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Index- P/E- EPS (ttm)- Insider Own8.16% Shs Outstand154.73M Perf Week5.80%
Market Cap479.66M Forward P/E- EPS next Y-0.03 Insider Trans-3.20% Shs Float142.11M Perf Month-17.55%
Income- PEG- EPS next Q-0.01 Inst Own62.69% Short Float5.07% Perf Quarter-22.69%
Sales- P/S- EPS this Y-53.57% Inst Trans7.25% Short Ratio6.86 Perf Half Y-19.06%
Book/sh0.47 P/B6.61 EPS next Y58.14% ROA- Short Interest7.20M Perf Year-22.31%
Cash/sh0.52 P/C5.96 EPS next 5Y6.69% ROE- 52W Range2.53 - 5.02 Perf YTD-11.43%
Dividend Est.- P/FCF- EPS past 5Y41.78% ROI- 52W High-38.25% Beta0.94
Dividend TTM- Quick Ratio6.10 Sales past 5Y-25.00% Gross Margin- 52W Low22.77% ATR (14)0.20
Dividend Ex-Date- Current Ratio6.10 EPS Y/Y TTM-21.83% Oper. Margin- RSI (14)46.50 Volatility4.96% 6.64%
Employees33 Debt/Eq0.09 Sales Y/Y TTM- Profit Margin- Recom1.12 Target Price7.34
Option/ShortYes / Yes LT Debt/Eq0.01 EPS Q/Q- Payout- Rel Volume0.92 Prev Close3.21
Sales Surprise- EPS Surprise-11.11% Sales Q/Q- EarningsNov 12 BMO Avg Volume1.05M Price3.10
SMA200.75% SMA50-8.48% SMA200-17.53% Trades Volume963,883 Change-3.43%
Date Action Analyst Rating Change Price Target Change
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Jun-13-24Initiated Robert W. Baird Outperform $8
Oct-13-23Resumed BTIG Research Buy $4
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Mereo BioPharma Group Plc is a biopharmaceutical company, which engages in the development and commercialization of therapeutics that aim to improve outcomes for oncology and rare diseases. Its portfolio include Etigilimab (MPH-313), Alvelestat (MPH-966), Setrusumab (BPS-804), Navicixizumab (OMP-305B83), Acumapimod (BCT-197), and Leflutrozole (BGS-649). The company was founded by Denise Vera Scots-Knight, Charles Edward Sermon, Alastair Graham MacKinnon, and John P. Richard in March 10, 2015 and is headquartered in London, the United Kingdom.
Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total SEC Form 4
Scots-Knight DeniseChief Executive OfficerSep 13 '24Sale4.2260,046253,454808,921Sep 16 08:50 PM
Scots-Knight DeniseChief Executive OfficerSep 12 '24Sale4.4728,611127,968868,967Sep 16 08:50 PM
Lewicki John A.Chief Scientific OfficerSep 13 '24Sale4.2210,93746,16578,630Sep 16 08:49 PM
Lewicki John A.Chief Scientific OfficerSep 12 '24Sale4.475,21223,31289,567Sep 16 08:49 PM
Sermon CharlesGeneral CounselSep 13 '24Sale4.2220,94688,413219,061Sep 16 08:48 PM
Sermon CharlesGeneral CounselSep 12 '24Sale4.479,98044,638240,007Sep 16 08:48 PM
Fox Christine AnnChief Financial OfficerSep 13 '24Sale4.2219,15880,86689,285Sep 16 08:47 PM
Fox Christine AnnChief Financial OfficerSep 12 '24Sale4.479,12840,827108,443Sep 16 08:47 PM
Hughes-Wilson AlexandraSee RemarksSep 13 '24Sale4.22100,312423,41750,475Sep 16 08:46 PM
Hughes-Wilson AlexandraSee RemarksSep 12 '24Sale4.4747,798213,786150,787Sep 16 08:46 PM
Sermon CharlesGeneral CounselSep 11 '24Option Exercise0.0065,6000249,987Sep 13 04:57 PM
Fox Christine AnnChief Financial OfficerSep 11 '24Option Exercise0.0060,0000117,571Sep 13 04:50 PM
Lewicki John A.Chief Scientific OfficerSep 11 '24Option Exercise0.0046,000094,779Sep 13 04:49 PM
Scots-Knight DeniseChief Executive OfficerSep 11 '24Option Exercise0.00188,0600897,578Sep 13 04:49 PM
Hughes-Wilson AlexandraSee RemarksSep 11 '24Option Exercise0.99208,333206,416242,881Sep 13 04:47 PM
Alexandra Hughes-WilsonOfficerSep 12 '24Proposed Sale4.66148,110690,193Sep 12 04:05 PM
Scots-Knight DeniseOfficerSep 12 '24Proposed Sale4.6688,657413,142Sep 12 04:05 PM
Sermon CharlesOfficerSep 12 '24Proposed Sale4.6630,926144,115Sep 12 04:05 PM
Lewicki John A.OfficerSep 12 '24Proposed Sale4.6616,14975,254Sep 12 04:05 PM
Fox Christine AnnOfficerSep 12 '24Proposed Sale4.6628,286131,813Sep 12 04:05 PM
PAKIANATHAN DEEPIKADirectorAug 22 '24Option Exercise1.44105,244151,116105,244Aug 23 06:13 PM
PAKIANATHAN DEEPIKADirectorAug 22 '24Sale4.43105,244466,2100Aug 23 06:13 PM
Deepika PakianathanDirectorAug 22 '24Proposed Sale4.43105,244466,210Aug 22 06:35 PM
Sermon CharlesGeneral CounselJun 26 '24Sale3.3932,187109,217184,387Jun 27 04:15 PM
Sermon CharlesGeneral CounselJun 25 '24Sale3.6914,20252,461216,574Jun 27 04:15 PM
Lewicki John A.Chief Scientific OfficerJun 26 '24Sale3.3916,80857,03348,779Jun 27 04:15 PM
Lewicki John A.Chief Scientific OfficerJun 25 '24Sale3.697,41627,39465,587Jun 27 04:15 PM
Fox Christine AnnChief Financial OfficerJun 26 '24Sale3.3929,43999,89257,571Jun 27 04:15 PM
Fox Christine AnnChief Financial OfficerJun 25 '24Sale3.6912,99047,98487,010Jun 27 04:15 PM
Scots-Knight DeniseChief Executive OfficerJun 26 '24Sale3.3992,273313,101709,518Jun 27 04:15 PM
Scots-Knight DeniseChief Executive OfficerJun 25 '24Sale3.6940,712150,386801,791Jun 27 04:15 PM
Hughes-Wilson AlexandraSee RemarksJun 26 '24Sale3.3922,96877,93534,548Jun 27 04:15 PM
Hughes-Wilson AlexandraSee RemarksJun 25 '24Sale3.6910,13437,43457,516Jun 27 04:15 PM
Lewicki John A.Chief Scientific OfficerJun 21 '24Option Exercise0.0069,000073,003Jun 25 06:21 PM
Scots-Knight DeniseChief Executive OfficerJun 21 '24Option Exercise0.00282,0900842,503Jun 25 06:15 PM
Sermon CharlesGeneral CounselJun 21 '24Option Exercise0.0098,4000230,776Jun 25 06:14 PM
Fox Christine AnnChief Financial OfficerJun 21 '24Option Exercise0.0090,0000100,000Jun 25 06:13 PM
Hughes-Wilson AlexandraSee RemarksJun 21 '24Option Exercise0.0060,000067,650Jun 25 06:13 PM
Hughes-Wilson AlexandraSee RemarksMay 22 '24Option Exercise1.23168,333206,416100,983May 23 09:54 PM
Hughes-Wilson AlexandraSee RemarksMay 22 '24Sale2.97100,432297,78832,568May 23 09:54 PM
Last Close
Feb 06 04:00PM ET
0.6570
Dollar change
-0.0150
Percentage change
-2.23
%
KPTI Karyopharm Therapeutics Inc daily Stock Chart
Index- P/E- EPS (ttm)-1.14 Insider Own7.58% Shs Outstand125.30M Perf Week-1.07%
Market Cap82.91M Forward P/E- EPS next Y-0.72 Insider Trans-0.44% Shs Float116.62M Perf Month-20.75%
Income-87.48M PEG- EPS next Q-0.26 Inst Own47.20% Short Float16.98% Perf Quarter-29.58%
Sales148.44M P/S0.56 EPS this Y45.03% Inst Trans6.24% Short Ratio21.88 Perf Half Y-21.79%
Book/sh-1.27 P/B- EPS next Y-4.57% ROA-38.08% Short Interest19.80M Perf Year-51.33%
Cash/sh1.06 P/C0.62 EPS next 5Y24.25% ROE- 52W Range0.58 - 1.95 Perf YTD-2.85%
Dividend Est.- P/FCF- EPS past 5Y16.79% ROI-282.69% 52W High-66.31% Beta0.08
Dividend TTM- Quick Ratio2.93 Sales past 5Y56.57% Gross Margin95.62% 52W Low13.10% ATR (14)0.06
Dividend Ex-Date- Current Ratio3.00 EPS Y/Y TTM43.16% Oper. Margin-84.86% RSI (14)46.49 Volatility8.27% 8.92%
Employees325 Debt/Eq- Sales Y/Y TTM1.77% Profit Margin-58.93% Recom1.57 Target Price4.50
Option/ShortYes / Yes LT Debt/Eq- EPS Q/Q14.92% Payout- Rel Volume0.57 Prev Close0.67
Sales Surprise2.27% EPS Surprise1.10% Sales Q/Q7.70% EarningsNov 05 BMO Avg Volume904.73K Price0.66
SMA20-1.66% SMA50-7.81% SMA200-23.21% Trades Volume517,875 Change-2.23%
Date Action Analyst Rating Change Price Target Change
Jan-19-23Initiated Piper Sandler Overweight $8
Nov-04-22Upgrade RBC Capital Mkts Sector Perform → Outperform $7 → $10
Feb-09-22Upgrade JP Morgan Underweight → Neutral $8
Nov-19-21Resumed Morgan Stanley Equal-Weight $27 → $10
Aug-06-21Downgrade SVB Leerink Outperform → Mkt Perform $6
Aug-06-21Downgrade RBC Capital Mkts Outperform → Sector Perform $17 → $8
Aug-06-21Downgrade JP Morgan Overweight → Neutral
Jul-02-20Initiated Morgan Stanley Overweight $34
Mar-04-20Initiated Barclays Overweight $30
Jan-17-20Downgrade Wedbush Outperform → Neutral
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Karyopharm Therapeutics, Inc. is a commercial-stage pharmaceutical company, which engages in the discovery, development, and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. Its Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1 (or CRM1). Karyopharm's compound, XPOVIO (selinexor), is approved in the U.S. in multiple hematologic malignancy indications, including in combination with Velcade (bortezomib) and dexamethasone for the treatment of adult patients with multiple myeloma after at least one prior therapy, in combination with dexamethasone for the treatment of adult patients with pretreated multiple myeloma and as a monotherapy for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma. In addition to single-agent and combination activity against a variety of human cancers, SINE compounds have also shown biological activity in models of neurodegeneration, inflammation, autoimmune disease, certain viruses, and wound-healing. Karyopharm has several investigational programs in clinical or preclinical development. The company was founded by Joseph Araujo, Ronald A. DePinho, Pamela A, Silver, Giulio Draetta, Michael G. Kauffman, and Sharon Shacham on December 22, 2008 and is headquartered in Newton, MA.
Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total SEC Form 4
Paulson Richard A.President and CEOFeb 04 '25Sale0.654,0992,6641,120,158Feb 05 04:16 PM
Paulson Richard A.President and CEOJan 06 '25Sale0.784,0553,1751,124,257Jan 07 04:03 PM
Paulson Richard A.President and CEODec 04 '24Sale0.813,6202,9321,128,312Dec 05 04:15 PM
Paulson Richard A.President and CEONov 05 '24Sale0.913,6753,3461,131,932Nov 06 04:06 PM
Paulson Richard A.President and CEOOct 04 '24Sale0.883,6073,1721,135,607Oct 07 04:44 PM
Mano MichaelSVP, General Counsel&SecretarySep 04 '24Sale0.723,9712,866273,881Sep 05 04:28 PM
Paulson Richard A.President and CEOSep 04 '24Sale0.723,6672,6471,139,214Sep 05 04:26 PM
Mason MichaelEVP, CFO & TreasurerSep 04 '24Sale0.727,0505,089391,054Sep 05 04:24 PM
Cheng Sohanya RoshanEVP & Chief Commercial OfficerSep 04 '24Sale0.725,3563,866404,051Sep 05 04:13 PM
Paulson Richard A.President and CEOAug 06 '24Sale0.933,6083,3551,142,881Aug 08 04:31 PM
Poulton StuartEVP, Chief Development OfficerJul 30 '24Sale1.062,8833,056326,628Jul 31 04:14 PM
Paulson Richard A.President and CEOJul 05 '24Sale0.853,6163,0771,146,489Jul 09 04:15 PM
PAKIANATHAN DEEPIKADirectorJun 05 '24Sale0.96468,044448,4803,385Jun 07 07:18 PM
PAKIANATHAN DEEPIKADirectorJun 07 '24Sale0.95231,548220,1330Jun 07 07:18 PM
PAKIANATHAN DEEPIKADirectorJun 06 '24Sale0.98118,452116,4152,240Jun 07 07:18 PM
Mason MichaelEVP, CFO & TreasurerJun 04 '24Sale0.99652645398,104Jun 06 04:03 PM
Paulson Richard A.President and CEOJun 04 '24Sale0.993,5923,5561,150,105Jun 06 04:02 PM
PAKIANATHAN DEEPIKADirectorJun 03 '24Sale1.00360,744360,99711,209Jun 04 06:51 PM
PAKIANATHAN DEEPIKADirectorJun 04 '24Sale0.95341,040324,7047,911Jun 04 06:51 PM
PAKIANATHAN DEEPIKADirectorMay 31 '24Sale0.95204,394194,99214,697Jun 04 06:51 PM
Paulson Richard A.President and CEOMay 06 '24Sale1.133,5764,0411,153,697May 07 04:56 PM
Rangwala ReshmaEVP & Chief Medical OfficerApr 22 '24Sale1.176,7897,943342,931Apr 23 04:02 PM
Paulson Richard A.President and CEOApr 04 '24Sale1.293,5634,5961,157,273Apr 05 05:20 PM
Paulson Richard A.President and CEOMar 05 '24Sale1.303,5734,6451,160,836Mar 06 04:14 PM
Rangwala ReshmaEVP & Chief Medical OfficerFeb 29 '24Sale1.1715,66718,330355,689Mar 04 07:41 PM
Rangwala ReshmaEVP & Chief Medical OfficerMar 01 '24Sale1.205,9697,163349,720Mar 04 07:41 PM
Poulton StuartEVP, Chief Development OfficerFeb 29 '24Sale1.1716,31119,084335,666Mar 04 07:40 PM
Poulton StuartEVP, Chief Development OfficerMar 01 '24Sale1.206,1557,386329,511Mar 04 07:40 PM
Mason MichaelEVP, CFO & TreasurerFeb 29 '24Sale1.1727,68732,394404,918Mar 04 07:39 PM
Mason MichaelEVP, CFO & TreasurerMar 01 '24Sale1.206,1627,394398,756Mar 04 07:39 PM
Mano MichaelSVP, General Counsel&SecretaryFeb 29 '24Sale1.1716,97319,858281,428Mar 04 07:38 PM
Mano MichaelSVP, General Counsel&SecretaryMar 01 '24Sale1.203,5764,291277,852Mar 04 07:38 PM
Cheng Sohanya RoshanEVP & Chief Commercial OfficerFeb 29 '24Sale1.1721,84025,553398,618Mar 04 07:37 PM
Cheng Sohanya RoshanEVP & Chief Commercial OfficerMar 01 '24Sale1.205,1096,131393,509Mar 04 07:37 PM
Paulson Richard A.President and CEOFeb 29 '24Sale1.1780,47094,1501,183,783Mar 04 07:36 PM
Paulson Richard A.President and CEOMar 01 '24Sale1.2019,37423,2491,164,409Mar 04 07:36 PM
Mason MichaelEVP, CFO & TreasurerFeb 27 '24Sale1.322,5453,369244,400Feb 29 05:35 PM
Poulton StuartEVP, Chief Development OfficerFeb 15 '24Sale1.335,8477,783163,772Feb 20 04:59 PM