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| Latest Insider Trading | Top Insider Trading Recent Week | Top 10% Owner Trading Recent Week | Filter
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| Ticker | Owner | Relationship | Date | Transaction | Cost  |
#Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| AGIO | Higgons John Duncan | Chief Operating Officer | Dec 15 '15 | Sale | 50.09 | 20,000 | 1,001,800 | 61,835 | Dec 17 04:02 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Nov 16 '15 | Option Exercise | 1.09 | 20,000 | 21,764 | 101,835 | Nov 18 04:19 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Nov 16 '15 | Sale | 61.51 | 20,000 | 1,230,200 | 81,835 | Nov 18 04:19 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Oct 15 '15 | Option Exercise | 0.31 | 20,000 | 6,244 | 101,835 | Oct 19 05:35 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Oct 15 '15 | Sale | 71.04 | 20,000 | 1,420,800 | 81,835 | Oct 19 05:35 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Sep 30 '15 | Option Exercise | 0.30 | 10,000 | 3,025 | 151,835 | Oct 02 04:11 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Sep 15 '15 | Option Exercise | 0.30 | 20,000 | 6,050 | 161,835 | Sep 17 06:39 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Sep 15 '15 | Sale | 91.11 | 20,000 | 1,822,200 | 141,835 | Sep 17 06:39 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Aug 20 '15 | Option Exercise | 0.30 | 10,000 | 3,025 | 141,835 | Aug 21 04:56 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Aug 17 '15 | Option Exercise | 0.30 | 20,000 | 6,050 | 151,835 | Aug 19 04:11 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Aug 17 '15 | Sale | 92.24 | 20,000 | 1,844,800 | 131,835 | Aug 19 04:11 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Aug 06 '15 | Option Exercise | 0.30 | 10,000 | 3,025 | 131,835 | Aug 10 05:19 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Jul 16 '15 | Option Exercise | 0.30 | 20,000 | 6,050 | 141,835 | Jul 17 04:46 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Jul 16 '15 | Sale | 114.02 | 20,000 | 2,280,400 | 121,835 | Jul 17 04:46 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Jun 15 '15 | Sale | 105.23 | 7,000 | 736,610 | 121,835 | Jun 16 05:23 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Jun 10 '15 | Option Exercise | 0.30 | 10,000 | 3,025 | 108,835 | Jun 12 04:53 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Jun 11 '15 | Option Exercise | 0.30 | 10,000 | 3,025 | 118,835 | Jun 12 04:53 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Jun 12 '15 | Option Exercise | 0.30 | 10,000 | 3,025 | 128,835 | Jun 12 04:53 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | May 15 '15 | Sale | 112.89 | 7,417 | 837,305 | 98,835 | May 18 07:06 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Mar 16 '15 | Sale | 106.24 | 7,000 | 743,680 | 112,835 | Mar 18 05:18 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Jan 02 '15 | Sale | 110.08 | 12,000 | 1,320,960 | 119,835 | Jan 06 05:23 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Jan 02 '15 | Sale | 110.08 | 12,000 | 1,320,960 | 119,835 | Jan 06 05:22 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Dec 01 '14 | Sale | 97.03 | 12,000 | 1,164,360 | 131,835 | Dec 02 06:16 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Nov 03 '14 | Sale | 81.71 | 13,000 | 1,062,230 | 143,835 | Nov 04 06:16 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Oct 01 '14 | Sale | 60.07 | 13,000 | 780,910 | 156,835 | Oct 03 05:05 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Aug 26 '14 | Option Exercise | 0.30 | 5,000 | 1,512 | 181,090 | Aug 28 05:00 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Aug 26 '14 | Sale | 45.05 | 5,000 | 225,250 | 176,090 | Aug 28 05:00 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Aug 01 '14 | Option Exercise | 0.30 | 7,000 | 2,118 | 183,090 | Aug 05 07:03 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Aug 01 '14 | Sale | 39.09 | 7,000 | 273,630 | 176,090 | Aug 05 07:03 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Jul 01 '14 | Sale | 46.52 | 12,000 | 558,240 | 176,090 | Jul 02 07:06 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Jun 13 '14 | Sale | 45.27 | 5,000 | 226,350 | 188,090 | Jun 16 06:01 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Jun 02 '14 | Sale | 33.87 | 3,300 | 111,771 | 196,790 | Jun 04 06:44 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Jun 03 '14 | Sale | 35.01 | 3,700 | 129,537 | 193,090 | Jun 04 06:44 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | May 06 '14 | Sale | 45.73 | 5,000 | 228,650 | 200,090 | May 07 06:33 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | May 01 '14 | Option Exercise | 0.30 | 3,000 | 908 | 212,090 | May 05 05:16 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | May 01 '14 | Sale | 42.39 | 7,000 | 296,730 | 205,090 | May 05 05:16 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Apr 07 '14 | Option Exercise | 0.30 | 3,000 | 908 | 212,090 | Apr 08 07:35 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Apr 07 '14 | Sale | 45.17 | 3,000 | 135,510 | 209,090 | Apr 08 07:35 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Apr 01 '14 | Option Exercise | 0.30 | 12,000 | 3,630 | 221,090 | Apr 03 05:46 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Apr 01 '14 | Sale | 38.08 | 12,000 | 456,960 | 209,090 | Apr 03 05:46 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Mar 19 '14 | Option Exercise | 0.30 | 80,000 | 24,200 | 209,090 | Mar 20 06:06 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Mar 10 '14 | Option Exercise | 0.30 | 20,000 | 6,050 | 129,090 | Mar 12 06:16 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Mar 07 '14 | Option Exercise | 0.30 | 9,000 | 2,722 | 118,090 | Mar 07 05:53 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Mar 06 '14 | Option Exercise | 0.30 | 5,646 | 1,708 | 114,736 | Mar 07 05:53 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Mar 06 '14 | Sale | 35.54 | 5,646 | 200,659 | 109,090 | Mar 07 05:53 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Mar 07 '14 | Sale | 45.10 | 9,000 | 405,900 | 109,090 | Mar 07 05:53 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Mar 03 '14 | Option Exercise | 0.30 | 8,000 | 2,420 | 117,090 | Mar 04 05:42 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Mar 03 '14 | Sale | 29.85 | 8,000 | 238,832 | 109,090 | Mar 04 05:42 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Feb 18 '14 | Option Exercise | 0.30 | 2,354 | 712 | 111,444 | Feb 20 05:58 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Feb 18 '14 | Sale | 35.06 | 2,354 | 82,531 | 109,090 | Feb 20 05:58 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Feb 03 '14 | Option Exercise | 0.30 | 8,000 | 2,420 | 117,090 | Feb 04 08:56 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Feb 03 '14 | Sale | 25.97 | 8,000 | 207,728 | 109,090 | Feb 04 08:56 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Jan 21 '14 | Option Exercise | 0.30 | 12,000 | 3,630 | 121,090 | Jan 23 06:02 PM |
| AGIO | Higgons John Duncan | Chief Operating Officer | Jan 21 '14 | Sale | 34.71 | 12,000 | 416,530 | 109,090 | Jan 23 06:02 PM |
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