VRTX

Vertex Pharmaceuticals, Inc

Oct 15 • 10:04AM ET

410.11

-2.11 -0.51 %

Healthcare • Biotechnology • USA • NASD

Peers: BIIB GILD AMGN REGN MRNA INCY ALNY NBIX EXEL

| Held by: VTI VOO QQQ IVV SPY VUG XLV IBB IWF QQQM

Index	NDX, S&P 500	P/E	29.31	EPS (ttm)	13.99	Insider Own	0.30%	Shs Outstand	256.29M	Perf Week	-2.62%
Market Cap	105.15B	Forward P/E	19.97	EPS next Y	20.54	Insider Trans	1.80%	Shs Float	255.62M	Perf Month	4.79%
Enterprise Value	100.28B	PEG	-	EPS next Q	4.57	Inst Own	95.39%	Short Float	1.39%	Perf Quarter	-11.47%
Income	3.64B	P/S	9.23	EPS this Y	4190.49%	Inst Trans	0.46%	Short Ratio	1.98	Perf Half Y	-18.06%
Sales	11.39B	P/B	6.12	EPS next Y	13.97%	ROA	16.47%	Short Interest	3.56M	Perf YTD	1.84%
Book/sh	67.01	P/C	16.45	EPS next 5Y	-	ROE	22.77%	52W High	519.88 -21.11%	Perf Year	-14.86%
Cash/sh	24.93	P/FCF	30.05	EPS past 3/5Y	- -	ROIC	19.45%	52W Low	362.50 13.14%	Perf 3Y	39.24%
Dividend Est.	-	EV/EBITDA	21.78	Sales past 3/5Y	13.04% 21.61%	Gross Margin	86.08%	Volatility	2.19% 2.29%	Perf 5Y	52.73%
Dividend TTM	-	EV/Sales	8.80	EPS Y/Y TTM	847.05%	Oper. Margin	38.66%	ATR (14)	8.78	Perf 10Y	274.88%
Dividend Ex-Date	-	Quick Ratio	2.16	Sales Y/Y TTM	10.38%	Profit Margin	31.92%	RSI (14)	56.24	Recom	1.89
Dividend Gr. 3/5Y	- -	Current Ratio	2.52	EPS Q/Q	128.65%	SMA20	2.95%	Beta	0.35	Target Price	487.00
Payout	-	Debt/Eq	0.09	Sales Q/Q	13.33%	SMA50	4.16%	Rel Volume	0.66	Prev Close	412.22
Employees	6100	LT Debt/Eq	0.09	Earnings	Aug 04 AMC	SMA200	-7.83%	Avg Volume	1.79M	Price	410.11
IPO	Jul 24, 1991	Option/Short	Yes / Yes	EPS/Sales Surpr.	5.80% 1.30%	Trades		Volume	157,538	Change	-0.51%

Date	Action	Analyst	Rating Change	Price Target Change
Sep-25-25	Upgrade	Leerink Partners	Market Perform → Outperform	$456
Sep-03-25	Initiated	Raymond James	Mkt Perform
Aug-06-25	Upgrade	Wells Fargo	Equal Weight → Overweight	$460
May-07-25	Downgrade	Wolfe Research	Outperform → Peer Perform
May-06-25	Downgrade	Leerink Partners	Outperform → Market Perform	$503
Apr-22-25	Resumed	Cantor Fitzgerald	Overweight	$535
Feb-12-25	Upgrade	Canaccord Genuity	Sell → Hold	$408 → $424
Feb-11-25	Upgrade	Canaccord Genuity	Sell → Hold
Jan-30-25	Downgrade	Wells Fargo	Overweight → Equal Weight	$460
Dec-20-24	Reiterated	H.C. Wainwright	Buy	$600 → $535
Dec-19-24	Downgrade	Oppenheimer	Outperform → Perform
Dec-09-24	Upgrade	Jefferies	Hold → Buy	$500 → $550
Nov-14-24	Initiated	Citigroup	Buy	$575
Oct-16-24	Initiated	Scotiabank	Sector Perform
Oct-10-24	Resumed	Raymond James	Mkt Perform
Aug-05-24	Downgrade	Barclays	Overweight → Equal Weight	$472 → $509
Jun-27-24	Initiated	Redburn Atlantic	Buy	$545
Apr-11-24	Upgrade	Evercore ISI	In-line → Outperform	$438
Feb-15-24	Initiated	Wolfe Research	Outperform	$515
Feb-06-24	Downgrade	Evercore ISI	Outperform → In-line	$436 → $438

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Vertex Pharmaceuticals, Inc. is a global biotechnology company, which engages in the business of discovering, developing, manufacturing, and commercializing small molecule drugs for patients with serious diseases. The firm focuses on development and commercializing therapies for the treatment of cystic fibrosis, infectious diseases including viral infections such as influenza and bacterial infections, autoimmune diseases such as rheumatoid arthritis, cancer, inflammatory bowel disease and neurological disorders including pain and multiple sclerosis. The company was founded by Joshua S. Boger in 1989 and is headquartered in Boston, MA.

Insider Trading	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
Biller Jonathan	EVP and Chief Legal Officer	Oct 02 '25	Sale	404.21	694	280,522	15,653	Oct 03 04:07 PM
Biller Jonathan	Officer	Oct 02 '25	Proposed Sale	404.21	694	280,522		Oct 02 10:39 AM
Bhatia Sangeeta N.	Director	Aug 27 '25	Sale	386.69	266	102,860	4,565	Aug 29 04:02 PM
Bhatia Sangeeta N.	Director	Aug 27 '25	Proposed Sale	386.69	266	102,860		Aug 27 09:38 AM
Kewalramani Reshma	CEO & President	Aug 06 '25	Buy	389.58	10,000	3,895,768	115,968	Aug 07 04:23 PM
SACHS BRUCE I	Director	Aug 06 '25	Buy	389.68	5,000	1,948,416	45,000	Aug 07 04:19 PM
LR 2019 Benefit Trust	Director	May 21 '25	Proposed Sale	447.18	170	76,021		May 21 04:58 PM
SR 2019 Benefit Trust	Director	May 21 '25	Proposed Sale	447.18	170	76,021		May 21 04:58 PM
ALTSHULER DAVID	EVP, Chief Scientific Officer	May 15 '25	Sale	424.69	52	22,084	23,281	May 19 05:07 PM
ALTSHULER DAVID	Officer	May 15 '25	Proposed Sale	424.69	52	22,084		May 15 10:36 AM
Bhatia Sangeeta N.	Director	May 02 '25	Sale	505.86	400	202,344	4,831	May 05 04:14 PM
Bhatia Sangeeta N.	Director	May 02 '25	Proposed Sale	505.86	400	202,344		May 02 09:47 AM
ALTSHULER DAVID	EVP, Chief Scientific Officer	Mar 13 '25	Sale	510.00	3,231	1,647,810	23,281	Mar 17 04:09 PM
ALTSHULER DAVID	Officer	Mar 13 '25	Proposed Sale	510.00	3,231	1,647,810		Mar 13 11:10 AM
WAGNER CHARLES F JR	EVP & Chief Financial Officer	Mar 10 '25	Sale	500.00	3,298	1,649,000	51,671	Mar 12 04:11 PM
Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Mar 10 '25	Sale	499.99	3,242	1,620,968	51,239	Mar 12 04:10 PM
ALTSHULER DAVID	EVP, Chief Scientific Officer	Mar 10 '25	Sale	500.00	3,231	1,615,500	26,512	Mar 12 04:08 PM
Tatsis Ourania	Officer	Mar 10 '25	Proposed Sale	499.99	3,242	1,620,968		Mar 10 01:58 PM
WAGNER CHARLES F JR	Officer	Mar 10 '25	Proposed Sale	500.00	3,298	1,649,000		Mar 10 01:02 PM
ALTSHULER DAVID	Officer	Mar 10 '25	Proposed Sale	500.00	3,231	1,615,500		Mar 10 12:42 PM
Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Mar 04 '25	Sale	485.49	4,058	1,970,118	54,481	Mar 06 04:08 PM
ALTSHULER DAVID	EVP, Chief Scientific Officer	Mar 03 '25	Sale	490.00	3,231	1,583,190	29,743	Mar 05 04:08 PM
Tatsis Ourania	Officer	Mar 04 '25	Proposed Sale	485.49	4,058	1,970,118		Mar 04 01:39 PM
ALTSHULER DAVID	Officer	Mar 03 '25	Proposed Sale	490.00	3,231	1,583,190		Mar 03 04:17 PM
Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Feb 27 '25	Sale	475.34	530	251,930	58,539	Feb 28 04:48 PM
Atkinson Edward Morrow III	EVP, Chief Technical Ops. Off.	Feb 27 '25	Sale	475.34	2,650	1,259,651	19,352	Feb 28 04:36 PM
ALTSHULER DAVID	EVP, Chief Scientific Officer	Feb 27 '25	Sale	480.00	1,272	610,560	32,974	Feb 28 04:23 PM
ALTSHULER DAVID	Officer	Feb 27 '25	Proposed Sale	480.00	1,272	610,560		Feb 27 11:20 AM
Atkinson Edward Morrow III	Officer	Feb 27 '25	Proposed Sale	475.34	2,650	1,259,651		Feb 27 10:18 AM
Tatsis Ourania	Officer	Feb 27 '25	Proposed Sale	475.34	530	251,930		Feb 27 10:14 AM
Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Feb 25 '25	Sale	480.95	354	170,256	64,031	Feb 26 04:15 PM
Atkinson Edward Morrow III	EVP, Chief Technical Ops. Off.	Feb 25 '25	Sale	480.95	1,767	849,839	24,484	Feb 26 04:09 PM
Ambrose Kristen	SVP & Chief Accounting Officer	Feb 25 '25	Sale	480.95	884	425,160	9,086	Feb 26 04:06 PM
ALTSHULER DAVID	EVP, Chief Scientific Officer	Feb 25 '25	Sale	480.95	848	407,846	40,200	Feb 26 04:04 PM
Tatsis Ourania	Officer	Feb 25 '25	Proposed Sale	480.95	354	170,256		Feb 25 11:38 AM
ALTSHULER DAVID	Officer	Feb 25 '25	Proposed Sale	480.95	848	407,846		Feb 25 11:13 AM
Atkinson Edward Morrow III	Officer	Feb 25 '25	Proposed Sale	480.95	1,767	849,839		Feb 25 10:59 AM
ALTSHULER DAVID	EVP, Chief Scientific Officer	Feb 20 '25	Sale	480.00	1,111	533,280	45,019	Feb 24 04:07 PM
ALTSHULER DAVID	Officer	Feb 20 '25	Proposed Sale	480.00	1,111	533,280		Feb 20 03:45 PM
Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Feb 18 '25	Sale	455.06	244	111,035	67,695	Feb 19 04:36 PM
Biller Jonathan	EVP and Chief Legal Officer	Feb 18 '25	Sale	455.06	1,657	754,034	17,606	Feb 19 04:28 PM
Ambrose Kristen	SVP & Chief Accounting Officer	Feb 18 '25	Sale	455.06	671	305,345	10,798	Feb 19 04:21 PM
Tatsis Ourania	Officer	Feb 18 '25	Proposed Sale	455.06	244	111,035		Feb 18 11:34 AM
Biller Jonathan	Officer	Feb 18 '25	Proposed Sale	455.06	1,657	754,034		Feb 18 11:29 AM
Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Feb 11 '25	Sale	459.83	310	142,547	64,021	Feb 12 04:50 PM
Biller Jonathan	EVP and Chief Legal Officer	Feb 11 '25	Sale	459.87	3,433	1,578,734	16,330	Feb 12 04:36 PM
Atkinson Edward Morrow III	EVP, Chief Technical Ops. Off.	Feb 11 '25	Sale	459.83	1,747	803,323	23,225	Feb 12 04:29 PM
Ambrose Kristen	SVP & Chief Accounting Officer	Feb 11 '25	Sale	459.83	1,376	632,726	9,953	Feb 12 04:24 PM
Biller Jonathan	Officer	Feb 11 '25	Proposed Sale	459.87	3,433	1,578,744		Feb 11 11:57 AM
Tatsis Ourania	Officer	Feb 11 '25	Proposed Sale	459.83	310	142,547		Feb 11 11:05 AM
Atkinson Edward Morrow III	Officer	Feb 11 '25	Proposed Sale	459.83	1,747	803,323		Feb 11 09:49 AM
ALTSHULER DAVID	EVP, Chief Scientific Officer	Nov 15 '24	Sale	478.56	15	7,178	25,813	Nov 19 04:08 PM
ALTSHULER DAVID	Officer	Nov 15 '24	Proposed Sale	478.56	15	7,178		Nov 15 10:31 AM
WAGNER CHARLES F JR	EVP & Chief Financial Officer	Nov 11 '24	Sale	518.27	3,000	1,554,810	44,137	Nov 13 04:15 PM
Kewalramani Reshma	CEO & President	Nov 08 '24	Sale	515.00	15,198	7,826,970	75,772	Nov 12 04:08 PM
Kewalramani Reshma	Officer	Nov 08 '24	Proposed Sale	515.00	15,198	7,826,970		Nov 08 02:58 PM

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VRTX

Vertex Pharmaceuticals, Inc

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