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| Ticker | Owner | Relationship | Date | Transaction | Cost |
#Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| CAGNONI PABLO J | President, Global Head of R&D | Aug 19 '26 | Sale | 125.56 | 10,801 | 1,356,174 | 183,200 | Aug 20 05:15 PM | |
| PABLO CAGNONI | Officer | Aug 19 '26 | Proposed Sale | 125.56 | 10,801 | 1,356,190 | Aug 19 04:20 PM | ||
| CAGNONI PABLO J | President, Global Head of R&D | Aug 12 '26 | Sale | 120.04 | 10,803 | 1,296,792 | 194,001 | Aug 14 04:01 PM | |
| PABLO CAGNONI | Officer | Aug 12 '26 | Proposed Sale | 120.04 | 10,803 | 1,296,774 | Aug 12 04:09 PM | ||
| CAGNONI PABLO J | President, Global Head of R&D | Aug 05 '26 | Sale | 122.69 | 10,640 | 1,305,422 | 204,804 | Aug 07 04:02 PM | |
| PABLO CAGNONI | Officer | Aug 05 '26 | Proposed Sale | 122.69 | 10,640 | 1,305,450 | Aug 05 04:15 PM | ||
| CAGNONI PABLO J | President, Global Head of R&D | Jul 31 '26 | Sale | 119.70 | 15,888 | 1,901,794 | 215,444 | Aug 04 04:04 PM | |
| PABLO CAGNONI | Officer | Jul 31 '26 | Proposed Sale | 119.70 | 15,888 | 1,901,833 | Jul 31 04:04 PM | ||
| CAGNONI PABLO J | President, Global Head of R&D | Apr 17 '26 | Option Exercise | 69.43 | 18,667 | 1,296,046 | 281,359 | Apr 21 04:09 PM | |
| CAGNONI PABLO J | President, Global Head of R&D | Apr 17 '26 | Sale | 96.50 | 18,667 | 1,801,366 | 262,692 | Apr 21 04:09 PM | |
| PABLO CAGNONI | Officer | Apr 17 '26 | Proposed Sale | 96.50 | 18,667 | 1,801,326 | Apr 17 04:07 PM | ||
| CAGNONI PABLO J | President, R&D | Mar 17 '26 | Option Exercise | 63.07 | 18,667 | 1,177,355 | 253,467 | Mar 19 04:20 PM | |
| CAGNONI PABLO J | President, R&D | Mar 17 '26 | Sale | 94.24 | 18,667 | 1,759,178 | 234,800 | Mar 19 04:20 PM | |
| PABLO CAGNONI | Officer | Mar 17 '26 | Proposed Sale | 94.24 | 18,667 | 1,759,102 | Mar 17 04:07 PM | ||
| CAGNONI PABLO J | President, R&D | Feb 19 '26 | Option Exercise | 61.59 | 18,668 | 1,149,702 | 253,468 | Feb 23 04:05 PM | |
| CAGNONI PABLO J | President, R&D | Feb 19 '26 | Sale | 100.91 | 18,668 | 1,883,788 | 234,800 | Feb 23 04:05 PM | |
| PABLO CAGNONI | Officer | Feb 19 '26 | Proposed Sale | 100.91 | 18,668 | 1,883,797 | Feb 19 04:02 PM | ||
| CAGNONI PABLO J | Director | Nov 19 '19 | Option Exercise | 5.59 | 7,500 | 41,925 | 7,500 | Nov 21 04:07 PM | |
| CAGNONI PABLO J | Director | Nov 19 '19 | Sale | 62.00 | 7,500 | 465,000 | 0 | Nov 21 04:07 PM | |
| CAGNONI PABLO J | Director | Nov 12 '19 | Option Exercise | 5.59 | 7,500 | 41,925 | 7,500 | Nov 13 04:30 PM | |
| CAGNONI PABLO J | Director | Nov 12 '19 | Sale | 55.00 | 7,500 | 412,500 | 0 | Nov 13 04:30 PM | |
| CAGNONI PABLO J | Director | Oct 30 '19 | Option Exercise | 5.59 | 7,500 | 41,925 | 7,500 | Nov 01 06:35 PM | |
| CAGNONI PABLO J | Director | Oct 30 '19 | Sale | 52.00 | 7,500 | 390,000 | 0 | Nov 01 06:35 PM | |
| CAGNONI PABLO J | Director | Jul 03 '18 | Option Exercise | 5.59 | 5,816 | 32,511 | 5,816 | Jul 05 06:25 PM | |
| CAGNONI PABLO J | Director | Jul 05 '18 | Option Exercise | 5.59 | 1,684 | 9,414 | 1,684 | Jul 05 06:25 PM | |
| CAGNONI PABLO J | Director | Jul 05 '18 | Sale | 62.00 | 1,684 | 104,408 | 0 | Jul 05 06:25 PM | |
| CAGNONI PABLO J | Director | Jul 03 '18 | Sale | 62.00 | 5,816 | 360,592 | 0 | Jul 05 06:25 PM | |
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