VRTX - Vertex Pharmaceuticals Incorporated Stock Price and Quote

VRTX [NASD]

Index	S&P 500	P/E	23.76	EPS (ttm)	12.67	Insider Own	0.10%	Shs Outstand	256.50M	Perf Week	-4.34%
Market Cap	77.98B	Forward P/E	19.09	EPS next Y	15.77	Insider Trans	-24.89%	Shs Float	256.21M	Perf Month	6.33%
Income	3.27B	PEG	2.93	EPS next Q	3.51	Inst Own	95.70%	Short Float / Ratio	1.03% / 1.83	Perf Quarter	-1.67%
Sales	8.70B	P/S	8.96	EPS this Y	-12.50%	Inst Trans	1.21%	Short Interest	2.63M	Perf Half Y	6.27%
Book/sh	50.80	P/B	5.93	EPS next Y	7.74%	ROA	21.80%	Target Price	329.71	Perf Year	25.58%
Cash/sh	37.72	P/C	7.98	EPS next 5Y	8.10%	ROE	28.50%	52W Range	225.28 - 325.19	Perf YTD	6.00%
Dividend	-	P/FCF	20.45	EPS past 5Y	85.00%	ROI	22.50%	52W High	-5.87%	Beta	0.46
Dividend %	-	Quick Ratio	4.60	Sales past 5Y	34.80%	Gross Margin	88.00%	52W Low	35.88%	ATR	6.86
Employees	3900	Current Ratio	4.70	Sales Q/Q	17.60%	Oper. Margin	47.70%	RSI (14)	49.01	Volatility	2.57% 2.18%
Optionable	Yes	Debt/Eq	0.03	EPS Q/Q	9.30%	Profit Margin	37.60%	Rel Volume	0.82	Prev Close	301.02
Shortable	Yes	LT Debt/Eq	0.03	Earnings	Feb 07 AMC	Payout	0.00%	Avg Volume	1.44M	Price	306.10
Recom	2.20	SMA20	-0.29%	SMA50	0.18%	SMA200	5.79%	Volume	160,367	Change	1.69%

Jan-18-23

Initiated

Canaccord Genuity

Hold

$311

Jan-17-23

Upgrade

SVB Leerink

Mkt Perform → Outperform

$374

Dec-19-22

Downgrade

Jefferies

Buy → Hold

$340

Jul-13-22

Initiated

Cantor Fitzgerald

Overweight

$365

Jun-01-22

Upgrade

Maxim Group

Hold → Buy

$325

May-23-22

Initiated

SVB Leerink

Mkt Perform

$265

May-06-22

Downgrade

Robert W. Baird

Outperform → Neutral

$250

May-03-22

Upgrade

Morgan Stanley

Underweight → Equal-Weight

$250

Feb-03-22

Downgrade

RBC Capital Mkts

Outperform → Sector Perform

$269

Jan-27-22

Reiterated

Wolfe Research

Outperform

$271 → $282

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Vertex Pharmaceuticals Incorporated, a biotechnology company, engages in developing and commercializing therapies for treating cystic fibrosis. The company markets SYMDEKO/SYMKEVI, ORKAMBI, and KALYDECO to treat patients with cystic fibrosis who have specific mutations in their cystic fibrosis transmembrane conductance regulator gene; and TRIKAFTA for the treatment of patients with CF 6 years of age or older who have at least one F508del mutation. Its pipeline includes VX-864 for the treatment of AAT deficiency, which is in Phase 2 clinical trial; VX-147 for the treatment of APOL1-mediated focal segmental glomerulosclerosis, or FSGS, and other serious kidney diseases which is in Phase 2 clinical trial; VX- 880, treatment for Type 1 Diabetes which is in Phase 1/2 clinical trial; VX-548, a NaV1.8 inhibitor for treatments of acute, neuropathic, musculoskeletal pain which is in Phase 2 clinical trial; and CTX001 for the treatment severe SCD and TDT which is in Phase 3 clinical trial. The company sells its products primarily to specialty pharmacy and specialty distributors in the United States, as well as specialty distributors and retail chains, and hospitals and clinics internationally. It has collaborations with Affinia Therapeutics, Inc.; Arbor Biotechnologies, Inc.; CRISPR Therapeutics AG.; Kymera Therapeutics, Inc.; Mammoth Biosciences, Inc.; Moderna, Inc.; Obsidian Therapeutics, Inc.; and Skyhawk Therapeutics, Inc.; as well as Ribometrix, Inc.; Genomics plc; Merck KGaA; Darmstadt, Germany, and X-Chem, Inc. Vertex Pharmaceuticals Incorporated was founded in 1989 and is headquartered in Boston, Massachusetts.

Insider Trading	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
SACHS BRUCE I	Director	Jan 31	Option Exercise	72.14	1,200	86,568	42,410	Feb 02 04:14 PM
Sanna Bastiano	EVP, Cell & Genetic Therapies	Jan 31	Sale	325.00	106	34,450	37,998	Feb 02 04:18 PM
SACHS BRUCE I	Director	Jan 31	Sale	325.01	1,200	390,012	41,210	Feb 02 04:14 PM
CARNEY LLOYD	Director	Jan 30	Sale	320.52	2,700	865,406	4,150	Jan 31 04:45 PM
Lee Yuchun	Director	Jan 27	Option Exercise	72.14	1,429	103,088	3,304	Jan 31 04:42 PM
Lee Yuchun	Director	Jan 27	Sale	322.03	1,429	460,177	1,875	Jan 31 04:42 PM
Lee Yuchun	Director	Jan 26	Option Exercise	72.14	4,000	288,560	5,875	Jan 27 04:18 PM
Lee Yuchun	Director	Jan 26	Sale	318.33	4,000	1,273,322	1,875	Jan 27 04:18 PM
Lee Yuchun	Director	Jan 25	Option Exercise	72.14	4,000	288,560	5,875	Jan 27 04:18 PM
Lee Yuchun	Director	Jan 25	Sale	313.96	4,000	1,255,852	1,875	Jan 27 04:18 PM
Kewalramani Reshma	CEO & President	Jan 25	Sale	315.05	10,000	3,150,500	89,598	Jan 27 04:13 PM
Lee Yuchun	Director	Jan 24	Option Exercise	72.14	4,000	288,560	5,875	Jan 25 04:08 PM
Lee Yuchun	Director	Jan 24	Sale	312.69	4,000	1,250,753	1,875	Jan 25 04:08 PM
Lee Yuchun	Director	Jan 23	Option Exercise	72.14	2,129	153,586	4,004	Jan 25 04:08 PM
Lee Yuchun	Director	Jan 23	Sale	312.02	2,129	664,291	1,875	Jan 25 04:08 PM
Lee Yuchun	Director	Jan 18	Option Exercise	72.14	442	31,886	2,317	Jan 19 04:07 PM
Lee Yuchun	Director	Jan 18	Sale	312.17	442	137,979	1,875	Jan 19 04:07 PM
Lee Yuchun	Director	Jan 17	Option Exercise	72.14	4,000	288,560	5,875	Jan 19 04:07 PM
Lee Yuchun	Director	Jan 17	Sale	312.03	4,000	1,248,120	1,875	Jan 19 04:07 PM
ALTSHULER DAVID	EVP, Global Research and CSO	Nov 15	Sale	308.61	34	10,493	36,077	Nov 17 04:08 PM
ALTSHULER DAVID	EVP, Global Research and CSO	Nov 07	Option Exercise	187.53	1,303	244,352	37,380	Nov 09 04:40 PM
ALTSHULER DAVID	EVP, Global Research and CSO	Nov 07	Sale	303.04	1,303	394,859	36,077	Nov 09 04:40 PM
Sanna Bastiano	EVP, Cell & Genetic Therapies	Nov 02	Sale	312.64	320	100,045	38,104	Nov 03 04:05 PM
Bhatia Sangeeta N.	Director	Oct 24	Sale	310.00	621	192,510	4,040	Oct 26 04:05 PM
Sanna Bastiano	EVP, Cell & Genetic Therapies	Oct 18	Sale	300.31	1,791	537,860	39,192	Oct 20 04:11 PM
Arbuckle Stuart A	EVP, COO	Aug 15	Option Exercise	155.57	6,571	1,022,250	67,451	Aug 17 05:39 PM
Liu Joy	SVP, General Counsel	Aug 15	Sale	303.90	3,747	1,138,723	9,605	Aug 17 05:36 PM
Kewalramani Reshma	CEO & President	Aug 15	Sale	305.06	11,689	3,565,846	99,598	Aug 17 05:40 PM
Arbuckle Stuart A	EVP, COO	Aug 15	Sale	303.93	22,173	6,738,991	45,278	Aug 17 05:39 PM
Arbuckle Stuart A	EVP, COO	Aug 10	Option Exercise	155.57	64	9,956	61,060	Aug 12 04:05 PM
Arbuckle Stuart A	EVP, COO	Aug 10	Sale	300.40	180	54,073	60,880	Aug 12 04:05 PM
Liu Joy	SVP, General Counsel	Aug 10	Sale	300.32	36	10,812	13,352	Aug 12 04:05 PM
Arbuckle Stuart A	EVP, COO	Aug 09	Option Exercise	155.57	1,926	299,628	66,686	Aug 10 04:06 PM
Liu Joy	SVP, General Counsel	Aug 09	Sale	300.00	946	283,800	13,388	Aug 10 04:06 PM
Arbuckle Stuart A	EVP, COO	Aug 09	Sale	300.67	5,690	1,710,817	60,996	Aug 10 04:06 PM
Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Aug 09	Sale	298.97	1,400	418,557	46,090	Aug 10 04:06 PM
ALTSHULER DAVID	EVP, Global Research and CSO	Aug 08	Option Exercise	187.53	1,304	244,539	37,381	Aug 10 04:06 PM
Bhatia Sangeeta N.	Director	Aug 08	Sale	293.03	621	181,972	4,661	Aug 10 04:07 PM
ALTSHULER DAVID	EVP, Global Research and CSO	Aug 08	Sale	292.54	1,304	381,469	36,077	Aug 10 04:06 PM
Bhatia Sangeeta N.	Director	Jul 29	Sale	278.77	621	173,116	5,282	Aug 02 04:16 PM
LEIDEN JEFFREY M	Executive Chairman	Jul 25	Option Exercise	91.05	60,342	5,494,139	134,502	Jul 27 04:17 PM
LEIDEN JEFFREY M	Executive Chairman	Jul 25	Sale	281.38	132,079	37,164,481	2,423	Jul 27 04:17 PM
ALTSHULER DAVID	EVP, Global Research and CSO	Jul 19	Option Exercise	174.33	17,765	3,096,948	53,942	Jul 21 04:48 PM
ALTSHULER DAVID	EVP, Global Research and CSO	Jul 19	Sale	288.65	17,865	5,156,730	36,077	Jul 21 04:48 PM
Kewalramani Reshma	CEO & President	Jun 24	Sale	291.30	11,689	3,405,006	111,153	Jun 28 04:05 PM
Sanna Bastiano	EVP, Cell & Genetic Therapies	May 16	Sale	252.83	45	11,377	41,749	May 18 04:22 PM
Arbuckle Stuart A	EVP, COO	May 16	Sale	251.19	133	33,408	64,760	May 18 04:21 PM
Liu Joy	SVP, General Counsel	May 16	Sale	252.88	133	33,633	14,334	May 18 04:18 PM
Sanna Bastiano	EVP, Cell & Genetic Therapies	May 04	Sale	275.09	36	9,903	41,660	May 06 04:05 PM
Arbuckle Stuart A	EVP, COO	May 02	Sale	263.98	306	80,778	64,760	May 04 05:21 PM
Sanna Bastiano	EVP, Cell & Genetic Therapies	May 02	Sale	259.16	320	82,930	41,696	May 04 05:10 PM
Bhatia Sangeeta N.	Director	May 02	Sale	258.94	737	190,842	5,903	May 04 05:09 PM
WAGNER CHARLES F JR	EVP & Chief Financial Officer	May 02	Sale	258.83	343	88,778	42,730	May 04 05:07 PM
Liu Joy	SVP, General Counsel	Apr 29	Sale	275.41	120	33,049	14,334	May 03 04:28 PM
Ambrose Kristen	SVP & Chief Accounting Officer	Apr 25	Sale	269.55	327	88,143	3,496	Apr 27 04:05 PM
Lee Yuchun	Director	Apr 18	Option Exercise	81.54	2,000	163,080	3,875	Apr 20 04:05 PM
Lee Yuchun	Director	Apr 18	Sale	284.23	2,000	568,467	1,875	Apr 20 04:05 PM
Lee Yuchun	Director	Apr 14	Option Exercise	81.54	2,000	163,080	3,875	Apr 18 04:05 PM
Lee Yuchun	Director	Apr 14	Sale	289.06	2,000	578,117	1,875	Apr 18 04:05 PM
Lee Yuchun	Director	Apr 13	Option Exercise	81.54	2,000	163,080	3,875	Apr 14 04:35 PM
Lee Yuchun	Director	Apr 13	Sale	287.50	2,000	575,010	1,875	Apr 14 04:35 PM
LEIDEN JEFFREY M	Executive Chairman	Apr 13	Sale	289.04	15,789	4,563,653	74,160	Apr 14 04:35 PM
Lee Yuchun	Director	Apr 12	Option Exercise	81.54	2,000	163,080	3,875	Apr 14 04:35 PM
Lee Yuchun	Director	Apr 12	Sale	281.03	2,000	562,051	1,875	Apr 14 04:35 PM
Lee Yuchun	Director	Apr 11	Option Exercise	81.54	2,000	163,080	3,875	Apr 12 04:07 PM
Lee Yuchun	Director	Apr 11	Sale	280.30	2,000	560,599	1,875	Apr 12 04:07 PM
MCGLYNN MARGARET G	Director	Apr 08	Option Exercise	127.54	5,000	637,700	6,099	Apr 12 04:05 PM
Bhatia Sangeeta N.	Director	Apr 08	Option Exercise	125.71	1,907	239,729	7,098	Apr 12 04:05 PM
Lee Yuchun	Director	Apr 08	Option Exercise	81.54	2,000	163,080	3,875	Apr 12 04:07 PM
Lee Yuchun	Director	Apr 08	Sale	278.57	2,000	557,141	1,875	Apr 12 04:07 PM
Bhatia Sangeeta N.	Director	Apr 08	Sale	280.20	1,907	534,341	5,191	Apr 12 04:05 PM
MCGLYNN MARGARET G	Director	Apr 08	Sale	280.22	5,000	1,401,080	1,099	Apr 12 04:05 PM
Lee Yuchun	Director	Apr 07	Option Exercise	81.54	2,000	163,080	3,875	Apr 08 05:57 PM
Lee Yuchun	Director	Apr 07	Sale	274.86	2,000	549,720	1,875	Apr 08 05:57 PM
Sanna Bastiano	EVP, Cell & Genetic Therapies	Apr 07	Sale	276.18	561	154,935	42,782	Apr 08 04:34 PM
Lee Yuchun	Director	Apr 06	Option Exercise	81.54	2,000	163,080	3,875	Apr 08 05:57 PM
Lee Yuchun	Director	Apr 06	Sale	271.62	2,000	543,243	1,875	Apr 08 05:57 PM
Lee Yuchun	Director	Apr 05	Option Exercise	81.54	2,000	163,080	3,875	Apr 06 04:59 PM
Sanna Bastiano	EVP, Cell & Genetic Therapies	Apr 05	Sale	275.23	3,163	870,552	43,343	Apr 06 05:02 PM
Lee Yuchun	Director	Apr 05	Sale	272.50	2,000	544,993	1,875	Apr 06 04:59 PM
Lee Yuchun	Director	Apr 04	Option Exercise	81.54	2,000	163,080	3,875	Apr 06 04:59 PM
Sanna Bastiano	EVP, Cell & Genetic Therapies	Apr 04	Sale	267.71	562	150,452	46,506	Apr 06 05:02 PM
Lee Yuchun	Director	Apr 04	Sale	267.72	2,000	535,431	1,875	Apr 06 04:59 PM
WAGNER CHARLES F JR	EVP & Chief Financial Officer	Apr 01	Sale	264.76	2,582	683,602	43,620	Apr 05 04:06 PM
MCGLYNN MARGARET G	Director	Mar 31	Option Exercise	127.54	5,000	637,700	6,099	Apr 04 04:05 PM
MCGLYNN MARGARET G	Director	Mar 31	Sale	262.27	5,000	1,311,346	1,099	Apr 04 04:05 PM
Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Mar 17	Sale	250.11	2,833	708,572	47,356	Mar 21 04:15 PM
WAGNER CHARLES F JR	EVP & Chief Financial Officer	Mar 17	Sale	250.15	3,171	793,218	46,202	Mar 21 04:12 PM
Sanna Bastiano	EVP, Cell & Genetic Therapies	Mar 17	Sale	250.06	2,122	530,627	48,412	Mar 21 04:10 PM
Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Feb 25	Sale	230.95	325	75,058	50,189	Feb 28 05:27 PM
Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Feb 18	Sale	231.00	519	119,889	53,104	Feb 22 05:03 PM
ALTSHULER DAVID	EVP, Global Research and CSO	Feb 18	Sale	230.97	4,312	995,949	49,687	Feb 22 04:51 PM
ALTSHULER DAVID	EVP, Global Research and CSO	Feb 14	Sale	232.02	2,444	567,057	57,438	Feb 16 04:05 PM
ALTSHULER DAVID	EVP, Global Research and CSO	Feb 11	Sale	235.02	2,297	539,837	59,882	Feb 14 04:11 PM

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