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| Latest Insider Trading | Top Insider Trading Recent Week | Top 10% Owner Trading Recent Week | Filter
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| Ticker | Owner | Relationship | Date | Transaction | Cost  |
#Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| VRTX | SMITH IAN F | EVP, COO | Jun 29 '18 | Option Exercise | 131.89 | 23,375 | 3,082,929 | 70,074 | Jul 03 04:25 PM |
| VRTX | SMITH IAN F | EVP, COO | Jun 29 '18 | Sale | 166.30 | 23,375 | 3,887,173 | 46,699 | Jul 03 04:25 PM |
| VRTX | SMITH IAN F | EVP, COO | Jun 22 '18 | Option Exercise | 109.14 | 4,250 | 463,845 | 50,949 | Jun 26 05:18 PM |
| VRTX | SMITH IAN F | EVP, COO | Jun 22 '18 | Sale | 160.00 | 4,250 | 680,000 | 46,699 | Jun 26 05:18 PM |
| VRTX | SMITH IAN F | EVP, COO | May 15 '18 | Sale | 155.78 | 217 | 33,804 | 46,699 | May 16 05:21 PM |
| VRTX | SMITH IAN F | EVP, COO | Apr 25 '18 | Option Exercise | 84.45 | 14,172 | 1,196,786 | 78,667 | Apr 27 04:37 PM |
| VRTX | SMITH IAN F | EVP, COO | Apr 26 '18 | Option Exercise | 108.65 | 53,125 | 5,771,989 | 99,824 | Apr 27 04:37 PM |
| VRTX | SMITH IAN F | EVP, COO | Apr 26 '18 | Sale | 160.12 | 53,125 | 8,506,375 | 46,699 | Apr 27 04:37 PM |
| VRTX | SMITH IAN F | EVP, COO | Apr 25 '18 | Sale | 155.33 | 31,968 | 4,965,526 | 46,699 | Apr 27 04:37 PM |
| VRTX | SMITH IAN F | EVP, COO | Jan 16 '18 | Sale | 157.29 | 2,125 | 334,232 | 40,888 | Jan 17 04:40 PM |
| VRTX | SMITH IAN F | EVP, COO | Nov 15 '17 | Sale | 147.29 | 7 | 1,031 | 40,888 | Nov 17 04:44 PM |
| VRTX | SMITH IAN F | EVP, COO | Nov 03 '17 | Option Exercise | 91.05 | 2,155 | 196,213 | 43,043 | Nov 07 05:26 PM |
| VRTX | SMITH IAN F | EVP, COO | Nov 06 '17 | Option Exercise | 77.31 | 4,250 | 328,568 | 45,138 | Nov 07 05:26 PM |
| VRTX | SMITH IAN F | EVP, COO | Nov 06 '17 | Sale | 150.00 | 4,250 | 637,500 | 40,888 | Nov 07 05:26 PM |
| VRTX | SMITH IAN F | EVP, COO | Nov 03 '17 | Sale | 150.00 | 2,155 | 323,250 | 40,888 | Nov 07 05:26 PM |
| VRTX | SMITH IAN F | EVP, COO | Oct 31 '17 | Sale | 145.06 | 75,000 | 10,879,858 | 40,888 | Oct 31 06:18 PM |
| VRTX | SMITH IAN F | EVP, COO | Oct 16 '17 | Option Exercise | 96.87 | 2,125 | 205,849 | 118,013 | Oct 18 05:41 PM |
| VRTX | SMITH IAN F | EVP, COO | Oct 16 '17 | Sale | 155.61 | 2,125 | 330,671 | 115,888 | Oct 18 05:41 PM |
| VRTX | SMITH IAN F | EVP, CFO & COO | Aug 07 '17 | Option Exercise | 77.31 | 4,250 | 328,568 | 120,138 | Aug 09 04:33 PM |
| VRTX | SMITH IAN F | EVP, CFO & COO | Aug 07 '17 | Sale | 155.39 | 4,250 | 660,415 | 115,888 | Aug 09 04:33 PM |
| VRTX | SMITH IAN F | EVP, CFO & COO | Aug 02 '17 | Option Exercise | 91.05 | 2,155 | 196,213 | 118,043 | Aug 04 04:48 PM |
| VRTX | SMITH IAN F | EVP, CFO & COO | Aug 02 '17 | Sale | 154.17 | 2,155 | 332,236 | 115,888 | Aug 04 04:48 PM |
| VRTX | SMITH IAN F | EVP, CFO & COO | Jul 31 '17 | Option Exercise | 83.36 | 2,125 | 177,140 | 118,013 | Aug 02 04:51 PM |
| VRTX | SMITH IAN F | EVP, CFO & COO | Jul 31 '17 | Sale | 152.88 | 2,125 | 324,865 | 115,888 | Aug 02 04:51 PM |
| VRTX | SMITH IAN F | EVP, CFO & COO | Jul 19 '17 | Option Exercise | 84.11 | 123,400 | 10,379,726 | 249,638 | Jul 21 08:09 PM |
| VRTX | SMITH IAN F | EVP, CFO & COO | Jul 19 '17 | Sale | 161.00 | 123,400 | 19,867,400 | 126,238 | Jul 21 08:09 PM |
| VRTX | SMITH IAN F | EVP, CFO & COO | Jul 21 '17 | Sale | 160.72 | 10,350 | 1,663,413 | 115,888 | Jul 21 08:09 PM |
| VRTX | SMITH IAN F | EVP, CFO & COO | Jun 01 '17 | Option Exercise | 43.99 | 98,553 | 4,334,887 | 224,791 | Jun 05 06:05 PM |
| VRTX | SMITH IAN F | EVP, CFO & COO | Jun 01 '17 | Sale | 124.00 | 98,553 | 12,220,572 | 126,238 | Jun 05 06:05 PM |
| VRTX | SMITH IAN F | EVP, CFO & COO | May 15 '17 | Sale | 114.92 | 294 | 33,786 | 126,238 | May 17 04:24 PM |
| VRTX | SMITH IAN F | EVP, CFO & COO | Feb 28 '17 | Sale | 90.00 | 3,842 | 345,780 | 126,238 | Mar 02 04:15 PM |
| VRTX | SMITH IAN F | EVP, CFO & COO | Feb 13 '17 | Sale | 87.66 | 3,842 | 336,790 | 130,080 | Feb 15 04:41 PM |
| VRTX | SMITH IAN F | EVP & CFO | May 16 '16 | Sale | 82.06 | 202 | 16,576 | 112,999 | May 18 09:25 AM |
| VRTX | SMITH IAN F | EVP & CFO | Feb 03 '16 | Sale | 90.84 | 12,084 | 1,097,691 | 112,999 | Feb 04 06:54 PM |
| VRTX | SMITH IAN F | EVP & CFO | May 15 '15 | Sale | 125.62 | 378 | 47,484 | 118,134 | May 18 06:22 PM |
| VRTX | SMITH IAN F | EVP & CFO | Mar 23 '15 | Sale | 125.67 | 6,042 | 759,277 | 118,134 | Mar 24 06:10 PM |
| VRTX | SMITH IAN F | EVP & CFO | Feb 18 '15 | Sale | 112.89 | 10,350 | 1,168,428 | 124,176 | Feb 20 04:08 PM |
| VRTX | SMITH IAN F | EVP & CFO | Dec 12 '14 | Sale | 120.12 | 6,042 | 725,738 | 113,826 | Dec 16 04:11 PM |
| VRTX | SMITH IAN F | EVP & CFO | Sep 30 '14 | Option Exercise | 42.08 | 107,624 | 4,528,419 | 152,894 | Oct 01 05:11 PM |
| VRTX | SMITH IAN F | EVP & CFO | Sep 30 '14 | Sale | 112.68 | 108,026 | 12,172,023 | 44,868 | Oct 01 05:11 PM |
| VRTX | SMITH IAN F | EVP & CFO | May 15 '13 | Sale | 79.67 | 609 | 48,521 | 24,168 | May 17 04:13 PM |
| VRTX | SMITH IAN F | EVP & CFO | Apr 19 '13 | Option Exercise | 34.54 | 739,643 | 25,545,249 | 769,853 | Apr 23 04:30 PM |
| VRTX | SMITH IAN F | EVP & CFO | Apr 19 '13 | Sale | 81.76 | 745,685 | 60,963,612 | 24,168 | Apr 23 04:30 PM |
| VRTX | SMITH IAN F | EVP & CFO | Nov 16 '12 | Sale | 41.26 | 6,042 | 249,293 | 18,126 | Nov 20 04:19 PM |
| VRTX | SMITH IAN F | EVP & CFO | Oct 11 '12 | Option Exercise | 24.35 | 14,043 | 341,943 | 38,211 | Oct 15 04:44 PM |
| VRTX | SMITH IAN F | EVP & CFO | Oct 11 '12 | Sale | 60.00 | 14,043 | 842,580 | 24,168 | Oct 15 04:44 PM |
| VRTX | SMITH IAN F | EVP & CFO | Oct 08 '12 | Option Exercise | 17.41 | 43,949 | 765,303 | 68,955 | Oct 09 04:25 PM |
| VRTX | SMITH IAN F | EVP & CFO | Oct 08 '12 | Sale | 60.00 | 44,787 | 2,687,220 | 24,168 | Oct 09 04:25 PM |
| VRTX | SMITH IAN F | EVP & CFO | Feb 08 '12 | Sale | 36.80 | 9,667 | 355,746 | 24,168 | Feb 09 04:10 PM |
| VRTX | SMITH IAN F | EVP & CFO | Jan 19 '12 | Sale | 37.00 | 6,042 | 223,554 | 21,751 | Jan 23 04:37 PM |
| VRTX | SMITH IAN F | EVP & CFO | Nov 15 '11 | Sale | 29.75 | 20 | 595 | 27,793 | Nov 16 02:47 PM |
| VRTX | SMITH IAN F | EVP & CFO | May 25 '11 | Sale | 55.95 | 12,084 | 676,106 | 27,793 | May 26 04:49 PM |
| VRTX | SMITH IAN F | EVP & CFO | May 17 '11 | Sale | 56.89 | 709 | 40,337 | 39,877 | May 18 01:49 PM |
| VRTX | SMITH IAN F | EVP & CFO | Jan 25 '11 | Sale | 40.71 | 6,042 | 245,970 | 27,793 | Jan 26 03:25 PM |
| VRTX | SMITH IAN F | EVP & CFO | Jan 21 '11 | Sale | 39.93 | 6,042 | 241,257 | 33,835 | Jan 25 01:09 PM |
| VRTX | SMITH IAN F | EVP & CFO | Nov 15 '10 | Sale | 34.47 | 77 | 2,654 | 39,877 | Nov 16 04:19 PM |
| VRTX | SMITH IAN F | EVP & CFO | May 18 '10 | Sale | 37.68 | 774 | 29,164 | 39,877 | May 19 03:38 PM |
| VRTX | SMITH IAN F | EVP & CFO | May 07 '10 | Sale | 35.99 | 15,000 | 539,818 | 39,877 | May 10 04:51 PM |
| VRTX | SMITH IAN F | EVP & CFO | Apr 05 '10 | Sale | 40.75 | 18,242 | 743,362 | 54,877 | Apr 06 02:37 PM |
| VRTX | SMITH IAN F | EVP & CFO | May 18 '09 | Sale | 28.44 | 925 | 26,307 | 61,035 | May 19 02:15 PM |
| VRTX | SMITH IAN F | EVP & CFO | May 07 '09 | Sale | 28.90 | 32,500 | 939,250 | 61,035 | May 11 02:57 PM |
| VRTX | SMITH IAN F | EVP & CFO | Feb 06 '09 | Option Exercise | 11.71 | 41,212 | 482,638 | 134,747 | Feb 10 04:11 PM |
| VRTX | SMITH IAN F | EVP & CFO | Feb 06 '09 | Sale | 35.00 | 41,212 | 1,442,420 | 93,535 | Feb 10 04:11 PM |
| VRTX | SMITH IAN F | EVP & CFO | Feb 04 '09 | Sale | 33.61 | 2,850 | 95,788 | 81,451 | Feb 06 04:18 PM |
| VRTX | SMITH IAN F | EVP & CFO | Nov 18 '08 | Sale | 26.18 | 16 | 419 | 84,301 | Nov 19 04:27 PM |
| VRTX | SMITH IAN F | EVP & CFO | Jul 09 '08 | Option Exercise | 15.95 | 81,436 | 1,299,292 | 165,737 | Jul 11 09:56 AM |
| VRTX | SMITH IAN F | EVP & CFO | Jul 09 '08 | Sale | 35.00 | 81,436 | 2,850,260 | 84,301 | Jul 11 09:56 AM |
| VRTX | SMITH IAN F | EVP & CFO | May 20 '08 | Sale | 27.63 | 930 | 25,691 | 84,301 | May 22 09:32 AM |
| VRTX | SMITH IAN F | EVP & CFO | May 13 '08 | Sale | 27.13 | 5,730 | 155,442 | 84,301 | May 15 03:09 PM |
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