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PRLD

Prelude Therapeutics Inc

Mar 10 • 04:00PM ET

3.60

+0.51 16.50 %

Healthcare • Biotechnology • USA • NASD

Today, 10:18 AMPrelude Therapeutics reports Q4 2025 non-GAAP EPS -0.20 on revenue $6.0M, misses EPS and revenue estimates, gains FDA IND clearance for its lead oncology program

Peers: BPMC RVMD ARGX ZLAB ALXO KURA CABA LYEL CRVS

| Held by: VTI VXF AVSC DCOR CHNA

Scroll to Statements

Index	-	P/E	-	EPS (ttm)	-1.35	Insider Own	63.29%	Shs Outstand	48.23M	Perf Week	36.88%
Market Cap	203.81M	Forward P/E	-	EPS next Y	-	Insider Trans	0.00%	Shs Float	20.79M	Perf Month	65.90%
Enterprise Value	118.39M	PEG	-	EPS next Q	-0.26	Inst Own	31.08%	Short Float	11.44%	Perf Quarter	146.58%
Income	-99.50M	P/S	16.79	EPS this Y	18.60%	Inst Trans	3.36%	Short Ratio	5.51	Perf Half Y	188.00%
Sales	12.14M	P/B	3.30	EPS next Y	-	ROA	-62.81%	Short Interest	2.38M	Perf YTD	24.14%
Book/sh	1.09	P/C	1.97	EPS next 5Y	-	ROE	-99.45%	52W High	4.22 -14.69%	Perf Year	437.31%
Cash/sh	1.82	P/FCF	-	EPS past 3/5Y	19.05% 0.15%	ROIC	-118.90%	52W Low	0.61 490.07%	Perf 3Y	-40.30%
Dividend Est.	-	EV/EBITDA	-	Sales past 3/5Y	- -	Gross Margin	85.91%	Volatility	14.16% 12.74%	Perf 5Y	-93.79%
Dividend TTM	-	EV/Sales	9.75	EPS Y/Y TTM	25.62%	Oper. Margin	-861.33%	ATR (14)	0.33	Perf 10Y	-
Dividend Ex-Date	-	Quick Ratio	1.99	Sales Y/Y TTM	73.43%	Profit Margin	-819.59%	RSI (14)	69.22	Recom	1.00
Dividend Gr. 3/5Y	- -	Current Ratio	1.99	EPS Q/Q	49.83%	SMA20	34.05%	Beta	0.84	Target Price	3.00
Payout	-	Debt/Eq	0.26	Sales Q/Q	41.00%	SMA50	47.33%	Rel Volume	0.98	Prev Close	3.09
Employees	79	LT Debt/Eq	0.22	Earnings	Mar 10 BMO	SMA200	134.31%	Avg Volume	431.81K	Price	3.60
IPO	Sep 25, 2020	Option/Short	Yes / Yes	EPS/Sales Surpr.	-566.67% -70.73%	Trades		Volume	424,631	Change	16.50%

Date	Action	Analyst	Rating Change	Price Target Change
Sep-19-24	Upgrade	H.C. Wainwright	Neutral → Buy	$5
Jun-20-24	Downgrade	Barclays	Equal Weight → Underweight	$3
Mar-13-24	Initiated	JMP Securities	Mkt Outperform	$7
Feb-20-24	Downgrade	H.C. Wainwright	Buy → Neutral	$5
Dec-19-23	Downgrade	Morgan Stanley	Equal-Weight → Underweight	$10 → $4
Nov-21-22	Downgrade	BofA Securities	Neutral → Underperform	$8 → $6
Sep-09-22	Downgrade	Morgan Stanley	Overweight → Equal-Weight	$19 → $11
Jul-29-22	Initiated	Jefferies	Buy	$9
Mar-15-22	Downgrade	BofA Securities	Buy → Neutral	$50 → $10
Feb-28-22	Downgrade	Barclays	Overweight → Equal Weight	$20 → $12
Oct-08-21	Upgrade	Morgan Stanley	Equal-Weight → Overweight
Jul-27-21	Upgrade	BofA Securities	Neutral → Buy	$60
Apr-26-21	Initiated	H.C. Wainwright	Buy	$62
Mar-09-21	Initiated	Barclays	Overweight	$80
Nov-20-20	Downgrade	BofA Securities	Buy → Neutral	$40 → $60
Oct-20-20	Initiated	Morgan Stanley	Equal-Weight	$34
Oct-20-20	Initiated	Goldman	Neutral	$37
Oct-20-20	Initiated	BofA Securities	Buy	$40

Show Previous Ratings

Today 07:01AM	Prelude Therapeutics Reports Full Year 2025 Financial Results and Provides Program Outlook for 2026 (GlobeNewswire) +16.50%
Feb-03-26 09:00AM	Prelude Therapeutics Receives FDA Clearance of Investigational New Drug Application (IND) for PRT12396, a Mutant-selective JAK2V617F Inhibitor (GlobeNewswire) +12.81%
Dec-06-25 11:00AM	Prelude Therapeutics Presents Data at the 2025 ASH Annual Meeting from its Myeloproliferative Neoplasm (MPN) Programs (GlobeNewswire)
Nov-24-25 08:10AM	Beat the Market the Zacks Way: Goldman Sachs, Micron, Prelude in Focus (Zacks) -16.17%
Nov-12-25 04:01PM	Prelude Therapeutics Inc (PRLD) Q3 2025 Earnings Call Highlights: Strategic Partnerships and ... (GuruFocus.com) +8.89%
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07:01AM	Prelude Therapeutics Reports Third Quarter 2025 Financial Results and Provides Corporate Update (GlobeNewswire)
Nov-04-25 07:05AM	Prelude Therapeutics Announces Strategic Business Update (GlobeNewswire) -55.78%
07:01AM	Prelude Therapeutics Announces Exclusive Option Agreement with Incyte to Advance Mutant Selective JAK2V617F JH2 Inhibitors (GlobeNewswire)
Nov-03-25 09:01AM	Prelude Therapeutics Announces Publication of Abstracts for Presentation at the American Society of Hematology 67th Annual Meeting (GlobeNewswire) +150.31%
Oct-17-25 07:30AM	Prelude Therapeutics Announces Appointment of Katina Dorton, J.D., MBA to its Board of Directors (GlobeNewswire) -9.16%
Aug-14-25 07:00AM	Prelude Therapeutics Reports Second Quarter 2025 Financial Results and Provides Corporate Update (GlobeNewswire)
Jun-02-25 07:30AM	Prelude Therapeutics to Participate in Upcoming Healthcare Conferences (GlobeNewswire)
May-06-25 04:05PM	Prelude Therapeutics Reports First Quarter 2025 Financial Results and Provides Corporate Update (GlobeNewswire)
May-01-25 07:30AM	Prelude Therapeutics to Participate in Citizens Life Sciences Conference (GlobeNewswire)
Apr-25-25 04:05PM	Prelude Announces Presentations at 2025 AACR Annual Meeting (GlobeNewswire)
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Apr-10-25 12:00PM	Prelude Therapeutics (PRLD) Upgraded to Buy: Here's What You Should Know (Zacks)
Mar-10-25 07:30AM	Prelude Therapeutics Reports Full Year 2024 Financial Results and Provides Program Outlook for 2025 (GlobeNewswire) -8.97%
Mar-05-25 07:30AM	Prelude Therapeutics to Participate in Barclays 27th Annual Global Healthcare Conference (GlobeNewswire)
Dec-12-24 07:35AM	Prelude Therapeutics presents first interim data from trial of PRT2527 (TipRanks) -5.83%
Dec-11-24 07:30AM	Prelude Therapeutics Presents Preliminary Results of Phase 1 Dose-escalation Study of PRT2527 as Monotherapy and in Combination with Zanubrutinib in Patients with Relapsed/Refractory Lymphoid Malignancies (GlobeNewswire)
Nov-27-24 09:35AM	After Plunging -31.47% in 4 Weeks, Here's Why the Trend Might Reverse for Prelude Therapeutics (PRLD) (Zacks) +7.14%
07:30AM	Prelude Therapeutics to Participate in Citizens JMP Securities Hematology and Oncology Summit (GlobeNewswire)
Nov-11-24 09:35AM	Down -39.13% in 4 Weeks, Here's Why You Should You Buy the Dip in Prelude Therapeutics (PRLD) (Zacks)
Nov-06-24 04:05PM	Prelude Therapeutics Reports Third Quarter 2024 Financial Results and Provides Corporate Update (GlobeNewswire)
Oct-27-24 01:15PM	Prelude Therapeutics price target lowered to $1 from $3 at Barclays (TipRanks)
Oct-24-24 07:30AM	Prelude Therapeutics Presents New Data from SMARCA Degrader Portfolio at the 36th EORTC-NCI-AACR Symposium (GlobeNewswire) -5.49%
Oct-09-24 07:30AM	Prelude Therapeutics Announces Publication of Abstracts for Presentation at the 36th EORTC-NCI-AACR Symposium (GlobeNewswire) -6.86%
Sep-13-24 10:00AM	Prelude Therapeutics' SMARCA2 Degrader PRT3789 Demonstrated Promising Initial Clinical Activity and Safety Profile in Phase 1 Trial (GlobeNewswire) -42.65%
Sep-09-24 07:30AM	Prelude Therapeutics Announces Publication of Abstract for Presentation at the European Society of Medical Oncology (ESMO) Congress 2024 (GlobeNewswire)
Aug-29-24 09:33AM	MSD discontinues two Phase III Keytruda trials (Clinical Trials Arena)
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Aug-12-24 07:01AM	Prelude Therapeutics Reports Second Quarter 2024 Financial Results and Provides Corporate Update (GlobeNewswire) -6.86%
Jul-10-24 06:53AM	Prelude and MSD partner to trial PRT3789 and Keytruda combination (Clinical Trials Arena)
Jul-09-24 07:30AM	Prelude Therapeutics Announces Clinical Collaboration with Merck to Evaluate PRT3789 in Combination with KEYTRUDA (pembrolizumab) in Patients with SMARCA4-Mutated Cancers (GlobeNewswire)
Jun-20-24 09:54AM	Spirit Aero downgraded, Skyworks upgraded: Wall Street's top analyst calls (The Fly)
Jun-03-24 07:01AM	Prelude Therapeutics to Participate in Upcoming Healthcare Conferences (GlobeNewswire)
May-09-24 07:01AM	Prelude Therapeutics to Participate in Citizens JMP Life Sciences Conference (GlobeNewswire) +13.37%
May-07-24 01:53PM	PRLD Stock Earnings: Prelude Therapeutics Beats EPS for Q1 2024 (InvestorPlace)
07:01AM	Prelude Therapeutics Reports First Quarter 2024 Financial Results and Provides Corporate Update (GlobeNewswire)
Apr-09-24 04:35PM	Prelude Highlights Continued Strength of Discovery Engine at 2024 AACR Annual Meeting (GlobeNewswire) +6.17%
Mar-05-24 04:45PM	Prelude Announces Acceptance of Multiple Preclinical Abstracts at the 2024 AACR Annual Meeting (GlobeNewswire)
Feb-29-24 04:05PM	Prelude Therapeutics to Participate in Barclays Global Healthcare Conference (GlobeNewswire) +6.74%
Feb-15-24 04:05PM	Prelude Therapeutics Reports Full Year 2023 Financial Results and Outlines Key Objectives for 2024 (GlobeNewswire) +33.05%
Dec-11-23 09:34AM	Prelude Therapeutics Announces $25 Million Private Placement (GlobeNewswire)
Nov-03-23 08:42AM	Q3 2023 Abcellera Biologics Inc Earnings Call (Thomson Reuters StreetEvents)
05:55AM	Prelude Therapeutics Inc (PRLD) Reports Q3 Financial Results and Strategic Pipeline Progress (GuruFocus.com)
Nov-01-23 04:10PM	Prelude Announces Strategic Pipeline Progress and Updates, including its Partnership with AbCellera, and Reports Third Quarter Financial Results (GlobeNewswire) +10.06% +18.82%
04:05PM	Prelude Therapeutics and AbCellera Enter Partnership to Develop First-in-Class Precision Antibody Drug Conjugates in Oncology (GlobeNewswire)
Oct-14-23 12:30PM	Prelude Announces Multiple Clinical and Preclinical Poster Presentations at AACR-NCI-EORTC International Conference (GlobeNewswire)
Oct-04-23 12:00PM	All You Need to Know About Prelude Therapeutics Incorporated (PRLD) Rating Upgrade to Buy (Zacks)
Aug-29-23 08:30AM	Prelude Therapeutics to Participate in Three Healthcare Investor Conferences in September (GlobeNewswire)
Aug-17-23 09:56AM	10 Healthcare Stocks with Insider Buying (Insider Monkey)
Aug-03-23 08:00AM	Prelude Therapeutics Announces Second Quarter 2023 Financial Results and Provides Corporate Update (GlobeNewswire)
Jul-10-23 08:13AM	We Think Prelude Therapeutics (NASDAQ:PRLD) Needs To Drive Business Growth Carefully (Simply Wall St.)
Jun-02-23 11:36AM	Insider Buying Alert: These 10 Stocks are Seeing Significant Insider Activity (Insider Monkey)
May-31-23 08:30AM	Prelude Therapeutics To Participate in Jefferies Healthcare Conference (GlobeNewswire)
May-28-23 08:11AM	Krishna Vaddi Buys Handful Of Shares In Prelude Therapeutics \ (Simply Wall St.)
May-18-23 07:00AM	Prelude Therapeutics Announces Pricing of Public Offering (GlobeNewswire) -11.43%
May-17-23 04:08PM	Prelude Therapeutics Announces Launch of Proposed Public Offering (GlobeNewswire)
May-08-23 08:30AM	Prelude Therapeutics Announces First Quarter 2023 Financial Results and Operations Update (GlobeNewswire)
Apr-27-23 08:30AM	Prelude Therapeutics to Participate in Three Healthcare Investor Conferences in May (GlobeNewswire)
Apr-11-23 08:30AM	Prelude Therapeutics to Present at American Association for Cancer Research 2023 Conference (GlobeNewswire) +9.01%
Apr-07-23 09:34AM	Prelude Therapeutics Incorporated (NASDAQ:PRLD) most popular amongst private equity firms who own 33% of the shares, institutions hold 24% (Simply Wall St.)
Mar-18-23 06:48PM	The 7 Worst Stocks to Buy Now (InvestorPlace)
Mar-16-23 12:06PM	Prelude (PRLD) Collaborates With BeiGene for Oncology Candidate (Zacks)
Mar-15-23 08:30AM	Prelude Therapeutics Reports Full Year 2022 Financial Results and Provides Corporate Update (GlobeNewswire) +8.49%
08:00AM	Prelude Therapeutics Announces Clinical Trial Collaboration with BeiGene to Evaluate PRT2527 in Combination with Zanubrutinib in Hematologic Cancers (GlobeNewswire)
Mar-01-23 08:30AM	Prelude Therapeutics To Participate in Barclays Global Healthcare Conference (GlobeNewswire)
Feb-09-23 09:05AM	Prelude Therapeutics To Participate in Two Upcoming Healthcare Investor Conferences (GlobeNewswire)
Jan-30-23 09:38AM	We're Not Very Worried About Prelude Therapeutics' (NASDAQ:PRLD) Cash Burn Rate (Simply Wall St.) -5.45%
Dec-24-22 07:05AM	Krishna Vaddi Is The Founder of Prelude Therapeutics Incorporated (NASDAQ:PRLD) And Just Spent US$98k On Shares (Simply Wall St.)
Nov-25-22 08:06AM	Prelude Therapeutics Incorporated (NASDAQ:PRLD) drops to US$317m and insiders who purchased earlier this year lose another US$17k (Simply Wall St.)
Nov-14-22 08:00AM	Prelude Therapeutics Announces Third Quarter 2022 Financial Results and Provides Business Update (GlobeNewswire) -8.82%
Oct-18-22 08:00AM	Prelude Therapeutics Receives FDA Clearance of IND for PRT3789, a Potent and Selective First-in-Class SMARCA2 Protein Degrader (GlobeNewswire)
Sep-06-22 08:00AM	Prelude Therapeutics To Participate in Upcoming HC Wainwright and Morgan Stanley Healthcare Conferences (GlobeNewswire) -5.48%
Aug-23-22 06:39AM	Prelude Therapeutics (NASDAQ:PRLD) Is In A Good Position To Deliver On Growth Plans (Simply Wall St.)
Aug-10-22 09:25AM	Is a Surprise Coming for Prelude Therapeutics (PRLD) This Earnings Season? (Zacks) +22.43%
Aug-09-22 08:00AM	Prelude Therapeutics Announces Second Quarter 2022 Financial Results and Business Update (GlobeNewswire)
Jul-05-22 09:22PM	'I wanted to build it here': Life sciences startup leaders talk about challenges of growing in Philadelphia (American City Business Journals) +7.18%
Jun-22-22 09:55AM	Wall Street Analysts Predict a 169% Upside in Prelude Therapeutics Incorporated (PRLD): Here's What You Should Know (Zacks)
May-25-22 06:35AM	Prelude Therapeutics Incorporated (NASDAQ:PRLD) drops to US$206m and insiders who purchased earlier this year lose another US$60k (Simply Wall St.)
May-10-22 08:00AM	Prelude Therapeutics Announces First Quarter 2022 Financial Results and Operations Update (GlobeNewswire) +9.50%
Mar-16-22 07:30AM	Prelude Therapeutics Reports Full Year 2021 Financial Results (GlobeNewswire) +8.39%
06:39AM	Companies Like Prelude Therapeutics (NASDAQ:PRLD) Are In A Position To Invest In Growth (Simply Wall St.)
Mar-11-22 08:00AM	Prelude Therapeutics to Participate at the Barclays 2022 Global Healthcare Conference (GlobeNewswire)
Mar-09-22 08:05AM	Prelude Therapeutics Provides Clinical Update and Announces Presentation of New Preclinical Data at the Upcoming 2022 AACR Annual Meeting (GlobeNewswire) +7.53%
08:00AM	Jane Huang, M.D., Joins Prelude Therapeutics as President and Chief Medical Officer (GlobeNewswire)
Feb-11-22 07:00AM	Prelude Therapeutics to Present at the 11th Annual SVB Leerink Global Healthcare Conference (GlobeNewswire)
Jan-04-22 07:00AM	Prelude Therapeutics to Present at the H.C. Wainwright BioConnect Virtual Conference (GlobeNewswire) -13.54%
Dec-24-21 12:38AM	Orbimed Advisors Llc Buys Adagio Therapeutics Inc, Zimmer Biomet Holdings Inc, Biogen Inc, ... (GuruFocus.com)
Dec-18-21 12:38AM	Orbimed Advisors Llc Buys Adagio Therapeutics Inc, Zimmer Biomet Holdings Inc, Biogen Inc, ... (GuruFocus.com)
Dec-16-21 09:41AM	In spite of Prelude Therapeutics Incorporated's recent pullback, insiders still gained about US$12k after buying earlier this year. (Simply Wall St.)
Dec-15-21 07:15PM	Prelude Therapeutics Inc (PRLD) EVP, Head of Chemistry Andrew Combs Bought $94,880 of Shares (GuruFocus.com) +11.86%
Dec-08-21 08:47AM	Prelude Therapeutics Inc. signs deal to move headquarters to Chestnut Run in Wilmington (American City Business Journals)
Nov-23-21 07:00AM	Prelude Therapeutics to Participate at the 4th Annual Evercore ISI HealthCONx Conference (GlobeNewswire) +5.51%
Nov-19-21 11:51AM	Notable Prelude Therapeutics Insider Trades $820K In Company Stock (Benzinga)
Nov-12-21 08:00AM	Prelude Therapeutics Announces Third Quarter 2021 Financial Results and Operations Update (GlobeNewswire)
Nov-08-21 09:00AM	Prelude Therapeutics Announces IND Clearance for PRT2527, a Highly Selective CDK9 Inhibitor (GlobeNewswire)
Oct-18-21 08:24PM	Morgan Stanley: Buy These 2 Stocks Before They Jump 80% (Or More) (TipRanks) +14.50%
Oct-07-21 03:12PM	Mid-Afternoon Market Update: Crude Oil Rises 1%; New Fortress Energy Shares Spike Higher (Benzinga) -39.75%
12:55PM	Why Did Prelude Therapeutics Stock Tumble To 52-Week Low Today? (Benzinga)

Prelude Therapeutics, Inc. is a clinical-stage oncology company, which engages in the development of novel precision cancer medicines. It also focuses on the design and development of small molecule agents for cancer medicines. The company was founded by Krishna Vaddi in 2016 and is headquartered in Wilmington, DE.

Insider Trading	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
Combs Andrew	Chief Chemistry Officer	Mar 25 '25	Buy	0.69	100,000	69,250	480,123	Mar 27 04:40 PM
Vaddi Krishna	CEO	Mar 25 '25	Buy	0.69	675,000	467,438	1,999,296	Mar 27 04:37 PM
Vaddi Krishna	CEO	Mar 21 '25	Buy	0.73	15,000	10,959	1,324,296	Mar 24 05:03 PM
Vaddi Krishna	CEO	Mar 20 '25	Buy	0.73	5,416	3,950	1,309,296	Mar 24 05:03 PM
Vaddi Krishna	CEO	Mar 14 '25	Buy	0.75	29,999	22,631	1,294,774	Mar 18 04:27 PM
Vaddi Krishna	CEO	Mar 17 '25	Buy	0.75	9,106	6,829	1,303,880	Mar 18 04:27 PM
Vaddi Krishna	CEO	Mar 13 '25	Buy	0.72	50,000	35,820	1,264,775	Mar 14 08:02 AM
Vaddi Krishna	CEO	Mar 12 '25	Buy	0.71	47,500	33,744	1,214,775	Mar 14 08:02 AM

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PRLD

Prelude Therapeutics Inc

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