INSP Inspire Medical Systems, Inc. Stock Quote

INSP [NYSE]

Index	-	P/E	-	EPS (ttm)	-2.32	Insider Own	0.60%	Shs Outstand	26.84M	Perf Week	0.99%
Market Cap	5.96B	Forward P/E	-	EPS next Y	-2.29	Insider Trans	-59.17%	Shs Float	25.92M	Perf Month	12.25%
Income	-58.80M	PEG	-	EPS next Q	-0.48	Inst Own	95.70%	Short Float	3.19%	Perf Quarter	23.53%
Sales	96.30M	P/S	61.88	EPS this Y	-49.70%	Inst Trans	-2.90%	Short Ratio	3.16	Perf Half Y	93.12%
Book/sh	8.53	P/B	26.52	EPS next Y	5.00%	ROA	-26.40%	Target Price	197.00	Perf Year	166.70%
Cash/sh	8.91	P/C	25.40	EPS next 5Y	4.80%	ROE	-32.20%	52W Range	40.53 - 239.40	Perf YTD	20.28%
Dividend	-	P/FCF	-	EPS past 5Y	-	ROI	-21.30%	52W High	-5.50%	Beta	-
Dividend %	-	Quick Ratio	14.20	Sales past 5Y	-	Gross Margin	84.70%	52W Low	458.20%	ATR	12.33
Employees	239	Current Ratio	14.70	Sales Q/Q	71.30%	Oper. Margin	-60.80%	RSI (14)	55.73	Volatility	6.54% 5.24%
Optionable	Yes	Debt/Eq	0.11	EPS Q/Q	-12.30%	Profit Margin	-61.10%	Rel Volume	1.21	Prev Close	231.21
Shortable	Yes	LT Debt/Eq	0.11	Earnings	Feb 23 AMC	Payout	-	Avg Volume	261.45K	Price	226.24
Recom	1.90	SMA20	2.79%	SMA50	9.44%	SMA200	60.39%	Volume	315,097	Change	-2.15%

Jan-04-21

Downgrade

BofA Securities

Buy → Neutral

Dec-15-20

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Goldman

Buy → Neutral

$162 → $209

Nov-03-20

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Oppenheimer

Underperform → Perform

Nov-03-20

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BofA Securities

Neutral → Buy

$125 → $155

Sep-22-20

Initiated

JP Morgan

Overweight

$148

Sep-02-20

Initiated

Robert W. Baird

Outperform

$130

Aug-06-20

Downgrade

BofA Securities

Buy → Neutral

$115

Jul-15-20

Initiated

Goldman

Buy

$148

Jun-18-20

Reiterated

Piper Sandler

Overweight

$81 → $98

May-18-20

Initiated

Lake Street

Buy

$90

Apr-28-20

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BofA/Merrill

Neutral → Buy

$90

Apr-09-20

Initiated

Piper Sandler

Overweight

$74

Jan-28-20

Initiated

Oppenheimer

Underperform

Jan-27-20

Initiated

Oppenheimer

Underperform

Nov-06-19

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Berenberg

Sell → Hold

$46 → $51

Feb-05-19

Initiated

Dougherty & Company

Buy

$64

Nov-28-18

Initiated

Berenberg

Sell

$31

Oct-29-18

Initiated

Leerink Partners

Outperform

$57

May-29-18

Initiated

Wells Fargo

Outperform

May-29-18

Initiated

Stifel

Buy

$42

Feb-24-21 07:26AM	Inspire Medical Pops 6.4% As 2021 Revenue Outlook Outpaces Estimates SmarterAnalyst
Feb-23-21 04:39PM	Recap: Inspire Medical Systems Q4 Earnings Benzinga
04:05PM	Inspire Medical Systems, Inc. Announces Fourth Quarter and Full Year 2020 Financial Results and Provides 2021 Guidance GlobeNewswire
03:15PM	Inspire Medical Systems, Inc. to Host Earnings Call ACCESSWIRE
Feb-11-21 08:00AM	Inspire Medical Systems, Inc. to Present at the 10th Annual SVB Leerink Global Healthcare Conference GlobeNewswire
Feb-03-21 03:08AM	Did You Miss Inspire Medical Systems' (NYSE:INSP) Impressive 184% Share Price Gain? Simply Wall St.
Jan-23-21 03:30PM	2021 Will be a Good Year for Inspire Medical Systems (INSP) Says Headwaters Capital Insider Monkey
Jan-20-21 04:05PM	Inspire Medical Systems, Inc. to Report Fourth Quarter and Fiscal 2020 Financial Results on February 23, 2021 GlobeNewswire
Jan-19-21 04:05PM	Inspire Medical Systems, Inc. Announces Appointment of Bryan Phillips as General Counsel GlobeNewswire +6.56%
Jan-15-21 08:51AM	NextGen (NXGN) Solution Acts as Financial Bridge Amid COVID-19 Zacks
Jan-14-21 04:59PM	Dow Jones Futures Await $1.9 Trillion Biden Stimulus Plan; K-Shaped Stock Market Rally Yields These Five Breakouts, But Apple, Microsoft Left Behind; JPMorgan, Citigroup On Tap Investor's Business Daily +5.28%
10:44AM	Inspire Medical Investor's Business Daily Video
Dec-22-20 08:00AM	Inspire Medical Systems, Inc. to Present at the 39th Annual J.P. Morgan Healthcare Conference GlobeNewswire
Dec-08-20 08:13AM	Pulmonx Welcomes Two New Members to Its Board of Directors, Adding Expertise in Consumer Marketing and Medical Device Company Growth GlobeNewswire
Nov-18-20 08:00AM	Inspire Medical Systems, Inc. to Present at the Piper Sandler 32nd Annual Virtual Healthcare Conference GlobeNewswire
Nov-10-20 08:00AM	Inspire Medical Systems, Inc. to Present at the 2020 Stifel Virtual Healthcare Conference GlobeNewswire
Nov-09-20 04:05PM	Inspire Medical Systems, Inc. Announces Full Integration of Inspire Therapy into German DRG Reimbursement System to Begin in 2021 GlobeNewswire
Nov-05-20 06:44AM	Inspire Medical Systems, Inc. (NYSE:INSP) Reported Earnings Last Week And Analysts Are Already Upgrading Their Estimates Simply Wall St.
Nov-03-20 04:23PM	Arista Networks, Telenav: 5 Top Stock Gainers for Tuesday TheStreet.com +31.83%
Nov-02-20 05:35PM	Inspire Medical Systems (INSP) Reports Q3 Loss, Tops Revenue Estimates Zacks
04:39PM	Recap: Inspire Medical Systems Q3 Earnings Benzinga
04:05PM	Inspire Medical Systems, Inc. Announces Third Quarter 2020 Financial Results and Updates 2020 Outlook GlobeNewswire
03:15PM	Inspire Medical Systems, Inc. to Host Earnings Call ACCESSWIRE
Oct-27-20 04:05PM	Inspire Medical Systems, Inc. to Present at the Credit Suisse 29th Annual Healthcare Conference GlobeNewswire
Oct-26-20 12:31PM	Analysts Estimate Inspire Medical Systems (INSP) to Report a Decline in Earnings: What to Look Out for Zacks
Oct-22-20 08:00AM	Inspire Medical Systems, Inc. Announces Appointment of Seasoned Senior Corporate Executive Shelley Broader to its Board of Directors GlobeNewswire
Oct-02-20 06:50PM	Why Isnt Everyone Investing in Stocks? Motley Fool
Sep-29-20 08:45AM	Do Hedge Funds Love Inspire Medical Systems, Inc. (INSP)? Insider Monkey
Sep-24-20 08:00AM	Inspire Medical Systems, Inc. to Report Third Quarter 2020 Financial Results on November 2, 2020 GlobeNewswire
Sep-02-20 04:05PM	Inspire Medical Systems, Inc. to Present at the Wells Fargo 2020 Virtual Healthcare Conference GlobeNewswire
10:20AM	Benzinga's Top Upgrades, Downgrades For September 2, 2020 Benzinga
Sep-01-20 07:00AM	Inspire Medical Systems, Inc. Announces Humana Coverage for Inspire Therapy GlobeNewswire
Aug-17-20 04:05PM	Inspire Medical Systems, Inc. Announces Two Additional Coverage Policies from Blue Cross Blue Shield Healthcare Plans GlobeNewswire
Aug-12-20 04:05PM	Inspire Medical Systems, Inc. Announces Regulatory Approval of Inspire Therapy in Australia GlobeNewswire
Aug-07-20 02:11PM	Does Inspire Medical Systems (NYSE:INSP) Have A Healthy Balance Sheet? Simply Wall St.
Aug-04-20 06:15PM	Inspire Medical Systems (INSP) Reports Q2 Loss, Tops Revenue Estimates Zacks
05:28PM	Recap: Inspire Medical Systems Q2 Earnings Benzinga
04:05PM	Inspire Medical Systems, Inc. Announces Second Quarter 2020 Financial Results and Updates 2020 Outlook GlobeNewswire
Jul-28-20 12:33PM	Earnings Preview: Inspire Medical Systems (INSP) Q2 Earnings Expected to Decline Zacks
Jul-21-20 09:56AM	Goldman Sachs: These 2 Stocks Are Poised to Soar by at Least 50% TipRanks
Jul-20-20 04:02PM	Did Hedge Funds Make The Right Call On Inspire Medical Systems, Inc. (INSP) ? Insider Monkey
Jul-09-20 04:05PM	Inspire Medical Systems, Inc. Announces Appointment of Veteran Consumer Marketing Executive Georgia Garinois-Melenikiotou to its Board of Directors GlobeNewswire
Jul-07-20 08:00AM	Inspire Medical Systems, Inc. to Report Second Quarter 2020 Financial Results on August 4, 2020 GlobeNewswire
Jun-16-20 04:05PM	Inspire Medical Systems, Inc. Announces Cigna Coverage for Inspire Therapy for the Treatment of Obstructive Sleep Apnea GlobeNewswire
03:09PM	Robinhood traders could learn from this growth-stock investor whos beaten indexes by a wide margin for years MarketWatch
Jun-15-20 08:58AM	Hedge Funds Keep Buying Inspire Medical Systems, Inc. (INSP) Insider Monkey
Jun-08-20 08:00AM	Inspire Medical Systems, Inc. Announces Appointment of Medical Technology Industry Veteran Phil Ebeling as Chief Operating Officer GlobeNewswire
Jun-03-20 04:05PM	Inspire Medical Systems, Inc. Introduces Digital Health Tools with Launch of New App GlobeNewswire
Jun-01-20 04:05PM	Inspire Medical Systems, Inc. to Present at the Goldman Sachs 41st Annual Global Healthcare Conference GlobeNewswire
May-11-20 07:00AM	Inspire Medical Systems, Inc. Announces Medicare Policy Release Date of Local Coverage Determination for Sole Remaining Region GlobeNewswire
May-07-20 01:54PM	Inspire Medical Systems, Inc. (NYSE:INSP) Just Reported And Analysts Have Been Cutting Their Estimates Simply Wall St.
May-06-20 04:05PM	Inspire Medical Systems, Inc. to Present at the UBS Global Healthcare Conference GlobeNewswire
12:02PM	Inspire Medical Systems, Inc. (INSP) Q1 2020 Earnings Call Transcript Motley Fool
May-05-20 07:25PM	Inspire Medical Systems (INSP) Reports Q1 Loss, Tops Revenue Estimates Zacks
04:10PM	Inspire Medical Systems, Inc. Announces First Quarter 2020 Financial Results GlobeNewswire
03:00PM	Inspire Medical Systems, Inc. to Host Earnings Call ACCESSWIRE
May-04-20 08:50AM	Is a Surprise Coming for Inspire Medical (INSP) This Earnings Season? Zacks
Apr-30-20 04:05PM	Inspire Medical Systems, Inc. to Present at the BofA Securities Virtual Health Care Conference 2020 GlobeNewswire
Apr-28-20 12:33PM	Inspire Medical Systems (INSP) Expected to Beat Earnings Estimates: Can the Stock Move Higher? Zacks
07:00AM	Inspire Medical Systems, Inc. to Report First Quarter 2020 Financial Results on May 5, 2020 GlobeNewswire
Apr-21-20 07:00AM	Inspire Medical Systems Announces FDA Approval of Expanded Age Range for Inspire Therapy GlobeNewswire -6.05%
Apr-16-20 04:05PM	Inspire Medical Systems, Inc. Announces Closing of Public Offering and Full Exercise of Underwriters Option to Purchase Additional Shares GlobeNewswire +5.57%
Apr-15-20 02:49PM	Hedge Funds Have Never Been This Bullish On Inspire Medical Systems, Inc. (INSP) Insider Monkey
09:03AM	Inspire Medical Systems, Inc. (NYSE:INSP) Analysts Are Reducing Their Forecasts For This Year Simply Wall St.
Apr-13-20 09:27PM	Inspire Medical Systems, Inc. Announces Pricing of Offering of Common Stock GlobeNewswire
04:19PM	Inspire Medical Systems, Inc. Announces Proposed Offering of Common Stock GlobeNewswire
04:01PM	Inspire Medical Systems, Inc. Provides First Quarter and Full Year 2020 Update GlobeNewswire
Apr-09-20 10:46AM	Why Inspire Medical Systems (INSP) Stock Might be a Great Pick Zacks
Feb-25-20 06:25PM	Inspire Medical Systems (INSP) Reports Q4 Loss, Tops Revenue Estimates Zacks
04:15PM	Inspire Medical Systems, Inc. Announces Fourth Quarter and Full Year 2019 Financial Results and Provides 2020 Guidance GlobeNewswire
Feb-24-20 08:36AM	Why Inspire Medical Systems (INSP) Might Surprise This Earnings Season Zacks
Feb-12-20 04:05PM	Inspire Medical Systems, Inc. to Present at the 9th Annual SVB Leerink Global Healthcare Conference GlobeNewswire
Feb-07-20 06:10AM	8 Stellar Small-Cap Stocks to Buy That Are in Major Industries InvestorPlace
Feb-03-20 04:22PM	Inspire Medical Systems, Inc. Announces Medicare Policy Release Dates and New Draft Local Coverage Determination for Remaining Region GlobeNewswire
Jan-28-20 04:05PM	Inspire Medical Systems, Inc. to Report Fourth Quarter and Fiscal 2019 Financial Results on February 25, 2020 GlobeNewswire
Jan-19-20 09:16AM	The Inspire Medical Systems (NYSE:INSP) Share Price Has Gained 49% And Shareholders Are Hoping For More Simply Wall St.
Jan-07-20 04:05PM	Inspire Medical Systems, Inc. to Present at the 38th Annual J.P. Morgan Healthcare Conference GlobeNewswire
Dec-24-19 12:47PM	Here is What Hedge Funds Really Think About Inspire Medical Systems, Inc. (INSP) Insider Monkey
Nov-20-19 04:05PM	Inspire Medical Systems, Inc. to Present at the 31st Annual Piper Jaffray Healthcare Conference GlobeNewswire
Nov-06-19 04:15PM	Inspire Medical Systems, Inc. to Present at the Stifel 2019 Healthcare Conference GlobeNewswire +5.22%
Nov-05-19 06:45PM	Inspire Medical Systems (INSP) Reports Q3 Loss, Tops Revenue Estimates Zacks
04:10PM	Inspire Medical Systems, Inc. Announces Third Quarter 2019 Financial Results and Increases 2019 Outlook GlobeNewswire
Oct-29-19 10:32AM	Earnings Preview: Inspire Medical Systems (INSP) Q3 Earnings Expected to Decline Zacks
Oct-26-19 12:36PM	Hedge Funds Have Never Been This Bullish On Inspire Medical Systems, Inc. (INSP) Insider Monkey
Oct-21-19 10:44AM	Despite Lacking Profits Inspire Medical Systems (NYSE:INSP) Seems To Be On Top Of Its Debt Simply Wall St.
Oct-08-19 04:15PM	Inspire Medical Systems, Inc. to Report Third Quarter 2019 Financial Results on November 5, 2019 GlobeNewswire
Sep-26-19 04:30PM	Inspire Medical Systems, Inc. Announces Additional Draft Local Coverage Determinations Proposing Coverage of Inspire Therapy GlobeNewswire
Sep-10-19 07:15PM	Inspire Medical Systems Inc (INSP) CEO and President Timothy P. Herbert Sold $700,000 of Shares GuruFocus.com
Aug-29-19 04:05PM	Inspire Medical Systems, Inc. Announces Additional Draft Local Coverage Determinations Proposing Coverage of Inspire Therapy GlobeNewswire +5.50%
Aug-28-19 06:15PM	Inspire Medical Systems Inc (INSP) CEO and President Timothy P. Herbert Sold $989,400 of Shares GuruFocus.com
Aug-26-19 10:03AM	3 Top Small-Cap Stocks to Buy Right Now Motley Fool
08:00AM	Inspire Medical Systems, Inc. Announces Draft Local Coverage Determinations Proposing Coverage of Inspire Therapy from Two Regional Medicare Administrators GlobeNewswire
Aug-22-19 09:08AM	Should You Be Worried About Insider Transactions At Inspire Medical Systems, Inc. (NYSE:INSP)? Simply Wall St.
Aug-21-19 04:05PM	Inspire Medical Systems, Inc. to Present at 2019 Wells Fargo Healthcare Conference GlobeNewswire
Aug-19-19 01:21PM	This Little-Known Med-Tech Company Is Growing Like Gangbusters Motley Fool
Aug-15-19 08:00AM	Inspire Medical Systems, Inc. Announces Additional 17.7 Million Covered Lives with Seven New Coverage Policies GlobeNewswire
Aug-13-19 08:00AM	Inspire Medical Systems, Inc. Announces New Brand Identity and Website to Better Reach Prospective Patients Struggling with Sleep Apnea GlobeNewswire
Aug-12-19 02:00AM	3 More Medtech Stocks for Your Watch List Motley Fool
Aug-09-19 12:20PM	14 Top Small-Cap Stocks to Buy Now Motley Fool
Aug-07-19 06:23AM	Inspire Medical Systems, Inc. (INSP) Q2 2019 Earnings Call Transcript Motley Fool +5.78%

Inspire Medical Systems, Inc., a medical technology company, focuses on the development and commercialization of minimally invasive solutions for patients with obstructive sleep apnea (OSA). It offers Inspire system, a neurostimulation technology that provides a safe and effective treatment for moderate to severe OSA. The company also develops a novel, a closed-loop solution that continuously monitors a patient's breathing and delivers mild hypoglossal nerve stimulation to maintain an open airway. Inspire Medical Systems, Inc. was founded in 2007 and is headquartered in Golden Valley, Minnesota.

Insider Trading	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
Ban Randy	Chief Commercial Officer	Jan 04	Option Exercise	1.60	30,187	48,363	30,416	Jan 06 04:58 PM
Ban Randy	Chief Commercial Officer	Jan 04	Sale	182.15	30,187	5,498,447	229	Jan 06 04:58 PM
Buchholz Richard	Chief Financial Officer	Dec 15	Sale	190.53	3,000	571,589	65,651	Dec 16 05:50 PM
Buchholz Richard	Chief Financial Officer	Nov 17	Sale	171.66	3,000	514,986	68,651	Nov 19 04:15 PM
Herbert Timothy P.	CEO and President	Nov 05	Sale	163.74	80,000	13,099,424	122,875	Nov 09 04:15 PM
NELSON MARILYN C	Director	Nov 03	Sale	144.65	7,000	1,012,550	138,017	Nov 05 04:19 PM
Buchholz Richard	Chief Financial Officer	Oct 20	Sale	122.84	3,000	368,510	71,651	Oct 22 04:19 PM
Buchholz Richard	Chief Financial Officer	Oct 09	Option Exercise	29.94	8,267	247,489	74,651	Oct 13 08:00 AM
NELSON MARILYN C	Director	Oct 09	Sale	130.00	1,000	130,000	145,017	Oct 16 05:38 PM
NELSON MARILYN C	Director	Oct 08	Sale	130.96	25,000	3,273,977	146,017	Oct 16 05:38 PM
Buchholz Richard	Chief Financial Officer	Sep 22	Sale	126.09	6,000	756,556	66,384	Sep 24 04:17 PM
Tansey Casey M	Director	Sep 14	Sale	129.27	12,000	1,551,211	18,830	Sep 16 05:47 PM
Ban Randy	Chief Commercial Officer	Sep 09	Option Exercise	1.14	30,000	34,200	30,189	Sep 11 04:15 PM
Ban Randy	Chief Commercial Officer	Sep 09	Sale	117.54	30,000	3,526,268	189	Sep 11 04:15 PM
Griffin Jerry C	Director	Aug 27	Sale	115.34	28,800	3,321,732	0	Aug 28 04:15 PM
Jandrich Steven	Chief Comp Off & VP, Human Res	Aug 18	Option Exercise	31.70	3,000	95,093	4,805	Aug 20 04:15 PM
Jandrich Steven	Chief Comp Off & VP, Human Res	Aug 18	Sale	110.00	3,000	330,000	1,805	Aug 20 04:15 PM
Khuong Chau Quang	Director	Aug 18	Sale	108.54	43,543	4,726,157	0	Aug 19 05:19 PM
ORBIMED ADVISORS LLC	Director	Aug 18	Sale	108.54	43,543	4,726,157	0	Aug 19 05:24 PM
ORBIMED ADVISORS LLC	Director	Aug 17	Sale	107.49	94,900	10,200,801	43,543	Aug 19 05:24 PM
Khuong Chau Quang	Director	Aug 17	Sale	107.49	94,900	10,200,801	43,543	Aug 19 05:19 PM
Khuong Chau Quang	Director	Aug 14	Sale	109.03	20,237	2,206,440	138,443	Aug 14 05:22 PM
ORBIMED ADVISORS LLC	Director	Aug 14	Sale	109.03	20,257	2,208,621	138,443	Aug 14 05:19 PM
ORBIMED ADVISORS LLC	Director	Aug 13	Sale	109.93	29,251	3,215,562	158,500	Aug 14 05:19 PM
Khuong Chau Quang	Director	Aug 13	Sale	109.93	29,251	3,215,562	158,500	Aug 14 05:22 PM
Khuong Chau Quang	Director	Aug 12	Sale	107.45	42,679	4,585,859	187,751	Aug 14 05:22 PM
ORBIMED ADVISORS LLC	Director	Aug 12	Sale	107.45	42,679	4,585,859	187,751	Aug 14 05:19 PM
ORBIMED ADVISORS LLC	Director	Aug 11	Sale	105.78	39,877	4,218,189	230,430	Aug 11 06:23 PM
Khuong Chau Quang	Director	Aug 11	Sale	105.78	39,877	4,218,189	230,430	Aug 11 06:19 PM
Khuong Chau Quang	Director	Aug 10	Sale	105.23	47,700	5,019,471	270,307	Aug 11 06:19 PM
ORBIMED ADVISORS LLC	Director	Aug 10	Sale	105.23	47,700	5,019,471	270,307	Aug 11 06:23 PM
ORBIMED ADVISORS LLC	Director	Aug 07	Sale	106.18	28,993	3,078,477	318,007	Aug 11 06:23 PM
Khuong Chau Quang	Director	Aug 07	Sale	106.18	28,993	3,078,477	318,007	Aug 11 06:19 PM
Herbert Timothy P.	CEO and President	Aug 06	Sale	105.66	80,000	8,452,716	202,875	Aug 10 06:22 PM
Buchholz Richard	Chief Financial Officer	Jul 22	Option Exercise	6.26	42,436	265,755	73,504	Jul 23 04:16 PM
Jandrich Steven	Chief Comp Off & VP, Human Res	Jul 21	Option Exercise	0.94	1,000	940	2,805	Jul 23 04:17 PM
Buchholz Richard	Chief Financial Officer	Jul 21	Option Exercise	2.07	3,000	6,210	34,068	Jul 23 04:16 PM
Jandrich Steven	Chief Comp Off & VP, Human Res	Jul 21	Sale	98.96	1,000	98,960	1,805	Jul 23 04:17 PM
Buchholz Richard	Chief Financial Officer	Jul 21	Sale	99.37	3,000	298,122	31,068	Jul 23 04:16 PM
Buchholz Richard	Chief Financial Officer	Jun 23	Option Exercise	2.07	12,000	24,840	42,871	Jun 25 06:01 PM
Jandrich Steven	Chief Comp Off & VP, Human Res	Jun 23	Option Exercise	0.94	1,000	940	2,805	Jun 25 06:01 PM
Buchholz Richard	Chief Financial Officer	Jun 23	Sale	97.25	12,000	1,167,008	30,871	Jun 25 06:01 PM
Jandrich Steven	Chief Comp Off & VP, Human Res	Jun 23	Sale	96.39	1,000	96,390	1,805	Jun 25 06:01 PM
NELSON MARILYN C	Director	Jun 16	Sale	87.94	10,000	879,409	176,517	Jun 18 09:07 PM
NELSON MARILYN C	Director	Jun 15	Sale	82.36	25,000	2,059,081	186,517	Jun 18 09:07 PM
Tansey Casey M	Director	Jun 15	Sale	84.04	100,000	8,404,255	30,681	Jun 17 04:15 PM
Jandrich Steven	Chief Comp Off & VP, Human Res	May 19	Option Exercise	0.94	1,000	940	2,805	May 20 04:15 PM
Jandrich Steven	Chief Comp Off & VP, Human Res	May 19	Sale	80.00	1,000	80,000	1,805	May 20 04:15 PM
Jandrich Steven	Chief Comp Off & VP, Human Res	Apr 21	Option Exercise	0.94	2,000	1,880	3,805	Apr 23 04:31 PM
Jandrich Steven	Chief Comp Off & VP, Human Res	Apr 21	Sale	72.68	2,000	145,360	1,805	Apr 23 04:31 PM
Ban Randy	Chief Commercial Officer	Apr 09	Option Exercise	1.14	10,000	11,400	10,142	Apr 10 05:05 PM
Ban Randy	Chief Commercial Officer	Apr 09	Sale	64.00	10,000	640,000	142	Apr 10 05:05 PM
Herbert Timothy P.	CEO and President	Mar 17	Option Exercise	0.97	178,786	174,274	178,786	Mar 19 06:07 PM
Khuong Chau Quang	Director	Mar 06	Sale	83.52	500,000	41,760,000	347,000	Mar 10 05:08 PM
ORBIMED ADVISORS LLC	Director	Mar 06	Sale	83.52	500,000	41,760,000	347,000	Mar 10 05:06 PM
Ban Randy	Chief Commercial Officer	Mar 04	Option Exercise	1.14	10,000	11,400	10,000	Mar 06 06:16 PM
Ban Randy	Chief Commercial Officer	Mar 04	Sale	86.55	10,000	865,465	0	Mar 06 06:16 PM
Khuong Chau Quang	Director	Mar 04	Sale	84.43	425,000	35,881,750	847,000	Mar 05 06:37 PM
Khuong Chau Quang	Director	Mar 03	Sale	83.21	75,000	6,240,750	1,272,000	Mar 05 06:37 PM
ORBIMED ADVISORS LLC	Director	Mar 03	Sale	84.25	500,000	42,122,500	847,000	Mar 05 06:34 PM
Tansey Casey M	Director	Feb 28	Sale	83.14	70,000	5,819,938	130,469	Mar 03 04:15 PM

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