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Compared to Estimates, Sarepta Therapeutics (SRPT) Q4 Earnings: A Look at Key Metrics

By Zacks Equity Research | February 26, 2026, 9:30 AM

Sarepta Therapeutics (SRPT) reported $442.93 million in revenue for the quarter ended December 2025, representing a year-over-year decline of 32.7%. EPS of -$3.58 for the same period compares to $1.50 a year ago.

The reported revenue represents a surprise of +8.42% over the Zacks Consensus Estimate of $408.53 million. With the consensus EPS estimate being -$0.71, the EPS surprise was -404.23%.

While investors scrutinize revenue and earnings changes year-over-year and how they compare with Wall Street expectations to determine their next move, some key metrics always offer a more accurate picture of a company's financial health.

As these metrics influence top- and bottom-line performance, comparing them to the year-ago numbers and what analysts estimated helps investors project a stock's price performance more accurately.

Here is how Sarepta Therapeutics performed in the just reported quarter in terms of the metrics most widely monitored and projected by Wall Street analysts:
  • Revenues- Product, net: $369.61 million compared to the $382.54 million average estimate based on eight analysts. The reported number represents a change of -42.1% year over year.
  • Revenues- Product, net- ELEVIDYS: $110 million versus the seven-analyst average estimate of $114.3 million. The reported number represents a year-over-year change of -71.4%.
  • Revenues- PMO Products: $259 million compared to the $270.1 million average estimate based on seven analysts. The reported number represents a change of +2% year over year.
  • Revenues- Collaboration: $73.33 million versus the seven-analyst average estimate of $25.24 million. The reported number represents a year-over-year change of +262%.

View all Key Company Metrics for Sarepta Therapeutics here>>>

Shares of Sarepta Therapeutics have returned -11% over the past month versus the Zacks S&P 500 composite's +0.6% change. The stock currently has a Zacks Rank #3 (Hold), indicating that it could perform in line with the broader market in the near term.

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This article originally published on Zacks Investment Research (zacks.com).

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