Biotech ETF (XBI) Hits New 52-Week High

By Zacks Equity Research | November 17, 2025, 8:09 AM

For investors seeking momentum, State Street SPDR S&P Biotech ETF XBI is probably on the radar. The fund just hit a 52-week high and rose 73.06% from its 52-week low price of $66.66/share.

But, are more gains in store for this ETF? Let’s take a quick look at the fund and the near-term outlook to get a better idea of where it might head:

XBI in Focus

The underlying S&P Biotechnology Select Industry Index represents the biotechnology sub-industry portion of the S&P Total Markets Index. The Biotech Index is a modified equal weight index. The product charges 35 bps in annual fees (See: All Health Care ETFs).

Why the Move?

The biotech market has regained momentum lately, driven by favorable regulatory developments and cheaper valuations. The Fed’s rate cuts have also improved funding conditions, and the increasing adoption of AI in U.S. healthcare continues to provide a meaningful tailwind for the sector.

More Gains Ahead?

Currently, XBI has a Zacks ETF Rank #3 (Hold) with a High risk outlook. However, it might continue its strong performance in the near term, with a positive weighted alpha of 36.61 (as per Barchart.com), which gives cues of a further rally.

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State Street SPDR S&P Biotech ETF (XBI): ETF Research Reports

This article originally published on Zacks Investment Research (zacks.com).

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