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| Insider Trading | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |  | CHRISTIANA STAMOULIS | Officer | Oct 30 '25 | Proposed Sale | 94.00 | 14,986 | 1,408,684 |  | Oct 30 04:31 PM |  | BARRY FLANNELLY | Officer | Oct 27 '25 | Proposed Sale | 91.73 | 33,452 | 3,068,539 |  | Oct 27 04:21 PM |  | Denton Sheila A. | EVP & General Counsel | Oct 15 '25 | Option Exercise | 64.25 | 277 | 17,797 | 26,846 | Oct 17 04:01 PM |  | Denton Sheila A. | EVP & General Counsel | Oct 15 '25 | Sale | 85.13 | 277 | 23,581 | 26,569 | Oct 17 04:01 PM |  | BARRY FLANNELLY | Officer | Oct 16 '25 | Proposed Sale | 92.38 | 18,495 | 1,708,609 |  | Oct 16 04:01 PM |  | SHEILA DENTON | Officer | Oct 15 '25 | Proposed Sale | 85.13 | 277 | 23,581 |  | Oct 15 04:03 PM |  | Denton Sheila A. | EVP & General Counsel | Oct 02 '25 | Option Exercise | 58.06 | 599 | 34,778 | 33,799 | Oct 06 04:02 PM |  | Denton Sheila A. | EVP & General Counsel | Oct 03 '25 | Sale | 85.54 | 3,501 | 299,476 | 26,569 | Oct 06 04:02 PM |  | Denton Sheila A. | EVP & General Counsel | Oct 02 '25 | Sale | 87.65 | 599 | 52,502 | 33,200 | Oct 06 04:02 PM |  | SHEILA DENTON | Officer | Oct 03 '25 | Proposed Sale | 85.54 | 3,501 | 299,464 |  | Oct 03 04:07 PM |  | SHEILA DENTON | Officer | Oct 02 '25 | Proposed Sale | 87.65 | 599 | 52,502 |  | Oct 02 04:01 PM |  | BARRY FLANNELLY | Officer | Sep 18 '25 | Proposed Sale | 85.26 | 17,447 | 1,487,531 |  | Sep 18 05:10 PM |  | Denton Sheila A. | EVP & General Counsel | Sep 16 '25 | Option Exercise | 64.25 | 278 | 17,862 | 33,478 | Sep 18 04:06 PM |  | Denton Sheila A. | EVP & General Counsel | Sep 16 '25 | Sale | 83.15 | 278 | 23,116 | 33,200 | Sep 18 04:06 PM |  | SHEILA DENTON | Officer | Sep 16 '25 | Proposed Sale | 83.15 | 278 | 23,116 |  | Sep 16 04:03 PM |  | Denton Sheila A. | EVP & General Counsel | Sep 02 '25 | Option Exercise | 58.06 | 598 | 34,720 | 33,798 | Sep 04 04:04 PM |  | Denton Sheila A. | EVP & General Counsel | Sep 02 '25 | Sale | 84.97 | 598 | 50,812 | 33,200 | Sep 04 04:04 PM |  | SHEILA DENTON | Officer | Sep 02 '25 | Proposed Sale | 84.97 | 598 | 50,812 |  | Sep 02 04:07 PM |  | Denton Sheila A. | EVP & General Counsel | Aug 15 '25 | Option Exercise | 64.25 | 277 | 17,797 | 33,477 | Aug 19 04:13 PM |  | Denton Sheila A. | EVP & General Counsel | Aug 15 '25 | Sale | 86.81 | 277 | 24,046 | 33,200 | Aug 19 04:13 PM |  | SHEILA DENTON | Officer | Aug 15 '25 | Proposed Sale | 86.81 | 277 | 24,046 |  | Aug 15 04:05 PM |  | BARRY FLANNELLY | Officer | Aug 13 '25 | Proposed Sale | 82.51 | 75,963 | 6,267,540 |  | Aug 13 04:18 PM |  | BARRY FLANNELLY | Officer | Aug 12 '25 | Proposed Sale | 80.00 | 14,037 | 1,122,970 |  | Aug 12 04:21 PM |  | Denton Sheila A. | EVP & General Counsel | Aug 04 '25 | Option Exercise | 58.06 | 598 | 34,720 | 33,798 | Aug 06 04:03 PM |  | Denton Sheila A. | EVP & General Counsel | Aug 04 '25 | Sale | 75.77 | 598 | 45,310 | 33,200 | Aug 06 04:03 PM |  | SHEILA DENTON | Officer | Aug 04 '25 | Proposed Sale | 75.77 | 598 | 45,310 |  | Aug 04 04:05 PM |  | Stein Steven H | EVP & Chief Medical Officer | Jul 21 '25 | Sale | 67.94 | 3,706 | 251,786 | 102,886 | Jul 23 03:56 PM |  | STEVEN STEIN | Officer | Jul 21 '25 | Proposed Sale | 67.94 | 3,706 | 251,786 |  | Jul 21 04:01 PM |  | Flannelly Barry P | EVP & General Manager US | Jul 16 '25 | Sale | 68.36 | 1,340 | 91,602 | 35,149 | Jul 17 04:06 PM |  | Iyengar Vijay K | EVP, GMAPPS | Jul 16 '25 | Sale | 68.36 | 983 | 67,198 | 40,540 | Jul 17 04:05 PM |  | Denton Sheila A. | EVP & General Counsel | Jul 15 '25 | Option Exercise | 64.25 | 3,330 | 213,952 | 29,834 | Jul 17 04:04 PM |  | Denton Sheila A. | EVP & General Counsel | Jul 15 '25 | Sale | 69.86 | 3,330 | 232,634 | 26,504 | Jul 17 04:04 PM |  | Denton Sheila A. | EVP & General Counsel | Jul 16 '25 | Sale | 68.36 | 785 | 53,663 | 33,200 | Jul 17 04:04 PM |  | VIJAY IYENGAR | Officer | Jul 16 '25 | Proposed Sale | 68.36 | 983 | 67,198 |  | Jul 16 04:07 PM |  | BARRY FLANNELLY | Officer | Jul 16 '25 | Proposed Sale | 68.36 | 1,340 | 91,602 |  | Jul 16 04:06 PM |  | Stein Steven H | EVP & Chief Medical Officer | Jul 14 '25 | Sale | 68.47 | 14,952 | 1,023,763 | 97,466 | Jul 16 04:05 PM |  | SHEILA DENTON | Officer | Jul 16 '25 | Proposed Sale | 68.36 | 785 | 53,663 |  | Jul 16 04:02 PM |  | Iyengar Vijay K | EVP, GMAPPS | Jul 15 '25 | Sale | 69.86 | 1,177 | 82,225 | 35,929 | Jul 16 04:02 PM |  | Flannelly Barry P | EVP & General Manager US | Jul 15 '25 | Sale | 69.86 | 1,192 | 83,273 | 37,630 | Jul 16 04:02 PM |  | BARRY FLANNELLY | Officer | Jul 15 '25 | Proposed Sale | 69.86 | 1,192 | 83,273 |  | Jul 15 04:41 PM |  | SHEILA DENTON | Officer | Jul 15 '25 | Proposed Sale | 69.86 | 3,330 | 232,634 |  | Jul 15 04:37 PM |  | VIJAY IYENGAR | Officer | Jul 15 '25 | Proposed Sale | 69.86 | 1,177 | 82,225 |  | Jul 15 04:20 PM |  | STEVEN STEIN | Officer | Jul 14 '25 | Proposed Sale | 68.47 | 14,952 | 1,023,714 |  | Jul 14 04:03 PM |  | Flannelly Barry P | EVP & General Manager US | Jul 03 '25 | Sale | 68.15 | 10,903 | 743,039 | 39,744 | Jul 07 04:46 PM |  | Denton Sheila A. | EVP & General Counsel | Jul 02 '25 | Option Exercise | 58.06 | 599 | 34,778 | 27,103 | Jul 07 04:44 PM |  | Denton Sheila A. | EVP & General Counsel | Jul 02 '25 | Sale | 68.61 | 599 | 41,097 | 26,504 | Jul 07 04:44 PM |  | Iyengar Vijay K | EVP, GMAPPS | Jul 03 '25 | Sale | 68.15 | 8,617 | 587,275 | 37,701 | Jul 07 04:43 PM |  | BARRY FLANNELLY | Officer | Jul 03 '25 | Proposed Sale | 68.15 | 10,903 | 743,048 |  | Jul 03 03:10 PM |  | VIJAY IYENGAR | Officer | Jul 03 '25 | Proposed Sale | 68.15 | 8,617 | 587,272 |  | Jul 03 02:46 PM |  | SHEILA DENTON | Officer | Jul 02 '25 | Proposed Sale | 68.61 | 599 | 41,097 |  | Jul 02 04:27 PM |  | Denton Sheila A. | EVP & General Counsel | Jun 03 '25 | Option Exercise | 58.06 | 1,795 | 104,218 | 28,299 | Jun 05 04:04 PM |  | Denton Sheila A. | EVP & General Counsel | Jun 03 '25 | Sale | 68.00 | 1,795 | 122,060 | 26,504 | Jun 05 04:04 PM |  | SHEILA DENTON | Officer | Jun 03 '25 | Proposed Sale | 68.00 | 1,795 | 122,060 |  | Jun 03 04:06 PM |  | Tray Thomas | Principal Accounting Officer | May 30 '25 | Sale | 65.71 | 963 | 63,279 | 22,654 | Jun 03 04:00 PM |  | Tray Thomas | Principal Accounting Officer | Jun 02 '25 | Sale | 64.88 | 651 | 42,237 | 22,003 | Jun 03 04:00 PM |  | THOMAS R TRAY | Officer | Jun 02 '25 | Proposed Sale | 64.88 | 651 | 42,237 |  | Jun 02 04:26 PM |  | THOMAS R TRAY | Officer | May 30 '25 | Proposed Sale | 65.71 | 963 | 63,279 |  | May 30 04:03 PM |  | Flannelly Barry P | EVP & General Manager US | Mar 14 '25 | Sale | 67.69 | 19,807 | 1,340,656 | 33,567 | Mar 18 04:01 PM |  | BARRY FLANNELLY | Officer | Mar 14 '25 | Proposed Sale | 67.69 | 19,807 | 1,340,728 |  | Mar 14 04:11 PM |  | Denton Sheila A. | EVP & General Counsel | Mar 04 '25 | Option Exercise | 58.06 | 599 | 34,778 | 26,447 | Mar 06 04:56 PM |  | Denton Sheila A. | EVP & General Counsel | Mar 04 '25 | Sale | 69.99 | 599 | 41,924 | 25,848 | Mar 06 04:56 PM |  | SHEILA DENTON | Officer | Mar 04 '25 | Proposed Sale | 69.99 | 599 | 41,924 |  | Mar 04 05:12 PM |  | Denton Sheila A. | EVP & General Counsel | Feb 26 '25 | Option Exercise | 58.06 | 9,574 | 555,866 | 39,917 | Feb 28 06:34 PM |  | Denton Sheila A. | EVP & General Counsel | Feb 26 '25 | Sale | 74.07 | 14,069 | 1,042,136 | 25,848 | Feb 28 06:34 PM |  | SHEILA DENTON | Officer | Feb 26 '25 | Proposed Sale | 74.07 | 14,069 | 1,042,138 |  | Feb 26 04:04 PM |  | Stein Steven H | EVP & Chief Medical Officer | Jan 21 '25 | Sale | 72.69 | 12,352 | 897,867 | 66,967 | Jan 22 04:05 PM |  | STEVEN STEIN | Officer | Jan 21 '25 | Proposed Sale | 72.69 | 12,352 | 897,906 |  | Jan 21 04:03 PM |  | Tray Thomas | Principal Accounting Officer | Dec 13 '24 | Sale | 70.64 | 650 | 45,916 | 23,962 | Dec 17 12:37 PM |  | Tray Thomas | Principal Accounting Officer | Dec 16 '24 | Sale | 69.31 | 650 | 45,052 | 23,312 | Dec 17 12:37 PM |  | THOMAS R TRAY | Officer | Dec 16 '24 | Proposed Sale | 69.31 | 650 | 45,052 |  | Dec 16 04:04 PM |  | Iyengar Vijay K | EVP, GMAPPS | Nov 29 '24 | Sale | 75.38 | 6,043 | 455,544 | 30,658 | Dec 03 12:52 PM |  | VIJAY IYENGAR | Officer | Nov 29 '24 | Proposed Sale | 75.39 | 6,043 | 455,555 |  | Nov 29 01:28 PM |  | Flannelly Barry P | EVP & General Manager US | Nov 06 '24 | Option Exercise | 70.03 | 3,680 | 257,719 | 61,722 | Nov 08 12:48 PM |  | Flannelly Barry P | EVP & General Manager US | Nov 06 '24 | Sale | 79.68 | 3,680 | 293,210 | 58,042 | Nov 08 12:48 PM |  | BARRY FLANNELLY | Officer | Nov 06 '24 | Proposed Sale | 79.68 | 3,680 | 293,210 |  | Nov 06 04:15 PM |  |