BioMarin Pharmaceutical Inc. develops and commercializes therapies for people with serious and life-threatening rare diseases and medical conditions. Its commercial products include Vimizim, an enzyme replacement therapy for the treatment of mucopolysaccharidosis (MPS) IV type A, a lysosomal storage disorder; Naglazyme, a recombinant form of N-acetylgalactosamine 4-sulfatase for patients with MPS VI; and Kuvan, a proprietary synthetic oral form of 6R-BH4 that is used to treat patients with phenylketonuria (PKU), an inherited metabolic disease. The company's commercial products also comprise Palynziq, a PEGylated recombinant phenylalanine ammonia lyase enzyme, which is delivered through subcutaneous injection to reduce blood Phe concentrations; Brineura, a recombinant human tripeptidyl peptidase 1 for the treatment of patients with ceroid lipofuscinosis type 2, a form of Batten disease; Voxzogo, a once daily injection analog of c-type natriuretic peptide for the treatment of achondroplasia; and Aldurazyme, a purified protein designed to be identical to a naturally occurring form of the human enzyme alpha-L-iduronidase. In addition, it develops Roctavian, an adeno associated virus vector, for the treatment of patients with severe hemophilia A; BMN 331, an AAV5 mediated gene therapy, which is in Phase 1/2 clinical trial for people living with Hereditary Angioedema (HAE); and BMN 255 that is in Phase 1/2 clinical trial for treating primary hyperoxaluria. The company serves specialty pharmacies, hospitals, and non-U.S. government agencies, as well as distributors and pharmaceutical wholesalers in the United States, Europe, Latin America, and internationally. BioMarin Pharmaceutical Inc. has license and collaboration agreements with Sarepta Therapeutics, Ares Trading S.A., Catalyst Pharmaceutical Partners, Inc., and Asubio Pharma Co., Ltd. The company was incorporated in 1996 and is headquartered in San Rafael, California. |
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SEC Form 4 |
BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 13 | Option Exercise | 67.81 | 8,000 | 542,480 | 495,856 | Mar 14 07:40 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 13 | Sale | 90.45 | 8,000 | 723,600 | 487,856 | Mar 14 07:40 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 10 | Option Exercise | 67.81 | 15,000 | 1,017,150 | 502,856 | Mar 14 07:40 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 10 | Sale | 92.28 | 15,000 | 1,384,200 | 487,856 | Mar 14 07:40 PM | Davis George Eric | EVP, Chief Legal Officer | Feb 24 | Option Exercise | 67.81 | 1,474 | 99,952 | 56,725 | Feb 28 09:22 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 13 | Option Exercise | 67.81 | 6,000 | 406,860 | 326,324 | Feb 14 08:00 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 13 | Sale | 109.15 | 6,000 | 654,900 | 320,324 | Feb 14 08:00 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 10 | Option Exercise | 67.81 | 15,000 | 1,017,150 | 335,324 | Feb 14 08:00 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 10 | Sale | 110.11 | 15,000 | 1,651,650 | 320,324 | Feb 14 08:00 PM | Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Jan 25 | Option Exercise | 67.81 | 49,000 | 3,322,690 | 90,088 | Jan 27 09:35 PM | Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Jan 25 | Sale | 115.70 | 49,000 | 5,669,134 | 41,088 | Jan 27 09:35 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 17 | Option Exercise | 67.81 | 10,000 | 678,100 | 330,424 | Jan 18 09:41 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 17 | Sale | 111.55 | 10,000 | 1,115,500 | 320,424 | Jan 18 09:41 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 13 | Option Exercise | 67.81 | 10,000 | 678,100 | 330,424 | Jan 18 09:41 PM | Mueller Brian | EVP, Chief Financial Officer | Jan 13 | Option Exercise | 63.10 | 2,500 | 157,750 | 30,246 | Jan 17 09:57 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 13 | Sale | 112.25 | 10,000 | 1,122,500 | 320,424 | Jan 18 09:41 PM | Mueller Brian | EVP, Chief Financial Officer | Jan 13 | Sale | 114.50 | 2,500 | 286,250 | 27,746 | Jan 17 09:57 PM | Mueller Brian | EVP, Chief Financial Officer | Dec 13 | Option Exercise | 63.10 | 2,500 | 157,750 | 30,246 | Dec 15 06:22 PM | Mueller Brian | EVP, Chief Financial Officer | Dec 13 | Sale | 107.50 | 2,500 | 268,750 | 27,746 | Dec 15 06:22 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 13 | Sale | 106.89 | 1,000 | 106,890 | 320,424 | Dec 15 04:43 PM | Mueller Brian | EVP, Chief Financial Officer | Dec 02 | Option Exercise | 67.81 | 5,900 | 400,079 | 31,507 | Dec 06 09:29 PM | Mueller Brian | EVP, Chief Financial Officer | Dec 02 | Sale | 104.50 | 7,001 | 731,604 | 27,746 | Dec 06 09:29 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 02 | Sale | 103.98 | 1,500 | 155,967 | 321,424 | Dec 06 09:09 PM | Mueller Brian | EVP, Chief Financial Officer | Nov 23 | Option Exercise | 67.81 | 3,500 | 237,335 | 32,347 | Nov 28 09:42 PM | Mueller Brian | EVP, Chief Financial Officer | Nov 23 | Sale | 98.73 | 5,379 | 531,092 | 28,847 | Nov 28 09:42 PM | Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Nov 02 | Sale | 86.12 | 3,000 | 258,360 | 41,088 | Nov 04 05:25 PM | Alles Mark J | Director | Oct 31 | Buy | 86.75 | 3,625 | 314,469 | 10,905 | Nov 02 06:42 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 31 | Sale | 86.55 | 1,500 | 129,825 | 322,824 | Nov 01 08:38 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 14 | Sale | 89.89 | 4,000 | 359,560 | 324,324 | Oct 18 08:01 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Aug 15 | Sale | 95.21 | 3,000 | 285,630 | 328,324 | Aug 16 07:36 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Aug 12 | Sale | 94.75 | 4,000 | 379,000 | 331,324 | Aug 16 07:36 PM | Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Aug 11 | Sale | 95.62 | 3,000 | 286,860 | 44,088 | Aug 12 07:07 PM | Davis George Eric | EVP, Chief Legal Officer | Aug 09 | Option Exercise | 67.81 | 47,526 | 3,222,738 | 102,777 | Aug 11 09:01 PM | Davis George Eric | EVP, Chief Legal Officer | Aug 09 | Sale | 95.96 | 51,216 | 4,914,664 | 55,251 | Aug 11 09:01 PM | Guyer Charles Greg | EVP, Chief Technical Officer | Aug 08 | Sale | 96.56 | 6,205 | 599,155 | 42,168 | Aug 10 07:52 PM | Davis George Eric | EVP, Chief Legal Officer | Jul 08 | Sale | 90.00 | 7,398 | 665,820 | 58,941 | Jul 11 07:46 PM | Mueller Brian | EVP, Chief Financial Officer | Jul 08 | Sale | 89.50 | 7,337 | 656,662 | 30,726 | Jul 12 02:25 PM | Ajer Jeffrey Robert | EVP, Chief Commercial Officer | May 26 | Sale | 78.94 | 1,308 | 103,254 | 54,109 | May 31 09:29 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | May 06 | Option Exercise | 37.46 | 20,000 | 749,200 | 355,324 | May 09 09:29 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | May 06 | Sale | 81.00 | 20,000 | 1,620,000 | 335,324 | May 09 09:29 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | May 05 | Option Exercise | 37.46 | 10,000 | 374,600 | 345,324 | May 09 09:29 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | May 05 | Sale | 84.14 | 10,000 | 841,400 | 335,324 | May 09 09:29 PM | Mueller Brian | EVP, Chief Financial Officer | May 04 | Option Exercise | 37.46 | 11,800 | 442,028 | 48,401 | May 06 07:45 PM | Mueller Brian | EVP, Chief Financial Officer | May 04 | Sale | 84.50 | 11,800 | 997,100 | 38,639 | May 06 07:45 PM | Davis George Eric | EVP, Chief Legal Officer | May 02 | Option Exercise | 37.46 | 15,347 | 574,899 | 81,686 | May 04 12:01 PM | MEIER RICHARD A | Director | May 02 | Option Exercise | 37.46 | 8,500 | 318,410 | 107,892 | May 04 12:21 PM | Davis George Eric | EVP, Chief Legal Officer | May 02 | Sale | 80.38 | 15,347 | 1,233,592 | 66,339 | May 04 12:01 PM | MEIER RICHARD A | Director | May 02 | Sale | 82.09 | 3,878 | 318,345 | 104,014 | May 04 12:21 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 29 | Option Exercise | 37.46 | 5,000 | 187,300 | 339,983 | May 02 09:27 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 29 | Sale | 81.95 | 5,000 | 409,750 | 334,983 | May 02 09:27 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 28 | Option Exercise | 37.46 | 20,000 | 749,200 | 354,983 | May 02 09:27 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 28 | Sale | 83.79 | 20,000 | 1,675,800 | 334,983 | May 02 09:27 PM | Davis George Eric | EVP, Chief Legal Officer | Apr 25 | Option Exercise | 37.46 | 2,669 | 99,981 | 65,998 | Apr 27 08:40 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 18 | Option Exercise | 37.46 | 20,000 | 749,200 | 354,983 | Apr 20 08:20 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 18 | Sale | 81.91 | 20,000 | 1,638,200 | 334,983 | Apr 20 08:20 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 14 | Option Exercise | 37.46 | 10,000 | 374,600 | 344,983 | Apr 18 09:46 PM | LAWLIS V BRYAN | Director | Apr 14 | Option Exercise | 37.46 | 4,250 | 159,205 | 28,220 | Apr 18 08:22 PM | BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 14 | Sale | 83.66 | 10,000 | 836,600 | 334,983 | Apr 18 09:46 PM | LAWLIS V BRYAN | Director | Apr 14 | Sale | 83.66 | 4,250 | 355,555 | 23,970 | Apr 18 08:22 PM | Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Apr 13 | Sale | 82.47 | 1,180 | 97,315 | 55,077 | Apr 14 07:54 PM | Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 30 | Sale | 79.56 | 1,381 | 109,872 | 56,257 | Mar 31 09:28 PM |
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