | 136.13 | 34,765 | 4,732,542 | 197,589 | Aug 21 04:06 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | May 20 | Option Exercise | 9.14 | 34,765 | 317,752 | 232,354 | May 22 04:03 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | May 20 | Sale | 143.22 | 34,765 | 4,978,983 | 197,589 | May 22 04:03 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Feb 20 | Option Exercise | 9.14 | 34,765 | 317,752 | 224,758 | Feb 21 04:02 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Feb 20 | Sale | 131.85 | 34,765 | 4,583,674 | 189,993 | Feb 21 04:02 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Oct 14 | Option Exercise | 16.43 | 49,456 | 812,562 | 239,449 | Oct 16 04:06 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Oct 14 | Sale | 79.45 | 49,456 | 3,929,210 | 189,993 | Oct 16 04:06 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | May 15 | Option Exercise | 16.43 | 49,457 | 812,579 | 239,450 | May 17 04:07 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | May 15 | Sale | 70.00 | 49,457 | 3,461,990 | 189,993 | May 17 04:07 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Nov 21 | Option Exercise | 21.35 | 98,636 | 2,105,879 | 249,933 | Nov 26 04:11 PM |
| AGIO | MARAGANORE JOHN | Director | Sep 11 | Sale | 72.75 | 13,555 | 986,129 | 36,209 | Sep 13 04:01 PM |
| AGIO | MARAGANORE JOHN | Director | Sep 12 | Sale | 71.74 | 14,162 | 1,015,982 | 22,047 | Sep 13 04:01 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Jul 25 | Option Exercise | 21.35 | 50,000 | 1,067,500 | 201,297 | Jul 27 04:07 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Jul 25 | Sale | 105.39 | 50,000 | 5,269,457 | 151,297 | Jul 27 04:07 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Dec 19 | Option Exercise | 63.00 | 1,587 | 99,981 | 151,297 | Dec 21 04:36 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Nov 22 | Option Exercise | 31.39 | 73,415 | 2,304,497 | 223,125 | Nov 24 06:55 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Nov 22 | Sale | 130.90 | 73,415 | 9,609,736 | 149,710 | Nov 24 06:55 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Nov 15 | Option Exercise | 31.39 | 74,000 | 2,322,860 | 223,710 | Nov 17 05:35 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Nov 15 | Sale | 126.86 | 74,000 | 9,387,951 | 149,710 | Nov 17 05:35 PM |
| BLUE | MARAGANORE JOHN | Director | Sep 14 | Option Exercise | 2.09 | 18,868 | 39,434 | 24,711 | Sep 18 04:09 PM |
| BLUE | MARAGANORE JOHN | Director | Sep 14 | Sale | 131.21 | 18,868 | 2,475,733 | 5,843 | Sep 18 04:09 PM |
| BLUE | MARAGANORE JOHN | Director | Aug 24 | Option Exercise | 2.09 | 13,839 | 28,924 | 19,682 | Aug 28 04:17 PM |
| BLUE | MARAGANORE JOHN | Director | Aug 24 | Sale | 95.81 | 11,085 | 1,062,108 | 8,597 | Aug 28 04:17 PM |
| BLUE | MARAGANORE JOHN | Director | Aug 02 | Sale | 96.74 | 2,754 | 266,425 | 5,843 | Aug 28 04:17 PM |
| BLUE | MARAGANORE JOHN | Director | Mar 03 | Option Exercise | 5.20 | 13,839 | 71,923 | 18,682 | Mar 06 05:24 PM |
| BLUE | MARAGANORE JOHN | Director | Mar 03 | Sale | 85.02 | 13,839 | 1,176,646 | 4,843 | Mar 06 05:24 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Jan 05 | Option Exercise | 18.66 | 1,340 | 25,004 | 149,710 | Jan 06 04:22 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Dec 12 | Option Exercise | 22.75 | 30,151 | 685,935 | 171,080 | Dec 14 04:18 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Oct 12 | Option Exercise | 13.26 | 7,540 | 99,994 | 140,929 | Oct 14 04:17 PM |
| ALNY | MARAGANORE JOHN | CEO | Jul 19 | Option Exercise | 22.75 | 15,076 | 342,979 | 148,465 | Jul 21 05:44 PM |
| ALNY | MARAGANORE JOHN | CEO | Jul 20 | Option Exercise | 22.75 | 15,075 | 342,956 | 148,464 | Jul 21 05:44 PM |
| ALNY | MARAGANORE JOHN | CEO | Jul 20 | Sale | 65.58 | 15,075 | 988,592 | 133,389 | Jul 21 05:44 PM |
| ALNY | MARAGANORE JOHN | CEO | Jul 19 | Sale | 63.81 | 15,076 | 961,998 | 133,389 | Jul 21 05:44 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Apr 20 | Option Exercise | 22.75 | 15,075 | 342,956 | 148,464 | Apr 21 05:01 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Apr 19 | Option Exercise | 22.75 | 15,076 | 342,979 | 148,465 | Apr 21 05:01 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Apr 19 | Sale | 67.41 | 15,076 | 1,016,199 | 133,389 | Apr 21 05:01 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Apr 20 | Sale | 67.51 | 15,075 | 1,017,773 | 133,389 | Apr 21 05:01 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Jan 19 | Option Exercise | 22.75 | 15,076 | 342,979 | 148,465 | Jan 21 06:59 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Jan 20 | Option Exercise | 22.75 | 15,076 | 342,979 | 148,465 | Jan 21 06:59 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Jan 20 | Sale | 69.46 | 15,076 | 1,047,234 | 133,389 | Jan 21 06:59 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Jan 19 | Sale | 74.09 | 15,076 | 1,116,985 | 133,389 | Jan 21 06:59 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Nov 20 | Option Exercise | 12.20 | 69,254 | 845,017 | 192,079 | Nov 20 06:12 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Nov 20 | Sale | 102.88 | 58,690 | 6,037,933 | 133,389 | Nov 20 06:12 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Jan 26 | Buy | 95.00 | 10,000 | 950,000 | 122,825 | Jan 28 05:19 PM |
| BLUE | MARAGANORE JOHN | Director | Dec 19 | Buy | 85.00 | 2,352 | 199,920 | 5,293 | Dec 22 08:03 AM |
| AGIO | MARAGANORE JOHN | Director | Dec 16 | Buy | 110.75 | 1,806 | 200,014 | 50,689 | Dec 18 05:42 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Dec 15 | Option Exercise | 9.14 | 8,205 | 74,994 | 112,825 | Dec 16 07:44 PM |
| BLUE | MARAGANORE JOHN | Director | Jul 14 | Buy | 34.00 | 2,941 | 99,994 | 2,941 | Jul 14 04:08 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Jun 25 | Option Exercise | 7.47 | 56,834 | 424,550 | 163,154 | Jun 27 04:47 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Jun 26 | Option Exercise | 7.47 | 56,834 | 424,550 | 163,154 | Jun 27 04:47 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Jun 26 | Sale | 64.80 | 56,834 | 3,682,926 | 106,320 | Jun 27 04:47 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | Jun 25 | Sale | 66.11 | 56,834 | 3,757,171 | 106,320 | Jun 27 04:47 PM |
| AGIO | MARAGANORE JOHN | Director | Jun 23 | Buy | 43.98 | 2,300 | 101,154 | 48,883 | Jun 24 08:20 AM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | May 15 | Option Exercise | 7.06 | 56,834 | 400,973 | 163,154 | May 16 04:59 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | May 14 | Option Exercise | 6.78 | 56,834 | 385,335 | 163,154 | May 16 04:59 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | May 14 | Sale | 57.36 | 56,834 | 3,259,715 | 106,320 | May 16 04:59 PM |
| ALNY | MARAGANORE JOHN | Chief Executive Officer | May 15 | Sale | 56.10 | 56,834 | 3,188,227 | 106,320 | May 16 04:59 PM |
| AGIO | MARAGANORE JOHN | Director | Apr 29 | Buy | 44.00 | 2,250 | 99,000 | 46,583 | Apr 30 06:11 PM |
| ALNY | MARAGANORE JOHN | CEO | Apr 14 | Option Exercise | 18.29 | 28,707 | 524,962 | 106,320 | Apr 15 04:43 PM |
| AGIO | MARAGANORE JOHN | Director | Jul 24 | Buy | 18.00 | 8,333 | 149,994 | 44,333 | Apr 03 05:41 PM |
| ALNY | MARAGANORE JOHN | CEO | Feb 03 | Option Exercise | 6.78 | 46,331 | 314,124 | 77,613 | Feb 04 05:27 PM |
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