Your browser is no longer supported. Please, upgrade your browser.
KPTI Karyopharm Therapeutics Inc. daily Stock Chart
KPTI [NASD]
Karyopharm Therapeutics Inc.
Index- P/E- EPS (ttm)-2.84 Insider Own1.90% Shs Outstand73.24M Perf Week-6.10%
Market Cap1.08B Forward P/E- EPS next Y-1.87 Insider Trans-14.57% Shs Float66.42M Perf Month-8.02%
Income-189.40M PEG- EPS next Q-0.72 Inst Own91.03% Short Float22.54% Perf Quarter-22.08%
Sales82.90M P/S13.02 EPS this Y-2.60% Inst Trans0.27% Short Ratio11.53 Perf Half Y-40.48%
Book/sh1.77 P/B8.36 EPS next Y30.20% ROA-54.50% Target Price- Perf Year32.76%
Cash/sh4.07 P/C3.64 EPS next 5Y- ROE-186.80% 52W Range10.70 - 29.61 Perf YTD-22.85%
Dividend- P/FCF- EPS past 5Y-5.80% ROI-81.20% 52W High-50.05% Beta0.99
Dividend %- Quick Ratio6.30 Sales past 5Y182.10% Gross Margin95.60% 52W Low38.22% ATR0.80
Employees347 Current Ratio6.30 Sales Q/Q252.60% Oper. Margin- RSI (14)47.01 Volatility4.88% 5.34%
OptionableYes Debt/Eq1.44 EPS Q/Q11.00% Profit Margin- Rel Volume1.20 Prev Close15.28
ShortableYes LT Debt/Eq1.44 EarningsAug 04 BMO Payout- Avg Volume1.30M Price14.79
Recom1.70 SMA20-1.54% SMA50-1.71% SMA200-17.48% Volume1,561,480 Change-3.21%
Jul-02-20Initiated Morgan Stanley Overweight $34
Mar-04-20Initiated Barclays Overweight $30
Jan-17-20Downgrade Wedbush Outperform → Neutral
Jul-23-19Upgrade JP Morgan Neutral → Overweight $8 → $16
Jul-05-19Reiterated Robert W. Baird Outperform $15 → $25
Jul-05-19Reiterated H.C. Wainwright Buy $29 → $32
Mar-01-19Downgrade JP Morgan Overweight → Neutral $21 → $7
Feb-28-19Reiterated BofA/Merrill Underperform $15 → $5
Feb-27-19Downgrade BofA/Merrill Neutral → Underperform $15 → $5
Jan-03-19Upgrade BofA/Merrill Underperform → Neutral
Dec-03-18Initiated B. Riley FBR Buy $23
Nov-09-18Upgrade Wedbush Neutral → Outperform $19
May-24-18Downgrade Wedbush Outperform → Neutral $20 → $19
Apr-02-18Resumed Leerink Partners Outperform $19
Nov-15-17Resumed H.C. Wainwright Buy $23
Sep-15-17Initiated RBC Capital Mkts Outperform $14
Sep-08-16Reiterated H.C. Wainwright Buy $15 → $16
Aug-30-16Upgrade Jefferies Hold → Buy
Aug-18-16Initiated H.C. Wainwright Buy $15
Jun-28-16Initiated Robert W. Baird Outperform $16
Oct-20-20 10:00AM  
Oct-19-20 04:01PM  
Oct-06-20 06:44PM  
08:00AM  
Oct-01-20 04:05PM  
Sep-14-20 10:27AM  
09:42AM  
Sep-11-20 08:35AM  
Sep-02-20 07:00AM  
Sep-01-20 04:05PM  
Aug-31-20 07:00AM  
Aug-21-20 08:00AM  
Aug-10-20 08:00AM  
Aug-04-20 10:01PM  
08:25AM  
07:00AM  
Aug-03-20 04:05PM  
Jul-29-20 02:32PM  
09:40AM  
Jul-28-20 12:33PM  
07:00AM  
Jul-27-20 08:32PM  
Jul-20-20 07:00AM  
Jul-17-20 07:00AM  
Jul-14-20 07:00AM  
Jul-01-20 04:05PM  
Jun-24-20 07:00AM  
Jun-23-20 11:50AM  
Jun-22-20 11:25AM  
Jun-21-20 02:53PM  
Jun-18-20 03:34PM  
Jun-12-20 03:58PM  
07:00AM  
Jun-10-20 10:04AM  
Jun-09-20 09:00AM  
Jun-03-20 08:32AM  
Jun-01-20 04:05PM  
May-29-20 07:22AM  
May-28-20 04:05PM  
May-26-20 04:05PM  
07:00AM  
May-20-20 08:00AM  
May-13-20 08:00AM  
May-12-20 07:00AM  
May-06-20 08:07AM  
May-05-20 07:51PM  
05:30PM  
10:45AM  
08:11AM  
07:00AM  
May-04-20 08:53AM  
May-01-20 04:05PM  
Apr-30-20 01:03PM  
12:00PM  
Apr-29-20 01:58PM  
07:47AM  
Apr-28-20 04:05PM  
Apr-27-20 12:00PM  
Apr-22-20 05:15PM  
09:08AM  
07:09AM  
Apr-21-20 12:32PM  
Apr-20-20 08:55AM  
07:00AM  
Apr-07-20 07:00AM  
Apr-01-20 04:05PM  
Mar-24-20 04:23PM  
Mar-19-20 08:57AM  
Mar-17-20 04:05PM  
Mar-12-20 07:00AM  
Mar-09-20 04:05PM  
Mar-06-20 04:05PM  
Mar-03-20 06:36PM  
09:53AM  
07:51AM  
Mar-02-20 04:11PM  
04:01PM  
12:57PM  
07:00AM  
Feb-28-20 07:00AM  
Feb-27-20 08:43AM  
Feb-20-20 09:16PM  
Feb-19-20 08:00AM  
Feb-18-20 07:03AM  
07:00AM  
Feb-13-20 08:35AM  
07:00AM  
Feb-11-20 07:00AM  
Feb-10-20 10:20AM  
10:13AM  
Feb-06-20 07:00AM  
Feb-03-20 04:05PM  
Jan-22-20 09:33AM  
Jan-20-20 08:45AM  
Jan-15-20 09:56AM  
Jan-13-20 05:03PM  
09:13AM  
07:00AM  
Jan-08-20 11:23AM  
Jan-07-20 09:03AM  
Karyopharm Therapeutics Inc., a pharmaceutical company, engages in the discovery, development, and commercialization of various drugs directed against nuclear export and related targets for the treatment of cancer and other diseases. The company is developing small molecule selective inhibitor of nuclear export (SINE) compounds that inhibit the nuclear export protein exportin 1. Its lead compound is XPOVIO (selinexor) tablets for the treatment of patients with heavily pretreated multiple myeloma. The company develops BOSTON, which is in Phase 3 clinical trial for the treatment of patients with multiple myeloma; STORM, which is in Phase 2b single-arm clinical trial for evaluating oral selinexor in combination with standard, low-dose dexamethasone in heavily pretreated patients, relapsed or refractory myeloma; STOMP, which is in Phase 1b/2 multi-arm clinical trial for the treatment of ow-dose dexamethasone plus standard therapies, including Velcade, Kyprolis, Revlimid, and Pomalyst or Darzalex; and SADAL, which is in Phase 2b clinical trial for the treatment of patients with relapsed or refractory diffuse large B-cell lymphoma. It also develops SEAL, which is in Phase 3 clinical trial for the treartment of liposarcoma; SIENDO, which is in Phase 2/3 clinical trial for treatment of endometrial cancer; and KING, which is in Phase 2 for the treatment of glioblastoma multiforme brain tumor. In addition, the company has various investigational programs in clinical or preclinical development, such as Eltanexor (KPT-8602), KPT-9274, and Verdinexor (KPT-335). The company has collaboration with PROMETRIKA, LLC to conduct the first randomized clinical trial for low-dose selinexor (XPOVIO), an XPO1 inhibitor for hospitalized patients with COVID-19; and a cooperative research and development agreement with the National Cancer Institute for cancer therapy evaluation program. Karyopharm Therapeutics Inc. was founded in 2008 and is headquartered in Newton, Massachusetts.
Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total SEC Form 4
Primiano Christopher BrettEVP, CBO, GC & SecretaryOct 13Option Exercise9.2339,271362,53743,199Oct 14 06:00 PM
Primiano Christopher BrettEVP, CBO, GC & SecretaryOct 13Sale16.8639,271661,9694,649Oct 14 06:00 PM
Shacham SharonPresident & CSOOct 12Option Exercise0.037,500248763,989Oct 14 05:54 PM
Kauffman MichaelChief Executive OfficerOct 12Option Exercise0.037,500248763,989Oct 14 05:56 PM
Kauffman MichaelChief Executive OfficerOct 12Sale14.897,500111,683756,489Oct 14 05:56 PM
Shacham SharonPresident & CSOOct 12Sale14.897,500111,683756,489Oct 14 05:54 PM
Primiano Christopher BrettEVP, CBO, GC & SecretarySep 08Option Exercise6.5410,05465,75314,703Sep 10 08:49 AM
Primiano Christopher BrettEVP, CBO, GC & SecretarySep 08Sale14.9810,054150,6094,649Sep 10 08:49 AM
DEMAREE JOHNChief Commercial OfficerAug 26Buy14.547,500109,0137,500Aug 27 04:00 PM
Kauffman MichaelChief Executive OfficerAug 17Option Exercise0.031,47749757,966Aug 18 06:07 PM
Shacham SharonPresident & CSOAug 17Option Exercise0.031,47749757,966Aug 18 06:05 PM
Kauffman MichaelChief Executive OfficerAug 17Sale15.001,47722,155756,489Aug 18 06:07 PM
Shacham SharonPresident & CSOAug 17Sale15.001,47722,155756,489Aug 18 06:05 PM
Kauffman MichaelChief Executive OfficerJul 15Option Exercise0.037,500248763,989Jul 17 04:26 PM
Shacham SharonPresident & CSOJul 15Option Exercise0.037,500248763,989Jul 17 04:24 PM
Shacham SharonPresident & CSOJul 15Sale19.437,500145,723756,489Jul 17 04:24 PM
Kauffman MichaelChief Executive OfficerJul 15Sale19.437,500145,723756,489Jul 17 04:26 PM
Shacham SharonPresident & CSOJul 10Option Exercise4.757,50035,640562,622Jul 13 06:43 PM
Kauffman MichaelChief Executive OfficerJul 10Option Exercise4.757,50035,640562,622Jul 13 06:45 PM
Shacham SharonPresident & CSOJul 10Sale19.017,500142,539555,122Jul 13 06:43 PM
Kauffman MichaelChief Executive OfficerJul 10Sale19.017,500142,539555,122Jul 13 06:45 PM
Kauffman MichaelChief Executive OfficerJul 09Option Exercise4.757,50035,640763,989Jul 13 06:45 PM
Shacham SharonPresident & CSOJul 09Option Exercise4.757,50035,640763,989Jul 13 06:43 PM
Shacham SharonPresident & CSOJul 09Sale19.537,500146,487756,489Jul 13 06:43 PM
Kauffman MichaelChief Executive OfficerJul 09Sale19.537,500146,487756,489Jul 13 06:45 PM
Shacham SharonPresident & CSOJun 22Option Exercise0.037,500248763,989Jun 24 04:05 PM
Kauffman MichaelChief Executive OfficerJun 22Option Exercise0.037,500248763,989Jun 24 04:07 PM
Shacham SharonPresident & CSOJun 22Sale20.007,500150,000756,489Jun 24 04:05 PM
Kauffman MichaelChief Executive OfficerJun 22Sale20.007,500150,000756,489Jun 24 04:07 PM
Shacham SharonPresident & CSOJun 15Option Exercise0.037,500248763,632Jun 17 04:05 PM
Kauffman MichaelChief Executive OfficerJun 15Option Exercise0.037,500248763,632Jun 17 04:07 PM
Shacham SharonPresident & CSOJun 15Sale16.377,500122,779756,489Jun 17 04:05 PM
Kauffman MichaelChief Executive OfficerJun 15Sale16.377,500122,779756,489Jun 17 04:07 PM
Shacham SharonPresident & CSOJun 10Option Exercise4.757,50035,640562,622Jun 11 04:36 PM
Kauffman MichaelChief Executive OfficerJun 10Option Exercise4.757,50035,640562,622Jun 11 04:39 PM
Kauffman MichaelChief Executive OfficerJun 10Sale18.137,500135,944555,122Jun 11 04:39 PM
Shacham SharonPresident & CSOJun 10Sale18.137,500135,944555,122Jun 11 04:36 PM
Kauffman MichaelChief Executive OfficerJun 09Option Exercise4.757,50035,640763,989Jun 11 04:39 PM
Shacham SharonPresident & CSOJun 09Option Exercise4.757,50035,640763,989Jun 11 04:36 PM
Kauffman MichaelChief Executive OfficerJun 09Sale18.507,500138,746756,489Jun 11 04:39 PM
Shacham SharonPresident & CSOJun 09Sale18.507,500138,746756,489Jun 11 04:36 PM
Kauffman MichaelChief Executive OfficerMay 18Option Exercise0.037,500248763,989May 19 05:36 PM
Shacham SharonPresident & CSOMay 18Option Exercise0.037,500248763,989May 19 05:34 PM
Shacham SharonPresident & CSOMay 18Sale20.007,500150,000756,489May 19 05:34 PM
Kauffman MichaelChief Executive OfficerMay 18Sale20.007,500150,000756,489May 19 05:36 PM
Kauffman MichaelChief Executive OfficerMay 15Option Exercise0.037,500248763,989May 19 05:36 PM
Shacham SharonPresident & CSOMay 15Option Exercise0.037,500248763,989May 19 05:34 PM
Shacham SharonPresident & CSOMay 15Sale18.657,500139,841756,489May 19 05:34 PM
Kauffman MichaelChief Executive OfficerMay 15Sale18.657,500139,841756,489May 19 05:36 PM
Kauffman MichaelChief Executive OfficerMay 07Option Exercise4.757,50035,640763,989May 11 04:19 PM
Kauffman MichaelChief Executive OfficerMay 07Option Exercise4.757,50035,640562,622May 11 04:19 PM
Shacham SharonPresident & CSOMay 07Option Exercise4.757,50035,640562,622May 11 04:22 PM
Shacham SharonPresident & CSOMay 07Option Exercise4.757,50035,640763,989May 11 04:22 PM
Primiano Christopher BrettEVP, CBO, GC & SecretaryMay 07Option Exercise6.542,94619,2677,595May 11 04:25 PM
Frenkel RanChief Dev Operations OfficerMay 07Sale20.001,97439,48035,088May 11 04:26 PM
Primiano Christopher BrettEVP, CBO, GC & SecretaryMay 07Sale19.739,660190,6274,649May 11 04:25 PM
Shacham SharonPresident & CSOMay 07Sale19.637,500147,209555,122May 11 04:22 PM
Shacham SharonPresident & CSOMay 07Sale19.637,500147,205756,489May 11 04:22 PM
Kauffman MichaelChief Executive OfficerMay 07Sale19.637,500147,205756,489May 11 04:19 PM
Kauffman MichaelChief Executive OfficerMay 07Sale19.637,500147,209555,122May 11 04:19 PM
Kauffman MichaelChief Executive OfficerApr 09Option Exercise4.7510,00047,520565,122Apr 10 05:09 PM
Shacham SharonPresident & CSOApr 09Option Exercise4.7510,00047,520565,122Apr 10 05:06 PM
Shacham SharonPresident & CSOApr 09Sale20.6410,000206,404555,122Apr 10 05:06 PM
Kauffman MichaelChief Executive OfficerApr 09Sale20.6410,000206,404555,122Apr 10 05:09 PM
Kauffman MichaelChief Executive OfficerApr 08Option Exercise4.7510,00047,520766,489Apr 10 05:09 PM
Shacham SharonPresident & CSOApr 08Option Exercise4.7510,00047,520766,489Apr 10 05:06 PM
Shacham SharonPresident & CSOApr 08Sale18.6110,000186,115756,489Apr 10 05:06 PM
Kauffman MichaelChief Executive OfficerApr 08Sale18.6110,000186,115756,489Apr 10 05:09 PM
Greene Barry EDirectorMar 13Option Exercise0.033,0301006,030Mar 17 05:35 PM
Kauffman MichaelChief Executive OfficerMar 10Option Exercise4.7510,00047,520565,122Mar 11 07:07 PM
Shacham SharonPresident & CSOMar 10Option Exercise4.7510,00047,520565,122Mar 11 07:10 PM
Kauffman MichaelChief Executive OfficerMar 10Sale22.2210,000222,186555,122Mar 11 07:07 PM
Shacham SharonPresident & CSOMar 10Sale22.2210,000222,186555,122Mar 11 07:10 PM
Kauffman MichaelChief Executive OfficerMar 09Option Exercise4.7510,00047,520766,489Mar 11 07:07 PM
Shacham SharonPresident & CSOMar 09Option Exercise4.7510,00047,520766,489Mar 11 07:10 PM
Kauffman MichaelChief Executive OfficerMar 09Sale22.5210,000225,195756,489Mar 11 07:07 PM
Shacham SharonPresident & CSOMar 09Sale22.5210,000225,195756,489Mar 11 07:10 PM
Mirza Mansoor RazaDirectorMar 02Option Exercise8.065,00040,3005,000Mar 04 06:51 PM
Primiano Christopher BrettEVP, CBO, GC & SecretaryMar 02Option Exercise10.3926,500275,33536,867Mar 04 08:33 PM
Mirza Mansoor RazaDirectorMar 02Sale23.505,000117,5000Mar 04 06:51 PM
Primiano Christopher BrettEVP, CBO, GC & SecretaryMar 02Sale25.3726,500672,27910,367Mar 04 08:33 PM
Frenkel RanChief Dev Operations OfficerFeb 19Sale16.482,97549,03436,066Feb 21 05:57 PM
Shah JatinEVP, Chief Medical OfficerFeb 19Sale16.481,37522,66340,759Feb 21 05:58 PM
Primiano Christopher BrettEVP, CBO, GC & SecretaryFeb 19Sale16.482,96148,80310,367Feb 21 05:55 PM
Shacham SharonPresident & CSOFeb 19Sale16.488,817145,321555,122Feb 21 05:54 PM
Shacham SharonPresident & CSOFeb 19Sale16.488,817145,321756,489Feb 21 05:54 PM
Kauffman MichaelChief Executive OfficerFeb 19Sale16.488,817145,321756,489Feb 21 05:53 PM
Kauffman MichaelChief Executive OfficerFeb 19Sale16.488,817145,321555,122Feb 21 05:53 PM
Kauffman MichaelChief Executive OfficerFeb 11Option Exercise4.7510,00047,520552,139Feb 12 04:20 PM
Shacham SharonPresident & CSOFeb 11Option Exercise4.7510,00047,520552,139Feb 12 04:21 PM
Kauffman MichaelChief Executive OfficerFeb 11Sale17.4310,000174,294542,139Feb 12 04:20 PM
Shacham SharonPresident & CSOFeb 11Sale17.4310,000174,294542,139Feb 12 04:21 PM
Kauffman MichaelChief Executive OfficerFeb 10Option Exercise4.7510,00047,520753,506Feb 12 04:20 PM
Shacham SharonPresident & CSOFeb 10Option Exercise4.7510,00047,520753,506Feb 12 04:21 PM
Kauffman MichaelChief Executive OfficerFeb 10Sale16.9310,000169,327743,506Feb 12 04:20 PM
Shacham SharonPresident & CSOFeb 10Sale16.9310,000169,327743,506Feb 12 04:21 PM
Shacham SharonPresident & CSOJan 09Option Exercise4.7510,00047,520552,139Jan 10 05:04 PM
Kauffman MichaelChief Executive OfficerJan 09Option Exercise4.7510,00047,520552,139Jan 10 05:07 PM
Mirza Mansoor RazaDirectorJan 09Option Exercise8.062,05616,5712,056Jan 13 05:02 PM
Shacham SharonPresident & CSOJan 09Sale19.1910,000191,880542,139Jan 10 05:04 PM