RA CAPITAL MANAGEMENT, L.P. - Insider Transactions

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Ticker	Owner	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
ANTX	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Aug 09 '24	Sale	1.08	3,525,094	3,807,102	300,853	Aug 13 05:03 PM
ARTV	RA CAPITAL MANAGEMENT, L.P.	Director	Jul 22 '24	Buy	12.00	8,333,333	99,999,996	8,693,579	Jul 24 04:27 PM
ELYM	RA CAPITAL MANAGEMENT, L.P.	Director	Jun 27 '24	Buy	3.84	13,008,546	49,952,817	23,521,757	Jul 01 09:29 PM
AVTE	RA CAPITAL MANAGEMENT, L.P.	Director	Jun 17 '24	Buy	1.67	928,110	1,549,944	7,893,678	Jun 20 05:56 PM
BOLD	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Apr 02 '24	Buy	16.00	312,500	5,000,000	1,884,787	Apr 04 04:15 PM

NKTX	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 27 '24	Buy	10.00	3,000,000	30,000,000	10,050,818	Mar 29 05:38 PM
SPRY	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 25 '24	Buy	9.06	437,600	3,964,656	8,994,374	Mar 27 07:37 PM
SPRY	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 26 '24	Buy	9.55	457,745	4,371,465	9,452,119	Mar 27 07:37 PM
SPRY	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 27 '24	Buy	9.79	505,954	4,953,290	9,958,073	Mar 27 07:37 PM
LENZ	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 21 '24	Buy	15.03	998,009	15,000,075	3,319,339	Mar 25 08:48 PM
ETNB	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 04 '24	Buy	15.35	1,350,000	20,722,500	12,431,584	Mar 06 05:40 PM
PEPG	RA CAPITAL MANAGEMENT, L.P.	Director	Feb 09 '24	Buy	10.64	2,557,593	27,212,790	9,179,273	Feb 13 04:33 PM
SLDB	RA CAPITAL MANAGEMENT, L.P.	Director	Jan 11 '24	Buy	5.53	904,160	5,000,005	4,192,216	Jan 12 05:01 PM
WVE	RA CAPITAL MANAGEMENT, L.P.	Director	Dec 11 '23	Buy	5.00	1,000,000	5,000,000	19,202,009	Dec 13 04:33 PM
SPRY	RA CAPITAL MANAGEMENT, L.P.	Director	Sep 21 '23	Buy	3.03	2,700,000	8,183,526	8,556,774	Sep 25 04:30 PM

SPRY	RA CAPITAL MANAGEMENT, L.P.	Director	Aug 29 '23	Buy	6.20	3,750,000	23,250,000	5,856,774	Aug 31 05:26 PM
ANTX	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Aug 18 '23	Buy	9.00	1,777,778	16,000,002	5,135,683	Aug 22 05:01 PM
ABOS	RA CAPITAL MANAGEMENT, L.P.	Director	Jul 21 '23	Buy	7.75	5,161,290	39,999,998	13,043,179	Jul 25 04:30 PM
JANX	RA CAPITAL MANAGEMENT, L.P.	Director	Jul 19 '23	Buy	12.46	495,008	6,167,800	8,117,246	Jul 21 04:31 PM
BDTX	RA CAPITAL MANAGEMENT, L.P.	Director	Jul 05 '23	Buy	5.00	935,850	4,679,250	3,213,828	Jul 07 04:30 PM
ETNB	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 24 '23	Buy	16.25	2,461,538	39,999,992	11,081,584	Mar 30 05:00 PM
MLYS	RA CAPITAL MANAGEMENT, L.P.	Director	Feb 14 '23	Buy	16.00	1,250,000	20,000,000	1,867,229	Feb 16 05:04 PM
FULC	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Jan 20 '23	Buy	13.00	1,923,076	24,999,988	11,609,704	Jan 24 04:30 PM
HOWL	RA CAPITAL MANAGEMENT, L.P.	Director	Jan 06 '23	Buy	2.21	1,853,000	4,095,130	5,701,056	Jan 10 05:14 PM
FULC	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Jan 04 '23	Buy	7.28	180,703	1,314,806	9,686,628	Jan 06 04:39 PM
FULC	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Dec 27 '22	Buy	5.99	4,089	24,510	9,505,925	Dec 29 05:00 PM
FULC	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Dec 19 '22	Buy	5.90	98,787	582,814	9,501,836	Dec 21 04:30 PM
FULC	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Dec 14 '22	Buy	5.46	824,600	4,501,574	7,824,600	Dec 16 04:41 PM
FULC	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Dec 15 '22	Buy	5.50	237,029	1,302,474	8,061,629	Dec 16 04:41 PM
FULC	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Dec 16 '22	Buy	5.42	1,341,420	7,269,826	9,403,049	Dec 16 04:41 PM

ACRV	RA CAPITAL MANAGEMENT, L.P.	Director	Nov 17 '22	Buy	12.50	3,389,500	42,368,750	4,384,206	Nov 21 04:31 PM
ETNB	RA CAPITAL MANAGEMENT, L.P.	Director	Oct 18 '22	Buy	7.65	1,172,741	8,971,469	8,955,410	Oct 20 05:28 PM
ANTX	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Aug 04 '22	Buy	7.99	100	799	3,773,517	Aug 05 04:06 PM
ANTX	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Aug 03 '22	Buy	7.48	1,809	13,531	3,773,417	Aug 05 04:06 PM
ANTX	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Jul 26 '22	Buy	7.71	14,938	115,172	3,763,327	Jul 28 05:16 PM
ANTX	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Jul 27 '22	Buy	7.91	8,281	65,503	3,771,608	Jul 28 05:16 PM
ETNB	RA CAPITAL MANAGEMENT, L.P.	Director	Jul 01 '22	Buy	3.55	2,816,900	9,999,995	7,782,669	Jul 06 05:27 PM
ANTX	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Jun 21 '22	Buy	7.99	302	2,413	3,748,389	Jun 23 04:31 PM
WVE	RA CAPITAL MANAGEMENT, L.P.	Director	Jun 16 '22	Buy	2.15	9,480,052	20,382,112	17,202,009	Jun 21 04:33 PM
ANTX	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Jun 13 '22	Buy	7.90	20,000	158,000	3,686,663	Jun 15 04:25 PM
ANTX	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Jun 14 '22	Buy	7.97	61,424	489,402	3,748,087	Jun 15 04:25 PM
KALA	RA CAPITAL MANAGEMENT, L.P.	10% Owner	May 26 '22	Sale	0.36	1,005,686	365,667	7,039,613	May 26 05:09 PM
KALA	RA CAPITAL MANAGEMENT, L.P.	10% Owner	May 23 '22	Sale	0.65	1,250,000	812,500	9,624,613	May 25 05:17 PM
KALA	RA CAPITAL MANAGEMENT, L.P.	10% Owner	May 24 '22	Sale	0.51	144,805	73,851	9,479,808	May 25 05:17 PM
KALA	RA CAPITAL MANAGEMENT, L.P.	10% Owner	May 25 '22	Sale	0.42	1,434,509	602,494	8,045,299	May 25 05:17 PM
NKTX	RA CAPITAL MANAGEMENT, L.P.	Director	Apr 26 '22	Buy	15.00	2,200,000	33,000,000	7,805,129	Apr 28 04:32 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 14 '22	Buy	12.35	342,143	4,223,926	13,139,327	Mar 16 05:10 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 15 '22	Buy	12.27	241,727	2,964,999	13,381,054	Mar 16 05:10 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 09 '22	Buy	12.99	40,154	521,753	12,202,700	Mar 11 05:27 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 10 '22	Buy	12.95	256,992	3,327,584	12,459,692	Mar 11 05:27 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 11 '22	Buy	12.77	337,492	4,309,334	12,797,184	Mar 11 05:27 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 04 '22	Buy	12.99	63,662	827,230	11,578,944	Mar 08 04:59 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 07 '22	Buy	12.61	337,901	4,260,965	11,916,845	Mar 08 04:59 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 08 '22	Buy	12.86	245,701	3,160,059	12,162,546	Mar 08 04:59 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Feb 28 '22	Buy	12.97	8,746	113,430	11,082,163	Mar 02 05:29 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 01 '22	Buy	12.98	294,864	3,826,303	11,377,027	Mar 02 05:29 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 02 '22	Buy	12.89	138,255	1,782,218	11,515,282	Mar 02 05:29 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Feb 23 '22	Buy	13.41	214,922	2,883,114	10,867,959	Feb 25 05:43 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Feb 24 '22	Buy	13.03	186,467	2,429,851	11,054,426	Feb 25 05:43 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Feb 25 '22	Buy	12.99	18,991	246,699	11,073,417	Feb 25 05:43 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Feb 17 '22	Buy	14.78	166,229	2,457,264	10,271,886	Feb 22 05:22 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Feb 18 '22	Buy	14.12	166,229	2,346,389	10,438,115	Feb 22 05:22 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Feb 22 '22	Buy	13.46	214,922	2,892,055	10,653,037	Feb 22 05:22 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Feb 14 '22	Buy	14.72	166,229	2,446,924	9,773,257	Feb 16 07:39 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Feb 15 '22	Buy	14.99	166,200	2,490,524	9,939,457	Feb 16 07:39 PM
CTKB	RA CAPITAL MANAGEMENT, L.P.	Director	Feb 16 '22	Buy	14.98	166,200	2,489,377	10,105,657	Feb 16 07:39 PM
ABOS	RA CAPITAL MANAGEMENT, L.P.	Director	Jul 06 '21	Buy	16.00	1,875,000	30,000,000	7,881,889	Jul 08 04:32 PM
HOWL	RA CAPITAL MANAGEMENT, L.P.	Director	Jun 14 '21	Buy	12.75	306,055	3,902,201	4,274,638	Jun 16 04:58 PM
HOWL	RA CAPITAL MANAGEMENT, L.P.	Director	Jun 15 '21	Buy	12.95	7,958	103,056	4,282,596	Jun 16 04:58 PM
HOWL	RA CAPITAL MANAGEMENT, L.P.	Director	Jun 16 '21	Buy	13.37	9,285	124,140	4,291,881	Jun 16 04:58 PM
ETNB	RA CAPITAL MANAGEMENT, L.P.	Director	Jun 02 '21	Buy	18.77	22,138	415,530	4,965,769	Jun 04 04:31 PM
ETNB	RA CAPITAL MANAGEMENT, L.P.	Director	May 26 '21	Buy	18.03	48,377	872,237	4,784,591	May 28 06:41 PM
ETNB	RA CAPITAL MANAGEMENT, L.P.	Director	May 27 '21	Buy	18.76	35,535	666,637	4,820,126	May 28 06:41 PM
ETNB	RA CAPITAL MANAGEMENT, L.P.	Director	May 28 '21	Buy	18.77	123,505	2,318,189	4,943,631	May 28 06:41 PM
HOWL	RA CAPITAL MANAGEMENT, L.P.	Director	May 04 '21	Buy	16.00	1,715,000	27,440,000	3,524,758	May 06 04:31 PM
SLDB	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 19 '21	Buy	5.75	2,206,685	12,688,439	10,916,567	Mar 23 04:30 PM
SCPH	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Mar 12 '21	Sale	7.22	39,469	284,816	2,838,034	Mar 16 04:30 PM
SCPH	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Mar 15 '21	Sale	7.03	110,588	777,788	2,727,446	Mar 16 04:30 PM
PHAT	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Mar 11 '21	Sale	43.75	710,000	31,062,500	3,115,008	Mar 15 04:36 PM
VOR	RA CAPITAL MANAGEMENT, L.P.	Director	Feb 09 '21	Buy	18.00	2,979,566	53,632,188	8,297,265	Feb 09 06:25 PM
RYTM	RA CAPITAL MANAGEMENT, L.P.	Former 10% Owner	Dec 02 '20	Sale	32.39	30,939	1,002,261	4,568,464	Dec 04 04:30 PM
RYTM	RA CAPITAL MANAGEMENT, L.P.	Former 10% Owner	Dec 03 '20	Sale	29.03	207,604	6,027,391	4,360,860	Dec 04 04:30 PM
PCVX	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Oct 07 '20	Sale	50.95	98,597	5,023,527	5,169,254	Oct 09 04:22 PM
PCVX	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Oct 08 '20	Sale	50.69	167,661	8,498,065	5,001,593	Oct 09 04:22 PM
PCVX	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Sep 29 '20	Sale	52.08	80,707	4,202,987	5,408,474	Oct 01 05:25 PM
PCVX	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Sep 30 '20	Sale	50.27	124,656	6,265,871	5,283,818	Oct 01 05:25 PM
ETNB	RA CAPITAL MANAGEMENT, L.P.	Director	Sep 17 '20	Buy	28.00	1,300,000	36,400,000	4,736,214	Sep 21 04:30 PM
TGTX	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Sep 09 '20	Sale	25.81	158,589	4,092,738	12,629,868	Sep 11 04:31 PM
NKTX	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Jul 14 '20	Buy	18.00	3,333,333	59,999,994	5,605,129	Jul 16 04:30 PM
ETNB	RA CAPITAL MANAGEMENT, L.P.	Director	Jul 08 '20	Buy	27.50	275,000	7,562,500	3,436,214	Jul 10 04:32 PM
RYTM	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Jun 30 '20	Sale	22.15	61,901	1,371,237	5,210,088	Jul 02 04:46 PM
RYTM	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Jul 01 '20	Sale	21.87	25,527	558,311	5,184,561	Jul 02 04:46 PM
RYTM	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Jul 02 '20	Sale	22.04	44,153	972,969	5,140,408	Jul 02 04:46 PM
RYTM	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Jun 25 '20	Sale	25.05	11,568	289,768	5,410,744	Jun 29 06:31 PM
RYTM	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Jun 26 '20	Sale	23.31	86,706	2,020,848	5,324,038	Jun 29 06:31 PM
RYTM	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Jun 29 '20	Sale	22.19	52,049	1,154,999	5,271,989	Jun 29 06:31 PM
VSTM	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Jun 25 '20	Sale	1.91	1,161,300	2,219,941	16,142,051	Jun 29 06:29 PM
VSTM	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Apr 27 '20	Sale	2.31	1,301,300	3,002,099	17,303,351	Apr 29 04:30 PM
PHAT	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Apr 01 '20	Buy	24.86	117,600	2,923,642	3,825,008	Apr 03 04:30 PM
PHAT	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Mar 27 '20	Buy	24.60	30,000	738,000	3,676,808	Mar 31 05:02 PM
PHAT	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Mar 31 '20	Buy	24.55	30,600	751,264	3,707,408	Mar 31 05:02 PM
KALA	RA CAPITAL MANAGEMENT, L.P.	Director	Mar 13 '20	Buy	7.89	6,337,135	49,999,995	10,874,613	Mar 13 06:45 PM
SCPH	RA CAPITAL MANAGEMENT, L.P.	10% Owner	Feb 14 '20	Buy	8.20	271,993	2,230,343	3,247,005	Feb 19 04:30 PM
KALA	RA CAPITAL MANAGEMENT, LLC	Director	Oct 03 '18	Buy	8.25	2,424,242	19,999,996	4,537,478	Oct 05 04:33 PM
KALV	RA CAPITAL MANAGEMENT, LLC	Director	Oct 12 '17	Buy	8.50	850,000	7,225,000	1,441,070	Oct 16 04:32 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jul 17 '14	Buy	12.26	37,215	456,211	2,199,753	Feb 18 09:54 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jul 24 '14	Sale	12.28	124,050	1,523,235	2,075,703	Feb 18 09:54 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jul 25 '14	Sale	12.31	47,429	583,951	2,028,274	Feb 18 09:54 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jul 28 '14	Sale	12.11	60,081	727,474	1,968,193	Feb 18 09:54 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jul 29 '14	Sale	12.41	1,407	17,464	1,966,786	Feb 18 09:54 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jul 30 '14	Sale	12.42	109,590	1,361,606	1,857,196	Feb 18 09:54 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Aug 01 '14	Sale	12.82	27,770	356,100	1,829,426	Feb 18 09:54 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jun 05 '14	Sale	14.13	115,102	1,626,669	2,714,339	Feb 18 09:54 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jun 06 '14	Sale	14.29	135,101	1,930,949	2,579,238	Feb 18 09:54 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jun 09 '14	Sale	15.50	83,500	1,294,159	2,495,738	Feb 18 09:54 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jun 16 '14	Sale	16.55	250,500	4,146,531	2,245,238	Feb 18 09:54 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jul 01 '14	Sale	16.01	82,700	1,323,999	2,162,538	Feb 18 09:54 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	May 07 '14	Buy	12.09	35,736	431,870	4,857,972	Feb 18 09:53 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	May 08 '14	Sale	12.40	83,300	1,032,587	4,774,672	Feb 18 09:53 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	May 12 '14	Sale	13.03	29,659	386,330	4,745,013	Feb 18 09:53 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	May 13 '14	Sale	13.12	56,060	735,305	4,688,953	Feb 18 09:53 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	May 22 '14	Sale	13.56	56,396	764,537	4,632,557	Feb 18 09:53 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	May 23 '14	Sale	13.27	51,597	684,713	4,580,960	Feb 18 09:53 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	May 27 '14	Sale	13.55	263,437	3,570,473	4,317,523	Feb 18 09:53 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	May 28 '14	Sale	13.43	148,689	1,996,952	4,168,834	Feb 18 09:53 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	May 29 '14	Sale	13.53	155,675	2,106,559	4,013,159	Feb 18 09:53 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	May 30 '14	Sale	13.40	65,884	883,147	3,947,275	Feb 18 09:53 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jun 03 '14	Sale	12.86	76,833	988,072	3,870,442	Feb 18 09:53 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jun 04 '14	Sale	13.10	70,640	925,227	3,799,802	Feb 18 09:53 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jun 05 '14	Sale	13.06	970,361	12,669,888	2,829,441	Feb 18 09:53 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 03 '14	Buy	16.61	195,126	3,241,999	4,262,326	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 04 '14	Buy	15.38	179,031	2,753,712	4,441,357	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 07 '14	Buy	15.42	33,667	519,310	4,475,024	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 08 '14	Buy	15.49	121,876	1,888,274	4,596,900	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 10 '14	Buy	14.91	83,000	1,237,339	4,610,044	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 11 '14	Buy	14.48	116,992	1,694,299	4,723,633	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 15 '14	Buy	13.16	21,829	287,206	4,742,407	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 25 '14	Buy	13.63	166,000	2,262,779	4,575,328	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 28 '14	Buy	13.29	74,844	995,014	4,650,172	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 30 '14	Buy	13.45	124,500	1,674,679	4,774,672	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	May 07 '14	Buy	11.73	47,564	557,989	4,822,236	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 17 '14	Buy	14.02	41,500	581,959	4,762,078	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 22 '14	Sale	14.86	352,750	5,243,538	4,409,328	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 16 '14	Sale	14.09	21,829	307,658	4,720,578	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 14 '14	Sale	14.78	3,055	45,165	4,720,578	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 10 '14	Sale	15.67	3,403	53,326	4,606,641	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 09 '14	Sale	16.27	69,856	1,136,424	4,527,044	Feb 18 09:52 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Mar 07 '14	Buy	22.25	258,377	5,748,552	3,683,000	Feb 18 09:51 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Mar 10 '14	Buy	22.30	12,522	279,180	3,683,000	Feb 18 09:51 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Mar 13 '14	Buy	22.76	71,319	1,623,356	3,683,000	Feb 18 09:51 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Mar 17 '14	Buy	23.02	52,161	1,200,835	3,683,000	Feb 18 09:51 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Mar 21 '14	Buy	21.22	101,808	2,159,989	3,683,000	Feb 18 09:51 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Mar 25 '14	Buy	19.42	84,000	1,631,041	3,767,000	Feb 18 09:51 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Mar 26 '14	Buy	18.14	210,013	3,808,711	3,977,013	Feb 18 09:51 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Mar 27 '14	Buy	17.65	256,187	4,522,356	4,233,200	Feb 18 09:51 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Mar 28 '14	Buy	17.10	84,000	1,436,056	4,317,200	Feb 18 09:51 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Apr 01 '14	Sale	18.01	250,000	4,502,381	4,067,200	Feb 18 09:51 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Mar 18 '14	Sale	23.74	84,000	1,994,573	3,683,000	Feb 18 09:51 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Mar 19 '14	Sale	24.28	17,808	432,432	3,683,000	Feb 18 09:51 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Mar 12 '14	Sale	23.40	123,480	2,889,432	3,683,000	Feb 18 09:51 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Mar 06 '14	Sale	24.10	61,483	1,481,538	3,683,000	Feb 18 09:51 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Feb 26 '14	Buy	19.57	74,194	1,452,243	3,757,196	Feb 18 09:49 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Feb 28 '14	Buy	18.10	42,000	760,145	3,767,000	Feb 18 09:49 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Mar 06 '14	Buy	22.50	84,001	1,890,245	3,683,000	Feb 18 09:49 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Feb 05 '14	Buy	18.23	42,000	765,828	3,725,002	Feb 18 09:49 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Feb 11 '14	Buy	19.65	42,000	825,275	3,725,002	Feb 18 09:49 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Feb 12 '14	Buy	18.04	42,000	757,621	3,767,002	Feb 18 09:49 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Feb 13 '14	Sale	18.46	15,409	284,438	3,751,593	Feb 18 09:49 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Feb 14 '14	Sale	18.61	15,380	286,166	3,736,213	Feb 18 09:49 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Feb 18 '14	Sale	18.11	11,172	202,278	3,725,041	Feb 18 09:49 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Feb 19 '14	Sale	18.51	6,720	124,420	3,718,321	Feb 18 09:49 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Feb 20 '14	Sale	18.40	35,319	649,869	3,683,002	Feb 18 09:49 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Feb 06 '14	Sale	18.42	7,312	134,683	3,717,690	Feb 18 09:49 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Feb 07 '14	Sale	18.52	34,688	642,432	3,683,002	Feb 18 09:49 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Mar 06 '14	Sale	23.28	293,417	6,831,412	3,683,000	Feb 18 09:49 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Mar 03 '14	Sale	18.21	84,000	1,529,902	3,683,000	Feb 18 09:49 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Feb 27 '14	Sale	19.37	32,196	623,499	3,725,000	Feb 18 09:49 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner.	Dec 12 '13	Buy	12.09	9,600	116,071	4,037,962	Feb 18 06:38 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner.	Dec 13 '13	Buy	12.09	5,040	60,921	4,043,002	Feb 18 06:38 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner.	Jan 09 '14	Sale	18.35	72,440	1,329,365	3,970,562	Feb 18 06:38 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jul 17 '13	Buy	9.79	19,200	187,895	3,645,703	Feb 18 06:37 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jul 17 '13	Sale	10.22	48,270	493,401	3,626,503	Feb 18 06:37 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jul 18 '13	Sale	10.02	74,035	741,498	3,626,503	Feb 18 06:37 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jul 19 '13	Sale	9.84	209,894	2,065,714	3,603,463	Feb 18 06:37 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jul 22 '13	Sale	9.57	111,363	1,065,610	3,492,100	Feb 18 06:37 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jul 23 '13	Sale	9.37	5,012	46,938	3,487,088	Feb 18 06:37 PM
SGMO	RA CAPITAL MANAGEMENT, LLC	Former 10% Owner	Jul 25 '13	Sale	9.71	368,870	3,582,848	3,118,218	Feb 18 06:37 PM
CRIS	RA CAPITAL MANAGEMENT, LLC	10% Owner	Apr 15 '08	Sale	1.40	1,300,000	1,820,000	6,250,564	Apr 17 05:49 PM

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RA CAPITAL MANAGEMENT, L.P. - Insider Transactions

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