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IONS [NASD]
Ionis Pharmaceuticals, Inc.
Index- P/E- EPS (ttm)-3.52 Insider Own0.20% Shs Outstand140.77M Perf Week4.65%
Market Cap5.27B Forward P/E- EPS next Y-1.75 Insider Trans-54.93% Shs Float134.10M Perf Month-6.80%
Income-492.90M PEG- EPS next Q-0.56 Inst Own87.50% Short Float7.69% Perf Quarter-32.98%
Sales707.50M P/S7.45 EPS this Y-257.00% Inst Trans0.33% Short Ratio6.67 Perf Half Y-22.29%
Book/sh4.83 P/B7.92 EPS next Y17.50% ROA-18.20% Target Price58.80 Perf Year-26.93%
Cash/sh13.21 P/C2.89 EPS next 5Y- ROE-46.00% 52W Range35.10 - 64.37 Perf YTD-32.37%
Dividend- P/FCF- EPS past 5Y-34.40% ROI-29.30% 52W High-40.59% Beta1.10
Dividend %- Quick Ratio6.70 Sales past 5Y20.80% Gross Margin98.30% 52W Low8.95% ATR1.72
Employees757 Current Ratio6.70 Sales Q/Q-16.30% Oper. Margin-28.70% RSI (14)36.99 Volatility3.89% 4.31%
OptionableYes Debt/Eq1.38 EPS Q/Q-124.60% Profit Margin-69.70% Rel Volume1.46 Prev Close37.37
ShortableYes LT Debt/Eq1.28 EarningsMay 05 BMO Payout- Avg Volume1.55M Price38.24
Recom2.70 SMA20-5.76% SMA50-14.71% SMA200-25.25% Volume2,258,923 Change2.33%
May-07-21Upgrade UBS Sell → Neutral $33 → $37.50
Mar-01-21Upgrade Barclays Underweight → Equal Weight $50 → $52
Dec-16-20Initiated UBS Sell $34
Dec-15-20Upgrade Cowen Market Perform → Outperform
Sep-14-20Resumed JP Morgan Neutral $63
Sep-02-20Initiated The Benchmark Company Hold
Jun-01-20Resumed Oppenheimer Outperform
May-13-20Initiated RBC Capital Mkts Outperform $71
Mar-05-20Initiated Citigroup Buy $73
Dec-13-19Initiated Oppenheimer Outperform
Nov-13-19Initiated BofA/Merrill Buy $70
Nov-07-19Downgrade Morgan Stanley Equal-Weight → Underweight $63 → $48
Sep-10-19Upgrade Bernstein Mkt Perform → Outperform
Aug-08-18Reiterated Stifel Hold $48 → $47
Aug-07-18Reiterated Stifel Hold $55 → $48
May-08-18Downgrade Evercore ISI Outperform → In-line
Oct-06-17Resumed Goldman Sell $30
Aug-17-17Initiated Evercore ISI Outperform $65
Aug-09-17Reiterated Stifel Hold $42 → $50
Mar-10-17Downgrade Goldman Neutral → Sell
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Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an injection for the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; and WAYLIVRA, a treatment for familial chylomicronemia syndrome and familial partial lipodystrophy. It is involved in developing neurology products that include Tominersen for Huntington's diseases; Tofersen for amyotrophic lateral sclerosis (ALS); IONIS-MAPTRx for Alzheimer's diseases; IONIS-C9Rx for genetic form of ALS; ION859 for Parkinson's disease; ION464 for multiple system atrophy and Parkinson's disease; ION541 for amyotrophic lateral sclerosis; and IONIS-DNM2-2.5Rx for centronuclear myopathy. The company is also developing products for cardiometabolic disease, such as IONIS-TTR-LRx for transthyretin amyloidosis and IONIS-GHR-LRx for acromegaly; IONIS-APOCIII-LRx for familial chylomicronemia syndrome and TG- driven diseases; IONIS-APOCIII-LRx for treatment resistant hypertension; Pelacarsen for Lp(a)cardiovascular disease risk reduction; Vupanorsen for sHTG/CVDRR; IONIS-FXI-LRx for clotting disorders; ION449 for cardiovascular diseases; and IONIS-GCGRRx for diabetics. In addition, it develops IONIS-ENAC-2.5Rx for cystic fibrosis and chronic obstructive pulmonary disease; IONIS-PKK-LRx for hereditary angioedema; Danvatirsen for cancer; IONIS-TMPRSS6-LRx for beta-thalassemia and iron toxicity; IONIS-HBVRx for hepatitis B virus; IONIS-AR-2.5Rx for prostate cancer; IONIS-FB-LRx for age-related macular degeneration and IgA nephropathy; and ION357 for retinitis pigmentosa. It has a collaboration agreement with AstraZeneca; GlaxoSmithKline plc; Janssen Biotech, Inc.; Bayer AG; Novartis AG; Pfizer, Inc.; Biogen Inc.; and Roche. Ionis Pharmaceuticals, Inc. was founded in 1989 and is based in Carlsbad, California.
Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total SEC Form 4
Cadoret-Manier OnaizaChief Corp Dev and Cml OfficerApr 15Option Exercise0.005,66706,159Apr 19 05:04 PM
Monia Brett PChief Executive OfficerMar 01Sale54.2723612,80950,114Mar 02 08:22 PM
CROOKE STANLEY TExec Chairman of the BoardJan 26Sale63.7428,3331,805,8122,021Jan 28 07:22 PM
O'NEIL PATRICK R.EVP & General CounselJan 25Sale63.505,324338,07426,502Jan 27 05:35 PM
CROOKE STANLEY TExec Chairman of the BoardJan 22Sale61.6740,0002,467,000494,391Jan 25 08:24 PM
CROOKE STANLEY TExec Chairman of the BoardJan 21Sale61.2035,0002,142,117534,391Jan 25 08:24 PM
CROOKE STANLEY TExec Chairman of the BoardJan 15Option Exercise0.004,37104,545Jan 20 07:12 PM
CROOKE STANLEY TExec Chairman of the BoardJan 15Option Exercise0.0047,257049,278Jan 20 07:12 PM
BENNETT C FRANKChief Scientific OfficerJan 15Option Exercise0.0015,520047,996Jan 20 07:08 PM
Geary Richard SEVP, Chief Development OffcJan 15Option Exercise0.0017,598047,904Jan 20 07:06 PM
HOUGEN ELIZABETH LEVP, Finance & CFOJan 15Option Exercise0.0017,151049,646Jan 20 07:04 PM
Monia Brett PChief Executive OfficerJan 15Option Exercise0.0034,823063,702Jan 20 07:02 PM
O'NEIL PATRICK R.EVP & General CounselJan 15Option Exercise0.0016,504037,682Jan 20 07:00 PM
PARSHALL B LYNNEDirectorJan 15Option Exercise0.0010,655068,119Jan 20 06:59 PM
Schneider EugeneEVP, Chf Clinical Develop OffcJan 15Option Exercise0.007,50309,621Jan 20 06:55 PM
Swayze EricEVP, ResearchJan 15Option Exercise0.008,944014,051Jan 20 06:53 PM
Geary Richard SEVP, Chief Development OffcJan 13Sale59.501418,39030,306Jan 15 05:55 PM
Swayze EricEVP, ResearchJan 05Sale55.9919510,9185,107Jan 06 09:23 PM
PARSHALL B LYNNEDirectorDec 23Sale60.0010,000600,00057,464Dec 28 05:29 PM
CROOKE STANLEY TExec Chairman of the BoardDec 17Sale50.501,40771,054174Dec 17 07:42 PM
CROOKE STANLEY TExec Chairman of the BoardDec 15Sale49.7739,0001,941,225600,391Dec 17 07:42 PM
CROOKE STANLEY TExec Chairman of the BoardDec 07Sale51.6711,000568,350639,391Dec 09 08:14 PM
BENNETT C FRANKChief Scientific OfficerDec 04Option Exercise39.877,947316,84740,423Dec 08 08:49 PM
Monia Brett PChief Executive OfficerDec 04Option Exercise39.8723,840950,50152,719Dec 08 08:51 PM
Monia Brett PChief Executive OfficerDec 04Sale51.0423,8401,216,79428,879Dec 08 08:51 PM
BENNETT C FRANKChief Scientific OfficerDec 04Sale51.047,947405,61532,476Dec 08 08:49 PM
Monia Brett PChief Executive OfficerDec 02Option Exercise39.8721,160843,64950,039Dec 04 08:49 PM
BENNETT C FRANKChief Scientific OfficerDec 02Option Exercise39.877,053281,20339,529Dec 04 08:53 PM
BENNETT C FRANKChief Scientific OfficerDec 02Sale51.327,053361,96032,476Dec 04 08:53 PM
Monia Brett PChief Executive OfficerDec 02Sale51.3221,1601,085,93128,879Dec 04 08:49 PM
CROOKE STANLEY TExec Chairman of the BoardNov 25Option Exercise39.8712,990517,91115,011Nov 30 06:48 PM
HOUGEN ELIZABETH LEVP, Finance & CFONov 25Option Exercise39.8721,680864,38254,175Nov 30 06:49 PM
PARSHALL B LYNNEDirectorNov 25Option Exercise39.873,590143,13371,054Nov 30 06:44 PM
Geary Richard SEVP, DevelopmentNov 25Option Exercise39.8711,920475,25042,367Nov 30 06:46 PM
PARSHALL B LYNNEDirectorNov 25Sale50.053,590179,68067,464Nov 30 06:44 PM
HOUGEN ELIZABETH LEVP, Finance & CFONov 25Sale50.0521,6801,085,08432,495Nov 30 06:49 PM
CROOKE STANLEY TExec Chairman of the BoardNov 25Sale50.0512,990650,1502,021Nov 30 06:48 PM
Geary Richard SEVP, DevelopmentNov 25Sale50.0511,920596,59630,447Nov 30 06:46 PM
PARSHALL B LYNNEDirectorNov 24Option Exercise39.8771028,30868,174Nov 25 06:56 PM
Geary Richard SEVP, DevelopmentNov 24Option Exercise39.872,38094,89132,827Nov 25 06:58 PM
HOUGEN ELIZABETH LEVP, Finance & CFONov 24Option Exercise39.874,320172,23836,815Nov 25 07:02 PM
CROOKE STANLEY TExec Chairman of the BoardNov 24Option Exercise39.872,590103,2634,611Nov 25 07:04 PM
CROOKE STANLEY TExec Chairman of the BoardNov 24Sale50.832,590131,6502,021Nov 25 07:04 PM
HOUGEN ELIZABETH LEVP, Finance & CFONov 24Sale50.834,320219,58632,495Nov 25 07:02 PM
Geary Richard SEVP, DevelopmentNov 24Sale50.832,380120,97530,447Nov 25 06:58 PM
PARSHALL B LYNNEDirectorNov 24Sale50.8271036,08267,464Nov 25 06:56 PM
PARSHALL B LYNNEDirectorNov 23Option Exercise39.873,200127,58470,664Nov 25 06:56 PM
Geary Richard SEVP, DevelopmentNov 23Option Exercise39.8710,700426,60941,147Nov 25 06:58 PM
HOUGEN ELIZABETH LEVP, Finance & CFONov 23Option Exercise39.8719,000757,53045,620Nov 25 07:02 PM
CROOKE STANLEY TExec Chairman of the BoardNov 23Option Exercise39.8750019,9352,081Nov 25 07:04 PM
CROOKE STANLEY TExec Chairman of the BoardNov 23Option Exercise39.8711,600462,49213,621Nov 25 07:04 PM
CROOKE STANLEY TExec Chairman of the BoardNov 23Sale50.0050025,0001,581Nov 25 07:04 PM
CROOKE STANLEY TExec Chairman of the BoardNov 23Sale50.1111,600581,2762,021Nov 25 07:04 PM
HOUGEN ELIZABETH LEVP, Finance & CFONov 23Sale50.1119,000952,09032,495Nov 25 07:02 PM
Geary Richard SEVP, DevelopmentNov 23Sale50.1110,700536,17730,447Nov 25 06:58 PM
PARSHALL B LYNNEDirectorNov 23Sale50.123,200160,38467,464Nov 25 06:56 PM
BENNETT C FRANKChief Scientific OfficerNov 03Option Exercise39.8715,000598,05047,476Nov 05 08:26 PM
BENNETT C FRANKChief Scientific OfficerNov 03Sale46.7715,000701,60032,476Nov 05 08:26 PM
KLEIN JOSEPH IIIDirectorOct 20Sale46.862,889135,38613,794Oct 22 05:36 PM
Hayden Michael RDirectorOct 15Option Exercise0.001,77805,334Oct 19 05:50 PM
Reikes Peter NDirectorOct 15Option Exercise0.001,77805,334Oct 19 05:46 PM
CROOKE STANLEY TExec Chairman of the BoardSep 22Sale50.4150,0002,520,460650,391Sep 23 06:44 PM
CROOKE STANLEY TExec Chairman of the BoardSep 21Sale50.182,000100,3601,581Sep 23 06:44 PM
WENDER JOSEPH HDirectorSep 16Option Exercise20.7022,500465,86288,305Sep 18 05:45 PM
Monia Brett PChief Executive OfficerSep 01Sale53.7031416,86228,879Sep 02 07:01 PM
LOSCALZO JOSEPHDirectorJul 06Option Exercise0.00667017,308Jul 06 05:49 PM
KLEIN JOSEPH IIIDirectorJul 06Option Exercise0.00667016,683Jul 06 05:32 PM
Castleman BreauxDirectorJul 06Option Exercise0.00667019,183Jul 06 05:30 PM
WENDER JOSEPH HDirectorJul 06Option Exercise0.00667065,805Jul 06 05:26 PM
BERTHELSEN SPENCER RDirectorJul 06Option Exercise0.006670100,983Jul 06 05:25 PM
MUTO FREDERICK TDirectorJul 06Option Exercise0.00667031,683Jul 06 05:23 PM
LOSCALZO JOSEPHDirectorJul 02Option Exercise0.00889016,641Jul 06 05:49 PM
PARSHALL B LYNNEDirectorJul 02Option Exercise0.00889067,464Jul 06 05:47 PM
KLEIN JOSEPH IIIDirectorJul 02Option Exercise0.00889016,016Jul 06 05:32 PM
Castleman BreauxDirectorJul 02Option Exercise0.00889018,516Jul 06 05:30 PM
WENDER JOSEPH HDirectorJul 02Option Exercise0.00889065,138Jul 06 05:26 PM
BERTHELSEN SPENCER RDirectorJul 02Option Exercise0.008890100,316Jul 06 05:25 PM
MUTO FREDERICK TDirectorJul 02Option Exercise0.00889031,016Jul 06 05:23 PM
Hayden Michael RDirectorJul 01Option Exercise0.001,77803,556Jul 06 06:48 PM
HERMAN JOAN EDirectorJul 01Option Exercise0.001,77805,334Jul 06 05:51 PM
LOSCALZO JOSEPHDirectorJul 01Option Exercise0.002,444015,752Jul 06 05:49 PM
PARSHALL B LYNNEDirectorJul 01Option Exercise0.001,778066,575Jul 06 05:47 PM
KLEIN JOSEPH IIIDirectorJul 01Option Exercise0.002,444015,127Jul 06 05:32 PM
Castleman BreauxDirectorJul 01Option Exercise0.002,444017,627Jul 06 05:30 PM
Reikes Peter NDirectorJul 01Option Exercise0.001,77803,556Jul 06 05:28 PM
WENDER JOSEPH HDirectorJul 01Option Exercise0.002,444064,249Jul 06 05:26 PM
BERTHELSEN SPENCER RDirectorJul 01Option Exercise0.002,444099,427Jul 06 05:25 PM
MUTO FREDERICK TDirectorJul 01Option Exercise0.002,444030,127Jul 06 05:23 PM
MUTO FREDERICK TDirectorJun 30Option Exercise9.2215,000138,30027,683Jul 02 05:11 PM
Castleman BreauxDirectorJun 25Option Exercise26.6610,000266,60025,183Jun 29 09:47 PM
BENNETT C FRANKEVP, Chief Scientific OfficerJun 25Option Exercise39.8715,000598,05047,364Jun 29 09:47 PM
CROOKE STANLEY TExec Chairman of the BoardJun 25Sale60.119,914595,9072,021Jun 26 07:47 PM
BENNETT C FRANKEVP, Chief Scientific OfficerJun 25Sale59.7715,000896,50532,364Jun 29 09:47 PM
Castleman BreauxDirectorJun 25Sale60.0010,000600,00015,183Jun 29 09:47 PM
CROOKE STANLEY TExec Chairman of the BoardJun 24Sale58.805,000294,00011,935Jun 26 07:47 PM
BERTHELSEN SPENCER RDirectorJun 23Option Exercise9.2215,000138,300111,983Jun 25 07:28 PM
BERTHELSEN SPENCER RDirectorJun 23Sale58.7615,000881,40096,983Jun 25 07:28 PM
CROOKE STANLEY TExec Chairman of the BoardJun 19Sale58.3310,000583,25016,935Jun 19 07:03 PM
CROOKE STANLEY TExec Chairman of the BoardJun 17Sale58.252,000116,5003,581Jun 19 07:03 PM
CROOKE STANLEY TExec Chairman of the BoardJun 17Sale57.9015,000868,52126,935Jun 19 07:03 PM