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AKRO

Akero Therapeutics Inc

Apr 25 • 04:00PM ET

41.00

Dollar change +0.01
Percentage change 0.02	%

Healthcare • Biotechnology • USA • NASD

Peers: MDGL ARWR HALO GNFT ALLK VKTX NBIX ENTA GALT SLDB

| Held by: VTI IWM VXF XBI IWN IBB VTWO SCHA VHT SURI

Scroll to Statements

Index	RUT	P/E	-	EPS (ttm)	-3.75	Insider Own	11.19%	Shs Outstand	72.38M	Perf Week	8.96%
Market Cap	3.26B	Forward P/E	-	EPS next Y	-4.70	Insider Trans	-2.93%	Shs Float	70.71M	Perf Month	-5.29%
Income	-252.06M	PEG	-	EPS next Q	-0.97	Inst Own	87.36%	Short Float	8.92%	Perf Quarter	56.61%
Sales	0.00M	P/S	-	EPS this Y	-14.49%	Inst Trans	-1.32%	Short Ratio	4.37	Perf Half Y	38.56%
Book/sh	10.36	P/B	3.96	EPS next Y	-9.37%	ROA	-35.85%	Short Interest	6.31M	Perf Year	95.24%
Cash/sh	9.33	P/C	4.39	EPS next 5Y	-8.19%	ROE	-39.22%	52W Range	17.86 - 58.40	Perf YTD	47.38%
Dividend Est.	-	P/FCF	-	EPS past 5Y	-5.28%	ROI	-32.07%	52W High	-29.79%	Beta	-0.11
Dividend TTM	-	Quick Ratio	19.38	Sales past 5Y	0.00%	Gross Margin	-	52W Low	129.56%	ATR (14)	2.51
Dividend Ex-Date	-	Current Ratio	19.38	EPS Y/Y TTM	-31.37%	Oper. Margin	-	RSI (14)	53.64	Volatility	4.66% 7.39%
Employees	63	Debt/Eq	0.05	Sales Y/Y TTM	-	Profit Margin	-	Recom	1.00	Target Price	77.64
Option/Short	Yes / Yes	LT Debt/Eq	0.05	EPS Q/Q	-0.17%	Payout	-	Rel Volume	0.66	Prev Close	40.99
Sales Surprise	-	EPS Surprise	14.75%	Sales Q/Q	-	Earnings	Feb 28 BMO	Avg Volume	1.44M	Price	41.00
SMA20	6.93%	SMA50	-4.75%	SMA200	22.39%	Trades		Volume	959,230	Change	0.02%

Date	Action	Analyst	Rating Change	Price Target Change
Jan-30-25	Upgrade	BofA Securities	Neutral → Buy	$35 → $63
Jan-27-25	Reiterated	H.C. Wainwright	Buy	$50 → $72
Nov-18-24	Initiated	Citigroup	Buy	$65
Apr-22-24	Resumed	BofA Securities	Neutral	$30
Sep-19-23	Initiated	Cantor Fitzgerald	Overweight	$69
Aug-28-23	Initiated	UBS	Buy	$83
Jan-27-23	Upgrade	Morgan Stanley	Equal-Weight → Overweight	$40 → $65
Sep-14-22	Upgrade	Evercore ISI	In-line → Outperform	$10 → $50
Oct-19-21	Downgrade	Morgan Stanley	Overweight → Equal-Weight	$27
Sep-10-21	Initiated	BofA Securities	Buy	$40
Feb-26-21	Initiated	Guggenheim	Buy	$54
Sep-10-20	Initiated	Morgan Stanley	Overweight	$70
Jul-20-20	Reiterated	H.C. Wainwright	Buy	$45 → $62
Jul-07-20	Initiated	Chardan Capital Markets	Buy	$79
Jul-01-20	Reiterated	H.C. Wainwright	Buy	$33 → $45
Mar-02-20	Initiated	H.C. Wainwright	Buy	$33
Feb-10-20	Initiated	Canaccord Genuity	Buy	$36
Jul-15-19	Initiated	ROTH Capital	Buy	$34
Jul-15-19	Initiated	JP Morgan	Overweight	$28
Jul-15-19	Initiated	Jefferies	Buy	$28

Show Previous Ratings

Apr-18-25 04:46AM	89bio: A Buy With Strong Market Opportunity In MASH And SHTG (Seeking Alpha)
Apr-17-25 10:28AM	89bio: Primary Asset Targeting 2 Potential Indications And Is In Late-Stage Development (Seeking Alpha)
Apr-06-25 01:47PM	Akero Therapeutics: Cirrhosis Reversal Data Derisks The Stock (Seeking Alpha)
Mar-24-25 09:13AM	Notice to Long-Term Shareholders of Akero Therapeutics, Inc. (Nasdaq: AKRO); Driven Brands Holdings, Inc. (Nasdaq: DRVN); Integra Lifesciences Holdings Corporation (Nasdaq: IART); and Kyverna Therapeutics, Inc. (Nasdaq: KYTX): Grabar Law Office is Investigating Claims on Your Behalf (GlobeNewswire)
Mar-02-25 09:34AM	Why Akero Therapeutics, Inc. (AKRO) is Skyrocketing So Far in 2025 (Insider Monkey)
07:00AM	Loading…
Feb-28-25 07:00AM	Akero Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results and Provides Business Update (GlobeNewswire)
Feb-27-25 01:23PM	Is Akero Therapeutics Inc. (AKRO) the Best Performing Mid Cap Stock to Buy According to Analysts? (Insider Monkey)
Feb-23-25 03:18PM	Akero Therapeutics, Inc. (AKRO): the Best Performing Pharma Stock So Far in 2025 (Insider Monkey)
Feb-20-25 08:42AM	Grabar Law Office is Investigating Claims on Behalf of Long-Term Shareholders of Akero Therapeutics, Inc. (NASDAQ: AKRO); Crocs, Inc. (NASDAQ: CROX); Extreme Networks, Inc. (NASDAQ: EXTR); and Domino's Pizza Corp. (NASDAQ: DPZ) (GlobeNewswire)
Feb-19-25 02:45PM	Akero Therapeutics, Inc. (AKRO): the Best Performing Healthcare Stock So Far in 2025 (Insider Monkey)
Feb-03-25 07:25PM	Why Akero Therapeutics Inc (AKRO) Is Skyrocketing So Far In 2025 (Insider Monkey)
12:28PM	Akero Therapeutics Inc. (AKRO): Among The Stocks That Started The Year On A High (Insider Monkey)
Feb-02-25 06:21PM	This Stock Just Doubled in 1 Day -- Is It Still a Buy? (Motley Fool)
04:35PM	Why Akero Therapeutics (AKRO) Is Among the Best Booming Stocks to Invest in Now? (Insider Monkey)
Jan-30-25 04:05PM	Akero Therapeutics Announces Closing of Upsized Public Offering of Common Stock and Pre-Funded Warrants and Full Exercise of Underwriters' Option to Purchase Additional Shares (GlobeNewswire)
05:39AM	Loading…
Jan-29-25 05:39AM	BioAge drops obesity drug; Akero, 89bio cash in on MASH data (BioPharma Dive)
Jan-28-25 09:30PM	Akero Therapeutics Announces Pricing of Upsized Public Offering of Common Stock and Pre-Funded Warrants (GlobeNewswire)
11:14AM	Akeros cirrhosis treatment shows promise in Phase IIb study (Clinical Trials Arena)
08:40AM	Why Akero Therapeutics Inc. (AKRO) Surged on Monday (Insider Monkey)
Jan-27-25 04:24PM	Akero Therapeutics Stock Nearly Doubles Pulling 89bio Higher On Positive MASH Study (Investor's Business Daily) +97.52%
04:01PM	Akero Therapeutics Announces Proposed Public Offering of Common Stock (GlobeNewswire)
12:13PM	Akero's Stock Skyrockets 112% After Game-Changing Liver Drug Data (GuruFocus.com)
11:27AM	Akero Therapeutics Stock Doubles on Liver Disease Drug Trial Results (Investopedia)
11:10AM	Akero Therapeutics Shares Surge 106% as Phase 2b Study Shows Significant Cirrhosis Reversal (GuruFocus.com)
10:57AM	Akero Therapeutics Stock Doubles on Liver Data (Barrons.com)
09:01AM	Liver Disease-Focused Akero Therapeutics Stock Soars Over 100% On Monday - Here's Why (Benzinga)
06:30AM	Akero Therapeutics Reports Preliminary Topline Results Showing Statistically Significant Reversal of Compensated Cirrhosis (F4) Due to MASH by Both Completer and ITT Analyses at Week 96 in Phase 2b SYMMETRY Study (GlobeNewswire)
Jan-24-25 04:05PM	Akero Therapeutics to Present Preliminary Topline Week 96 Results from Phase 2b SYMMETRY Study Investigating Efruxifermin in Patients with Compensated Cirrhosis (F4) Due to MASH (GlobeNewswire)
Jan-13-25 07:00AM	Akero Therapeutics Completes Enrollment of the Double-Blind Portion of the Phase 3 SYNCHRONY Real-World Study Evaluating Efruxifermin (EFX) in Patients with Non-Invasively Diagnosed MASH or MASLD (GlobeNewswire) -8.90%
Jan-09-25 12:18PM	Notice to Akero Therapeutics, Inc. (AKRO) Shareholders: Grabar Law Office Is Investigating Claims on Your Behalf (Newsfile)
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Jan-07-25 07:00AM	Akero Therapeutics to Present at the 43rd Annual J.P. Morgan Healthcare Conference (GlobeNewswire)
Dec-04-24 12:59PM	Why Is Akero Therapeutics, Inc. (AKRO) Among the Best Small-Cap Biotech Stocks With Massive Potential According to Hedge Funds? (Insider Monkey)
Nov-26-24 07:00AM	Akero Therapeutics to Present at the 7th Annual Evercore ISI HealthCONx Conference (GlobeNewswire)
Nov-15-24 11:00AM	Akero Therapeutics to Showcase New Analyses of Phase 2b HARMONY Study in Presentations at 75th Annual AASLD The Liver Meeting 2024 (GlobeNewswire) -5.61%
Nov-13-24 04:05PM	Akero Therapeutics to Present at the Jefferies London Healthcare Conference (GlobeNewswire)
Nov-12-24 11:00PM	Akero Therapeutics Advances in MASH Treatment Trials (TipRanks)
Nov-08-24 07:00AM	Akero Therapeutics Reports Third Quarter 2024 Financial Results and Provides Business Update (GlobeNewswire)
Nov-02-24 12:00PM	Madrigal, 89Bio jump after Novos semaglutide shows promise in MASH (TipRanks)
Nov-01-24 04:06AM	Notice to Akero Therapeutics, Inc. (AKRO) Shareholders: Grabar Law Office Is Investigating Claims of Misconduct on Your Behalf (Newsfile)
Oct-30-24 06:00AM	Axonis Therapeutics Announces $115 Million Series A Financing (PR Newswire)
Oct-21-24 07:00AM	Akero Therapeutics to Present Data Reinforcing the Efficacy of Efruxifermin at the 75th Annual AASLD The Liver Meeting 2024 (GlobeNewswire)
Oct-17-24 03:02PM	State Street Corp's Strategic Reduction in Akero Therapeutics Inc Shares (GuruFocus.com)
Oct-16-24 08:44AM	Akero Therapeutics (AKRO): Leading the Charge in MASH Treatment with Efruxifermin (Insider Monkey)
Oct-15-24 06:10PM	Akero Therapeutics, Inc. (AKRO): A Visionary Small-Cap Stock Pick by Hedge Funds (Insider Monkey)
Sep-30-24 07:00AM	Akero Therapeutics to Present at the H.C. Wainwright 8th Annual MASH Virtual Conference (GlobeNewswire)
Sep-12-24 01:12AM	Wellington Management Group LLP's Strategic Acquisition in Akero Therapeutics Inc (GuruFocus.com)
Sep-09-24 07:00AM	Akero Therapeutics Announces First Patient Dosed in Phase 3 SYNCHRONY Outcomes Study of Efruxifermin in Patients with Compensated Cirrhosis Due to MASH (GlobeNewswire)
Sep-05-24 12:02AM	Akero Therapeutics, Inc. (AKRO): This Small-Cap Healthcare Stock Is A Good Buy Right Now (Insider Monkey)
Sep-02-24 05:22PM	10 Best Small-Cap Healthcare Stocks To Buy Now (Insider Monkey)
Aug-28-24 04:05PM	Akero Therapeutics to Present at the Morgan Stanley 22nd Annual Global Healthcare Conference (GlobeNewswire)
Aug-09-24 02:53PM	AKRO Stock Earnings: Akero Therapeutics Beats EPS for Q2 2024 (InvestorPlace)
07:00AM	Akero Therapeutics Reports Second Quarter 2024 Financial Results and Provides Business Update (GlobeNewswire)
Jul-16-24 12:00PM	Akero Therapeutics (AKRO) Moves to Buy: Rationale Behind the Upgrade (Zacks)
Jun-28-24 10:40AM	Lowey Dannenberg, P.C. is Investigating Akero Therapeutics, Inc. ( Akero ) (NASDAQ: AKRO) for Potential Violations of the Federal Securities Laws and Encourages Investors with Losses to Contact the Firm (GlobeNewswire)
Jun-24-24 01:04PM	Lowey Dannenberg, P.C. is Investigating Akero Therapeutics, Inc. ( Akero ) (NASDAQ: AKRO) for Potential Violations of the Federal Securities Laws and Encourages Investors with Losses to Contact the Firm (GlobeNewswire)
Jun-21-24 11:06AM	Lowey Dannenberg, P.C. is Investigating Akero Therapeutics, Inc. ( Akero ) (NASDAQ: AKRO) for Potential Violations of the Federal Securities Laws and Encourages Investors with Losses to Contact the Firm (GlobeNewswire) +6.52%
Jun-19-24 02:45PM	Lowey Dannenberg, P.C. is Investigating Akero Therapeutics, Inc. ( Akero ) (NASDAQ: AKRO) for Potential Violations of the Federal Securities Laws and Encourages Investors with Losses to Contact the Firm (GlobeNewswire)
Jun-17-24 10:23AM	Lowey Dannenberg, P.C. is Investigating Akero Therapeutics, Inc. ( Akero ) (NASDAQ: AKRO) for Potential Violations of the Federal Securities Laws and Encourages Investors with Losses to Contact the Firm (GlobeNewswire)
Jun-13-24 03:57PM	Lowey Dannenberg, P.C. is Investigating Akero Therapeutics, Inc. ( Akero ) (NASDAQ: AKRO) for Potential Violations of the Federal Securities Laws and Encourages Investors with Losses to Contact the Firm (GlobeNewswire)
09:00AM	The Lustgarten Foundation Appoints Two New Board Members (PR Newswire)
Jun-11-24 07:00AM	Akero Therapeutics Announces Initiation of Phase 3 SYNCHRONY Outcomes Trial of Efruxifermin in Patients with Compensated Cirrhosis (F4) Due to MASH (GlobeNewswire)
Jun-10-24 10:14AM	Lowey Dannenberg, P.C. is Investigating Akero Therapeutics, Inc. ( Akero ) (NASDAQ: AKRO) for Potential Violations of the Federal Securities Laws and Encourages Investors with Losses to Contact the Firm (GlobeNewswire)
Jun-08-24 08:15AM	Akero Therapeutics Presents Poster and Late-breaking Oral Presentation on EFX at the EASL Congress 2024 (GlobeNewswire)
Jun-06-24 10:39AM	Lowey Dannenberg, P.C. is Investigating Akero Therapeutics, Inc. ( Akero ) (NASDAQ: AKRO) for Potential Violations of the Federal Securities Laws and Encourages Investors with Losses to Contact the Firm (GlobeNewswire)
Jun-03-24 09:57AM	Lowey Dannenberg, P.C. is Investigating Akero Therapeutics, Inc. ( Akero ) (NASDAQ: AKRO) for Potential Violations of the Federal Securities Laws and Encourages Investors with Losses to Contact the Firm (GlobeNewswire)
May-30-24 09:16PM	Lowey Dannenberg, P.C. is Investigating Akero Therapeutics, Inc. ( Akero ) (NASDAQ: AKRO) for Potential Violations of the Federal Securities Laws and Encourages Investors with Losses to Contact the Firm (GlobeNewswire)
May-29-24 07:00AM	Akero Therapeutics to Present at the Jefferies Global Healthcare Conference (GlobeNewswire)
May-23-24 02:12PM	Lowey Dannenberg, P.C. is Investigating Akero Therapeutics, Inc. ( Akero ) (NASDAQ: AKRO) for Potential Violations of the Federal Securities Laws and Encourages Investors with Losses to Contact the Firm (GlobeNewswire) -7.76%
May-15-24 09:26AM	Evercore ISI Adjusts Price Target on Akero Therapeutics to $38 From $50, Maintains Outperform Rating (MT Newswires)
May-12-24 09:01PM	Akero Therapeutics Inc (AKRO) Q1 2024 Earnings: Misses Analyst Forecast Amid Continued ... (GuruFocus.com)
May-10-24 01:54PM	AKRO Stock Earnings: Akero Therapeutics Beats EPS for Q1 2024 (InvestorPlace) -5.53%
07:45AM	Akero Therapeutics' Q1 Net Loss Widens; Cash Expected to Fund Operations Into H2 2027 (MT Newswires)
07:00AM	Akero Therapeutics Reports First Quarter 2024 Financial Results and Provides Business Update (GlobeNewswire)
May-08-24 07:00AM	Akero Therapeutics to Present at the BofA Securities 2024 Health Care Conference (GlobeNewswire)
Apr-30-24 08:00AM	Akero Therapeutics Appoints Scott Gangloff as Chief Technology Officer (GlobeNewswire)
Apr-22-24 06:00AM	6 Stocks Positioned to Soar as Investors Focus on MASH (News Direct)
Mar-20-24 01:32PM	Billionaire Steve Cohen and Insiders Are Buying These 10 Stocks (Insider Monkey)
12:58PM	AKRO Investor Notice: Abraham, Fruchter & Twersky, LLP Investigating Claims on Behalf of Investors of Akero Therapeutics (NASDAQ:AKRO) (GlobeNewswire)
Mar-18-24 07:00AM	Ozempic Cant Do It AllA Potential New Blockbuster Is a Reminder of That (The Wall Street Journal)
Mar-08-24 04:02PM	Akero Therapeutics Announces Closing of Public Offering of Common Stock and Full Exercise of Underwriters' Option to Purchase Additional Shares (GlobeNewswire) -6.00%
Mar-07-24 04:01PM	Akero Therapeutics Announces Publication of Phase 2b SYMMETRY Cohort D Study in Clinical Gastroenterology and Hepatology (GlobeNewswire)
Mar-06-24 11:54PM	President and CEO Andrew Cheng Sells 75,000 Shares of Akero Therapeutics Inc (AKRO) (GuruFocus.com)
Mar-05-24 09:13PM	Akero Therapeutics Announces Pricing of Public Offering of Common Stock (GlobeNewswire)
02:12PM	Akero (AKRO) Up on Upbeat Week 96 Data From Liver Disease Study (Zacks)
Mar-04-24 04:21PM	Akero Therapeutics Announces Proposed Public Offering of Common Stock (GlobeNewswire) +11.72%
04:04PM	Why Akero Rocketed And Pulled Rival 89bio Higher On Results In Liver Disease Treatment (Investor's Business Daily)
12:30PM	Data Suggests Makers of Fatty Liver Treatments Wont Be Displaced by Obesity Drugs (The Wall Street Journal)
11:59AM	Akero Therapeutics Bats Back Challenge From Lilly in Emerging Liver-Drug Market (Barrons.com)
09:23AM	Akero Rockets 27%, Prodding Rival 89bio Higher, On Promising Liver Disease Treatment (Investor's Business Daily)
06:22AM	UPDATE 1-Akero's lead drug helps reduce scarring in fatty liver disease patients (Reuters)
06:09AM	Akero's lead drug helps improve scarring in fatty liver disease patients (Reuters)
06:00AM	Akero Therapeutics Reports Statistically Significant Histological Improvements at Week 96 in Phase 2b HARMONY Study (GlobeNewswire)
04:00AM	Akero strengthens MASH drugs case with new study data (BioPharma Dive)
Mar-01-24 09:55AM	Wall Street Analysts Predict a 58.87% Upside in Akero Therapeutics, Inc. (AKRO): Here's What You Should Know (Zacks)
Feb-29-24 08:00AM	Akero Therapeutics to Present Topline Week 96 Results from Phase 2b HARMONY Study Investigating Efruxifermin in Patients with Pre-Cirrhotic MASH (GlobeNewswire)
07:00AM	Akero Therapeutics Reports Fourth Quarter and Full Year 2023 Financial Results and Provides Business Update (GlobeNewswire)
Feb-06-24 10:48AM	Cramer's Stop Trading: Akero Therapeutics (CNBC TV) -12.25%
Feb-05-24 09:55AM	Here's Why Akero Therapeutics, Inc. (AKRO) Is a Great 'Buy the Bottom' Stock Now (Zacks)
Jan-30-24 09:40AM	Is Akero Therapeutics (AKRO) Stock Outpacing Its Medical Peers This Year? (Zacks) -5.22%
Jan-03-24 08:15AM	Akero Therapeutics to Present at the 42nd Annual J.P. Morgan Healthcare Conference (GlobeNewswire) -5.41%

Akero Therapeutics, Inc. is a clinical-stage company, which engages in the development of treatments for patients with serious metabolic diseases. The firm's lead product candidate, efruxifermin (EFX), is an analog of fibroblast growth factor 21, or FGF21, which is an endogenously expressed hormone that protects against cellular stress and regulates metabolism of lipids, carbohydrates, and proteins throughout the body. The company was founded by Jonathan Young and Timothy Rolph in January 2017 and is headquartered in South San Francisco, CA.

Insider Trading	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
Yale Catriona	Chief Development Officer	Apr 15 '25	Option Exercise	21.10	9,073	191,440	104,107	Apr 16 06:00 PM
Yale Catriona	Chief Development Officer	Apr 15 '25	Sale	37.91	9,073	343,962	95,034	Apr 16 06:00 PM
Cheng Andrew	President and CEO	Apr 10 '25	Sale	35.23	30,000	1,056,780	624,324	Apr 11 06:00 PM
Rolph Timothy	Chief Scientific Officer	Apr 07 '25	Option Exercise	21.10	6,250	131,875	175,971	Apr 10 06:00 PM
Rolph Timothy	Chief Scientific Officer	Apr 07 '25	Sale	35.88	6,250	224,262	169,721	Apr 10 06:00 PM
PATRICK D LAMY	Officer	Apr 07 '25	Proposed Sale	36.73	8,000	293,840		Apr 07 04:24 PM
Graham G. Walmsley	Director	Mar 25 '25	Buy	44.75	91,309	4,085,804	1,091,309	Mar 27 07:42 PM
Graham G. Walmsley	Director	Mar 26 '25	Buy	43.01	58,691	2,524,417	1,150,000	Mar 27 07:42 PM
Graham G. Walmsley	Director	Mar 27 '25	Buy	43.55	50,000	2,177,700	1,200,000	Mar 27 07:42 PM
Yale Catriona	Chief Development Officer	Mar 17 '25	Option Exercise	21.10	10,000	211,000	105,034	Mar 18 05:30 PM
Yale Catriona	Chief Development Officer	Mar 17 '25	Sale	44.76	10,000	447,605	95,034	Mar 18 05:30 PM
Cheng Andrew	President and CEO	Mar 12 '25	Sale	44.88	1,738	78,001	654,324	Mar 14 09:18 PM
Young Jonathan	Chief Operating Officer	Mar 12 '25	Sale	44.88	607	27,242	200,540	Mar 14 08:33 PM
Yale Catriona	Chief Development Officer	Mar 12 '25	Sale	44.88	614	27,556	95,034	Mar 14 08:30 PM
White William Richard	Chief Financial Officer	Mar 12 '25	Sale	44.88	676	30,339	61,959	Mar 14 08:24 PM
Rolph Timothy	Chief Scientific Officer	Mar 12 '25	Sale	44.88	516	23,158	169,721	Mar 14 08:18 PM
Cheng Andrew	President and CEO	Mar 10 '25	Sale	41.77	30,000	1,253,069	656,062	Mar 12 06:00 PM
Rolph Timothy	Chief Scientific Officer	Mar 05 '25	Option Exercise	21.10	12,500	263,750	182,737	Mar 07 05:30 PM
Rolph Timothy	Chief Scientific Officer	Mar 05 '25	Sale	44.53	12,500	556,590	170,237	Mar 07 05:30 PM
Young Jonathan	Chief Operating Officer	Mar 04 '25	Sale	44.86	50,000	2,243,213	201,147	Mar 05 06:56 PM
Lamy Patrick	Senior VP, Commercial Strategy	Mar 03 '25	Option Exercise	19.87	1,000	19,870	34,492	Mar 05 06:55 PM
Lamy Patrick	Senior VP, Commercial Strategy	Mar 03 '25	Sale	48.09	1,000	48,090	33,492	Mar 05 06:55 PM
Yale Catriona	Chief Development Officer	Feb 18 '25	Option Exercise	21.10	10,000	211,000	105,648	Feb 21 05:31 PM
Yale Catriona	Chief Development Officer	Feb 18 '25	Sale	49.87	10,000	498,660	95,648	Feb 21 05:31 PM
Cheng Andrew	President and CEO	Feb 10 '25	Sale	52.73	30,000	1,581,994	686,062	Feb 11 09:30 PM
Graham G. Walmsley	Director	Jan 30 '25	Buy	48.00	200,000	9,600,000	1,000,000	Feb 07 07:54 PM
Rolph Timothy	Chief Scientific Officer	Feb 05 '25	Option Exercise	21.10	18,750	395,625	188,987	Feb 07 06:05 PM
Rolph Timothy	Chief Scientific Officer	Feb 05 '25	Sale	56.51	18,750	1,059,630	170,237	Feb 07 06:05 PM
Young Jonathan	Chief Operating Officer	Feb 03 '25	Sale	53.81	10,000	538,061	251,147	Feb 05 09:03 AM
Yale Catriona	Chief Development Officer	Jan 27 '25	Option Exercise	10.48	53,590	561,807	149,238	Jan 31 09:14 AM
Yale Catriona	Chief Development Officer	Jan 27 '25	Sale	56.25	53,590	3,014,216	95,648	Jan 31 09:14 AM
Yale Catriona	Chief Development Officer	Jan 27 '25	Option Exercise	21.10	49,074	1,035,461	144,722	Jan 31 09:14 AM
Yale Catriona	Chief Development Officer	Jan 27 '25	Sale	55.72	49,074	2,734,212	95,648	Jan 31 09:14 AM
Rolph Timothy	Chief Scientific Officer	Jan 27 '25	Option Exercise	20.51	31,250	640,942	201,487	Jan 29 08:43 PM
Rolph Timothy	Chief Scientific Officer	Jan 27 '25	Sale	55.77	31,250	1,742,958	170,237	Jan 29 08:43 PM
Lamy Patrick	Senior VP, Commercial Strategy	Jan 27 '25	Option Exercise	19.87	4,000	79,480	38,492	Jan 29 08:43 PM
Lamy Patrick	Senior VP, Commercial Strategy	Jan 27 '25	Sale	57.03	5,000	285,150	33,492	Jan 29 08:43 PM
Cheng Andrew	President and CEO	Jan 27 '25	Sale	54.90	30,000	1,646,978	716,062	Jan 29 08:43 PM
Young Jonathan	Chief Operating Officer	Jan 24 '25	Option Exercise	6.36	43,064	274,059	261,147	Jan 27 06:08 PM
Cheng Andrew	President and CEO	Jan 23 '25	Option Exercise	0.61	50,000	30,750	746,062	Jan 27 06:07 PM
CATRIONA YALE	Officer	Jan 27 '25	Proposed Sale	26.18	53,591	1,403,012		Jan 27 04:24 PM
CATRIONA YALE	Officer	Jan 27 '25	Proposed Sale	26.18	69,073	1,808,331		Jan 27 04:24 PM
PATRICK D LAMY	Officer	Jan 27 '25	Proposed Sale	26.18	6,000	157,080		Jan 27 04:23 PM
Andrew Cheng	President, CEO and Director	Jan 27 '25	Proposed Sale	57.03	120,000	6,843,600		Jan 27 04:19 PM
Timothy Rolph	Officer	Jan 27 '25	Proposed Sale	57.03	68,750	3,920,813		Jan 27 04:06 PM
Young Jonathan	Chief Operating Officer	Jan 02 '25	Sale	28.03	10,000	280,330	218,083	Jan 06 02:08 PM
Jonathan Young	Officer	Jan 02 '25	Proposed Sale	27.82	70,000	1,947,400		Jan 02 04:29 PM
Lamy Patrick	Senior VP, Commercial Strategy	Dec 16 '24	Sale	29.13	1,000	29,130	34,258	Dec 18 09:03 PM
Yale Catriona	Chief Development Officer	Dec 16 '24	Option Exercise	21.10	9,074	191,461	104,722	Dec 18 09:01 PM
Yale Catriona	Chief Development Officer	Dec 16 '24	Sale	29.11	9,074	264,117	95,648	Dec 18 09:01 PM
Rolph Timothy	Chief Scientific Officer	Dec 17 '24	Option Exercise	19.87	3,800	75,506	182,137	Dec 18 08:52 PM
Rolph Timothy	Chief Scientific Officer	Dec 17 '24	Sale	31.10	3,800	118,172	178,337	Dec 18 08:52 PM
PATRICK D LAMY	Officer	Dec 16 '24	Proposed Sale	28.89	1,000	28,890		Dec 16 04:30 PM
Rolph Timothy	Chief Scientific Officer	Dec 10 '24	Option Exercise	19.87	2,450	48,682	180,787	Dec 12 08:44 PM
Rolph Timothy	Chief Scientific Officer	Dec 10 '24	Sale	30.91	4,818	148,934	178,337	Dec 12 08:44 PM
Young Jonathan	Chief Operating Officer	Dec 10 '24	Sale	30.79	2,503	77,067	203,783	Dec 12 08:38 PM
Lamy Patrick	Senior VP, Commercial Strategy	Dec 10 '24	Sale	30.79	925	28,481	17,858	Dec 12 08:29 PM
Yale Catriona	Chief Development Officer	Dec 10 '24	Sale	30.79	2,810	86,520	71,348	Dec 12 08:28 PM
White William Richard	Chief Financial Officer	Dec 10 '24	Sale	30.79	2,817	86,735	38,335	Dec 12 08:26 PM
Cheng Andrew	President and CEO	Dec 10 '24	Sale	30.79	7,855	241,855	597,562	Dec 12 08:24 PM
Timothy Rolph	Officer	Dec 10 '24	Proposed Sale	30.79	25,000	769,750		Dec 10 04:25 PM
Cheng Andrew	President and CEO	Dec 02 '24	Option Exercise	21.10	25,000	527,500	630,417	Dec 04 07:36 PM
Cheng Andrew	President and CEO	Dec 02 '24	Sale	32.09	25,000	802,250	605,417	Dec 04 07:36 PM
Young Jonathan	Chief Operating Officer	Dec 02 '24	Sale	32.13	10,000	321,310	206,286	Dec 04 07:34 PM
Yale Catriona	Chief Development Officer	Nov 15 '24	Option Exercise	21.10	9,061	191,187	83,219	Nov 19 09:57 PM
Yale Catriona	Chief Development Officer	Nov 15 '24	Sale	27.73	9,061	251,274	74,158	Nov 19 09:57 PM
Yale Catriona	Chief Development Officer	Nov 06 '24	Option Exercise	0.61	10,000	6,150	84,158	Nov 08 05:06 PM
Yale Catriona	Chief Development Officer	Nov 06 '24	Sale	35.19	10,000	351,890	74,158	Nov 08 05:06 PM
CATRIONA YALE	Officer	Nov 06 '24	Proposed Sale	32.74	10,000	327,400		Nov 06 05:01 PM
Young Jonathan	Chief Operating Officer	Nov 01 '24	Option Exercise	21.09	40,716	858,700	267,002	Nov 05 09:04 AM
Young Jonathan	Chief Operating Officer	Nov 01 '24	Sale	31.57	50,716	1,601,252	216,286	Nov 05 09:04 AM
Cheng Andrew	President and CEO	Nov 01 '24	Option Exercise	21.10	108,366	2,286,523	686,697	Nov 05 09:00 AM
Cheng Andrew	President and CEO	Nov 01 '24	Sale	31.73	108,366	3,438,312	605,417	Nov 05 09:00 AM
Yale Catriona	Chief Development Officer	Nov 01 '24	Option Exercise	21.10	15,485	326,734	89,643	Nov 01 08:59 PM
Yale Catriona	Chief Development Officer	Oct 30 '24	Option Exercise	21.10	4,515	95,266	78,673	Nov 01 08:59 PM
Yale Catriona	Chief Development Officer	Nov 01 '24	Sale	32.62	15,485	505,105	74,158	Nov 01 08:59 PM
Yale Catriona	Chief Development Officer	Oct 30 '24	Sale	32.53	4,515	146,855	74,158	Nov 01 08:59 PM
CATRIONA YALE	Officer	Nov 01 '24	Proposed Sale	30.83	29,074	896,351		Nov 01 04:46 PM
Cheng Andrew	President and CEO	Oct 18 '24	Option Exercise	21.10	63,539	1,340,673	668,956	Oct 18 08:57 PM
Cheng Andrew	President and CEO	Oct 16 '24	Option Exercise	21.10	24,992	527,331	630,409	Oct 18 08:57 PM
Cheng Andrew	President and CEO	Oct 17 '24	Option Exercise	21.10	3,103	65,473	608,520	Oct 18 08:57 PM
Cheng Andrew	President and CEO	Oct 18 '24	Sale	31.53	63,539	2,003,328	605,417	Oct 18 08:57 PM
Cheng Andrew	President and CEO	Oct 16 '24	Sale	31.14	24,992	778,151	605,417	Oct 18 08:57 PM
Cheng Andrew	President and CEO	Oct 17 '24	Sale	31.12	3,103	96,559	605,417	Oct 18 08:57 PM
Young Jonathan	Chief Operating Officer	Oct 14 '24	Option Exercise	21.09	40,000	843,600	266,286	Oct 16 08:06 PM
Young Jonathan	Chief Operating Officer	Oct 14 '24	Sale	30.15	40,000	1,206,080	226,286	Oct 16 08:06 PM
Yale Catriona	Chief Development Officer	Oct 15 '24	Option Exercise	0.61	14,825	9,117	90,119	Oct 16 08:06 PM
Yale Catriona	Chief Development Officer	Oct 14 '24	Option Exercise	0.61	5,000	3,075	80,294	Oct 16 08:06 PM
Yale Catriona	Chief Development Officer	Oct 15 '24	Sale	30.50	14,825	452,232	75,294	Oct 16 08:06 PM
Yale Catriona	Chief Development Officer	Oct 14 '24	Sale	30.03	6,136	184,258	74,158	Oct 16 08:06 PM
Andrew Cheng	President, CEO and Director	Oct 16 '24	Proposed Sale	29.82	225,000	6,709,500		Oct 16 04:50 PM
CATRIONA YALE	Officer	Oct 15 '24	Proposed Sale	30.01	32,960	989,130		Oct 15 04:38 PM
CATRIONA YALE	Officer	Oct 14 '24	Proposed Sale	29.63	6,136	181,810		Oct 15 08:04 AM
Young Jonathan	Chief Operating Officer	Oct 01 '24	Sale	28.18	10,000	281,770	226,286	Oct 03 08:09 PM
Jonathan Young	Officer	Oct 01 '24	Proposed Sale	28.51	110,716	3,156,513		Oct 01 04:03 PM
Yale Catriona	Chief Development Officer	Sep 20 '24	Option Exercise	0.61	5,500	3,382	80,794	Sep 23 06:00 PM
Yale Catriona	Chief Development Officer	Sep 20 '24	Sale	27.65	5,500	152,086	75,294	Sep 23 06:00 PM
Yale Catriona	Chief Development Officer	Sep 18 '24	Option Exercise	0.61	3,871	2,381	79,165	Sep 18 09:19 PM
Yale Catriona	Chief Development Officer	Sep 16 '24	Option Exercise	0.61	2,485	1,528	77,779	Sep 18 09:19 PM
Yale Catriona	Chief Development Officer	Sep 17 '24	Option Exercise	0.61	2,037	1,253	77,331	Sep 18 09:19 PM

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