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INSM

Insmed Inc

Jan 09 • 04:00PM ET

175.97

+5.70 3.35 %

Healthcare • Biotechnology • USA • NASD

Jan 09, 7:07 AMInsmed announces today preliminary 2025 results with ARIKAYCE revenue of about $433.8 million exceeding guidance and BRINSUPRI at roughly $172.7 million including $144.6 million in its first full quarter, and issues 2026 ARIKAYCE revenue guidance of $450 to $470 million.

Peers: VRTX BIIB REGN GILD RARE NBIX UTHR SRPT EXEL BMRN

| Held by: VTI VB QQQ VBK VXF IBB IWP QQQM IWF VHT

Scroll to Statements

Index	NDX	P/E	-	EPS (ttm)	-6.18	Insider Own	1.37%	Shs Outstand	212.58M	Perf Week	-0.65%
Market Cap	37.53B	Forward P/E	-	EPS next Y	-3.24	Insider Trans	-22.86%	Shs Float	210.36M	Perf Month	-9.37%
Enterprise Value	36.59B	PEG	-	EPS next Q	-1.24	Inst Own	100.37%	Short Float	4.24%	Perf Quarter	7.04%
Income	-1.18B	P/S	83.96	EPS this Y	-7.86%	Inst Trans	0.22%	Short Ratio	3.15	Perf Half Y	79.23%
Sales	447.02M	P/B	39.56	EPS next Y	46.02%	ROA	-53.64%	Short Interest	8.93M	Perf YTD	1.11%
Book/sh	4.45	P/C	22.34	EPS next 5Y	62.87%	ROE	-165.69%	52W High	212.75 -17.29%	Perf Year	166.18%
Cash/sh	7.88	P/FCF	-	EPS past 3/5Y	-12.84% -13.12%	ROIC	-70.54%	52W Low	60.40 191.34%	Perf 3Y	786.50%
Dividend Est.	-	EV/EBITDA	-	Sales past 3/5Y	24.50% 21.66%	Gross Margin	75.35%	Volatility	5.06% 3.76%	Perf 5Y	426.54%
Dividend TTM	-	EV/Sales	81.86	EPS Y/Y TTM	-11.26%	Oper. Margin	-221.53%	ATR (14)	7.48	Perf 10Y	837.51%
Dividend Ex-Date	-	Quick Ratio	4.34	Sales Y/Y TTM	30.34%	Profit Margin	-264.83%	RSI (14)	43.49	Recom	1.15
Dividend Gr. 3/5Y	- -	Current Ratio	4.63	EPS Q/Q	-37.66%	SMA20	-2.55%	Beta	1.11	Target Price	214.94
Payout	-	Debt/Eq	0.79	Sales Q/Q	52.36%	SMA50	-7.40%	Rel Volume	1.92	Prev Close	170.27
Employees	1271	LT Debt/Eq	0.77	Earnings	Oct 30 BMO	SMA200	37.38%	Avg Volume	2.84M	Price	175.97
IPO	Feb 15, 1991	Option/Short	Yes / Yes	EPS/Sales Surpr.	-31.72% 23.30%	Trades		Volume	5,432,053	Change	3.35%

Date	Action	Analyst	Rating Change	Price Target Change
Dec-19-25	Resumed	Truist	Buy	$202
Dec-04-25	Initiated	Rothschild & Co Redburn	Buy	$263
Oct-28-25	Resumed	Cantor Fitzgerald	Overweight	$192
Oct-20-25	Initiated	Wells Fargo	Overweight	$171
Aug-20-25	Initiated	William Blair	Outperform
Aug-13-25	Downgrade	Morgan Stanley	Overweight → Equal-Weight	$126
May-13-25	Initiated	Jefferies	Buy	$105
Feb-25-25	Initiated	RBC Capital Mkts	Outperform	$100
Apr-23-24	Initiated	Truist	Buy	$48
Feb-15-24	Initiated	Wolfe Research	Outperform	$42
Dec-08-23	Initiated	Wells Fargo	Overweight	$55
Nov-20-23	Resumed	JP Morgan	Overweight	$36
Jul-26-23	Initiated	Guggenheim	Buy	$50
Dec-09-22	Initiated	Mizuho	Buy	$28
Dec-07-22	Initiated	Barclays	Overweight	$37
Nov-18-22	Initiated	BofA Securities	Buy	$39
Apr-27-22	Initiated	Goldman	Buy	$56
Dec-06-21	Initiated	JP Morgan	Overweight	$45
Oct-19-21	Resumed	Morgan Stanley	Overweight	$56 → $52
Oct-19-21	Resumed	Monness Crespi & Hardt	Buy	$52

Show Previous Ratings

Today 11:19AM	Healthcare dealmakers head to San Francisco hoping for megamergers in 2026 (Reuters)
10:58AM	Insmed Maps Aggressive 2026 As Newly Approved Lung Disease Drug Gains Traction, Pipeline Advances (Benzinga)
09:44AM	Stock Market Today: Dow Up After Surprise Jobs Data; Trump Tariff Ruling Looms (Live Coverage) (Investor's Business Daily)
07:00AM	Insmed Provides Business Update at 44th Annual J.P. Morgan Healthcare Conference (PR Newswire)
06:28AM	Insmeds ginormous lung drug sales; J&Js US pricing deal (BioPharma Dive)
07:20AM	Loading…
Jan-08-26 07:20AM	Jim Cramer on Insmed: "This One Is Worth Keeping an Eye On" (Insider Monkey)
Jan-05-26 10:19AM	Stock Market Today: Dow Jumps After U.S. Ousts Maduro; Energy Shines, Nvidia Rallies Ahead (Live Coverage) (Investor's Business Daily)
09:01AM	Bet on These 3 Small-Cap ETFs to Ride the January Effect (Zacks)
Jan-02-26 08:15AM	INSM Stock Up 78% in 6 Months: Here's What You Need to Know (Zacks)
07:00AM	Insmed To Present at the 44th Annual J.P. Morgan Healthcare Conference (PR Newswire)
Dec-31-25 09:01AM	Ultragenyx (RARE) Moves 15.5% Higher: Will This Strength Last? (Zacks)
Dec-30-25 04:31PM	Stocks Fall Slightly in Thin Holiday Trade (Barchart)
11:06AM	Stocks Slip as Bond Yields Rise (Barchart)
Dec-26-25 02:33AM	The Zacks Analyst Blog Mineralys, Lyell, Insmed and Nektar (Zacks)
Dec-24-25 10:51AM	4 Drug, Biotech Stocks Rising More Than 50% in 2025 With Room to Grow (Zacks)
06:15PM	Loading…
Dec-18-25 06:15PM	Mizuho's Jared Holz talks Insmed sinking double digits on sinus drug trial news (CNBC TV) -16.08%
04:33PM	Stocks Settle Higher on Upbeat Tech Outlook and Cooling Inflation (Barchart)
04:15PM	The 'Worst-Case Scenario' Why Insmed Just Reversed After A 181% Six-Month Sprint (Investor's Business Daily)
04:13PM	These Stocks Moved the Most Today: Micron, DJT, Accenture, Tilray, Lululemon, Medline, Rivian, and More (Barrons.com)
03:13PM	These Stocks Are Moving the Most Today: Micron, DJT, Accenture, Tilray, Lululemon, Medline, Rivian, and More (Barrons.com)
07:59AM	INSM Stock Plummets on Sinus Study Failure, Adds New Pipeline Asset (Zacks)
07:12AM	Insmed Stock Plummets 19%. This Is What Sparked the Selloff. (Barrons.com)
06:10AM	These Stocks Are Moving the Most Today: Micron, Sandisk, Lululemon, Insmed, Rivian, PayPal, and More (Barrons.com)
06:02AM	Insmeds win streak ends as top drug fails study in chronic nasal condition (BioPharma Dive)
Dec-17-25 04:01PM	Insmed Provides Clinical and Business Update (PR Newswire)
Dec-15-25 12:15PM	MicroStrategy retains place in key index despite delisting threats (TheStreet)
09:11AM	Western Digital stock rises after inclusion in Nasdaq-100 Index (Investing.com)
07:03AM	200% Surge? These 6 Stocks Just Crashed the Nasdaq 100 Party (GuruFocus.com)
Dec-13-25 11:04AM	Walmart was too late for a Nasdaq-100 spot - but these 6 stocks made the cut (MarketWatch)
Dec-12-25 08:21PM	Bitcoin hoarding company Strategy remains in Nasdaq 100 (Reuters)
10:11AM	Loading…
Dec-11-25 10:11AM	Crypto Market 2026 Predictions: Which Coins Will 10x and Which Will Crash? (24/7 Wall St.)
10:11AM	Billionaire Stanley Druckenmiller is Betting $1.2 Billion in These 3 Stocks (24/7 Wall St.)
Dec-10-25 11:30AM	Immunovant (IMVT) Down 0.6% Since Last Earnings Report: Can It Rebound? (Zacks)
Dec-04-25 11:30AM	Why Is Amgen (AMGN) Up 8% Since Last Earnings Report? (Zacks)
07:00AM	Insmed Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4) (PR Newswire)
Nov-30-25 03:14AM	30% of Billionaire Stanley Druckenmiller's Portfolio Is Invested in These 3 Biotech Stocks (Motley Fool)
Nov-28-25 10:07AM	Biotechs Are On A Big Run, And Two Stocks Have Buy Points (Investor's Business Daily)
Nov-25-25 07:35AM	Insmed (INSM) Rose Following Drug Approval (Insider Monkey)
Nov-24-25 12:38PM	This Investor Beat the Market for 3 Decades Without a Single Losing Year. 3 Stocks Hes Buying Now. (24/7 Wall St.)
Nov-20-25 03:45PM	These 15 stocks are still showing momentum - and a market-beating edge (MarketWatch)
Nov-19-25 10:59AM	Insmed Stock Rise on EU Nod for Lung Disease Drug, Brinsupri (Zacks)
05:03AM	Insmed receives EC approval for Brinsupri to treat NCFB (Pharmaceutical Business Review)
Nov-18-25 11:06AM	European Commission Approves BRINSUPRI (brensocatib) as the First and Only Treatment To Date Approved for Non-Cystic Fibrosis Bronchiectasis in the European Union (PR Newswire)
11:00AM	European Commission Approves BRINSUPRI (brensocatib) as the First and Only Treatment Approved for Non-Cystic Fibrosis Bronchiectasis in the European Union (PR Newswire)
Nov-17-25 10:10AM	Here's What Lifted Insmed Incorporated (INSM) in Q3 (Insider Monkey)
Nov-13-25 07:00AM	Insmed Strengthens Communities Worldwide During Fourth Annual Global Day of Good (PR Newswire)
Nov-05-25 07:00AM	Insmed To Present at November and December 2025 Investor Conferences (PR Newswire)
Nov-03-25 07:06PM	Latest read on rare disease gene therapy from Insmed CEO Will Lewis (CNBC TV)
09:16AM	Approval of Brinsupri Lifted Insmed Incorporated (INSM) in Q3 (Insider Monkey)
Oct-31-25 10:03AM	Insmed (INSM) Hits All-Time High as Firm Posts Highly Optimistic Outlook (Insider Monkey)
08:58AM	Insmed Misses on Q3 Earnings, Stock Rises on Strong Brinsupri Uptake (Zacks)
Oct-30-25 04:21PM	Insmed Inc (INSM) Q3 2025 Earnings Call Highlights: Strong Launch for Brin Suri and Robust ... (GuruFocus.com) +16.33%
04:12PM	Insmed Screams To A 25-Year High, While IBD 50's Argenx Slides (Investor's Business Daily)
08:46AM	Insmed Catapults While IBD 50's Argenx Creeps Higher On Bullish Reports (Investor's Business Daily)
08:20AM	Insmed (INSM) Reports Q3 Loss, Beats Revenue Estimates (Zacks)
07:17AM	Insmed: Q3 Earnings Snapshot (Associated Press Finance)
07:00AM	Insmed Reports Third-Quarter 2025 Financial Results and Provides Business Update (PR Newswire)
05:08AM	Apple and Amazon headline earnings slate (MarketWatch)
04:29AM	Stock Market Today: Dow, S&P 500 and Nasdaq hover near record highs after U.S.-China trade deal, while Meta stock dives but Alphabet pops on earnings; Apple and Amazon results on tap; Treasury yields up on December rate-cut pushback. (MarketWatch)
Oct-29-25 04:14PM	United Therapeutics Rockets 10% On Growing Enthusiasm For Its Top Drug (Investor's Business Daily)
09:55AM	The Mixed Results For United Therapeutics' Bread-And-Butter Drug (Investor's Business Daily)
09:15AM	Gear Up for Insmed (INSM) Q3 Earnings: Wall Street Estimates for Key Metrics (Zacks)
Oct-27-25 10:00AM	Vertex Pharmaceuticals (VRTX) Earnings Expected to Grow: Should You Buy? (Zacks)
Oct-23-25 04:05PM	Insmed Ranks No. 1 on Science's 2025 Top Biopharma Employers List (PR Newswire)
10:00AM	Analysts Estimate Insmed (INSM) to Report a Decline in Earnings: What to Look Out for (Zacks)
Oct-17-25 07:00AM	CHMP Recommends EU Approval of BRINSUPRI (brensocatib) for the Treatment of Non-Cystic Fibrosis Bronchiectasis (PR Newswire)
Oct-16-25 07:00AM	Insmed to Present Multiple Analyses from Phase 3 ASPEN Study at the American College of Chest Physicians Annual Meeting 2025 (PR Newswire)
Oct-15-25 08:07AM	Does Insmed Incorporated (INSM) Have a Promising Pipeline? (Insider Monkey)
07:00AM	Insmed to Host Third-Quarter 2025 Financial Results Conference Call on Thursday, October 30, 2025 (PR Newswire)
Oct-13-25 05:30AM	Why Biotech's Rally Can Last This Time (The Wall Street Journal)
Oct-08-25 10:30AM	This Strong Buy Stock Is Trading at New 20-Year Highs (Barchart)
Oct-03-25 05:24PM	Top Stock Reports for AMD, Abbott & Micron Technology (Zacks)
Oct-02-25 09:44AM	Ohio Retirement Fund Invests in Insmed Incorporated (INSM) (Insider Monkey)
Oct-01-25 10:40AM	Is IPF the Next Big Market Opportunity for United Therapeutics? (Zacks)
Sep-30-25 12:32PM	Insmed Incorporated (INSM) Rallies After FDA Approves Brinsupri, Shares Jump 9% (Insider Monkey)
Sep-27-25 12:58AM	RBC Capital Remains Bullish on Insmed Incorporated (INSM) (Insider Monkey)
Sep-22-25 07:00AM	Insmed to Present Multiple Abstracts at the European Respiratory Society Congress 2025 (PR Newswire)
Sep-12-25 08:09AM	Insmed (INSM) Reported Impressive Results from the Phase 2 Trial Of Its Inhalation Powder (Insider Monkey)
Sep-05-25 05:11PM	Top Analyst Reports for Microsoft, Amazon.com & Philip Morris (Zacks)
07:00AM	Insmed Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4) (PR Newswire)
Sep-04-25 09:42AM	Insmed scores pivotal win in bronchiectasis with FDA approval of Brinsupri (Pharmaceutical Technology)
Sep-03-25 01:48PM	UTHR Stock Hits Record High on Tyvaso Meeting IPF Study Goals (Zacks)
Sep-02-25 04:09PM	Why United Therapeutics Catapulted 33%, Pulling Insmed, Liquidia With It (Investor's Business Daily) +6.76%
09:34AM	Why United Therapeutics Just Catapulted 35%, Pulling Insmed, Liquidia With It (Investor's Business Daily)
01:04AM	What Does Wall Street Think About Insmed Incorporated (INSM)? (Insider Monkey)
Aug-27-25 04:32PM	Bloomberg 500 (B500) Index Adds Sixteen Securities Following Semi-Annual Reconstitution (PR Newswire)
Aug-22-25 05:11AM	Magazine: Big biopharma take on the ADC challenge (Pharmaceutical Technology)
Aug-21-25 07:00AM	Insmed To Present at September Investor Conferences (PR Newswire)
Aug-19-25 01:21PM	Josh Brown's Best Stocks in the Market: Insmed (CNBC TV)
10:15AM	This Strong Buy Pharma Stock Is Surging to New Highs (Barchart)
Aug-14-25 02:05PM	Mizuho's Jared Holz on how to play the underperforming health care sector (CNBC TV)
09:45AM	C3 AI downgraded, Capri upgraded: Wall Streets top analyst calls (TipRanks)
Aug-13-25 06:56PM	Insmed CEO on what's next for company after FDA greenlights lung disease drug (CNBC TV)
12:31PM	VytlOne Announces New Partnership with Insmed (PR Newswire)
09:40AM	C3 AI downgraded, Capri upgraded: Wall Street's top analyst calls (The Fly)
08:30AM	PANTHERx® Rare Selected by Insmed to Dispense BRINSUPRI (brensocatib) for the Treatment of Non-Cystic Fibrosis Bronchiectasis (PR Newswire)
07:56AM	Insmed wins FDA approval for future blockbuster Brinsupri (Pharmaceutical Technology)
Aug-12-25 04:30PM	Top 5% Biotech, Insmed, Hits A Record High On Its 'Skeleton Key' Approval (Investor's Business Daily) +8.07%
02:20PM	FDA Approves Insmed's Drug As First Treatment For Type Of Chronic Lung Disease (Benzinga)
01:04PM	Insmed gains US approval of lung disease drug forecast to be blockbuster (BioPharma Dive)

Insmed, Inc. is a global biopharmaceutical company, which engages in the development and commercialization of therapies for patients with rare diseases. Its focuses on Brensocatib, and Treprostinil Palmitil Inhalation Powder (TPIP) pipeline. The company was founded in 1988 and is headquartered in Bridgewater, NJ.

Insider Trading	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
Sara Bonstein	Officer	Jan 08 '26	Proposed Sale	174.17	1,447	252,023		Jan 08 05:40 PM
Martina Flammer	Officer	Jan 08 '26	Proposed Sale	174.17	5,138	894,885		Jan 08 05:35 PM
Martina Flammer	Officer	Jan 08 '26	Proposed Sale	173.90	1,660	288,674		Jan 08 05:28 PM
Roger Adsett	Officer	Jan 08 '26	Proposed Sale	174.17	2,059	358,616		Jan 08 05:23 PM
Adsett Roger	Chief Operating Officer	Jan 08 '26	Sale	174.17	2,059	358,616	107,601	Jan 08 05:22 PM
Adsett Roger	Chief Operating Officer	Jan 06 '26	Sale	173.33	1,429	247,689	110,462	Jan 08 05:22 PM
Adsett Roger	Chief Operating Officer	Jan 07 '26	Sale	175.07	802	140,406	109,660	Jan 08 05:22 PM
Bonstein Sara	Chief Financial Officer	Jan 07 '26	Sale	175.07	1,678	293,767	81,953	Jan 08 05:21 PM
Bonstein Sara	Chief Financial Officer	Jan 06 '26	Sale	173.33	1,517	262,942	83,631	Jan 08 05:21 PM
Bonstein Sara	Chief Financial Officer	Jan 08 '26	Sale	174.17	1,447	252,024	80,506	Jan 08 05:21 PM
Flammer Martina M.D.	Chief Medical Officer	Jan 06 '26	Option Exercise	26.43	8,570	226,505	103,324	Jan 08 05:20 PM
Flammer Martina M.D.	Chief Medical Officer	Jan 06 '26	Sale	173.80	10,185	1,770,134	93,139	Jan 08 05:20 PM
Flammer Martina M.D.	Chief Medical Officer	Jan 08 '26	Sale	174.07	4,911	854,851	86,794	Jan 08 05:20 PM
Flammer Martina M.D.	Chief Medical Officer	Jan 07 '26	Sale	175.84	1,434	252,155	91,705	Jan 08 05:20 PM
Lewis William	Chair and CEO	Jan 06 '26	Sale	173.33	4,096	709,960	320,987	Jan 08 05:20 PM
Lewis William	Chair and CEO	Jan 08 '26	Sale	174.17	3,223	561,350	315,407	Jan 08 05:20 PM
Lewis William	Chair and CEO	Jan 07 '26	Sale	175.07	2,357	412,640	318,630	Jan 08 05:20 PM
Smith Michael Alexander	Chief Legal Officer	Jan 06 '26	Sale	173.33	1,396	241,969	58,799	Jan 08 05:19 PM
Smith Michael Alexander	Chief Legal Officer	Jan 08 '26	Sale	174.17	1,053	183,401	57,037	Jan 08 05:19 PM
Smith Michael Alexander	Chief Legal Officer	Jan 07 '26	Sale	175.07	709	124,125	58,090	Jan 08 05:19 PM
Michael Smith	Officer	Jan 08 '26	Proposed Sale	174.17	1,053	183,401		Jan 08 05:19 PM
William Lewis	Officer	Jan 08 '26	Proposed Sale	174.17	3,223	561,349		Jan 08 05:08 PM
Roger Adsett	Officer	Jan 07 '26	Proposed Sale	175.07	802	140,406		Jan 07 05:10 PM
Michael Smith	Officer	Jan 07 '26	Proposed Sale	175.07	709	124,124		Jan 07 05:04 PM
William Lewis	Officer	Jan 07 '26	Proposed Sale	175.07	2,357	412,636		Jan 07 04:59 PM
Sara Bonstein	Officer	Jan 07 '26	Proposed Sale	175.17	1,678	293,935		Jan 07 04:42 PM
Martina Flammer	Officer	Jan 07 '26	Proposed Sale	175.84	1,434	252,154		Jan 07 04:42 PM
Sara Bonstein	Officer	Jan 06 '26	Proposed Sale	173.33	1,517	262,941		Jan 06 04:40 PM
Martina Flammer	Officer	Jan 06 '26	Proposed Sale	173.33	1,615	279,927		Jan 06 04:37 PM
Roger Adsett	Officer	Jan 06 '26	Proposed Sale	173.33	1,429	247,688		Jan 06 04:33 PM
Michael Smith	Officer	Jan 06 '26	Proposed Sale	173.33	1,396	241,969		Jan 06 04:26 PM
William Lewis	Officer	Jan 06 '26	Proposed Sale	173.33	4,096	709,959		Jan 06 04:20 PM
Flammer Martina M.D.	Chief Medical Officer	Jan 05 '26	Option Exercise	25.80	12,303	317,465	107,057	Jan 06 04:06 PM
Flammer Martina M.D.	Chief Medical Officer	Jan 05 '26	Sale	171.38	12,303	2,108,507	94,754	Jan 06 04:06 PM
Schaeffer Orlov S Nicole	Chief People Strategy Officer	Jan 02 '26	Option Exercise	13.91	87,290	1,214,204	129,044	Jan 06 04:03 PM
Schaeffer Orlov S Nicole	Chief People Strategy Officer	Jan 02 '26	Sale	175.20	87,290	15,293,422	41,754	Jan 06 04:03 PM
Martina Flammer	Officer	Jan 05 '26	Proposed Sale	171.39	20,873	3,577,423		Jan 05 04:33 PM
Stacey Nicole Schaeffer Orlov	Officer	Jan 02 '26	Proposed Sale	175.11	87,290	15,285,351		Jan 02 04:29 PM
Lewis William	Chair and CEO	Dec 18 '25	Option Exercise	24.94	10,699	266,840	314,610	Dec 19 04:12 PM
Lewis William	Chair and CEO	Dec 18 '25	Sale	166.97	10,699	1,786,457	303,911	Dec 19 04:12 PM
William Lewis	Officer	Dec 18 '25	Proposed Sale	166.97	10,699	1,786,437		Dec 18 04:45 PM
SHAROKY MELVIN MD	Director	Dec 05 '25	Sale	205.01	20,000	4,100,200	243,948	Dec 09 04:05 PM
MELVIN SHAROKY	DIRECTOR	Dec 05 '25	Proposed Sale	205.00	20,000	4,100,000		Dec 05 05:39 PM
Lewis William	Chair and CEO	Dec 04 '25	Option Exercise	24.94	10,699	266,840	314,610	Dec 05 04:11 PM
Lewis William	Chair and CEO	Dec 04 '25	Sale	205.62	10,699	2,199,915	303,911	Dec 05 04:11 PM
William Lewis	Officer	Dec 04 '25	Proposed Sale	205.59	10,699	2,199,583		Dec 04 05:10 PM
Flammer Martina M.D.	Chief Medical Officer	Dec 01 '25	Option Exercise	25.83	8,895	229,758	92,006	Dec 03 04:01 PM
Flammer Martina M.D.	Chief Medical Officer	Dec 01 '25	Sale	206.98	8,895	1,841,101	83,111	Dec 03 04:01 PM
Martina Flammer	Officer	Dec 01 '25	Proposed Sale	206.95	8,895	1,840,841		Dec 01 04:08 PM
ANDERSON ELIZABETH M	Director	Nov 24 '25	Sale	204.58	5,000	1,022,900	58,729	Nov 26 04:31 PM
ANDERSON ELIZABETH M	Director	Nov 24 '25	Proposed Sale	204.00	5,000	1,020,000		Nov 24 03:07 PM
LEE LEO	Director	Nov 17 '25	Sale	195.90	75,000	14,692,249	54,677	Nov 18 04:21 PM
ANDERSON ELIZABETH M	Director	Nov 14 '25	Sale	195.87	10,000	1,958,700	63,729	Nov 18 04:20 PM
Leo Lee	Director	Nov 17 '25	Proposed Sale	193.22	75,000	14,491,500		Nov 17 05:29 PM
Schaeffer Orlov S Nicole	Chief People Strategy Officer	Nov 12 '25	Option Exercise	26.46	30,000	793,800	66,461	Nov 14 04:12 PM
Schaeffer Orlov S Nicole	Chief People Strategy Officer	Nov 12 '25	Sale	194.00	30,000	5,820,061	36,461	Nov 14 04:12 PM
Flammer Martina M.D.	Chief Medical Officer	Nov 11 '25	Option Exercise	18.17	31,226	567,389	114,337	Nov 13 04:32 PM
Flammer Martina M.D.	Chief Medical Officer	Nov 11 '25	Sale	189.68	31,226	5,922,795	83,111	Nov 13 04:32 PM
ANDERSON ELIZABETH M	Director	Nov 13 '25	Proposed Sale	194.00	10,000	1,940,000		Nov 13 12:53 PM
Stacey Nicole Schaeffer Orlov	Officer	Nov 12 '25	Proposed Sale	194.51	30,000	5,835,300		Nov 12 04:57 PM
Martina Flammer	Officer	Nov 11 '25	Proposed Sale	189.64	31,226	5,921,820		Nov 12 08:28 AM
Smith Michael Alexander	Chief Legal Officer	Nov 03 '25	Option Exercise	23.75	27,130	644,338	82,032	Nov 05 04:08 PM
Smith Michael Alexander	Chief Legal Officer	Nov 03 '25	Sale	183.78	27,130	4,985,911	54,902	Nov 05 04:08 PM
Michael A Smith	Officer	Nov 03 '25	Proposed Sale	183.75	27,130	4,985,054		Nov 03 05:01 PM
Schaeffer Orlov S Nicole	Chief People Strategy Officer	Sep 12 '25	Option Exercise	23.75	56,520	1,342,350	112,981	Sep 15 04:23 PM
Schaeffer Orlov S Nicole	Chief People Strategy Officer	Sep 12 '25	Sale	145.45	76,520	11,129,927	36,461	Sep 15 04:23 PM
SHAROKY MELVIN MD	Director	Sep 12 '25	Sale	145.39	10,000	1,453,900	262,675	Sep 15 04:22 PM
Schaeffer Orlov S Nicole	Officer	Sep 12 '25	Proposed Sale	145.42	76,520	11,127,662		Sep 12 05:03 PM
SHAROKY MELVIN MD	Director	Sep 12 '25	Proposed Sale	145.00	10,000	1,450,000		Sep 12 03:55 PM
Smith Michael Alexander	Chief Legal Officer	Sep 02 '25	Option Exercise	30.46	12,780	389,279	79,174	Sep 04 05:26 PM
Smith Michael Alexander	Chief Legal Officer	Sep 02 '25	Sale	143.89	24,272	3,492,378	54,902	Sep 04 05:26 PM
Flammer Martina M.D.	Chief Medical Officer	Sep 02 '25	Option Exercise	23.40	186,648	4,366,788	269,759	Sep 04 05:24 PM
Flammer Martina M.D.	Chief Medical Officer	Sep 02 '25	Sale	144.34	186,648	26,941,272	83,111	Sep 04 05:24 PM
Flammer Martina M.D.	Officer	Sep 02 '25	Proposed Sale	144.31	186,648	26,935,498		Sep 02 04:49 PM
Smith Michael Alexander	Officer	Sep 02 '25	Proposed Sale	143.85	24,272	3,491,647		Sep 02 04:41 PM
SHAROKY MELVIN MD	Director	Aug 20 '25	Sale	129.50	10,000	1,295,000	274,516	Aug 21 05:07 PM
Adsett Roger	Chief Operating Officer	Aug 19 '25	Sale	127.58	25,000	3,189,586	105,637	Aug 21 05:05 PM
Lewis William	Chair and CEO	Aug 18 '25	Option Exercise	10.85	6,865	74,485	240,789	Aug 20 04:28 PM
Lewis William	Chair and CEO	Aug 18 '25	Sale	128.40	6,865	881,470	233,924	Aug 20 04:28 PM
SHAROKY MELVIN MD	Director	Aug 20 '25	Proposed Sale	129.46	10,000	1,294,600		Aug 20 12:53 PM
Adsett Roger	Officer	Aug 19 '25	Proposed Sale	127.55	25,000	3,188,795		Aug 19 05:19 PM
Lewis William	Officer	Aug 18 '25	Proposed Sale	128.37	6,865	881,244		Aug 18 04:58 PM
Schaeffer Orlov S Nicole	Chief People Strategy Officer	Aug 14 '25	Sale	127.34	10,000	1,273,363	79,764	Aug 18 04:19 PM
SHAROKY MELVIN MD	Director	Aug 12 '25	Sale	121.58	10,000	1,215,800	290,616	Aug 14 04:21 PM
Schaeffer Orlov S Nicole	Officer	Aug 14 '25	Proposed Sale	127.31	10,000	1,273,070		Aug 14 04:10 PM
ALFRED ALTOMARI	Former Affiliate	Aug 13 '25	Proposed Sale	121.64	13,600	1,654,338		Aug 13 04:22 PM
SHAROKY MELVIN MD	Director	Aug 12 '25	Proposed Sale	121.53	10,000	1,215,350		Aug 12 04:37 PM
Lewis William	Chair and CEO	Aug 04 '25	Option Exercise	10.85	6,830	74,106	240,754	Aug 06 04:21 PM
Lewis William	Chair and CEO	Aug 04 '25	Sale	109.81	6,830	750,008	233,924	Aug 06 04:21 PM
Flammer Martina M.D.	Chief Medical Officer	Aug 04 '25	Option Exercise	19.74	8,715	172,034	91,826	Aug 06 04:19 PM
Flammer Martina M.D.	Chief Medical Officer	Aug 04 '25	Sale	109.50	8,715	954,292	83,111	Aug 06 04:19 PM
Lewis William	Officer	Aug 04 '25	Proposed Sale	109.78	6,830	749,801		Aug 04 04:37 PM
Flammer Martina M.D.	Officer	Aug 04 '25	Proposed Sale	109.47	8,715	954,031		Aug 04 04:24 PM
Bonstein Sara	Chief Financial Officer	Jul 21 '25	Option Exercise	30.63	47,888	1,466,711	131,905	Jul 23 04:35 PM
Bonstein Sara	Chief Financial Officer	Jul 21 '25	Sale	102.67	58,400	5,996,094	73,505	Jul 23 04:35 PM
Bonstein Sara	Officer	Jul 21 '25	Proposed Sale	102.64	58,400	5,994,443		Jul 21 04:13 PM
Lewis William	Chair and CEO	Jul 15 '25	Option Exercise	10.85	6,830	74,106	240,754	Jul 15 05:53 PM
Lewis William	Chair and CEO	Jul 15 '25	Sale	102.37	6,830	699,220	233,924	Jul 15 05:53 PM
Smith Michael Alexander	Chief Legal Officer	Jul 15 '25	Sale	102.51	933	95,642	66,394	Jul 15 05:52 PM
Smith Michael Alexander	Chief Legal Officer	Jul 11 '25	Sale	96.41	748	72,115	67,327	Jul 15 05:52 PM

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