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Denali Therapeutics Inc.
Index- P/E556.00 EPS (ttm)0.14 Insider Own2.60% Shs Outstand120.89M Perf Week4.48%
Market Cap9.00B Forward P/E- EPS next Y-2.06 Insider Trans-49.67% Shs Float100.78M Perf Month45.18%
Income57.90M PEG- EPS next Q-0.40 Inst Own76.90% Short Float5.67% Perf Quarter21.04%
Sales340.00M P/S26.47 EPS this Y130.50% Inst Trans-0.26% Short Ratio11.20 Perf Half Y-5.26%
Book/sh9.14 P/B8.21 EPS next Y-12.60% ROA4.80% Target Price78.40 Perf Year203.76%
Cash/sh11.78 P/C6.37 EPS next 5Y- ROE6.40% 52W Range22.36 - 93.94 Perf YTD-10.39%
Dividend- P/FCF21.67 EPS past 5Y38.50% ROI5.40% 52W High-22.32% Beta1.89
Dividend %- Quick Ratio26.20 Sales past 5Y- Gross Margin- 52W Low226.34% ATR3.26
Employees311 Current Ratio26.20 Sales Q/Q119.40% Oper. Margin15.10% RSI (14)67.92 Volatility3.74% 5.22%
OptionableYes Debt/Eq0.00 EPS Q/Q-4.50% Profit Margin17.00% Rel Volume0.40 Prev Close75.06
ShortableYes LT Debt/Eq0.00 Earnings- Payout0.00% Avg Volume510.03K Price72.97
Recom2.10 SMA2012.35% SMA5023.50% SMA20023.86% Volume161,329 Change-2.78%
May-18-21Initiated UBS Buy $70
Feb-26-21Reiterated H.C. Wainwright Buy $80 → $95
Feb-10-21Upgrade Cantor Fitzgerald Neutral → Overweight $105
Nov-11-20Reiterated H.C. Wainwright Buy $65 → $80
Oct-16-20Downgrade BTIG Research Buy → Neutral
Sep-14-20Resumed JP Morgan Overweight $35
Aug-20-20Reiterated H.C. Wainwright Buy $28 → $45
Mar-13-20Upgrade Evercore ISI In-line → Outperform $20
Feb-28-20Upgrade Wedbush Neutral → Outperform $24
Feb-24-20Initiated Jefferies Buy $35
Feb-19-20Initiated Stifel Hold $26
Jan-27-20Upgrade Goldman Neutral → Buy $20 → $37
Sep-26-19Initiated Wedbush Neutral $19
Sep-13-19Initiated Nomura Buy
Aug-09-19Initiated BTIG Research Buy $30
Jun-26-19Initiated H.C. Wainwright Buy $28
Nov-15-18Initiated Cantor Fitzgerald Overweight $25
Nov-12-18Initiated Janney Buy
Mar-12-18Downgrade Evercore ISI Outperform → In-line
Jan-02-18Initiated Morgan Stanley Overweight
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Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutic candidates for neurodegenerative diseases in the United States. The company offers leucine-rich repeat kinase 2 (LRRK2) inhibitor product candidates, including DNL201 that has completed Phase 1b clinical trials and DNL151, which are in Phase 1 and Phase 1b clinical trials for Parkinson's disease. It is also developing receptor interacting serine/threonine protein kinase 1 (RIPK1) product candidates, such as DNL747, a selective and brain-penetrant small molecule RIPK1 inhibitor product candidate that is in Phase 1b clinical trial for Alzheimer's disease and amyotrophic lateral sclerosis (ALS). In addition, the company develops enzyme transport vehicle: iduronate 2-sulfatase, an enzyme replacement therapy program for MPS II, a lysosomal storage disorder; antibody transport vehicle (ATV): alpha-synuclein (aSyn) program, a protein that spreads throughout the brain in Parkinson's disease; ATV: triggering receptor expressed in myeloid cells 2, a therapeutic candidate designed to rescue microglial function in Alzheimer's disease; and ATV: Tau, a therapeutic targeting the spreading of Tau. Denali Therapeutics Inc. has collaboration agreement with Takeda Pharmaceutical Company and Genentech, Inc., Sanofi, F-star Gamma Limited, F-star Biotechnologische Forschungs-Und Entwicklungsges M.B.H, F-star Biotechnology Limited, SIRION Biotech GmbH, Genzyme Corporation, Harvard University, the Michael J. Fox Foundation, Centogene, and MedGenome Labs Private Ltd; and a research and option agreement with Secarna Pharmaceuticals GmbH & Co. KG. to develop antisense therapies in the field of neurodegenerative diseases. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is headquartered in South San Francisco, California.
Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total SEC Form 4
Tessier-Lavigne MarcDirectorJun 07Option Exercise18.7094,3781,765,2752,638,748Jun 08 05:10 PM
Tessier-Lavigne MarcDirectorJun 07Sale70.3594,3786,639,5232,544,370Jun 08 05:10 PM
Schuth Alexander O.COO and SecretaryJun 04Sale64.5510,000645,500501,582Jun 08 05:10 PM
Schenkein David PDirectorJun 01Option Exercise0.003,25303,253Jun 03 08:57 PM
NELSEN ROBERTDirectorJun 01Option Exercise0.003,253010,358Jun 03 08:55 PM
Klein Peter SDirectorJun 01Option Exercise0.003,25303,253Jun 03 08:54 PM
FLATLEY JAY TDirectorJun 01Option Exercise0.003,2530328,253Jun 03 08:53 PM
Cook Jennifer E.DirectorJun 01Option Exercise0.003,25303,253Jun 03 08:52 PM
Cole Douglas G.DirectorJun 01Option Exercise0.003,25303,253Jun 03 08:51 PM
Watts Ryan J.President and CEOJun 01Sale61.4018,3331,125,6482,210,742Jun 03 08:08 PM
SATO VICKI LDirectorMay 26Sale65.371,666108,911134,089May 28 04:03 PM
Tessier-Lavigne MarcDirectorMay 24Sale60.028,806528,5802,542,296May 24 08:05 PM
Tessier-Lavigne MarcDirectorMay 21Sale60.1337,9572,282,4682,551,102May 24 08:05 PM
Schuth Alexander O.COO and SecretaryMay 04Sale55.4910,000554,864511,582May 06 06:50 PM
SATO VICKI LDirectorApr 28Sale62.151,666103,538135,755Apr 30 05:07 PM
Schuth Alexander O.COO and SecretaryApr 05Sale56.0910,000560,901521,582Apr 06 08:39 PM
Tessier-Lavigne MarcDirectorApr 01Sale56.6250,0002,831,0712,592,296Apr 05 04:10 PM
Watts Ryan J.President and CEOApr 01Sale56.6018,3341,037,6842,247,408Apr 05 04:09 PM
Ho CaroleChief Medical OfficerMar 29Sale54.622,822154,126162,319Mar 31 06:30 PM
Krognes Steve E.CFO and TreasurerMar 15Sale61.8950,0003,094,563850,000Mar 16 07:16 PM
Schuth Alexander O.COO and SecretaryMar 04Sale61.0210,000610,171531,582Mar 04 06:38 PM
SATO VICKI LDirectorMar 03Sale61.611,666102,641139,087Mar 04 06:04 PM
Ho CaroleChief Medical OfficerMar 01Sale66.387,092470,741165,141Mar 03 04:21 PM
Tessier-Lavigne MarcDirectorMar 01Sale66.22100,0006,622,2072,642,296Mar 03 04:20 PM
Watts Ryan J.President and CEOMar 01Sale66.3518,3341,216,5512,305,742Mar 03 04:19 PM
Krognes Steve E.CFO and TreasurerFeb 16Sale65.0950,0003,254,710900,000Feb 18 06:12 PM
BRATTON DOUGLAS K10% OwnerFeb 12Sale65.002,216,798144,091,8709,984,836Feb 17 08:39 PM
Ho CaroleChief Medical OfficerFeb 11Sale70.333,156221,972172,233Feb 16 07:43 PM
Schuth Alexander O.COO and SecretaryFeb 11Sale70.353,047214,341541,582Feb 16 07:43 PM
Krognes Steve E.CFO and TreasurerFeb 11Sale70.343,035213,48097,587Feb 16 07:42 PM
Watts Ryan J.President and CEOFeb 11Sale70.309,473665,9842,324,076Feb 16 07:40 PM
Schuth Alexander O.COO and SecretaryFeb 09Sale74.801,468109,809537,344Feb 11 07:13 PM
Krognes Steve E.CFO and TreasurerFeb 09Sale74.681,448108,13512,979Feb 11 07:11 PM
Ho CaroleChief Medical OfficerFeb 09Sale74.681,470109,785167,921Feb 11 07:10 PM
Watts Ryan J.President and CEOFeb 09Sale73.795,112377,2112,313,853Feb 10 07:40 PM
Watts Ryan J.President and CEOFeb 08Option Exercise0.0014,31602,318,965Feb 10 07:40 PM
Schuth Alexander O.COO and SecretaryFeb 07Option Exercise0.004,2500538,812Feb 11 07:13 PM
Krognes Steve E.CFO and TreasurerFeb 07Option Exercise0.004,250014,427Feb 11 07:11 PM
Ho CaroleChief Medical OfficerFeb 07Option Exercise0.004,2500169,391Feb 11 07:10 PM
Schuth Alexander O.COO and SecretaryFeb 04Sale67.8410,000678,361534,562Feb 05 04:44 PM
Watts Ryan J.President and CEOFeb 01Sale68.4418,3341,254,8192,304,649Feb 02 09:21 PM
Krognes Steve E.CFO and TreasurerJan 15Sale71.4550,0003,572,556950,000Jan 20 06:46 PM
Schuth Alexander O.COO and SecretaryJan 04Sale74.9570,0005,246,408544,562Jan 06 06:50 PM
Watts Ryan J.President and CEOJan 04Sale74.9688,3346,621,7822,322,978Jan 06 06:49 PM
Schenkein David PDirectorDec 21Sale90.015,000450,02726,232Dec 23 09:52 PM
Schenkein David PDirectorDec 21Sale90.0625,0002,251,5550Dec 23 09:52 PM
BRATTON DOUGLAS K10% OwnerDec 14Sale80.3817,8251,432,842383,411Dec 15 04:47 PM
BRATTON DOUGLAS K10% OwnerDec 11Sale80.0546,7993,746,442401,236Dec 15 04:47 PM
Schenkein David PDirectorNov 12Sale70.0530,0002,101,59025,000Nov 13 05:13 PM
Schenkein David PDirectorNov 10Sale60.0310,000600,31055,000Nov 12 04:21 PM
Schenkein David PDirectorNov 04Sale50.1810,000501,83065,000Nov 06 05:53 PM
Ho CaroleChief Medical OfficerOct 09Option Exercise5.2830,000158,400196,617Oct 13 06:45 PM
Ho CaroleChief Medical OfficerOct 09Sale41.2230,0001,236,614166,617Oct 13 06:45 PM
Ho CaroleChief Medical OfficerOct 08Option Exercise5.2822,906120,944189,523Oct 13 06:45 PM
Ho CaroleChief Medical OfficerOct 08Sale40.1222,906918,989166,617Oct 13 06:45 PM
Ho CaroleChief Medical OfficerSep 10Sale31.003,689114,359165,141Sep 14 09:38 PM
BRATTON DOUGLAS K10% OwnerAug 12Sale31.651,443,24745,678,76812,201,634Aug 14 04:50 PM
BRATTON DOUGLAS K10% OwnerJun 30Sale24.0145,3451,088,601448,035Jun 30 07:17 PM
BRATTON DOUGLAS K10% OwnerJun 29Sale24.0182,5781,982,373493,380Jun 30 07:17 PM
BRATTON DOUGLAS K10% OwnerJun 26Sale23.94122,0772,922,078575,958Jun 30 07:17 PM
BRATTON DOUGLAS K10% OwnerJun 23Sale25.7720,024515,969698,035Jun 23 05:41 PM
BRATTON DOUGLAS K10% OwnerJun 22Sale24.7890,0562,231,902718,059Jun 23 05:41 PM
BRATTON DOUGLAS K10% OwnerJun 19Sale24.54144,9203,556,503808,115Jun 23 05:41 PM
Tessier-Lavigne MarcDirectorJun 16Sale26.10400,00010,440,0002,739,043Jun 18 09:41 PM