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| Insider Trading | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |  | Brege Laura | Director | Sep 11 '25 | Option Exercise | 15.00 | 17,000 | 255,000 | 32,703 | Sep 12 08:00 PM |  | Brege Laura | Director | Sep 11 '25 | Sale | 74.40 | 17,000 | 1,264,868 | 15,703 | Sep 12 08:00 PM |  | BJERKHOLT ERIC | CHIEF FINANCIAL OFFICER | Sep 12 '25 | Sale | 76.01 | 9,578 | 728,024 | 39,945 | Sep 12 08:00 PM |  | LAURA BREGE | Director | Sep 11 '25 | Proposed Sale | 74.41 | 17,000 | 1,264,917 |  | Sep 11 04:04 PM |  | Ramasastry Saira | Director | Sep 08 '25 | Option Exercise | 23.51 | 17,000 | 399,670 | 17,000 | Sep 10 05:50 PM |  | SAIRA RAMASASTRY | Director | Sep 08 '25 | Proposed Sale | 77.04 | 17,000 | 1,309,716 |  | Sep 08 04:06 PM |  | BJERKHOLT ERIC | CHIEF FINANCIAL OFFICER | Aug 12 '25 | Option Exercise | 26.49 | 2,954 | 78,251 | 31,190 | Aug 12 08:00 PM |  | Peetz Christopher | CHIEF EXECUTIVE OFFICER | Aug 11 '25 | Option Exercise | 2.94 | 40,000 | 117,440 | 178,641 | Aug 12 07:57 PM |  | Peetz Christopher | CHIEF EXECUTIVE OFFICER | Aug 11 '25 | Sale | 62.00 | 40,000 | 2,480,000 | 138,641 | Aug 12 07:57 PM |  | CHRISTOPHER PEETZ | Officer | Aug 11 '25 | Proposed Sale | 62.00 | 40,000 | 2,480,000 |  | Aug 11 04:06 PM |  | Howe Jolanda | SVP, GLOBAL CONTROLLER | Aug 07 '25 | Option Exercise | 6.27 | 10,000 | 62,700 | 12,426 | Aug 08 04:50 PM |  | Howe Jolanda | SVP, GLOBAL CONTROLLER | Aug 07 '25 | Sale | 58.00 | 10,000 | 580,000 | 2,426 | Aug 08 04:50 PM |  | Peetz Christopher | CHIEF EXECUTIVE OFFICER | Aug 07 '25 | Option Exercise | 2.94 | 40,000 | 117,440 | 178,641 | Aug 08 04:49 PM |  | Peetz Christopher | CHIEF EXECUTIVE OFFICER | Aug 07 '25 | Sale | 55.25 | 40,000 | 2,210,040 | 138,641 | Aug 08 04:49 PM |  | JOLANDA MARIE HOWE | Officer | Aug 07 '25 | Proposed Sale | 58.00 | 10,000 | 580,000 |  | Aug 07 04:26 PM |  | CHRISTOPHER PEETZ | Officer | Aug 07 '25 | Proposed Sale | 55.25 | 40,000 | 2,210,040 |  | Aug 07 04:25 PM |  | Howe Jolanda | SVP, GLOBAL CONTROLLER | Jul 02 '25 | Sale | 48.25 | 564 | 27,213 | 2,903 | Jul 03 06:48 PM |  | Howe Jolanda | SVP, GLOBAL CONTROLLER | Jul 03 '25 | Sale | 49.08 | 477 | 23,411 | 2,426 | Jul 03 06:48 PM |  | JOLANDA MARIE HOWE | Officer | Jul 03 '25 | Proposed Sale | 49.08 | 477 | 23,411 |  | Jul 03 01:13 PM |  | Fairey William | Director | Jun 11 '25 | Sale | 48.42 | 3,203 | 155,091 | 2,500 | Jun 13 04:18 PM |  | WILLIAM C FAIREY | Director | Jun 11 '25 | Proposed Sale | 48.42 | 3,203 | 155,091 |  | Jun 11 04:05 PM |  | Ramasastry Saira | Director | Jun 03 '25 | Option Exercise | 14.12 | 2,500 | 35,300 | 2,500 | Jun 04 04:11 PM |  | Ramasastry Saira | Director | Jun 02 '25 | Sale | 46.20 | 5,703 | 263,492 | 0 | Jun 04 04:11 PM |  | Ramasastry Saira | Director | Jun 03 '25 | Sale | 45.74 | 2,500 | 114,352 | 0 | Jun 04 04:11 PM |  | SAIRA RAMASASTRY | Director | Jun 03 '25 | Proposed Sale | 45.74 | 2,500 | 114,352 |  | Jun 03 05:07 PM |  | SAIRA RAMASASTRY | Director | Jun 02 '25 | Proposed Sale | 46.20 | 5,703 | 263,492 |  | Jun 02 06:43 PM |  | Howe Jolanda | SVP, GLOBAL CONTROLLER | Mar 18 '25 | Sale | 44.45 | 2,415 | 107,343 | 2,426 | Mar 19 05:40 PM |  | Howe Jolanda | SVP, GLOBAL CONTROLLER | Mar 17 '25 | Option Exercise | 2.94 | 52,900 | 155,526 | 59,547 | Mar 18 09:30 PM |  | Howe Jolanda | SVP, GLOBAL CONTROLLER | Mar 17 '25 | Sale | 44.35 | 57,606 | 2,554,763 | 4,841 | Mar 18 09:30 PM |  | Radovich Peter | PRESIDENT AND COO | Mar 17 '25 | Sale | 44.21 | 7,879 | 348,364 | 18,672 | Mar 18 09:30 PM |  | Peetz Christopher | CHIEF EXECUTIVE OFFICER | Mar 17 '25 | Sale | 44.21 | 27,279 | 1,206,122 | 138,641 | Mar 18 09:30 PM |  | Heron Patrick J | Director | Mar 14 '25 | Buy | 44.11 | 528 | 23,291 | 168,651 | Mar 18 05:04 PM |  | Heron Patrick J | Director | Mar 17 '25 | Buy | 43.93 | 21 | 923 | 168,672 | Mar 18 05:04 PM |  | JOLANDA MARIE HOWE | Officer | Mar 18 '25 | Proposed Sale | 44.45 | 2,415 | 107,343 |  | Mar 18 04:12 PM |  | JOLANDA MARIE HOWE | Officer | Mar 17 '25 | Proposed Sale | 44.36 | 54,706 | 2,426,540 |  | Mar 17 04:21 PM |  | Heron Patrick J | Director | Mar 10 '25 | Buy | 42.97 | 1,335 | 57,363 | 167,160 | Mar 12 04:51 PM |  | Heron Patrick J | Director | Mar 11 '25 | Buy | 43.77 | 963 | 42,155 | 168,123 | Mar 12 04:51 PM |  | Heron Patrick J | Director | Mar 06 '25 | Buy | 43.89 | 1,335 | 58,597 | 165,245 | Mar 10 05:12 PM |  | Heron Patrick J | Director | Mar 07 '25 | Buy | 43.21 | 580 | 25,064 | 165,825 | Mar 10 05:12 PM |  | Heron Patrick J | Director | Mar 04 '25 | Buy | 45.57 | 1,335 | 60,830 | 163,643 | Mar 06 05:30 PM |  | Heron Patrick J | Director | Mar 05 '25 | Buy | 44.55 | 267 | 11,894 | 163,910 | Mar 06 05:30 PM |  | Radovich Peter | PRESIDENT AND COO | Mar 04 '25 | Sale | 45.58 | 14,850 | 676,928 | 12,111 | Mar 05 04:28 PM |  | Radovich Peter | Officer | Mar 04 '25 | Proposed Sale | 45.52 | 14,850 | 675,956 |  | Mar 04 04:43 PM |  | Peetz Christopher | CHIEF EXECUTIVE OFFICER | Mar 03 '25 | Option Exercise | 2.94 | 40,000 | 117,440 | 155,920 | Mar 04 04:26 PM |  | Peetz Christopher | CHIEF EXECUTIVE OFFICER | Mar 03 '25 | Sale | 46.91 | 40,000 | 1,876,353 | 115,920 | Mar 04 04:26 PM |  | CHRISTOPHER PEETZ | Officer | Mar 03 '25 | Proposed Sale | 46.91 | 40,000 | 1,876,280 |  | Mar 03 04:49 PM |  | Radovich Peter | PRESIDENT AND COO | Feb 03 '25 | Sale | 48.22 | 2,627 | 126,681 | 26,961 | Feb 04 05:30 PM |  | Peetz Christopher | CHIEF EXECUTIVE OFFICER | Feb 03 '25 | Sale | 48.22 | 9,102 | 438,921 | 115,920 | Feb 04 05:30 PM |  | Howe Jolanda | SVP, GLOBAL CONTROLLER | Feb 03 '25 | Sale | 48.22 | 1,064 | 51,309 | 4,232 | Feb 04 05:30 PM |  | Radovich Peter | PRESIDENT AND COO | Jan 24 '25 | Sale | 47.92 | 3,177 | 152,256 | 29,588 | Jan 27 04:50 PM |  | Howe Jolanda | SVP, GLOBAL CONTROLLER | Jan 24 '25 | Sale | 47.92 | 902 | 43,228 | 3,524 | Jan 27 04:48 PM |  | Peetz Christopher | CHIEF EXECUTIVE OFFICER | Jan 24 '25 | Sale | 47.92 | 6,837 | 327,658 | 125,022 | Jan 27 04:48 PM |  | Quan Joanne | CHIEF MEDICAL OFFICER | Jan 17 '25 | Sale | 45.86 | 6,969 | 319,598 | 5,649 | Jan 21 04:21 PM |  | Radovich Peter | PRESIDENT AND COO | Jan 07 '25 | Sale | 42.82 | 1,998 | 85,545 | 27,015 | Jan 08 04:44 PM |  | Peetz Christopher | CHIEF EXECUTIVE OFFICER | Jan 07 '25 | Sale | 42.82 | 7,489 | 320,644 | 119,359 | Jan 08 04:42 PM |  | Howe Jolanda | SVP, GLOBAL CONTROLLER | Jan 07 '25 | Sale | 42.82 | 750 | 32,111 | 2,926 | Jan 08 04:38 PM |  | Howe Jolanda | SVP, GLOBAL CONTROLLER | Nov 14 '24 | Option Exercise | 2.94 | 2,500 | 7,350 | 4,926 | Nov 15 05:34 PM |  | Howe Jolanda | SVP, GLOBAL CONTROLLER | Nov 14 '24 | Sale | 47.10 | 2,500 | 117,752 | 2,426 | Nov 15 05:34 PM |  |