| Insider Trading | 
Relationship | 
Date | 
Transaction | 
Cost | 
#Shares | 
Value ($) | 
#Shares Total | 
SEC Form 4 | 
 
| Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Nov 03 '25 | Option Exercise | 19.34 | 5,000 | 96,700 | 78,740 | Nov 03 04:37 PM |  | Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Nov 03 '25 | Sale | 30.38 | 9,000 | 273,442 | 69,740 | Nov 03 04:37 PM |  | Hopkinson Craig C. | Officer | Nov 03 '25 | Proposed Sale | 30.38 | 9,000 | 273,442 |  | Nov 03 04:35 PM |  | Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Oct 15 '25 | Option Exercise | 19.34 | 5,000 | 96,700 | 82,740 | Oct 15 06:47 PM |  | Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Oct 15 '25 | Sale | 31.53 | 9,000 | 283,776 | 73,740 | Oct 15 06:47 PM |  | Hopkinson Craig C. | Officer | Oct 15 '25 | Proposed Sale | 31.53 | 9,000 | 283,777 |  | Oct 15 04:07 PM |  | Nichols Christian Todd | SVP, Chief Commercial Officer | Jun 09 '25 | Sale | 31.95 | 3,333 | 106,489 | 89,542 | Jun 10 04:39 PM |  | Nichols Christian Todd | SVP, Chief Commercial Officer | Jun 10 '25 | Sale | 31.09 | 3,334 | 103,654 | 86,208 | Jun 10 04:39 PM |  | Nichols Christian Todd | Officer | Jun 10 '25 | Proposed Sale | 31.09 | 3,334 | 103,654 |  | Jun 10 04:29 PM |  | Nichols Christian Todd | Officer | Jun 09 '25 | Proposed Sale | 31.95 | 3,333 | 106,489 |  | Jun 09 04:08 PM |  | Parisi Samuel Joseph | VP, Finance (Interim PAO) | Feb 28 '25 | Sale | 34.00 | 1,938 | 65,892 | 7,717 | Feb 28 05:19 PM |  | Parisi Samuel Joseph | VP, Finance (Interim PAO) | Feb 25 '25 | Sale | 35.26 | 3,743 | 131,978 | 7,717 | Feb 25 06:38 PM |  | Parisi Samuel Joseph | VP, Finance (Interim PAO) | Feb 20 '25 | Sale | 35.69 | 1,327 | 47,361 | 7,717 | Feb 20 05:18 PM |  | Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Feb 13 '25 | Option Exercise | 30.12 | 144,419 | 4,350,097 | 202,294 | Feb 14 05:12 PM |  | Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Feb 12 '25 | Option Exercise | 19.64 | 199,196 | 3,912,871 | 262,796 | Feb 14 05:12 PM |  | Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Feb 12 '25 | Sale | 32.78 | 204,921 | 6,718,278 | 57,875 | Feb 14 05:12 PM |  | Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Feb 13 '25 | Sale | 35.53 | 144,419 | 5,130,698 | 57,875 | Feb 14 05:12 PM |  | Hopkinson Craig C. | Officer | Feb 13 '25 | Proposed Sale | 35.53 | 144,419 | 5,130,694 |  | Feb 13 04:36 PM |  | Hopkinson Craig C. | Officer | Feb 12 '25 | Proposed Sale | 32.78 | 204,921 | 6,718,276 |  | Feb 12 04:19 PM |  | Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Jan 30 '25 | Option Exercise | 22.22 | 97,632 | 2,169,137 | 145,208 | Jan 31 08:42 PM |  | Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Jan 30 '25 | Sale | 32.05 | 100,918 | 3,234,382 | 44,290 | Jan 31 08:42 PM |  | Hopkinson Craig C. | Officer | Jan 30 '25 | Proposed Sale | 32.05 | 100,918 | 3,234,380 |  | Jan 30 05:12 PM |  | Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Dec 09 '24 | Option Exercise | 22.70 | 48,997 | 1,112,259 | 108,727 | Dec 09 08:53 PM |  | Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Dec 09 '24 | Sale | 32.07 | 61,151 | 1,961,406 | 47,576 | Dec 09 08:53 PM |  | LAURENCIN CATO T | Director | Dec 09 '24 | Option Exercise | 22.52 | 2,691 | 60,601 | 25,704 | Dec 09 08:51 PM |  | LAURENCIN CATO T | Director | Dec 09 '24 | Sale | 31.85 | 2,691 | 85,708 | 23,013 | Dec 09 08:51 PM |  | LAURENCIN CATO T | Director | Dec 09 '24 | Proposed Sale | 31.85 | 2,691 | 85,708 |  | Dec 09 05:27 PM |  | Hopkinson Craig C. | Officer | Dec 09 '24 | Proposed Sale | 32.07 | 61,151 | 1,961,404 |  | Dec 09 05:24 PM |  | Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Dec 05 '24 | Sale | 31.50 | 9,221 | 290,462 | 59,730 | Dec 05 06:01 PM |  | Hopkinson Craig C. | Officer | Dec 05 '24 | Proposed Sale | 31.50 | 9,221 | 290,462 |  | Dec 05 04:12 PM |  | Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Dec 04 '24 | Sale | 30.77 | 14,349 | 441,550 | 68,951 | Dec 04 04:52 PM |  | Hopkinson Craig C. | Officer | Dec 04 '24 | Proposed Sale | 30.77 | 14,349 | 441,550 |  | Dec 04 04:19 PM |  | Nichols Christian Todd | Officer | Nov 27 '24 | Proposed Sale | 29.15 | 5,208 | 151,813 |  | Nov 27 04:33 PM |  | Nichols Christian Todd | SVP, Chief Commercial Officer | Nov 27 '24 | Sale | 29.15 | 5,208 | 151,813 | 60,703 | Nov 27 04:22 PM |  | Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Nov 11 '24 | Option Exercise | 20.03 | 43,058 | 862,452 | 142,296 | Nov 12 04:48 PM |  | Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Nov 11 '24 | Sale | 30.08 | 58,996 | 1,774,576 | 83,300 | Nov 12 04:48 PM |  | Hopkinson Craig C. | Officer | Nov 11 '24 | Proposed Sale | 30.08 | 58,996 | 1,774,578 |  | Nov 12 04:15 PM |  | Hopkinson Craig C. | EVP R&D, Chief Medical Officer | Nov 06 '24 | Sale | 29.53 | 10,471 | 309,169 | 99,238 | Nov 06 07:47 PM |  | Hopkinson Craig C. | Officer | Nov 06 '24 | Proposed Sale | 29.53 | 10,471 | 309,169 |  | Nov 06 04:33 PM |   
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