Regulus Therapeutics Inc., a biopharmaceutical company, focuses on the discovery and development of drugs that target microRNAs for the treatment of various diseases in the United States. The company uses its microRNA product platform to develop anti-miRs, which is chemically modified and single-stranded oligonucleotide. Its clinical candidate products include RG-101, which is a GalNAc-conjugated anti-miR that targets microRNA-122 for the treatment of patients with chronic hepatitis C virus infection. The company has strategic collaboration with Biogen Idec MA Inc. for the evaluation of the use of microRNA signatures as a biomarker for human patients with multiple sclerosis; AstraZeneca AB to discover and develop microRNA therapeutics for cardiovascular diseases, metabolic diseases, and oncology; and GlaxoSmithKline plc to discover and develop microRNA therapeutics for immuno-inflammatory diseases. It also has strategic collaboration with Sanofi for the discovery and development of microRNA therapeutics comprising miR-21 pre-clinical fibrosis program for the treatment of alport syndrome and preclinical program for oncology indications; and preclinical programs targeting miR-221/222 for oncology indications. Regulus Therapeutics Inc. was founded in 2007 and is headquartered in San Diego, California.
Avanir Pharmaceuticals, Inc., together with its subsidiaries, is engaged in acquiring, developing, and commercializing novel therapeutic products for the treatment of central nervous system disorders primarily in the United States. It primarily offers NUEDEXTA, a dual N-methyl-D-aspartate receptor antagonist and sigma-1 agonist for the treatment of pseudobulbar affect; and Docosanol 10% cream, an over-the-counter product for the treatment of cold sores. The company's clinical development stage products comprise AVP-923, which has completed Phase II clinical trials for the treatment of central neuropathic pain in patients with multiple sclerosis; is in Phase II clinical trials for the treatment of agitation in patients with Alzheimer's disease; and is in Phase II clinical trials for the treatment of levodopa-induced-dyskinesia in Parkinson's disease, as well as completed Phase III trials for the treatment of patients with diabetic peripheral neuropathic pain. It is also developing AVP-786, a Phase I clinical trial novel investigational drug product for the treatment of neurologic and psychiatric disorders; and AVP-825, an investigational drug-device combination product, which is in Phase III clinical trials, to treat acute migraine. The company has a license agreement with Concert Pharmaceuticals, Inc. to develop and commercialize deuterium-modified dextromethorphan for the potential treatment of neurologic and psychiatric disorders, as well as rights to other deuterium-modified dextromethorphan compounds; and a license agreement with OptiNose AS for the development and commercialization of a novel breath powered intranasal delivery system to treat acute migraine. Avanir Pharmaceuticals, Inc. was founded in 1988 and is headquartered in Aliso Viejo, California.
salesforce.com, inc. provides enterprise cloud computing solutions to various businesses and industries worldwide. The company offers social and mobile cloud apps and platform services, including Sales Cloud for sales force automation, which enables companies to grow their sales pipelines, close deals, improve sales productivity, and gain business insights; Service Cloud that enables companies to connect with their customers and address their service and support needs; Marketing Cloud, which enables companies to bring in data from any source and deliver personalized interactions to any customer across any channel through email, mobile, social, Web, marketing automation, and data analytics from a single platform; and Salesforce1 Platform, a cloud platform for developing customer apps. It also provides professional services, including consulting, deployment, training, implementation, integration, and campaign services to its customers to facilitate the adoption of its social and mobile cloud solutions. salesforce.com, inc. sells and markets its services primarily through its direct sales force, as well as through global consulting firms, systems integrators, and regional partners. The company has a strategic alliance with Koninklijke Philips N.V. to develop and deliver an open cloud-based healthcare platform. salesforce.com, inc. was founded in 1999 and is headquartered in San Francisco, California.
Twitter, Inc. is a global platform for public self-expression and conversation in real time. It provides various products for users, including Twitter that allows users to express themselves and create, distribute, and discover content; Vine, a mobile application available on the iOS, Android, and Windows operating systems that enables users to create and distribute short looping videos; and #Music, a mobile application that helps users discover new music and artists based on Tweets. The company also provides a set of tools, public APIs, and embeddable widgets that developers can use to contribute their content to its platform; distribute Twitter content across their properties; and enhance their Websites and applications with Twitter content. In addition, Twitter, Inc. offers promoted products, including promoted tweets, promoted accounts, and promoted trends that enable its advertisers to promote their brands, products, and services; and provides subscription access to its data feed for data partners. The company was founded in 2006 and is headquartered in San Francisco, California.
Synchronoss Technologies, Inc. provides cloud solutions and software-based activation for connected devices worldwide. The company's services include intelligent connectivity management and content synchronization, backup, and sharing services, as well as device and service procurement, provisioning, activation, and support services that enable communications service providers, cable operators/multi-services operators, original equipment manufacturers with embedded connectivity, multi-channel retailers, and other customers to accelerate and monetize their go-to-market strategies for connected devices. Its Activation Services, Synchronoss Personal Cloud, Synchronoss WorkSpace, and Synchronoss Integrated Life platforms provide end-to-end seamless integration between customer-facing channels/applications, communication services or devices, and back-office infrastructure-related systems and processes. The company markets and sells its services through direct sales force and strategic partners. Synchronoss Technologies, Inc. was founded in 2000 and is headquartered in Bridgewater, New Jersey.
Barracuda Networks, Inc. designs and delivers security and storage solutions. It offers cloud-connected solutions that help its customers address security threats, enhance network performance, and protect and store their data. The company provides various security solutions, including Barracuda Spam & Virus Firewall, an email security solution; Barracuda Web Filter, a Web security solution to protect users from rapidly evolving Web-based threats, as well as to enhance productivity and optimize bandwidth; next-generation firewall solutions; Barracuda Web Application Firewall, an application security solution for protecting Web servers from data breaches and downtime; Barracuda Load Balancer ADC that optimizes application performance, availability, and security; and Barracuda SSL VPN, which offers remote users with secure access to internal network resources from any Web browser while providing the security needed to protect internal systems from unauthorized access, viruses, and other malware. It also offers storage solutions comprising Barracuda Backup, an end-to-end solution that simplifies the backup process and enables secure offsite replication; Barracuda Message Archiver that reduces archive sizes through eliminating duplicate messages, storing only one instance of each message attachment, and then compressing the stored data; Copy, a cloud-based file storage platform that allows its customers to securely access, share, and sync files of any size from any device; and SignNow, a mobile eSignature application. The company sells its appliances, services, and software products to education, government, financial services, healthcare, professional services, telecommunications, retail, and manufacturing industries through its sales personnel, distribution partners, and value added resellers in approximately 100 countries worldwide. Barracuda Networks, Inc. was founded in 2003 and is headquartered in Campbell, California.
Ambarella, Inc. develops semiconductor processing solutions for video that enable high-definition (HD) video capture, sharing, and display worldwide. The company's system-on-a-chip designs integrated HD video processing, image processing, audio processing, and system functions onto a single chip for delivering video and image quality, differentiated functionality, and low power consumption. Its solutions enable the creation of video content for wearable sports cameras, automotive aftermarket cameras, Internet Protocol (IP) security cameras, and camcorders in the camera market; and manage IP video traffic, broadcast encoding, transcoding, and IP video delivery applications in the infrastructure market. The company sells its solutions to original design manufacturers and original equipment manufacturers through its direct sales force and logistics providers. Ambarella, Inc. was founded in 2004 and is headquartered in Santa Clara, California.
AZZ incorporated manufactures electrical equipment and provides engineered services to power generation, transmission and distribution, and general industrial markets. The company operates through two segments, Electrical and Industrial Products and Services, and the Galvanizing Services. The Electrical and Industrial Products and Services segment offers specialty equipment for transmission of power from generation sources, including custom switchgear, electrical enclosures, and medium and high voltage bus ducts, as well as explosion proof and hazardous duty lighting and tubular products to multi-national companies, and small independent companies. This segment also supplies safety related equipment for the nuclear industry. It sells its products through manufacturers' representatives, distributors, agents, and internal sales force. The Galvanizing Services segment offers hot dip galvanizing services to the steel fabrication industry. This segment serves fabricators or manufacturers that provide services to the electrical and telecommunications, bridge and highway, petrochemical, and general industrial markets, as well as original equipment manufacturers. As of February 28, 2014, the company operated 35 galvanizing plants located in Alabama, Arkansas, Arizona, Colorado, Indiana, Illinois, Louisiana, Kentucky, Minnesota, Mississippi, Missouri, Ohio, Oklahoma, Tennessee, Texas, Virginia, and West Virginia, the United States; and Ontario, Quebec, and Nova Scotia, Canada. AZZ incorporated was founded in 1956 and is headquartered in Fort Worth, Texas.
United Continental Holdings, Inc., through its subsidiaries, provides passenger and cargo transportation services. The company transports people and cargo through its mainline operations, which use jet aircraft with 118 seats, and its regional operations. It operates in the United States, the Asia-Pacific, Europe, the Middle East, Africa, and Latin America. The company also sells fuel, as well as offers catering, ground handling, and maintenance services for third parties. As of May 12, 2014, it operated through a fleet of approximately 700 mainline aircraft. The company was formerly known as UAL Corporation and changed its name to United Continental Holdings, Inc. in October 2010. United Continental Holdings, Inc. was founded in 1934 and is headquartered in Chicago, Illinois.
NxStage Medical, Inc., a medical device company, develops, manufactures, and markets products for the treatment of kidney failure, fluid overload, and related blood treatments and procedures. Its primary product is the NxStage System One, a portable hemodialysis system used for the treatment of acute and chronic kidney failure, and fluid overload. The company operates in two segments, System One and In-Center. The System One segment sells and rents the NxStage System One and PureFlow SL dialysate preparation equipment. This segment also sells extracorporeal disposable products, which are primarily used for in-center dialysis treatments for patients with end-stage renal disease (ESRD) in the home and critical care markets. The In-Center segment sells blood tubing sets and needles for hemodialysis primarily for the treatment of ESRD patients at dialysis centers; and needles for apheresis. NxStage Medical, Inc. markets its products through direct sales force and distributors to hospitals and dialysis centers in the United States and internationally. The company, formerly known as QB Medical, Inc., was founded in 1998 and is headquartered in Lawrence, Massachusetts.