VRTX Vertex Pharmaceuticals Incorporated Stock Quote

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VRTX [NASD]

Vertex Pharmaceuticals Incorporated

Healthcare | Biotechnology | USA

statements

Index	S&P 500	P/E	50.99	EPS (ttm)	5.76	Insider Own	0.10%	Shs Outstand	259.82M	Perf Week	-1.75%
Market Cap	76.43B	Forward P/E	26.76	EPS next Y	10.98	Insider Trans	-73.53%	Shs Float	258.88M	Perf Month	9.41%
Income	1.51B	PEG	2.13	EPS next Q	2.06	Inst Own	97.10%	Short Float	1.67%	Perf Quarter	11.97%
Sales	4.82B	P/S	15.86	EPS this Y	118.10%	Inst Trans	0.09%	Short Ratio	2.24	Perf Half Y	29.73%
Book/sh	24.87	P/B	11.81	EPS next Y	22.48%	ROA	19.00%	Target Price	290.36	Perf Year	66.60%
Cash/sh	16.11	P/C	18.24	EPS next 5Y	23.96%	ROE	26.40%	52W Range	165.23 - 306.08	Perf YTD	34.20%
Dividend	-	P/FCF	38.54	EPS past 5Y	28.00%	ROI	14.70%	52W High	-4.00%	Beta	0.93
Dividend %	-	Quick Ratio	3.40	Sales past 5Y	48.30%	Gross Margin	87.20%	52W Low	77.83%	ATR	9.22
Employees	3000	Current Ratio	3.50	Sales Q/Q	76.50%	Oper. Margin	34.00%	RSI (14)	55.48	Volatility	3.50% 3.05%
Optionable	Yes	Debt/Eq	0.00	EPS Q/Q	121.50%	Profit Margin	31.40%	Rel Volume	0.89	Prev Close	284.82
Shortable	Yes	LT Debt/Eq	0.08	Earnings	Apr 29 AMC	Payout	0.00%	Avg Volume	1.94M	Price	293.83
Recom	2.00	SMA20	1.86%	SMA50	4.66%	SMA200	24.77%	Volume	1,732,932	Change	3.16%

Jul-08-20

Downgrade

Morgan Stanley

Overweight → Equal-Weight

$300

Apr-30-20

Reiterated

H.C. Wainwright

Buy

$270 → $295

Apr-28-20

Downgrade

RBC Capital Mkts

Outperform → Sector Perform

$250 → $260

Mar-04-20

Initiated

Barclays

Overweight

$271

Jan-31-20

Downgrade

Robert W. Baird

Outperform → Neutral

$210 → $230

Nov-19-19

Upgrade

Guggenheim

Neutral → Buy

$252

Nov-12-19

Initiated

SunTrust

Buy

$235

Oct-17-19

Resumed

BofA/Merrill

Buy

$220

Sep-03-19

Upgrade

Goldman

Neutral → Buy

$226 → $254

Aug-01-19

Downgrade

Needham

Buy → Hold

May-23-19

Resumed

Citigroup

Buy

$205

May-21-19

Initiated

Credit Suisse

Outperform

$209

Apr-12-19

Initiated

Evercore ISI

In-line

Mar-26-19

Upgrade

William Blair

Mkt Perform → Outperform

Mar-19-19

Downgrade

SVB Leerink

Outperform → Mkt Perform

Feb-06-19

Downgrade

Maxim Group

Buy → Hold

Jan-02-19

Downgrade

Raymond James

Outperform → Mkt Perform

Oct-26-18

Upgrade

H.C. Wainwright

Neutral → Buy

$220

Oct-01-18

Initiated

Cantor Fitzgerald

Overweight

$217

Aug-07-18

Reiterated

Stifel

Buy

$182 → $200

Jul-12-20 06:42AM	3 Absolutely Rock-Solid Stocks to Buy Before the Market Crashes Again Motley Fool
Jul-09-20 05:45PM	Vertex Pharmaceuticals (VRTX) Stock Moves -0.18%: What You Should Know Zacks
Jul-08-20 01:35PM	Here's Why CRISPR Therapeutics Shares Jumped 13.8% in June Motley Fool
01:23PM	Were Hedge Funds Right About Vertex Pharmaceuticals Incorporated (VRTX)? Insider Monkey
08:17AM	Dow Jones Futures: Coronavirus Stock Market Rally Steps Back, But For How Long? Facebook, Tesla, Nio Move On News Investor's Business Daily
Jul-07-20 06:48PM	5 Greenblatt Magic Formula Biotech Stocks to Weather the Summer Coronavirus Storm GuruFocus.com
02:49PM	Calculating The Intrinsic Value Of Vertex Pharmaceuticals Incorporated (NASDAQ:VRTX) Simply Wall St.
11:35AM	Vertex Breaks Out Above 300 Investor's Business Daily Video
10:00AM	These 3 Biotech Stocks Are Outperforming Their Peers Here's Why Investor's Business Daily
Jul-03-20 12:36PM	5 Booming Biotech Stocks to Buy Kiplinger
Jul-02-20 05:45PM	Vertex Pharmaceuticals (VRTX) Outpaces Stock Market Gains: What You Should Know Zacks
10:38AM	Better Buy: Vertex Pharmaceuticals vs. Galapagos Motley Fool
Jul-01-20 09:43AM	Biotech Stock Roundup: GILD Prices Remdesivir, VXRT Rises, ICPT Plunges & More Zacks
07:37AM	Forget Vertex, Biogen Is a Better Value Stock Motley Fool
Jun-30-20 08:34AM	Vertex Announces Expansion of Reimbursement Agreement With NHS England to Include KAFTRIO® (ivacaftor/tezacaftor/elexacaftor) in Combination With KALYDECO® (ivacaftor) Business Wire
08:33AM	Can Vertex (VRTX) Stock Continue to Grow Earnings? Zacks
07:36AM	3 Reasons Why Vertex Is a Great Stock to Buy and Hold for the Long Term Motley Fool
Jun-29-20 11:30AM	Has Vertex Pharmaceuticals (VRTX) Outpaced Other Medical Stocks This Year? Zacks
09:12AM	Vertex's Triple Combo Cystic Fibrosis Pill Gets CHMP Backing Zacks
08:23AM	Market to Stay Northbound Despite Volatility: 5 Growth Picks Zacks
Jun-26-20 10:10AM	Vertex treatment for rare genetic disorder wins EU watchdog backing Reuters
08:25AM	EU drug regulator endorses Vertex's triple-combo cystic fibrosis treatment Reuters
08:20AM	The Future Could Be Soon for Crispr Therapeutics InvestorPlace
08:14AM	CHMP Grants Positive Opinion for KAFTRIO® (ivacaftor/tezacaftor/elexacaftor) in Combination With KALYDECO® (ivacaftor) in People Ages 12 and Older With Cystic Fibrosis With the Most Common Genotypes Business Wire
07:55AM	EU drug regulator endorses Vertex's triple-combo cystic fibrosis treatment Reuters
Jun-25-20 09:18AM	Vertex and the Vertex Foundation Commit $4 Million to Support Racial Equity and Social Justice Business Wire
Jun-24-20 05:45PM	Vertex Pharmaceuticals (VRTX) Stock Moves -1.56%: What You Should Know Zacks
11:54AM	The Zacks Analyst Blog Highlights: Tesla, NVIDIA, ServiceNow, Vertex and Activision Blizzard Zacks
09:15AM	Vertex (VRTX) Hits Fresh High: Is There Still Room to Run? Zacks
08:15AM	Dow Jones Futures Tumble 300 Points After Apple Fuels Record Breaking Stock Market Rally; Netflix, StoneCo In Buy Zones Investor's Business Daily
Jun-23-20 12:01PM	Dow Jones Jumps 275 Points On China News, Trump Tweet; Apple Advances To Record Highs, While Vertex Breaks Out Investor's Business Daily
07:07AM	What Pandemic? These 5 Large Caps Are Up More Than 25% YTD Zacks
Jun-22-20 11:59AM	Dow Jones Slides 200 Points On Coronavirus Fears; 3 Breakout Stocks To Watch Investor's Business Daily
08:12AM	Dow Jones Futures Slash Losses: Stock Market Rally Faces Coronavirus Wave; Apple WWDC, Tesla News In Focus Investor's Business Daily
Jun-18-20 05:50PM	Vertex Pharmaceuticals (VRTX) Stock Sinks As Market Gains: What You Should Know Zacks
08:15AM	Dow Jones Futures Swing Lower As Stock Market Rally Hits Resistance On Coronavirus News; Netflix, Tesla In Focus Investor's Business Daily
Jun-17-20 03:45PM	Dow Jones Eases; Alteryx Crosses Buy Point, Enphase Hits This Sell Signal Investor's Business Daily
11:14AM	The Zacks Analyst Blog Highlights: Boxlight, ChannelAdvisor, Vertex Pharmaceuticals, Murphy USA and Sprouts Farmers Market Zacks
11:05AM	Zacks.com featured highlights include: Vertex Pharmaceuticals, Sprouts Farmers Market, Dollar General and Tractor Supply Company Zacks
09:53AM	Biotech Stock Roundup: REGN Begins Coronavirus Study, VRTX, BIIB Give Updates Zacks
05:58AM	Edited Transcript of VRTX.OQ earnings conference call or presentation 29-Apr-20 9:00pm GMT Thomson Reuters StreetEvents
Jun-16-20 10:15AM	Here Are 4 Stocks With Remarkable Interest Coverage Ratio Zacks
09:50AM	3 Big Biotechs Poised for Growth Amid Coronavirus Pandemic Zacks
06:30AM	Bluebird and Crispr Show Promise for Sickle-Cell Cures Barrons.com
06:20AM	Fed's Bond-Buying Plan Eases Second-Wave Fears: 5 Picks Zacks
Jun-12-20 04:23PM	CRISPR Rally: The First Gene-Editing Drug Continues To Show Promise Investor's Business Daily
03:41PM	CRISPR Rally: The First Gene-Editing Drug Continues To Show Promise Investor's Business Daily
02:12PM	CRISPR Therapeutics and Vertex Pharmaceuticals Deliever New CTX001 Data Motley Fool
11:30AM	Is Vertex Pharmaceuticals (VRTX) Stock Outpacing Its Medical Peers This Year? Zacks
11:25AM	Biotechs Get Wall Street Nod on New Blood Disorder Drugs Data Bloomberg
08:00AM	Top Fund Manager Bought These Stocks Despite The Pandemic Investor's Business Daily
07:30AM	The Daily Biotech Pulse: FDA Nod For Viela, 3 IPOs And Hematology Congress Presentations Benzinga
02:30AM	CRISPR Therapeutics and Vertex Announce New Clinical Data for Investigational Gene-Editing Therapy CTX001 in Severe Hemoglobinopathies at the 25th Annual European Hematology Association (EHA) Congress GlobeNewswire
Jun-10-20 05:50PM	Vertex Pharmaceuticals (VRTX) Gains As Market Dips: What You Should Know Zacks
05:24PM	IBD 50 Stocks To Watch: Vertex Enters A Buy Range On A Rebound From Support Investor's Business Daily
11:46AM	Vertex's Kalydeco Wins Approval in EU for CF in Children Zacks
07:57AM	Dow Jones Futures Rally Ahead Of Fed Meeting; Tesla Set To Hit All-Time Highs On Tesla Semi, Price Target Hike Investor's Business Daily
03:00AM	Vertex Announces European Commission Approval for KALYDECO® (ivacaftor) for Children and Adolescents With Cystic Fibrosis Between the Ages of 6 Months and 18 Years With the R117H Mutation in the CFTR Gene Business Wire
Jun-09-20 04:25PM	How IBD Stock Of The Day Vertex Launched A New Buying Opportunity Investor's Business Daily
02:09PM	Top Biotech Stocks for Q3 2020 Investopedia
Jun-08-20 12:29PM	Vertex CEO Provided Best Value for Investors GuruFocus.com
12:00PM	Dow Jones Jumps 300 Points, As Boeing Soars 14%; Tesla Races 5% Higher On China Sales Investor's Business Daily
Jun-07-20 01:43PM	The Week Ahead In Biotech: Viela FDA Decision, Hematology Conference Take Center Stage Benzinga
07:04AM	Worried Another Stock Market Crash Is Coming? 3 Things You Should Do Right Now Motley Fool
Jun-06-20 12:29PM	3 Top Biotech Stocks to Buy in June Motley Fool
07:55AM	2 Healthcare Stocks That Have a Killer Advantage Motley Fool
Jun-05-20 08:02AM	Looking for Earnings Beat? Play These 5 Stocks Zacks
Jun-04-20 05:50PM	Vertex Pharmaceuticals (VRTX) Dips More Than Broader Markets: What You Should Know Zacks
11:41AM	Zacks Market Edge Highlights: Vertex Pharmaceuticals, Channel Advisor, Gold Fields, AngloGold Ashanti and Dropbox Zacks
Jun-03-20 11:54AM	5 Strong Buy Growth Stocks for this Secular Bull Rally Zacks
10:02AM	Vertex Appoints Diana McKenzie to its Board of Directors Business Wire
09:40AM	Zacks.com featured highlights include: Vertex Pharmaceuticals, Dollar General, CVS Health and Tractor Supply Zacks
Jun-02-20 10:53AM	AstraZeneca Ranked Most Inventive, Roche Most Innovative GuruFocus.com
10:30AM	4 Stocks That Flaunt an Impressive Interest Coverage Ratio Zacks
Jun-01-20 03:28PM	3 Strong Pharmaceutical and Biotech Stocks to Buy for Coronavirus Immunity Zacks
10:35AM	2 Best Biotech Stocks to Buy Right Now Motley Fool
May-29-20 11:31AM	Why Is Vertex (VRTX) Up 10.4% Since Last Earnings Report? Zacks
07:03AM	Got $3,000? Here Are 3 Great Biotech Stocks to Buy Right Now Motley Fool
May-28-20 12:29PM	Despite Coronavirus, These 22 Fastest-Growing Companies Expect 25%-150% Growth In 2020 Investor's Business Daily
11:34AM	Zacks.com featured highlights include: BJs Wholesale Club, Fortinet, Vertex Pharmaceuticals, SPS Commerce and Repligen Zacks
08:14AM	Dow Jones Futures Rise As Coronavirus Market Rally Rotation Continues; China OKs Hong Kong Security Law Investor's Business Daily
May-27-20 01:06PM	Hedge Funds Have Never Been This Bullish On Vertex Pharmaceuticals (VRTX) Insider Monkey
11:40AM	VRTX vs. ILMN: Which Stock Should Value Investors Buy Now? Zacks
11:30AM	Has Vertex Pharmaceuticals (VRTX) Outpaced Other Medical Stocks This Year? Zacks
09:15AM	Profit From 5 Stocks Likely to Beat on Earnings Zacks
May-26-20 08:17AM	2 Top Factors Buoy Wall Street Since Memorial Day: 5 Picks Zacks -6.48%
May-24-20 02:04PM	Is Vertex Pharmaceuticals Stock a Buy? Motley Fool
May-21-20 02:49PM	Top Health Care Stocks for June 2020 Investopedia
May-20-20 09:07AM	The Zacks Analyst Blog Highlights: Chegg, Quidel, MarketAxess, Dropbox and Vertex Pharmaceuticals Zacks
09:06AM	The Zacks Analyst Blog Highlights: Chegg, Nautilus Group, Sprouts Farmers Market, VeriSign and Vertex Pharmaceuticals Zacks
07:02AM	2 Top Biotech Picks for May Motley Fool
May-19-20 08:45AM	The Zacks Analyst Blog Highlights: The Hain Celestial Group, Murphy USA, Vertex Pharmaceuticals, Sprouts Farmers Market and ASE Technology Zacks
08:37AM	Vertex Pharmaceuticals, Align Technology, Walmart, Home Depot and Target highlighted as Zacks Bull and Bear of the Day Zacks
07:02AM	3 Great Stocks to Buy If You Get a Second Stimulus Check Motley Fool
06:46AM	Major Indexes Defying "Sell in May" Adage: 5 Growth Picks Zacks
05:09AM	Bull of the Day: Vertex Pharma (VRTX) Zacks
May-18-20 11:24AM	Surging Earnings Estimates Signal Good News for Vertex Pharmaceuticals (VRTX) Zacks
07:45AM	Wall Street to Rally as Powell Talks Recovery: 5 Big Winners Zacks
May-14-20 12:45PM	3 Reasons Growth Investors Will Love Vertex (VRTX) Zacks
09:02AM	New Data for Investigational CRISPR/Cas9 Gene-Editing Therapy CTX001 for Severe Hemoglobinopathies Accepted for Oral Presentation at the 25th European Hematology Association (EHA) Congress GlobeNewswire

Vertex Pharmaceuticals Incorporated engages in developing and commercializing therapies for treating cystic fibrosis. The company markets SYMDEKO/SYMKEVI, ORKAMBI, and KALYDECO to treat patients with cystic fibrosis who have specific mutations in their cystic fibrosis transmembrane conductance regulator gene; and TRIKAFTA for the treatment of patients with CF 12 years of age or older who have at least one F508del mutation in the cystic fibrosis transmembrane conductance regulator, or CFTR, gene. Its pipeline includes Pipeline for Alpha-1 antitrypsin deficiency that is in Phase 2 clinical trial; VX-864, a second investigational small molecule corrector for the treatment of AAT deficiency, which is in Phase 1 clinical trial; and VX-147 that completed a Phase 1 clinical trial for the treatment of APOL1-mediated focal segmental glomerulosclerosis, or FSGS, and other serious kidney diseases. The company sells its products primarily to specialty pharmacy and specialty distributors in the United States, as well as specialty distributors and retail chains, and hospitals and clinics internationally. Vertex Pharmaceuticals Incorporated has collaborations with CRISPR Therapeutics AG; Arbor Biotechnologies, Inc.; Moderna Therapeutics, Inc.; Genomics plc; Merck KGaA; Darmstadt, Germany; X-Chem, Inc.; Janssen Pharmaceuticals, Inc.; Merck KGaA; Kymera Therapeutics; Ribometrix, Inc.; Molecular Templates, Inc.; and Affinia Therapeutics. The company was founded in 1989 and is headquartered in Boston, Massachusetts.

Insider Trading	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
WAGNER CHARLES F JR	EVP & Chief Financial Officer	Jul 10	Sale	293.15	700	205,206	16,126	Jul 14 04:16 PM
Arbuckle Stuart A	EVP, Chief Commercial Officer	Jul 07	Option Exercise	173.51	2,786	483,403	37,965	Jul 09 04:13 PM
Arbuckle Stuart A	EVP, Chief Commercial Officer	Jul 07	Sale	300.00	2,786	835,800	35,179	Jul 09 04:13 PM
LEIDEN JEFFREY M	Executive Chairman	Jun 30	Sale	286.15	32,792	9,383,304	2,261	Jul 02 04:15 PM
Bhatia Sangeeta N.	Director	Jun 02	Sale	282.88	952	269,298	5,695	Jun 03 04:22 PM
ALTSHULER DAVID	EVP, Global Research and CSO	May 15	Sale	284.37	82	23,318	28,902	May 19 04:21 PM
Arbuckle Stuart A	EVP, Chief Commercial Officer	May 15	Sale	283.98	113	32,089	35,179	May 19 04:22 PM
Parini Michael	EVP, Chief Adm, Leg & BD Off	May 15	Sale	284.40	68	19,339	26,838	May 19 04:28 PM
Sachdev Amit	EVP, Chief Patient Officer	May 15	Sale	284.41	58	16,496	35,103	May 19 04:29 PM
Silva Paul M	SVP & Controller	May 15	Sale	284.00	151	42,885	14,932	May 19 04:31 PM
Tatsis Ourania	EVP, Chief Regulatory Officer	May 15	Sale	284.00	120	34,080	12,738	May 19 04:33 PM
Kewalramani Reshma	CEO & President	May 15	Sale	284.17	99	28,132	26,626	May 19 04:35 PM
ALTSHULER DAVID	EVP, Global Research and CSO	May 12	Option Exercise	187.53	1,304	244,539	30,206	May 14 04:17 PM
LEIDEN JEFFREY M	Executive Chairman	May 12	Option Exercise	137.52	88,532	12,174,639	129,353	May 14 04:19 PM
ALTSHULER DAVID	EVP, Global Research and CSO	May 12	Sale	287.33	1,304	374,678	28,902	May 14 04:17 PM
LEIDEN JEFFREY M	Executive Chairman	May 12	Sale	283.47	94,370	26,751,440	34,983	May 14 04:19 PM
Parini Michael	EVP, Chief Adm, Leg & BD Off	May 11	Option Exercise	187.53	1,304	244,539	28,142	May 13 04:18 PM
Sachdev Amit	EVP, Chief Patient Officer	May 11	Option Exercise	131.89	10,665	1,406,607	45,768	May 13 04:20 PM
Parini Michael	EVP, Chief Adm, Leg & BD Off	May 11	Sale	286.00	1,304	372,944	26,838	May 13 04:18 PM
Sachdev Amit	EVP, Chief Patient Officer	May 11	Sale	282.61	10,665	3,014,014	35,103	May 13 04:20 PM
LEIDEN JEFFREY M	Executive Chairman	May 07	Option Exercise	137.52	88,534	12,174,982	135,190	May 08 04:20 PM
SACHS BRUCE I	Director	May 07	Option Exercise	70.55	45,000	3,174,525	56,210	May 08 04:24 PM
LEIDEN JEFFREY M	Executive Chairman	May 07	Sale	269.78	94,369	25,459,013	40,821	May 08 04:20 PM
SACHS BRUCE I	Director	May 07	Sale	269.80	45,000	12,140,806	11,210	May 08 04:24 PM
Tatsis Ourania	EVP, Chief Regulatory Officer	May 06	Option Exercise	174.06	966	168,146	13,704	May 08 04:28 PM
ALTSHULER DAVID	EVP, Global Research and CSO	May 06	Option Exercise	155.57	1,222	190,107	30,124	May 08 04:17 PM
Kewalramani Reshma	CEO & President	May 06	Option Exercise	179.67	2,074	372,638	28,700	May 08 04:19 PM
Parini Michael	EVP, Chief Adm, Leg & BD Off	May 06	Option Exercise	155.57	1,222	190,107	28,060	May 08 04:22 PM
Sachdev Amit	EVP, Chief Patient Officer	May 06	Option Exercise	131.89	669	88,234	35,772	May 08 04:23 PM
Silva Paul M	SVP & Controller	May 06	Option Exercise	169.38	1,076	182,255	16,008	May 08 04:26 PM
Tatsis Ourania	EVP, Chief Regulatory Officer	May 06	Sale	272.70	966	263,431	12,738	May 08 04:28 PM
ALTSHULER DAVID	EVP, Global Research and CSO	May 06	Sale	272.66	1,222	333,195	28,902	May 08 04:17 PM
Kewalramani Reshma	CEO & President	May 06	Sale	272.85	2,074	565,882	26,626	May 08 04:19 PM
Parini Michael	EVP, Chief Adm, Leg & BD Off	May 06	Sale	272.64	1,222	333,165	26,838	May 08 04:22 PM
Sachdev Amit	EVP, Chief Patient Officer	May 06	Sale	275.28	669	184,162	35,103	May 08 04:23 PM
Silva Paul M	SVP & Controller	May 06	Sale	272.74	1,076	293,472	14,932	May 08 04:26 PM
Sachdev Amit	EVP, Chief Patient Officer	May 05	Option Exercise	131.89	13,356	1,761,523	48,459	May 06 04:43 PM
LEIDEN JEFFREY M	Executive Chairman	May 05	Option Exercise	137.52	88,537	12,175,273	141,028	May 07 04:24 PM
Sachdev Amit	EVP, Chief Patient Officer	May 05	Sale	270.01	13,356	3,606,232	35,103	May 06 04:43 PM
LEIDEN JEFFREY M	Executive Chairman	May 05	Sale	269.94	94,372	25,475,037	46,656	May 07 04:24 PM
ALTSHULER DAVID	EVP, Global Research and CSO	May 04	Option Exercise	86.52	2,330	201,592	31,232	May 06 04:17 PM
Parini Michael	EVP, Chief Adm, Leg & BD Off	May 04	Option Exercise	86.52	2,330	201,592	29,168	May 06 04:25 PM
Silva Paul M	SVP & Controller	May 04	Option Exercise	86.52	809	69,995	15,741	May 06 04:27 PM
Arbuckle Stuart A	EVP, Chief Commercial Officer	May 04	Option Exercise	86.52	1,553	134,366	36,732	May 06 04:38 PM
Sachdev Amit	EVP, Chief Patient Officer	May 04	Option Exercise	112.98	43,752	4,942,968	78,855	May 06 04:43 PM
ALTSHULER DAVID	EVP, Global Research and CSO	May 04	Sale	260.86	2,330	607,803	28,902	May 06 04:17 PM
Parini Michael	EVP, Chief Adm, Leg & BD Off	May 04	Sale	260.87	2,330	607,827	26,838	May 06 04:25 PM
Silva Paul M	SVP & Controller	May 04	Sale	260.87	809	211,048	14,932	May 06 04:27 PM
Arbuckle Stuart A	EVP, Chief Commercial Officer	May 04	Sale	260.76	1,553	404,957	35,179	May 06 04:38 PM
Sachdev Amit	EVP, Chief Patient Officer	May 04	Sale	262.28	43,752	11,475,179	35,103	May 06 04:43 PM
Parini Michael	EVP, Chief Adm, Leg & BD Off	Apr 29	Option Exercise	90.29	2,125	191,866	28,963	May 01 04:22 PM
Parini Michael	EVP, Chief Adm, Leg & BD Off	Apr 29	Sale	254.95	2,125	541,769	26,838	May 01 04:22 PM
Lee Yuchun	Director	Apr 28	Option Exercise	57.27	1,125	64,429	3,000	Apr 29 04:14 PM
Lee Yuchun	Director	Apr 28	Sale	257.88	1,125	290,115	1,875	Apr 29 04:14 PM
Lee Yuchun	Director	Apr 27	Option Exercise	57.27	2,000	114,540	3,875	Apr 28 04:23 PM
Lee Yuchun	Director	Apr 27	Sale	271.21	2,000	542,419	1,875	Apr 28 04:23 PM
Lee Yuchun	Director	Apr 24	Option Exercise	57.27	2,000	114,540	3,875	Apr 28 04:23 PM
Lee Yuchun	Director	Apr 24	Sale	268.14	2,000	536,286	1,875	Apr 28 04:23 PM
Lee Yuchun	Director	Apr 23	Option Exercise	57.27	2,000	114,540	3,875	Apr 24 04:17 PM
Lee Yuchun	Director	Apr 23	Sale	272.53	2,000	545,052	1,875	Apr 24 04:17 PM
Lee Yuchun	Director	Apr 22	Option Exercise	57.27	2,000	114,540	3,875	Apr 24 04:17 PM
Lee Yuchun	Director	Apr 22	Sale	267.88	2,000	535,753	1,875	Apr 24 04:17 PM
Lee Yuchun	Director	Apr 21	Option Exercise	57.27	2,000	114,540	3,875	Apr 22 04:14 PM
Lee Yuchun	Director	Apr 21	Sale	266.76	2,000	533,523	1,875	Apr 22 04:14 PM
Lee Yuchun	Director	Apr 20	Option Exercise	57.27	2,000	114,540	3,875	Apr 22 04:14 PM
Lee Yuchun	Director	Apr 20	Sale	273.16	2,000	546,310	1,875	Apr 22 04:14 PM
Silva Paul M	SVP & Controller	Apr 13	Option Exercise	90.29	859	77,559	15,791	Apr 15 04:15 PM
Silva Paul M	SVP & Controller	Apr 13	Sale	248.72	859	213,650	14,932	Apr 15 04:15 PM
Silva Paul M	SVP & Controller	Apr 06	Option Exercise	155.57	4,891	760,893	19,823	Apr 08 04:17 PM
Silva Paul M	SVP & Controller	Apr 06	Sale	255.57	4,891	1,249,993	14,932	Apr 08 04:17 PM
ALTSHULER DAVID	EVP, Global Research and CSO	Feb 25	Sale	233.41	3,028	706,776	28,902	Feb 26 04:29 PM
Arbuckle Stuart A	EVP, Chief Commercial Officer	Feb 25	Sale	233.74	3,634	849,418	35,179	Feb 26 04:30 PM
Kewalramani Reshma	EVP and CMO	Feb 25	Sale	233.45	3,634	848,371	26,626	Feb 26 04:32 PM
LEIDEN JEFFREY M	CEO & President	Feb 25	Sale	233.46	10,550	2,463,046	92,581	Feb 26 04:34 PM
Parini Michael	EVP, CL&AO	Feb 25	Sale	233.49	3,028	707,005	26,838	Feb 26 04:35 PM
Sachdev Amit	EVP, Chief Patient Officer	Feb 25	Sale	233.53	3,376	788,402	32,915	Feb 26 04:36 PM
Silva Paul M	SVP & Controller	Feb 25	Sale	233.45	1,080	252,127	14,932	Feb 26 04:37 PM
Tatsis Ourania	SVP, CRO	Feb 25	Sale	233.17	1,296	302,187	12,738	Feb 26 04:39 PM
ALTSHULER DAVID	EVP, Global Research and CSO	Feb 18	Sale	243.67	3,128	762,201	34,346	Feb 19 04:31 PM
Kewalramani Reshma	EVP and CMO	Feb 18	Sale	243.51	1,183	288,070	33,158	Feb 19 04:33 PM
Arbuckle Stuart A	EVP, Chief Commercial Officer	Feb 18	Sale	243.56	3,128	761,842	41,711	Feb 19 04:32 PM
LEIDEN JEFFREY M	CEO & President	Feb 18	Sale	243.52	11,685	2,845,518	111,541	Feb 19 04:35 PM
Parini Michael	EVP, CL&AO	Feb 18	Sale	243.61	3,128	762,020	32,282	Feb 19 04:36 PM
Sachdev Amit	EVP, Chief Patient Officer	Feb 18	Sale	243.56	3,489	849,780	39,447	Feb 19 04:37 PM
Silva Paul M	SVP & Controller	Feb 18	Sale	243.58	1,564	380,957	16,876	Feb 19 04:38 PM
Tatsis Ourania	SVP, CRO	Feb 18	Sale	243.62	1,279	311,585	15,070	Feb 19 04:39 PM
ALTSHULER DAVID	EVP, Global Research and CSO	Feb 11	Sale	246.11	17,032	4,191,771	39,970	Feb 12 05:11 PM
Arbuckle Stuart A	EVP, Chief Commercial Officer	Feb 11	Sale	246.09	11,286	2,777,325	47,335	Feb 12 05:13 PM
LEIDEN JEFFREY M	CEO & President	Feb 11	Sale	246.09	47,523	11,694,933	132,540	Feb 12 05:19 PM
Parini Michael	EVP, CL&AO	Feb 11	Sale	246.11	16,882	4,154,832	37,906	Feb 12 05:20 PM
Sachdev Amit	EVP, Chief Patient Officer	Feb 11	Sale	246.08	13,070	3,216,311	46,198	Feb 12 05:22 PM
Silva Paul M	SVP & Controller	Feb 11	Sale	246.04	5,862	1,442,301	19,688	Feb 12 05:24 PM
Lee Yuchun	Director	Feb 10	Option Exercise	57.27	1,181	67,636	3,056	Feb 12 05:14 PM
Lee Yuchun	Director	Feb 10	Sale	242.51	1,181	286,403	1,875	Feb 12 05:14 PM
Lee Yuchun	Director	Feb 07	Option Exercise	57.27	2,000	114,540	3,875	Feb 11 04:17 PM
Lee Yuchun	Director	Feb 07	Sale	237.82	2,000	475,643	1,875	Feb 11 04:17 PM
Silva Paul M	SVP & Controller	Feb 06	Option Exercise	187.53	466	87,389	30,689	Feb 07 04:27 PM
Tatsis Ourania	SVP, CRO	Feb 06	Option Exercise	174.05	967	168,302	17,913	Feb 07 04:28 PM
Arbuckle Stuart A	EVP, Chief Commercial Officer	Feb 06	Option Exercise	173.51	2,787	483,559	70,350	Feb 07 04:08 PM
Parini Michael	EVP, CL&AO	Feb 06	Option Exercise	172.06	2,526	434,614	70,772	Feb 07 04:17 PM

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