VIR | Vir Biotechnology, Inc.

Index	-	P/E	-	EPS (ttm)	-1.10	Insider Own	1.70%	Shs Outstand	133.55M	Perf Week	-0.22%
Market Cap	3.53B	Forward P/E	-	EPS next Y	-4.91	Insider Trans	-63.97%	Shs Float	114.86M	Perf Month	6.00%
Income	-143.70M	PEG	-	EPS next Q	-1.20	Inst Own	76.10%	Short Float / Ratio	4.40% / 5.44	Perf Quarter	18.01%
Sales	446.30M	P/S	7.92	EPS this Y	-3.40%	Inst Trans	-5.43%	Short Interest	5.05M	Perf Half Y	-1.04%
Book/sh	14.76	P/B	1.81	EPS next Y	-18.30%	ROA	-5.30%	Target Price	49.71	Perf Year	-0.11%
Cash/sh	16.98	P/C	1.57	EPS next 5Y	7.00%	ROE	-7.10%	52W Range	18.05 - 31.78	Perf YTD	5.37%
Dividend	-	P/FCF	3.81	EPS past 5Y	92.00%	ROI	28.60%	52W High	-16.08%	Beta	0.26
Dividend %	-	Quick Ratio	4.90	Sales past 5Y	259.00%	Gross Margin	87.00%	52W Low	47.76%	ATR	0.95
Employees	576	Current Ratio	4.90	Sales Q/Q	-94.90%	Oper. Margin	-	RSI (14)	62.04	Volatility	4.24% 4.01%
Optionable	Yes	Debt/Eq	0.00	EPS Q/Q	-127.40%	Profit Margin	-32.20%	Rel Volume	0.00	Prev Close	26.67
Shortable	Yes	LT Debt/Eq	0.00	Earnings	May 04 AMC	Payout	0.00%	Avg Volume	928.59K	Price	26.67
Recom	1.90	SMA20	5.43%	SMA50	8.89%	SMA200	8.71%	Volume	0	Change	0.00%

Date	Action	Analyst	Rating Change	Price Target Change
Mar-06-23	Upgrade	JP Morgan	Neutral → Overweight	$35 → $34
Feb-21-23	Upgrade	Goldman	Neutral → Buy	$41 → $53
Jan-27-23	Upgrade	Morgan Stanley	Underweight → Equal-Weight	$18 → $30
Sep-14-22	Initiated	SVB Leerink	Outperform	$40
Sep-09-22	Initiated	Morgan Stanley	Underweight	$15
Mar-03-22	Upgrade	Robert W. Baird	Underperform → Neutral	$36 → $28
Dec-21-21	Downgrade	Robert W. Baird	Neutral → Underperform	$36
Oct-25-21	Upgrade	JP Morgan	Underweight → Neutral	$29 → $37
Sep-22-21	Downgrade	Goldman	Buy → Neutral	$64 → $62
Jun-04-21	Resumed	Robert W. Baird	Neutral	$45
Jan-27-21	Downgrade	JP Morgan	Neutral → Underweight	$30
Jan-20-21	Reiterated	H.C. Wainwright	Buy	$100 → $125
Oct-05-20	Initiated	BofA Securities	Buy	$55
Sep-14-20	Upgrade	Goldman	Neutral → Buy	$48 → $54
Sep-11-20	Upgrade	JP Morgan	Underweight → Neutral	$29
Aug-20-20	Initiated	Needham	Buy	$62
Mar-19-20	Downgrade	JP Morgan	Neutral → Underweight	$26
Mar-13-20	Downgrade	Goldman	Buy → Neutral
Feb-27-20	Downgrade	Robert W. Baird	Neutral → Underperform	$17
Feb-04-20	Downgrade	JP Morgan	Overweight → Neutral	$25 → $26

Show Previous Ratings

May-17-23 04:05PM	Vir Biotechnology to Host a Virtual-Only 2023 Annual Meeting of Stockholders (GlobeNewswire)
May-16-23 09:25AM	Billionaire Steve Cohen Snaps Up These 2 Strong Buy Stocks Heres Why You Might Want to Ride His Coattails (TipRanks)
May-15-23 08:35AM	Vir Biotechnology, Inc. (NASDAQ:VIR) is favoured by institutional owners who hold 50% of the company (Simply Wall St.)
08:00AM	Vir Biotechnology Appoints Jeff Calcagno, M.D., as Executive Vice President and Chief Business Officer (GlobeNewswire)
May-11-23 08:30AM	Vir Biotechnology Announces First Patient Dosed in New Phase 2 Chronic Hepatitis B Virus Trial Evaluating Combinations of VIR-2218, VIR-3434, PEG-IFN and an NRTI (GlobeNewswire)
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May-10-23 02:07PM	7 Top-Rated Stocks That Will Boost Your Portfolio in 2023 (InvestorPlace)
May-04-23 07:45PM	Vir Biotechnology, Inc. (VIR) Reports Q1 Loss, Tops Revenue Estimates (Zacks)
05:48PM	The 7 Best Bargain Stocks to Buy for May 2023 (InvestorPlace)
04:05PM	Vir Biotechnology Provides Corporate Update and Reports First Quarter 2023 Financial Results (GlobeNewswire)
May-03-23 04:05PM	Vir Biotechnology to Participate in the BofA Securities 2023 Health Care Conference (GlobeNewswire)
May-02-23 09:00AM	Vir Biotechnology Receives Expanded Support to Develop Its Novel T Cell Vaccine Platform with New $10 Million Grant for HIV Prevention (GlobeNewswire)
Apr-28-23 10:00AM	Twist Bioscience (TWST) Expected to Beat Earnings Estimates: Should You Buy? (Zacks)
Apr-27-23 10:03AM	Earnings Preview: Vir Biotechnology, Inc. (VIR) Q1 Earnings Expected to Decline (Zacks)
Apr-26-23 08:00PM	VIR: What does Argus have to say about VIR? (Argus Research)
Apr-11-23 04:05PM	Vir Biotechnology to Participate in the 22nd Annual Needham Virtual Healthcare Conference (GlobeNewswire)
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Apr-05-23 01:40PM	7 Thrilling Biotech Stocks for Aggressive Investors to Buy (InvestorPlace)
Mar-29-23 08:40AM	Is the Options Market Predicting a Spike in Vir Biotechnology (VIR) Stock? (Zacks)
Mar-21-23 02:33PM	Strong week for Vir Biotechnology (NASDAQ:VIR) shareholders doesn't alleviate pain of three-year loss (Simply Wall St.)
Mar-08-23 04:05PM	Vir Biotechnology to Participate in the Barclays Global Healthcare Conference (GlobeNewswire)
Mar-05-23 07:30AM	As Covid Threat Weakens, This Biotech Is Still Worth a Shot (TheStreet.com)
Mar-03-23 06:57PM	The Top 7 Growth Stocks in Biotech (InvestorPlace)
Feb-28-23 04:05PM	Vir Biotechnology to Participate in the Cowen 43rd Annual Health Care Conference (GlobeNewswire)
Feb-26-23 07:13AM	Positive Sentiment Still Eludes Vir Biotechnology, Inc. (NASDAQ:VIR) Following 25% Share Price Slump (Simply Wall St.)
Feb-23-23 05:35PM	Vir Biotechnology, Inc. (VIR) Reports Q4 Loss, Misses Revenue Estimates (Zacks)
04:05PM	Vir Biotechnology Provides Corporate Update and Reports Fourth Quarter and Full Year 2022 Financial Results (GlobeNewswire)
Feb-22-23 08:30AM	Vir Biotechnology Announces Positive Final Draft Guidance on Sotrovimab from the UKs National Institute for Health and Care Excellence (NICE) (GlobeNewswire)
Feb-20-23 10:00AM	BioMarin Pharmaceutical (BMRN) Reports Next Week: Wall Street Expects Earnings Growth (Zacks)
Feb-16-23 04:05PM	Vir Biotechnology to Provide Corporate Update and Report Fourth Quarter and Full Year 2022 Financial Results on February 23, 2023 (GlobeNewswire)
10:01AM	Vir Biotechnology, Inc. (VIR) Expected to Beat Earnings Estimates: Should You Buy? (Zacks)
08:30AM	Vir Biotechnology Appoints Sung Lee as Chief Financial Officer (GlobeNewswire)
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Feb-14-23 04:33PM	11 Most Undervalued Biotech Stocks To Buy According To Hedge Funds (Insider Monkey)
08:19AM	Vir Biotech To Work On Next-Gen COVID-19 Solutions Independently, Or With Other Partners, As GSK Walks Out (Benzinga)
Feb-13-23 04:45PM	Vir Biotechnology Announces Amended Collaboration Agreement with GSK (GlobeNewswire)
Feb-02-23 02:19PM	The 7 Most Undervalued Biotech Stocks to Buy in February 2023 (InvestorPlace)
Jan-31-23 10:06AM	7 Healthcare Stocks That Will Be Big Winners in 2023 (InvestorPlace)
Jan-25-23 06:05PM	'You have to have the goods': Retiring Vir CEO George Scangos looks back on building great companies (American City Business Journals)
08:29AM	Vir Biotechnology Announces Retirement of CEO George Scangos, Ph.D.; Appoints Marianne De Backer, MSc, Ph.D., MBA, as Successor (GlobeNewswire)
Jan-24-23 12:00PM	Vir Biotechnology, Inc. (VIR) Moves to Strong Buy: Rationale Behind the Upgrade (Zacks)
Jan-22-23 07:15AM	2 Stocks That Could Turn $100 Into $1,000 by 2028 (Motley Fool)
Jan-21-23 04:51PM	10 Best Healthcare Stocks For the Long Term (Insider Monkey)
07:36AM	Are Robust Financials Driving The Recent Rally In Vir Biotechnology, Inc.'s (NASDAQ:VIR) Stock? (Simply Wall St.)
Jan-20-23 09:40AM	Is Vir Biotechnology (VIR) Outperforming Other Medical Stocks This Year? (Zacks)
Jan-03-23 04:05PM	Vir Biotechnology to Highlight Anticipated 2023 Catalysts and Long-Term Growth Strategy at 41st Annual J.P. Morgan Healthcare Conference (GlobeNewswire)
Dec-31-22 08:44AM	Are Investors Undervaluing Vir Biotechnology, Inc. (NASDAQ:VIR) By 32%? (Simply Wall St.)
Dec-22-22 05:30PM	Vir Biotechnology: A 'Magic Formula' Top Performer (GuruFocus.com)
Dec-21-22 08:00AM	Vir Biotechnology Achieves Target Enrollment for Groundbreaking Phase 2 PENINSULA Trial Evaluating VIR-2482 for Prevention of Seasonal Influenza A (GlobeNewswire)
Dec-06-22 06:04AM	With 49% stake, Vir Biotechnology, Inc. (NASDAQ:VIR) seems to have captured institutional investors' interest (Simply Wall St.)
Dec-02-22 07:10AM	2 Fast-Growing Healthcare Stocks to Buy and Hold (Motley Fool)
Nov-24-22 09:55AM	Wall Street Analysts Believe Vir Biotechnology, Inc. (VIR) Could Rally 71%: Here's is How to Trade (Zacks)
Nov-22-22 09:40AM	Should Value Investors Buy Vir Biotechnology (VIR) Stock? (Zacks)
Nov-17-22 04:48PM	99 Bay Area companies named in Deloitte's Technology Fast 500 list, including its No. 1 (American City Business Journals)
04:48PM	99 Bay Area companies named in Deloitte 'fast 500' list, including its No. 1 (American City Business Journals)
09:15AM	Genmab AS Sponsored ADR (GMAB) Hits Fresh High: Is There Still Room to Run? (Zacks)
Nov-16-22 08:30AM	Vir Biotechnology Ranked the Fastest-Growing Company in North America on the 2022 Deloitte Technology Fast 500 (GlobeNewswire)
Nov-09-22 05:32AM	Vir Biotechnology Third Quarter 2022 Earnings: Beats Expectations (Simply Wall St.)
Nov-08-22 09:55AM	Wall Street Analysts Predict a 107% Upside in Vir Biotechnology, Inc. (VIR): Here's What You Should Know (Zacks)
09:40AM	Are Investors Undervaluing Dynavax Technologies (DVAX) Right Now? (Zacks)
Nov-07-22 08:57AM	Data From Multiple Ongoing Trials Of Vir Biotech's HBV Therapies Show Promising Action (Benzinga) +6.16%
Nov-06-22 10:35AM	Vir Biotechnology Presents New Data Evaluating the Potential for VIR-2218 and VIR-3434 to Achieve a Functional Cure for Chronic Hepatitis B Virus (HBV) Infection (GlobeNewswire)
Nov-05-22 08:18AM	Analyst Forecasts For Vir Biotechnology, Inc. (NASDAQ:VIR) Are Surging Higher (Simply Wall St.)
Nov-04-22 05:46PM	Top Biotech Stocks for Q4 2022 (Investopedia) +17.71%
04:16PM	Why Vir Biotechnology Jumped Nearly 19% Today (Motley Fool)
Nov-03-22 06:05PM	Vir Biotechnology, Inc. (VIR) Q3 Earnings and Revenues Surpass Estimates (Zacks)
04:03PM	Vir Biotechnology Provides Corporate Update and Reports Third Quarter 2022 Financial Results (GlobeNewswire)
Oct-31-22 07:20PM	7 Undervalued Biotech Stocks to Buy Before They Boom (InvestorPlace)
04:05PM	Vir Biotechnology Announces Multiple Abstracts Highlighting New Hepatitis B Data Accepted for Presentation at AASLDs The Liver Meeting® 2022 (GlobeNewswire)
Oct-28-22 06:06PM	Vir Biotechnology to Provide Corporate Update and Report Third Quarter 2022 Financial Results on November 3, 2022 (GlobeNewswire)
Oct-18-22 08:32AM	Vir begins dosing participants in Phase 2 clinical trial for new type of flu shot (MarketWatch)
08:00AM	Vir Biotechnology Announces First Patient Dosed in Groundbreaking Phase 2 Trial of VIR-2482 for Antibody Prophylaxis of Influenza A (GlobeNewswire)
Oct-12-22 01:27PM	Vir Biotechnology (NASDAQ:VIR shareholders incur further losses as stock declines 4.7% this week, taking one-year losses to 50% (Simply Wall St.)
Oct-11-22 04:03PM	Vir Biotechnology to Participate in the H. C. Wainwright 3rd Annual Hepatitis B Virus (HBV) Conference (GlobeNewswire)
Oct-07-22 12:33PM	Vir Biotechnology (VIR) Gains 11% This Week on BARDA Contract (Zacks)
Oct-05-22 09:37AM	How $1 billion deal with San Francisco biotech could change how we prep for flu season (American City Business Journals)
Oct-04-22 12:56PM	Vir Biotech Secures US Government Contract For Influenza & Other Infectious Disease Candidates (Benzinga) +7.67%
09:01AM	Vir's stock gains 10% after announcing new flu contract with the U.S. (MarketWatch)
08:00AM	Vir Biotech gets U.S. funding for flu-prevention antibody (Reuters)
08:00AM	Vir Biotechnology Awarded U.S. Government Contract to Support Pandemic Preparedness for Influenza and Other Infectious Disease Threats (GlobeNewswire)
Sep-22-22 08:00AM	Vir Biotechnology Announces First Patient Dosed in the Phase 2 SOLSTICE Trial Evaluating VIR-2218 and VIR-3434 for the Treatment of Chronic Hepatitis D Virus Infection (GlobeNewswire)
Sep-20-22 09:16PM	3 Biotech Stocks to Buy Now for Extraordinary Gains (InvestorPlace)
Sep-16-22 03:49PM	San Francisco biotech company opens new $41M office in Cortex (Photos) (American City Business Journals)
Sep-14-22 02:11PM	This Hepatitis Stock Has 'Multiple Paths To Value Creation,' Expects To Double, Bullish Analyst Predicts (Benzinga)
08:56AM	Is the Options Market Predicting a Spike in Vir Biotechnology (VIR) Stock? (Zacks)
Sep-06-22 04:05PM	Vir Biotechnology to Participate in the Morgan Stanley 20th Annual Global Healthcare Conference (GlobeNewswire) -6.67%
Aug-10-22 07:35AM	Vir Biotech Shuns FDA Submission Plans For GSK-Partnered COVID-19 Treatment (Benzinga) +6.28%
Aug-09-22 06:05PM	Vir Biotechnology, Inc. (VIR) Reports Q2 Loss, Misses Revenue Estimates (Zacks)
04:02PM	Vir Biotechnology Provides Corporate Update and Reports Second Quarter 2022 Financial Results (GlobeNewswire)
Aug-01-22 10:01AM	Avidity Biosciences, Inc. (RNA) Expected to Beat Earnings Estimates: What to Know Ahead of Q2 Release (Zacks)
Jul-31-22 09:00AM	3 Fast-Growing Stocks to Buy Now (Motley Fool)
Jul-30-22 06:15AM	2 Biotech Stocks That Could Help Make You a Fortune (Motley Fool)
Jul-28-22 10:03AM	Analysts Estimate Vir Biotechnology, Inc. (VIR) to Report a Decline in Earnings: What to Look Out for (Zacks)
Jul-21-22 04:05PM	Vir Biotechnology to Provide Corporate Update and Report Second Quarter 2022 Financial Results on August 4, 2022 (GlobeNewswire)
Jul-14-22 08:30AM	Vir Biotechnology Announces Transition of Chief Scientific Officer (GlobeNewswire) -7.97%
Jul-12-22 11:30AM	3 Cheap Stocks To Buy Now (Motley Fool)
Jul-06-22 02:22PM	Vir Biotechnology, Inc.'s (NASDAQ:VIR) Stock Is Going Strong: Is the Market Following Fundamentals? (Simply Wall St.)
Jul-05-22 06:32AM	Brii Biosciences Exercises Option For Vir Biotechnology's Hepatitis B Antibody In Greater China (Benzinga) +7.50%
Jun-27-22 10:47AM	Immatics (IMTX) Stock Jumps 5.2%: Will It Continue to Soar? (Zacks) +7.29%
Jun-25-22 07:00AM	Vir Biotechnology Announces New Clinical Data From its Broad Hepatitis B Program (GlobeNewswire)
Jun-19-22 11:25AM	Buy the Dip on These 3 Healthcare Stocks (Motley Fool)
Jun-08-22 07:34AM	Vir Biotechnology Announces Multiple Abstracts Highlighting New Hepatitis B Data Accepted for Presentation at the International Liver Congress 2022 (GlobeNewswire) -5.66%
Jun-06-22 01:20PM	What Percentage Of Vir Biotechnology, Inc. (NASDAQ:VIR) Shares Do Insiders Own? (Simply Wall St.)

Vir Biotechnology, Inc., a commercial-stage immunology company, develops therapeutic products to treat and prevent serious infectious diseases. It develops Sotrovimab (VIR-7832), a SARS-CoV-2-neutralizing mAbs to treat and prevent COVID-19 infection under the Xevudy brand; VIR-2218 and VIR-3434 for the treatment of hepatitis B virus; VIR-2482 for the prevention of influenza A virus; and VIR-1111 for the prevention of human immunodeficiency virus. The company has grant agreements with Bill & Melinda Gates Foundation and National Institutes of Health; an option and license agreement with Brii Biosciences Limited and Brii Biosciences Offshore Limited; a collaboration and license agreement with Alnylam Pharmaceuticals, Inc.; license agreements with MedImmune; collaboration with WuXi Biologics and Glaxo Wellcome UK Ltd.; and a collaborative research agreement with GlaxoSmithKline Biologicals SA. It also has a manufacturing agreement with Samsung Biologics Co.,Ltd. for the manufacture of SARS-COV-2 antibodies; and clinical collaboration with Gilead Sciences, Inc. for chronic hepatitis B virus. The company was incorporated in 2016 and is headquartered in San Francisco, California.

Insider Trading	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
SVF Endurance (Cayman) Ltd	10% Owner	May 24	Sale	26.15	104,384	2,729,599	17,178,585	May 25 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	May 23	Sale	26.66	170,067	4,533,230	17,282,969	May 25 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	May 22	Sale	25.72	91,896	2,363,905	17,453,036	May 23 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	May 19	Sale	25.38	91,651	2,326,231	17,544,932	May 23 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	May 05	Sale	25.10	136	3,414	17,636,583	May 09 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	May 04	Sale	25.55	114,332	2,921,160	17,636,719	May 05 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	May 03	Sale	25.51	83,674	2,134,691	17,751,051	May 05 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	May 01	Sale	25.30	3,075	77,812	17,834,725	May 03 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Apr 25	Sale	25.30	961	24,313	17,837,800	Apr 26 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Apr 24	Sale	25.42	66,038	1,678,633	17,838,761	Apr 26 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Apr 21	Sale	25.78	305,393	7,872,247	17,904,799	Apr 24 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Apr 20	Sale	25.06	6,590	165,147	18,210,192	Apr 24 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Apr 19	Sale	25.12	76,114	1,911,968	18,216,782	Apr 20 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Apr 18	Sale	25.12	6,953	174,661	18,292,896	Apr 20 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Apr 17	Sale	25.06	10,524	263,741	18,299,849	Apr 18 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Apr 14	Sale	25.11	9,565	240,152	18,310,373	Apr 18 09:00 PM
HANLY ANN M.	Chief Technology Officer	Mar 30	Sale	22.77	2,627	59,817	114,576	Mar 31 02:40 PM
SATO VICKI L	Director	Mar 08	Sale	22.59	17,935	405,062	1,327,324	Mar 09 02:36 PM
Friedl-Naderer Johanna	EVP & Chief Operating Officer	Mar 03	Sale	22.82	1,482	33,819	148,518	Mar 07 02:04 PM
Sigal Charles Elliott	Director	Mar 01	Buy	22.73	2,500	56,816	10,000	Mar 02 04:27 PM
SCANGOS GEORGE A	President and CEO	Feb 24	Sale	23.33	15,119	352,682	168,489	Feb 24 08:34 PM
SCANGOS GEORGE A	President and CEO	Feb 23	Sale	25.97	12,631	328,065	183,608	Feb 24 08:34 PM
Pang Phillip	Chief Medical Officer	Feb 23	Sale	25.97	2,878	74,750	198,320	Feb 24 08:29 PM
HANLY ANN M.	Chief Technology Officer	Feb 23	Sale	25.97	2,302	59,790	117,203	Feb 24 08:35 PM
Horn Howard	CFO	Feb 23	Sale	25.97	2,248	58,387	230,712	Feb 24 08:36 PM
Rice Steven J.	Chief Administrative Officer	Feb 23	Sale	25.97	1,795	46,622	108,414	Feb 24 08:28 PM
SVF Endurance (Cayman) Ltd	10% Owner	Feb 21	Sale	28.43	74,477	2,117,336	18,319,938	Feb 23 09:00 PM
SCANGOS GEORGE A	President and CEO	Feb 21	Sale	28.30	17,856	505,318	196,239	Feb 21 07:29 PM
SCANGOS GEORGE A	President and CEO	Feb 17	Sale	25.29	9,894	250,199	214,095	Feb 21 07:29 PM
Pang Phillip	Chief Medical Officer	Feb 17	Sale	25.29	2,802	70,857	141,198	Feb 21 07:24 PM
Horn Howard	CFO	Feb 17	Sale	25.29	2,424	61,298	232,960	Feb 21 07:22 PM
Rice Steven J.	Chief Administrative Officer	Feb 17	Sale	25.29	1,981	50,096	37,209	Feb 21 07:25 PM
SVF Endurance (Cayman) Ltd	10% Owner	Feb 15	Sale	26.75	38,964	1,042,384	18,394,415	Feb 17 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Feb 14	Sale	26.81	38,907	1,043,108	18,433,379	Feb 15 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Feb 13	Sale	26.02	79,050	2,056,585	18,472,286	Feb 15 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Feb 10	Sale	26.13	97,221	2,540,300	18,551,336	Feb 13 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Feb 09	Sale	26.38	137,050	3,615,729	18,648,557	Feb 13 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Feb 08	Sale	27.88	81,914	2,284,153	18,785,607	Feb 09 09:00 PM
SATO VICKI L	Director	Feb 08	Sale	28.38	17,915	508,343	1,345,259	Feb 09 11:27 AM
SVF Endurance (Cayman) Ltd	10% Owner	Feb 07	Sale	29.33	63,508	1,862,396	18,867,521	Feb 09 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Feb 06	Sale	29.92	45,249	1,353,849	18,931,029	Feb 07 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Feb 03	Sale	30.40	68,786	2,091,135	18,976,278	Feb 07 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Feb 02	Sale	29.70	86,801	2,578,016	19,045,064	Feb 03 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Feb 01	Sale	29.02	61,834	1,794,159	19,131,865	Feb 03 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Jan 31	Sale	29.47	73,883	2,177,232	19,193,699	Feb 01 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Jan 30	Sale	29.46	78,930	2,325,106	19,267,582	Feb 01 09:00 PM
Pang Phillip	Chief Medical Officer	Jan 24	Sale	30.00	30,000	900,057	144,000	Jan 25 08:01 PM
SVF Endurance (Cayman) Ltd	10% Owner	Jan 23	Sale	28.34	36,512	1,034,707	19,346,512	Jan 25 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Jan 20	Sale	27.41	144,358	3,956,801	19,383,024	Jan 23 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Jan 19	Sale	26.56	69,839	1,854,610	19,527,382	Jan 23 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Jan 18	Sale	26.31	102,467	2,696,409	19,597,221	Jan 19 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Jan 17	Sale	26.24	88,372	2,318,749	19,699,688	Jan 19 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Jan 13	Sale	26.54	94,199	2,499,749	19,788,060	Jan 17 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Jan 12	Sale	26.61	117,479	3,126,129	19,882,259	Jan 17 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Jan 11	Sale	26.24	79,065	2,074,607	19,999,738	Jan 12 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Jan 10	Sale	26.41	70,575	1,863,886	20,078,803	Jan 12 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Jan 09	Sale	25.85	34,801	899,574	20,149,378	Jan 10 09:00 PM
SATO VICKI L	Director	Jan 09	Sale	25.83	17,915	462,784	1,363,174	Jan 11 11:40 AM
SVF Endurance (Cayman) Ltd	10% Owner	Jan 06	Sale	26.13	66,179	1,729,399	20,184,179	Jan 10 09:00 PM
Sigal Charles Elliott	Director	Jan 05	Buy	24.96	2,500	62,396	7,500	Jan 09 11:51 AM
Sigal Charles Elliott	Director	Jan 04	Buy	25.25	2,500	63,136	5,000	Jan 05 05:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Jan 04	Sale	25.47	1,000	25,468	20,250,358	Jan 05 09:00 PM
Sigal Charles Elliott	Director	Jan 03	Buy	25.60	2,500	63,992	2,500	Jan 05 05:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Jan 03	Sale	25.58	8,177	209,145	20,251,358	Jan 05 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Dec 29	Sale	25.55	44,169	1,128,461	20,259,535	Jan 03 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Dec 27	Sale	25.59	6,850	175,304	20,303,704	Dec 29 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Dec 23	Sale	25.76	80,081	2,063,115	20,310,554	Dec 27 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Dec 22	Sale	26.07	95,144	2,480,399	20,390,635	Dec 27 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Dec 21	Sale	26.13	111,730	2,919,291	20,485,779	Dec 22 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Dec 20	Sale	25.53	104,026	2,656,294	20,597,509	Dec 22 09:00 PM
SATO VICKI L	Director	Dec 08	Sale	25.81	17,915	462,366	1,381,089	Dec 09 03:43 PM
SVF Endurance (Cayman) Ltd	10% Owner	Dec 05	Sale	27.25	8,831	240,644	20,701,535	Dec 06 09:30 PM
SVF Endurance (Cayman) Ltd	10% Owner	Dec 02	Sale	27.47	88,462	2,430,414	20,710,366	Dec 06 09:30 PM
SVF Endurance (Cayman) Ltd	10% Owner	Dec 01	Sale	27.48	46,376	1,274,334	20,798,828	Dec 02 05:51 PM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 30	Sale	27.85	165,953	4,621,607	20,845,204	Dec 02 05:51 PM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 29	Sale	27.39	71,126	1,948,205	21,011,157	Nov 30 08:50 PM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 28	Sale	27.46	37,989	1,043,180	21,082,283	Nov 30 08:50 PM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 25	Sale	27.21	17,264	469,671	21,120,272	Nov 28 05:04 PM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 23	Sale	27.30	39,729	1,084,745	21,137,536	Nov 28 05:04 PM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 22	Sale	27.27	65,213	1,778,195	21,177,265	Nov 23 04:30 PM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 21	Sale	27.13	720	19,535	21,242,478	Nov 22 06:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 18	Sale	27.21	25,259	687,282	21,243,198	Nov 22 06:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 17	Sale	27.18	73,030	1,984,700	21,268,457	Nov 18 04:30 PM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 16	Sale	27.54	137,001	3,772,909	21,341,487	Nov 18 04:30 PM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 15	Sale	27.72	87,800	2,434,046	21,478,488	Nov 16 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 14	Sale	27.41	50,173	1,375,222	21,566,288	Nov 16 09:00 PM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 11	Sale	27.27	159,354	4,346,046	21,616,461	Nov 14 04:31 PM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 10	Sale	27.35	123,113	3,367,301	21,775,815	Nov 14 04:31 PM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 09	Sale	27.21	5,269	143,392	21,898,928	Nov 14 04:31 PM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 08	Sale	27.38	49,105	1,344,407	21,904,197	Nov 09 04:30 PM
SATO VICKI L	Director	Nov 08	Sale	27.38	17,915	490,549	1,399,004	Nov 09 11:09 AM
SVF Endurance (Cayman) Ltd	10% Owner	Nov 07	Sale	27.22	132,978	3,619,674	21,953,302	Nov 09 04:30 PM
SATO VICKI L	Director	Oct 10	Sale	20.67	17,915	370,278	1,416,919	Oct 11 01:12 PM
SATO VICKI L	Director	Sep 08	Sale	21.90	17,915	392,335	1,434,834	Sep 09 01:47 PM
SVF Endurance (Cayman) Ltd	10% Owner	Aug 16	Sale	27.64	7,800	215,614	22,086,280	Aug 17 04:53 PM
SVF Endurance (Cayman) Ltd	10% Owner	Aug 15	Sale	27.99	122,564	3,430,144	22,094,080	Aug 17 04:53 PM
Virgin Herbert	EVP, Research & CSO	Aug 09	Option Exercise	2.43	78,093	189,658	262,500	Aug 10 04:50 PM
Pang Phillip	Chief Medical Officer	Jul 20	Sale	30.00	5,000	150,000	144,000	Jul 21 04:10 PM
Ramasastry Saira	Director	Jul 11	Sale	30.00	5,000	150,000	8,092	Jul 13 04:05 PM
SATO VICKI L	Director	Jul 08	Sale	29.06	17,915	520,694	1,470,664	Jul 12 04:46 PM

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